Lediga jobb som Biomedicinare i Göteborg

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. The Institute is composed of the following four departments:


• The Department of Infectious Diseases
• The Department of Microbiology and Immunology
• The Department of Medical Biochemistry and Cell Biology
• The Department of Laboratory Medicine

At present, the institute has about 340 employees and approximately 450 million SEK in total assets.

The Sahlgrenska Academy, Department of Biomedical and Clinical Sciences, Division of Medical Chemistry and Cell Biology, Mitochondrial Genome Maintenance and Expression Group is recruiting a researcher for a temporary position. The group currently consists of approximately 15 researchers, including 4 PhD students and 2 principal investigators.

Duties 
In this project, the candidate will investigate the biochemical and cell biological mechanisms that regulate mitochondrial DNA replication. The focus is on understanding how the involved proteins interact and how disease-causing mutations affect replication efficiency and genome stability. The work includes a combination of in vitro biochemical assays and cell-based methods. More information about the research group and our work is available at www.falkenberglab.org.

Qualifications 
PhD in a relevant subject area. The applicant should have experience conducting research at an internationally competitive level in mitochondrial biology. Research experience will be assessed based on scientific publications. In-depth knowledge and extensive experience in mitochondrial DNA replication and gene expression is required, as well as documented expertise in protein chemistry and cell biology methods. The working language in the laboratory is English, and excellent proficiency in both spoken and written English is an absolute requirement.

Employment 
The position is a temporary appointment (80%) until August 31, 2026, or until the regular position holder is back in service, with placement at the Institute of Biomedicine. Start date as agreed upon. 

Contact information for the post 
If you have questions about the position, you are welcome to contact Professor Maria Falkenberg. Phone: +46 (0)73 230 91 19. Email: [email protected]

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. 

The application should contain proof of completed PhD.

Applications must be received by: 2025-06-05.

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.På institutionen för biomedicin bedrivs forskning och undervisning inom prekliniska och kliniska medicinska ämnen. Institutionen är indelad i följande fyra avdelningar: infektionssjukdomar, mikrobiologi och immunologi, medicinsk kemi och cellbiologi samt laboratoriemedicin. För närvarande har institutionen cirka 340 medarbetare och cirka 450 Mkr i omsättning.

Arbetsuppgifter 
Vi söker dig med spetskompetens i de senaste state-of-the-art-lösningarna inom AI applicerat på patologi. I rollen som forskningsassistent kommer du att jobba med implementeringen och optimeringen av både egna och befintliga AI-lösningar för bildanalys inom patologi. Du kommer att vara involverad i hela utvecklingscykeln, från koncept till implementering.

Arbetsverktyg inkluderar primärt Python och specifika bibliotek som Pytorch, Tensorflow samt OpenSlide. Du förväntas skriva robust och prestandaoptimerad kod som är i linje med de senaste framstegen inom området.

Alla implementerade AI-modeller körs i en containerbaserad miljö vilket kräver konfiguration och optimering för smidig drift och tillgänglighet. Du förväntas driva och optimera AI-modellerna med hjälp av GPUer för att säkerställa hög prestanda och effektiv bearbetning av stora dataset inom patologi.

Kvalifikationer 
Mastersexamen (eller minst 75% avklarade högskolepoäng) inom relevant ämnesområde.

Erfarenhet inom AI utveckling inom patologi

Anställning 
Anställningen är på deltid 20% och tidsbegränsad 11 månader, med placering tills vidare vid Institutionen för Biomedicin. Tillträde sker enligt överenskommelse.  

Kontaktuppgifter för anställningen 
Har du frågor om anställningen är du välkommen att kontakta Docent, Gruppledare: Noora Neittaanmäki, Email: [email protected] Telefon: 0727190367

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Ansökan 
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Ansökan ska vara inkommen senast: 2025-05-16

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Are you looking for the next challenge in your career in the pharmaceutical industry? If you're driven by curiosity and courage, inspired by the possibility of doing things that have never been done before, then you should submit your application of interest for future assignments today!

OM TJÄNSTEN
Our client is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. We are looking for talented and motivated candidates to our client, where you will be a part of a team that makes a positive impact on people's lives.

You will play a pivotal role in various projects, providing your technical and scientific expertise in different possible areas. You will be collaborating with cross-functional teams to deliver high-quality results. The work is independent and the tasks are varied, offering great opportunities for personal learning. As a representative of your field, courage, commitment, determination, and integrity are required. If your passion is science & technology and you want to be part of a team that makes a positive impact on patients’ lives, then there’s no better place to be.

This is a consulting assignment where you will be hired by Academic Work and work on an assignment at our client. This is an expression of interest, and we will only contact candidates based on our client's needs. Upon registration, your details will be saved and can be retrieved in connection with future recruitments.

You are offered
- Work at an attractive company in the pharmaceutical industry
- A unique workplace culture that inspires innovation and collaboration and values new ideas and creativity
- A dedicated consultant manager at Academic Work who supports your development

VI SÖKER DIG SOM
- Completed BSc, MSc or PhD degree in natural/technical sciences or a relevant scientific discipline (e.g., Analytical Chemistry, Biochemistry, Biotechnology or Pharmacy)
- Strong scientific interest and passion in innovation
- Excellent communication skills in English, both oral and written, as you will be working in global teams

It is meritorious if you have
- Previous industrial experience in the pharmaceutical industry, research and development, clinical trials, or manufacturing is valuable. Experience working in a regulated environment is also an advantage.

To be successful, you will need an analytical background combined with excellent communication skills and the ability to engage and collaborate cross-functionally. You are flexible and possess strong teamwork abilities. Attention to detail is crucial, ensuring adherence to written procedures and proper documentation of tasks. You are positive and solution-oriented, enjoying a large network and broad collaboration across various functions. You excel at seeing the big picture and managing both long and short deadlines. Your effective and credible communication skills enable you to handle numerous points of contact and make tough decisions with commitment and integrity.

Our recruitment process

This recruitment process is handled by Academic Work and it is our client’s wish that all questions regarding the position is directed to Academic Work.

This is an expression of interest, and we will only contact candidates based on our client's needs. Upon registration, your details will be saved and can be retrieved in connection with future recruitments.

Our selection process is continuous and the advert may close before the recruitment process is completed if we have moved forward to the next phase. The process includes two tests: one personality test and one cognitive test. The tests are tools to find the right talent for the right position, to enable equality, diversity, and a fair process. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. At present, the institute has about 360 employees and approximately 450 million SEK in total assets.

Subject area 
Single-cell Genomics of Human Development

Subject area description 
The overall goal of this project is to bridge current in vitro models of human embryonic development with the latest progress in developmental hematopoiesis studied in vivo. This will lead to new frameworks for defining the prenatal transformation events leading to childhood cancer.

We harness single-cell genomics, and advanced experimental models to chart the mammalian developmental processes modelled during in vitro stem cell differentiation. Specifically, we are interested in the variety of molecular programmes underlying the emergence of hematopoietic cells at multiple anatomical locations and timepoints in the developing embryo, and into what extent these are reproduced in the dish.

Duties 
The selected candidate will be working in a cross-disciplinary team, and will apply computational biology approaches to analyse high-throughput next generation sequencing data for uncovering novel drivers of mammalian embryonic development. The selected candidate will be expected to contribute to co-supervision of younger colleagues, to manuscript writing and will be expected to present their work regularly at group and department meetings.

Eligibility 
The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg. 

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. 

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area. 

Assessment criteria 
The candidate selection will be based on the cover letter, Curriculum Vitae, interview and contact with references.

Specific selection criteria:

1 – Prior hands-on experience with R and/or Python language, bash shell environment, high performance computing, next-generation sequencing data analysis, and single-cell analysis workflows

2 – Communication and team work skills

3 – Interest and theoretical background in stem cells and developmental biology and hematology

4 – Interest in the development and implementation of novel computational workflows to uncover novel biology.

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.

Employment 
The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed.

Selection process 
How to apply for a position | University of Gothenburg

Contact information 
If you have any questions about the position, please contact Carolina Guibentif, Researcher, +46 702253076, [email protected]

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

The application should contain:

- A cover letter giving a brief description of previous research experience, and a motivation to why you are applying

- A CV including a list of publications

- Contact details of two references

- Proof of completed PhD

Applications must be received by: 2025-05-06

Information for International Applicants 

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: 

https://www.gu.se/en/about-the-university/welcome-services 
https://www.movetogothenburg.com/ 

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Are you an experienced drug discovery scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!



We are now looking for an experienced and motivated individual to join the team as a DMPK Project Leader. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress. Your level of professional experience will be relevant for your initial career level (Associate Principal Scientist or Principal Scientist).



Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into late-stage clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.



What you'll do:
With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area. In the DMPK project lead role you will work collaboratively with project representatives from other disciplines. These may include biology, antibody Discovery/Protein Engineering, medicinal chemistry, safety, clinical pharmacology, and pharmaceutical sciences, where your task is to influence candidate profiling by providing the necessary DMPK support for clinical investigations.



It is your responsibility to ensure delivery of all DMPK related activities. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction.



You will work on projects from candidate selection to Phase 2a. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex drug discovery data.



Main Duties and Responsibilities
* Communicate scientific progresses both externally and internally
* Deliver DMPK input and data to projects within agreed timelines and to the right quality
* Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy
* Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
* Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
* Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
* Prepare clear presentations related to the above for internal governance bodies

Essential requirements:
* PhD or equivalent experience in a relevant field
* Expert in DMPK sciences with profound knowledge of drug discovery and development processes
* Broad experience across different modalities (small molecules & biologics) drug development (PK & Bioanalysis)
* Experience with regulatory submissions for biologics and small molecules
* Good knowledge of all DMPK assays including the use of in silico tools for PK prediction
* Experience in project leadership
* Collaborative mindset
* Team player
* Proactive and good communication skills

Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Work policy:
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until April 30, 2025.

Where can I find out more?

Life at AstraZeneca

This is what we're made of

Relocate to Gothenburg Visa mindre

På Knightec förstår vi att förbättrad livskvalitet för patienter genom att säkra medicintekniska produkter är av yttersta vikt. Som senior konsult har du en central roll i att forma och implementera strategier för våra kunder, med fokus på kvalitet och regulatorisk efterlevnad. Du är rådgivaren, ledaren och experten som gör skillnad i utvecklingen av medicintekniska produkter. Varför detta jobbet är för dig:
Du vill förbättra livskvaliteten för patienter genom säkra och innovativa medicintekniska lösningar.
Du har en vision för hur kvalitet och regulatorisk efterlevnad kan bli en konkurrensfördel för våra kunder.
Du är van vid att ta ledande roller i komplexa projekt, från start-ups till etablerade internationella företag.
Du brinner för att dela med dig av din expertis och fungera som mentor för kollegor, samtidigt som du bidrar till kunders framgång.
Du är inte bara en expert inom Design Control, teknisk dokumentation, Quality Assurance eller regulatoriska krav – du är en strategisk partner som hjälper våra kunder att nå nya höjder.
Du drivs av att skapa långsiktiga affärsrelationer och ser möjligheter att utmana och utveckla både kunder och vår verksamhet.

Dina erfarenheter:
Du är en erfaren ledare inom compliance, med förmågan att både tänka strategiskt och agera operativt. Du har ett öga för detaljer men förstår också helheten. Med ett starkt tekniskt kunnande och en djup förståelse för medicinteknikens regulatoriska landskap, är du redo att kliva in i en roll där du leder och inspirerar. Vidare ser vi gärna att du har:
Ingenjörsexamen i bioteknik, medicinteknik, kemiteknik eller liknande.
Minst 7 års erfarenhet av att arbeta med produktutvecklingskvalitet inom den medicintekniska industrin, inklusive områden som Design Control, CE-märkning, Quality Assurance, Regulatory Affairs eller kvalitetsledningssystem.
Djup kunskap om relevanta standarder och regulatoriska krav såsom MDD/MDR, ISO 13485, ISO 14971, IEC 62304 och GMP.
Erfarenhet av att leda projekt, bygga kundrelationer och bidra till affärsutveckling.
Starka kommunikationsförmågor på svenska och engelska, och en förmåga att navigera komplexa organisationer.

Skapa en karriär att vara stolt över:
Som senior konsult hos oss är du inte bara en del av teamet – du är en nyckelspelare i vår nationella satsning på Medtech Compliance. Genom att driva utbildningar, workshops och strategiska initiativ formar du vår riktning och påverkar både kunder och kollegor på djupet.
Vi erbjuder dig en unik möjlighet att växa professionellt i en organisation där din erfarenhet och dina idéer värdesätts. Genom mentorskap och samarbete med branschens bästa får du chansen att ytterligare fördjupa din kompetens och ta din karriär till nästa nivå.

En spännande resa med Knightec Group
Vi på Knightec går nu samman med vårt systerbolag Semcon och bildar Knightec Group. Tillsammans blir vi den ledande aktören i norra Europa inom produkt- och digital tjänsteutveckling – hur häftigt är inte det? Vårt gemensamma erbjudande blir både bredare och djupare, vilket gör att vi kan ta oss an stora, strategiska kundprojekt på högsta nivå av innovation och komplexitet. För våra medarbetare innebär detta fantastiska möjligheter till kompetensutveckling och karriärvägar. Låter detta som platsen för dig? Häng med oss på denna spännande resa!

Ansökningsprocessen: Skicka gärna in din ansökan med CV och personligt brev. Ansökningsperioden är öppen tills vidare. Visa mindre

Are you a curious and enthusiastic Statistician? Would you like to join us on our journey where your contributions will have a profound impact on R&D using the latest statistical methods? If yes, we have the position for you!



We see you as our new Statistician in our Data Sciences & Quantitative Biology department based at AstraZeneca in Gothenburg, Sweden. The team you will join is built up of statisticians, bioinformaticians, machine learning specialists and image analysts. In this position you will be a part of our Discovery Sciences function that applies deep technical expertise in specialist technologies to support the delivery of targets and molecules to the early AstraZeneca pipeline.



As a dedicated BioPharmaceuticals R&D organisation, we accelerate promising early-stage assets and lifecycle management programmes. From discovery to late-stage development, we always follow and push the boundaries of science. At AstraZeneca, we're also committed to being a Great Place to Work and there is no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.



What you will do:
You will get the opportunity to apply your statistical knowledge to collaborate with researchers in a variety of project teams. To be successful in this you have a problem-solving attitude and a perceptive approach.

We will rely on you to:

*

Identify and deliver solutions for addressing key biological questions by using statistics
*

Apply your knowledge of quality by design and or design of experiments to developing cellular based assays and standardizing screens
*

Build and internalize appropriate algorithms and techniques to answer biological questions
*

Develop and implement statistical learning models
*

Expand knowledge of quantitative biology capabilities across R&D
*

Engage with external collaborators via publications and presentations



Essential requirements:
We believe that your focus is set on solving challenging problems through partnerships. You are a specialist in your field and you know that the best results are achieved by utilizing the strengths of every individual.

*

Excellent interpersonal skills, especially when communicating statistical concepts to non-statisticians
*

Expert in quality by design and or design of experiments
*

Strong understanding of statistical theories and methods in at least two of these areas:
- experimental design,
- linear/nonlinear models,
- Bayesian methods,
- and statistical learning/artificial intelligence
*

Programming experience with tools such as R, Shiny, Julia, Stan or similar.
*

PhD in statistics, mathematics, data science or similar



Desirable requirements:

*

Experience in CMC-related statistical applications, such as assay validation, process development, and quality control
*

Proficiency in JMP or similar software
*

Experience of working in a non-clinical statistics team in an industry setting



The successful candidate has the ability to operate effectively in a multi-disciplinary research environment. You enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.



Why AstraZeneca Gothenburg?
This is an onsite position, placed at our spectacular campus in Gothenburg which is one of AstraZeneca's strategic science centers. The site is home to over 3,000 employees, from 70 different nationalities. The Gothenburg site includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. The site itself is designed with collaboration in mind: from the Coffee Lab to the gym, we have built a series of environments where innovation can happen.



If this sounds like the position and place for you - apply today!

We look forward to receive your application, but no later than April 4, 2025. The interview process will be ongoing, do not hesitate to apply early. For more information about the position please contact the hiring manager Natalie van Zuydam, [email protected]



Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
AstraZeneca R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Are you an experienced drug discovery scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!



We are now looking for an experienced and motivated individual to join the team as a DMPK Project Leader. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress. Your level of professional experience will be relevant for your initial career level (Associate Principal Scientist or Principal Scientist).



Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into late-stage clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.



What you'll do:
With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area. In the DMPK project lead role you will work collaboratively with project representatives from other disciplines. These may include biology, antibody Discovery/Protein Engineering, medicinal chemistry, safety, clinical pharmacology, and pharmaceutical sciences, where your task is to influence candidate profiling by providing the necessary DMPK support for clinical investigations.



It is your responsibility to ensure delivery of all DMPK related activities. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction.



You will work on projects from candidate selection to Phase 2a. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex drug discovery data.



Main Duties and Responsibilities
* Communicate scientific progresses both externally and internally
* Deliver DMPK input and data to projects within agreed timelines and to the right quality
* Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy
* Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
* Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
* Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
* Prepare clear presentations related to the above for internal governance bodies

Essential requirements:
* PhD or equivalent experience in a relevant field
* Expert in DMPK sciences with profound knowledge of drug discovery and development processes
* Broad experience across different modalities (small molecules & biologics) drug development (PK & Bioanalysis)
* Experience with regulatory submissions for biologics and small molecules
* Good knowledge of all DMPK assays including the use of in silico tools for PK prediction
* Experience in project leadership
* Collaborative mindset
* Team player
* Proactive and good communication skills

Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Work policy:
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until March 14, 2025.

Where can I find out more?

Life at AstraZeneca

This is what we're made of

Relocate to Gothenburg Visa mindre

Do you have extensive Drug Metabolism and Pharmacokinetic (DMPK) expertise with a background in medicinal chemistry, pharmacy, pharmaceutical science and/or drug discovery, and would you like to apply your expertise in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for!

We are now seeking an experienced and motivated individual to join the team as a Preclinical DMPK Project Leader (Senior Scientist/Associate Principal Scientist/Principal Scientist, depending on your level of professional experience), preferably with experience across multiple modalities.


At AstraZeneca Respiratory & Immunology, we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

What you'll do:
In the role you would work collaboratively with discovery project representatives from other disciplines including medicinal chemistry, biology, safety and pharmaceutical sciences. You will influence drug design and optimization of ADMET (absorption, distribution, metabolism, excretion, toxicity) properties. Hence, it is your responsibility to ensure delivery of all DMPK related activities, including in vitro ADME, biotransformation, bioanalysis, preclinical PK and PD underpinning human dose prediction to early drug projects from target selection to candidate drug selection. We believe that you have a solid understanding of DMPK and chemistry and that you will be able to provide expert advice and interpretation of complex drug discovery data.

Main Duties and Responsibilities
* Responsible for leading all DMPK related activities, including coordinating and engaging with internal and external DMPK colleagues and collaborators, on project related activities. Deliver DMPK input and data to projects within agreed timelines and to the right quality to ensure that DMPK challenges are thoroughly assessed and resolved.
* Contribute to the design of preclinical in vivo studies to answer crucial project questions.
* Accountable, together with other functions such as Medicinal Chemistry, Bioscience and Safety, for compound design and effective cross-discipline optimization. Apply an understanding of DMPK and PKPD to support/influence project progression and strategy as well as providing the framework for human dose predictions.
* Prepare clear presentations related to the above for internal governance interactions

Essential requirements:
* PhD in Medicinal, Organic or Physical Chemistry or bio-pharmaceutics/pharmacokinetics or equivalent experience in a relevant field
* Formal training or proven experience of working with pharmacokinetics and drug metabolism and a good understanding of pharmacodynamics
* Understanding of correlations between physicochemical characteristics and their influence on DMPK properties and subsequent design of new compounds
* Have (at least) basic PK modelling skills, experience of human dose and PK prediction as well as understanding of disease biology and linking to PKPD understanding
* Extensive experience (5+ years) of working in preclinical DMPK
* Experience from drug discovery, cross-functional working and compound/project progression
* Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery
* Strong communication skills



Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development



What's next?
This is an exciting opportunity for a talented DMPK scientist to join a strong, dynamic team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the beautiful city of Gothenburg, Sweden. If you are ready to make a difference - apply today and together we will make it happen! We welcome your application until March 14, 2025.


Find Out More:

Life at AstraZeneca

This is what we're made of

Relocate to Gothenburg Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.På institutionen för biomedicin bedrivs forskning och undervisning inom prekliniska och kliniska medicinska ämnen. Institutionen är indelad i följande fyra avdelningar: infektionssjukdomar, mikrobiologi och immunologi, medicinsk kemi och cellbiologi samt laboratoriemedicin. För närvarande har institutionen cirka 340 medarbetare och cirka 450 Mkr i omsättning.

Vårt lab arbetar med hjärtinfarktsmarkören troponin som visat sig frisättas från hjärtat även då man inte har hjärtinfarkt. Denna frisättning ökar vid hög ålder och vid njur- och hjärtsjukdom och orsakar problem då man vill utesluta hjärtinfarkt på akuten.  Vi vill ta reda på hur troponin frisätts från levande hjärtceller. Vi utvecklar även metoder att avslöja analytisk interferens. 

Arbetsuppgifter 
Odla hjärtceller. Analysera troponin och andra biomarkörer i blod och odlingsmedium på kliniskt lab. Utföra histologisk undersökning av hjärtvävnad. Skriva manuskript. Utveckla metod att avslöja antikroppsmedierad analytisk interferens. 

Kvalifikationer 
Doktorsexamen inom relevant område. Visat prov på självtändigt arbete i lab och förmåga att själv lösa uppgifter med viss handledning. Ha god kunskap om hjärtinfarktsmakörer och hur de analyseras. Kunna immunhistokemi och dokumenterad erfarenhet av hjärthistologi är meriterande. Dokumenterad erfarenhet att odla och differentiera iPS celler till hjärtceller. 

Anställning 
Anställningen är på heltid och tidsbegränsad 4 månader, med placering tills vidare på institutionen för biomedicin. Tillträde sker enligt överenskommelse.  

Kontaktuppgifter för anställningen 
Har du frågor om anställningen är du välkommen att kontakta Ola Hammarsten, Professor. E-post: [email protected] 

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Ansökan 
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Ansökan ska vara inkommen senast: 2025-01-31

Ansökan ska innehålla kopia på doktorsexamen.

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

På Knightec förstår vi att förbättrad livskvalitet för patienter genom att säkra medicintekniska produkter är av yttersta vikt. Genom att balansera kvalitet och regulatorisk efterlevnad under produktutvecklingsprocessen, spelar du en avgörande roll i att introducera ny teknik och effektivare medicinteknisk utrustning till marknaden.
Varför detta jobbet är för dig:
Du vill förbättra livskvaliteten för patienter genom säkra medicintekniska produkter
Du strävar efter att hitta rätt balans mellan kvalitet och regulatorisk efterlevnad under produktutvecklingsprocessen
Du vill vara en viktig del av att introducera ny teknik och mer effektiv medicinteknisk utrustning till marknaden
Du vill använda hela din kompetens i varierande projekt, från start-ups till väletablerade internationella företag
Du har erfarenhet inom Design Control, teknisk dokumentation, Quality Assurance eller regulatoriska krav och vill ta stort ansvar i dina uppdrag
Du värdesätter att arbeta i en miljö präglad av tillit, transparens och samarbete



Dina erfarenheter:
Dina viktigaste egenskaper är din vilja att lära och dela din kunskap med andra. Då vår ambition är att hjälpa våra kunder ta nästa steg in i framtiden genom digitala verktyg, ser vi att du har intresse för ny teknik och digitalisering. Extra intressant är det om du har erfarenhet eller intresse för att arbeta med kvalitetssäkring av mjukvara eller uppkopplad utrustning.
Du har även:
Ingenjörsexamen i bioteknik, medicinteknik, kemiteknik eller liknande
Minst 3 års erfarenhet av att ha arbetat med produktutvecklingskvalitet inom den medicintekniska industrin, exempelvis Design Control, CE-märkning, Quality Assurance, Regulatory Affairs eller kvalitetsledningssystem
God kunskap om relevanta regulatoriska krav och standarder som MDD/MDR, ISO 13485, ISO 14971, IEC 62304 och GMP
Utmärkta kommunikationsförmågor på svenska och engelska



Skapa en karriär att vara stolt över:
Som senior konsult hos oss är du inte bara en del av teamet – du är en nyckelspelare i vår nationella satsning på Medtech Compliance. Genom att driva utbildningar, workshops och strategiska initiativ formar du vår riktning och påverkar både kunder och kollegor på djupet.
Vi erbjuder dig en unik möjlighet att växa professionellt i en organisation där din erfarenhet och dina idéer värdesätts. Genom mentorskap och samarbete med branschens bästa får du chansen att ytterligare fördjupa din kompetens och ta din karriär till nästa nivå.

En spännande resa med Knightec Group
Vi på Knightec går nu samman med vårt systerbolag Semcon och bildar Knightec Group. Tillsammans blir vi den ledande aktören i norra Europa inom produkt- och digital tjänsteutveckling – hur häftigt är inte det? Vårt gemensamma erbjudande blir både bredare och djupare, vilket gör att vi kan ta oss an stora, strategiska kundprojekt på högsta nivå av innovation och komplexitet. För våra medarbetare innebär detta fantastiska möjligheter till kompetensutveckling och karriärvägar. Låter detta som platsen för dig? Häng med oss på denna spännande resa!

Ansökningsprocessen: Skicka gärna in din ansökan med CV och personligt brev. Ansökningsperioden är öppen tills vidare. Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.På institutionen för biomedicin bedrivs forskning och undervisning inom prekliniska och kliniska medicinska ämnen. Institutionen är indelad i följande fyra avdelningar: infektionssjukdomar, mikrobiologi och immunologi, medicinsk kemi och cellbiologi samt laboratoriemedicin. För närvarande har institutionen cirka 340 medarbetare och cirka 450 Mkr i omsättning. 

Arbetsuppgifter 
Vi söker dig med spetskompetens i de senaste state-of-the-art-lösningarna inom AI applicerat på patologi. I rollen som forskningsassistent kommer du att jobba med implementeringen och optimeringen av både egna och befintliga AI-lösningar för bildanalys inom patologi. Du kommer att vara involverad i hela utvecklingscykeln, från koncept till implementering.

Arbetsverktyg inkluderar primärt Python och specifika bibliotek som Pytorch, Tensorflow samt OpenSlide. Du förväntas skriva robust och prestandaoptimerad kod som är i linje med de senaste framstegen inom området.

Alla implementerade AI-modeller körs i en containerbaserad miljö vilket kräver konfiguration och optimering för smidig drift och tillgänglighet. Du förväntas driva och optimera AI-modellerna med hjälp av GPUer för att säkerställa hög prestanda och effektiv bearbetning av stora dataset inom patologi.

Kvalifikationer 
Mastersexamen (eller minst 75% avklarade högskolepoäng) inom relevant ämnesområde (komplexa adaptiva system).

Erfarenhet inom AI utveckling inom patologi, med speciell inriktning mot hud

Anställning 
Anställningen är tidsbegränsad 11 månder, omfattning 20%, med placering tills vidare vid institutionen för biomedicine. Tillträde enligt överenskommelse. 

Kontaktuppgifter för anställningen 
Har du frågor om anställningen är du välkommen att kontakta docent, gruppledare Noora Neittaanmäki. E-mail: [email protected] Telefon: 0727190367 

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande  

Ansökan 
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Ansökan ska vara inkommen senast: 2024-12-11 

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. The Institute is composed of the following four departments:


• The Department of Infectious Diseases
• The Department of Microbiology and Immunology
• The Department of Medical Biochemistry and Cell Biology
• The Department of Laboratory Medicine

At present, the institute has about 340 employees and approximately 450 million SEK in total assets.

Sahlgrenska Academy, Institute of Biomedicine, Department Medical Biochemistry and Cell Biology, Mucin Biology Groups is recruiting a researcher for a temporary position. The Mucin Biology research groups currently comprises around 25 researchers with 9 PIs, see also www.medkem.gu.se/mucinbiology/

 

Duties 
The small intestine has a complex protection system based on two different types of mucins. This project deals specifically with transmembrane mucins and their function in normal and diseased intestine, especially Crohn's disease. The project uses mouse models with a similar chronic disease. The project includes several sub-projects. Own independent research, compilation of results, and publication.

 

Qualifications 
A PhD degree in a relevant field. Certificate for animal experiment in Sweden. Must be Docent. Shall have experience of research at an internationally leading position on transmembrane mucins. Research experience is evaluated on publications. Knowledge and extensive experience in mucin biology research is a requirement. The laboratory uses English as the main language of communication and proficient in spoken and written English is essential.

 

Employment 
The employment is part time 80%, temporary and limited to 2025-08-31 with placement at the Institute of Biomedicine. First day of employment as agreed.

 

Contact information for the post 
If you have any questions about the position, please contact Professor Gunnar C. Hansson. Phone: +31-786 3488, +709 490005. E-mail: [email protected]

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

 

Application 
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. 

The application should contain proof of completed PhD.

Applications must be received by: 2024-12-03

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Do you have extensive Drug Metabolism and Pharmacokinetic (DMPK) expertise with a background in medicinal chemistry, pharmacy, pharmaceutical science and/or drug discovery, and would you like to apply your expertise in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now recruiting a highly skilled and passionate scientist with expertise in DMPK to join the team as a Preclinical (DMPK) Project Lead, preferably with experience across multiple modalities, to join the Drug Metabolism and Pharmacokinetics (DMPK) team of project leads within the Early Respiratory and Immunology (R&I) therapeutic area at AstraZeneca in Gothenburg, Sweden.

At AstraZeneca Respiratory & Immunology, we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

This position will be on-site in Gothenburg, Sweden and will not have the ability to be located remotely. The position can be filled at Senior Scientist, Associate Principal Scientist or Principal Scientist level, depending on background, experience and skills.

What you'll do?
In the role you would work collaboratively with discovery project representatives from other disciplines including medicinal chemistry, biology, safety and pharmaceutical sciences. You will influence drug design and optimization of ADMET (absorption, distribution, metabolism, excretion, toxicity) properties. Hence, it is your responsibility to ensure delivery of all DMPK related activities, including in vitro ADME, biotransformation, bioanalysis, preclinical PK and PD underpinning human dose prediction to early drug projects from target selection to candidate drug selection. We believe that you have a solid understanding of DMPK and chemistry and that you will be able to provide expert advice and interpretation of complex drug discovery data.

Main Duties and Responsibilities will include:
* Responsible for leading all DMPK related activities, including coordinating and engaging with internal and external DMPK colleagues and collaborators, on project related activities. Deliver DMPK input and data to projects within agreed timelines and to the right quality to ensure that DMPK challenges are thoroughly assessed and resolved.
* Contribute to the design of preclinical in vivo studies to answer crucial project questions.
* Accountable, together with other functions such as Medicinal Chemistry, Bioscience and Safety, for compound design and effective cross-discipline optimization. Apply an understanding of DMPK and PKPD to support/influence project progression and strategy as well as providing the framework for human dose predictions.
* Inform and influence the design of preclinical PK and PKPD studies to answer relevant pharmacological questions and contribute to estimation of safety margins
* Report results and interpretations to project teams and communicate scientific progress to internal and external stakeholders.



Essential requirements for the role:
* PhD in Medicinal, Organic or Physical Chemistry or biopharmaceutics/pharmacokinetics or equivalent experience in a relevant field, and at least 5 years' experience of working in DMPK science.
* Comprehensive understanding and proven experience of working within DMPK/ADME and excellent knowledge in ADME/Enzymology/Drug Transporters, and a solid understanding of pharmacodynamics (PD)
* Wide understanding of correlations between physicochemical characteristics and their influence on DMPK properties and subsequent design of new compounds.
* Have (at least) basic PK modelling skills, experience of human dose and PK prediction as well as understanding of disease biology and linking to PKPD understanding.
* Experience from drug discovery, working in cross-functional project teams with compound/project progression.
* A proactive and collaborative mindset and excellent communication skills.
* Ability to engage and collaborate across boundaries with a problem-solving attitude and focus on delivery.
* Strong communication skills and proven scientific leadership with the ability to mentor junior colleagues.

What's next?
This is an exciting opportunity for a talented DMPK scientist to join a strong, dynamic team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the beautiful city of Gothenburg, Sweden. If you are ready to make a difference - apply today and together we will make it happen!

We welcome your application until 29 November, 2024. For more information about the position, please contact recruiting manager Nina Lawrence at [email protected]

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Visa mindre

Are you a highly motivated scientist who would like to dedicate your passion for science and your capabilities to discovering novel therapies for patients? We have an opening to join us as a Research Scientist in the Assays, Profiling & Cell Sciences department within the Discovery Sciences organization in Gothenburg, Sweden. You will have the opportunity to apply proven molecular biology and cell biology expertise to contribute to the discovery and development of therapeutic oligonucleotides, such as antisense oligonucleotides (ASOs) and small interfering RNA (siRNA), and their Targeted Delivery to relevant tissue, in a highly collaborative environment.

The successful candidate demonstrates a passion for delivery to team objectives, combined with strong team working ethics, and thrives from working in drug discovery projects. You will join a team whose remit is to support our drug discovery projects globally with early DMPK assessment, SAR profiling and in-depth mechanism of action data. We offer a highly rewarding scientific environment with ample learning opportunities.

You will be strongly encouraged and supported to think creatively in our dynamic environment. Here, we are free from fear of failure, free to ask the right questions and make bold decisions.


What you will do:
This is a lab-based role focused on generating in vitro data on therapeutic oligonucleotides in support of drug discovery projects. The work includes independent troubleshooting and timely reporting of data according to agreed timelines. All work is conducted in dialog with project teams, where you are expected to present and contribute in advancing the project science, specifically in support of the Cardiovascular, Renal and Metabolism as well as Respiratory & Immunology disease area organizations.

For this role, we seek a candidate with experience in the development and/or application of assays for quantitative measurements of RNA transcripts. The candidate will reinforce our team for discovery and development of therapeutic oligonucleotides (naked and conjugated oligos).


Essential for the role:

*

MSc or PhD degree in Biology or related Science.

*

1 to 3 years of additional experience in Biotech/Pharma.

*

Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment.

*

Knowledge of oligonucleotide modalities.

*

Experience in the development and/or application of assays for quantitative measurements of RNA transcripts.

*

Independent analysis and evaluation of complex data and delivery of data to agreed timelines.





Desirable for the role:

*

Previous experience working with siRNA or ASO.

*

Experience with imaging assays to localise and quantify protein levels.

*

Good understanding of precision delivery of active compound to relevant tissue.

*

Previous experience working with various cell types including primary cells and iPSCs.





Why AstraZeneca in Gothenburg?
You can ask anybody who has ever set foot here - our Gothenburg site has a vibrant culture that pulls you in! It is a mix of both local and international talent. We welcome the contribution of people from all backgrounds, beliefs and walks of life.

So, what's next? If this sounds like your next challenge - please apply today!

We look forward to your application, but please send it to us no later than October 9, 2024.

For more information about the positions please contact hiring manager David Gilot at +46 72 206 97 40 or [email protected]. Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Vid Institutionen för neurovetenskap och fysiologi vid Sahlgrenska akademin bedrivs omfattande forskning och undervisning över stora kunskapsområden - från molekyl till människa. Verksamheten utgörs av fem sektioner; farmakologi, fysiologi, hälsa och rehabilitering, klinisk neurovetenskap samt psykiatri och neurokemi.

Institutionen för neurovetenskap och fysiologi, söker nu en biträdande forskare, med placering vid Sektionen för klinisk neurovetenskap.

Forskargruppen ”klinisk hjärntumörforskning” är baserad vid Institutionen för neurovetenskap och fysiologi och leds av Asgeir Jakola. Gruppen består av doktorander, forskande kliniker, forskningssjuksköterskor, en forskningsassistent och studenter. Vi arbetar med frågor kring patienter med hjärntumörer och i huvudsak med studier som har klinisk inriktning. Gruppen har flera nationella och internationella samarbeten.

Arbetsuppgifter

Som biträdande forskare är du delaktig i hantering av kliniska databaser, och i vävnadshantering i studier där syftet är att identifiera biomarkörer för att bättre prognostisera eller ge stöd för skräddarsydd behandling av vuxna patienter med hjärntumörer.

Histologiska och immunohistokemiska analyser av humana vävnader ingår, särskilt paraffininbäddat material. I dina arbetsuppgifter ingår att ha hand om frysta prover, DNA/RNA extraktion, snittning, provhämtning från operation, immunofärgning som även inkluderar multiplexfärgningar samt bedömning av histologiska och immunohistokemiska humana analyser. I hantering av kliniska databaser krävs också grundläggande kunskaper inom medicinsk statistik. Inom arbetet finns även möjlighet att bedriva självständiga forskningsprojekt. Arbetet kräver en god förmåga att uttrycka sig på engelska och svenska i tal såväl som skrift.

Kvalifikationer

Krav om utbildning inom molekylärbiologi/biomedicin/bioteknik, biomedicinsk analytikerutbildning, laboratorieingenjör eller motsvarande. Examen på lägst master/magister eller motsvarande.

Det är meriterande med erfarenhet av cellbiologiska och molekylärbiologiska metoder, särskilt immunohistokemi av TMA, multiplexfärgning, DNA och RNA extraktion. Meriterande är också om du har publicerat vetenskaplig arbete och har dokumenterade kunskaper inom medicisk statistik.

Det är lämpligt om du har erfarenhet av forskningsprojekt och arbete i större forskningsgrupper. Detta för att rollen kräver att du har förmåga arbeta självständigt, men också att du samarbetar med andra på ett bra sätt.

Det är vidare lämpligt om du är noggrann och tar ansvar för att leverera ett arbete med god kvalitet och i tid. Vi lägger stor vikt vid personlig lämplighet. 

Anställning

Anställningen är en tillsvidareanställning, 100% av heltid, med placering tills vidare vid Institutionen för neurovetenskap och fysiologi. Tillträde: snarast eller enligt överenskommelse. Provanställning kan komma att tillämpas. 

Tillsättningsförfarande

Du söker anställningen via Göteborgs universitets rekryteringsportal.

Kontaktuppgifter för anställningen

Har du frågor om anställningen är du välkommen att kontakta professor/biträdande sektionschef Asgeir Jakola, tfn: 031 342 97 41, epost: [email protected]

Ansvarig chef är professor/sektionschef Katharina Stibrant Sunnerhagen, tfn: 0709 52 00 23, e-post: [email protected]

Ansökningshandlingar skickas inte till kontaktpersonerna.

Fackliga organisationer

Fackliga företrädare vid Göteborgs universitet hittar du här: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Ansökan

Du söker anställningen via Göteborgs universitets rekryteringsportal genom att registrera din ansökan elektroniskt via hemsidan: https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar

Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag.

Ansökan ska vara inkommen senast: 2024-10-21

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Are you a curious Scientist who wants to join a team working with outstanding science that have a direct impact for patients? Do you also want to contribute to our larger purpose with great colleagues by your side working in a collaborative, global environment? If yes, welcome to join AstraZeneca!



We are now looking for a Translational Scientist to join our Precision Medicine Discovery and Development team. This role is based at our site in Gothenburg, Sweden.

The Early Respiratory and Immunology (Early R&I) Translational Science and Experimental Medicine (TSEM) department is a fast-paced environment, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and to close the gap between bench science and bedside clinical practice.



A key role of Precision Medicine Discovery and Development is to lead the development of precision medicine in immunological and respiratory diseases, driving patient stratification and delivering translational clinical validation, underpinned by the understanding of disease relevant pathways and drivers.



What you'll do?
The Translational Scientist is accountable as member of the Translational Science team for the development and optimisation of molecular biology techniques and biomarker assays to enable precision medicine and target validation strategies. Continuous collaboration with Translational Science Leads, Bioscience, and Biomarker Discovery colleagues will be essential to qualify relevant experimental techniques, disease models and biomarkers according to projects requirements. This is a laboratory role, requiring flexibility to ensure all experimental aspects of the projects are supported according to timelines.



This is a key scientific laboratory role, where you will be focusing on:



* Enabling precision medicine strategies to select the patients most likely to benefit from our medicines by developing biomarker assays and analysing biomarkers in experimental medicine cohorts
* Building mechanistic understanding of targets and diseases through setting up and execution of novel molecular biology techniques
* Establishing and using advanced human disease models to deliver human target validation data and early target engagement assessments
* Identifying Proof of Mechanism (PoM) biomarkers to demonstrate target engagement in clinical studies

Essential for the role:
* Bachelor's degree with a strong experimental drive and background in relevant scientific field
* Experience in a pharmaceutical or biotechnology industry setting
* Broad understanding of relevant technologies and methodologies along with excellent laboratory skills and ability to experimentally address key scientific questions
* Experience in setting up novel molecular biology techniques
* Experience in working with human biological samples
* Understanding of the Immunology and/ or Respiratory therapy area and disease biology, including related molecular pathways and mechanisms
* Skilled in hypothesis forming and testing
* Skilled in data analysis, interpretation and archiving
* Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects
* Proven written, oral, presentation and interpersonal skills



Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we're proud to have an outstanding workplace culture that encourages innovation, entrepreneurship, and collaboration through scientific research. Employees are empowered to express diverse perspectives and are made to feel valued, energised and rewarded for their ideas and creativity.



What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! Visa mindre

Are you a quantitatively-minded scientist looking to apply bioinformatics and machine learning to design oligonucleotides for therapeutic use? At AstraZeneca, we turn ideas into life changing medicines. Working here means thinking big and working together to deliver impact from our contributions that make the impossible a reality.


We have an exciting opportunity to join our Data Sciences and Quantitative Biology team that works as part of the Discovery Sciences organisation, within BioPharma R&D and contribute as a Senior Bioinformatician for Oligonucleotide Therapeutics. This position will be based at our vibrant R&D site in Gothenburg, Sweden.

Discovery Sciences work with all AstraZeneca therapy areas to deliver candidate drugs into late-stage clinical development. The Data Sciences and Quantitative Biology team is a multi-disciplinary team of data scientists with the purpose of providing quantitative insights to biology. In partnership with our experimentalist colleagues, we provide computational analysis and solutions to enable and drive our drug discovery efforts forward.

What you will do
As Senior Bioinformatician for Oligonucleotide therapeutics, you'll be using bioinformatics and machine learning to identify and deliver oligonucleotide sequence designs. You will be responsible for developing and internalizing appropriate algorithms, techniques and datasets to advance our ability to rapidly discover oligonucleotide candidate drugs.

You will also enhance our data analysis capabilities on complex, high-dimensional omics data to identify biologically induced effects of oligonucleotides. Further you will be contributing to and leading local and global projects for NGS applied in oligonucleotide projects and ensuring that results are scientifically robust and documented.


Essential for the role

*

PhD, or equivalent, in bioinformatics, mathematics, computer science, statistics, engineering or the life sciences
*

Expertise and experience in therapeutic oligonucleotide sequence design and analysis
*

Expertise in one or more of the competency areas: DNA/RNA sequence analysis, next generation sequencing analysis, multivariate and/or high dimensional omics data analysis
*

Experience with relevant software tools such as R and/or Python
*

Proficiency in working in a Linux environment, experience with shell scripting and standard command line tools
*

Understanding of molecular biology, cell biology, and human physiology, ontologies, data management, machine learning, statistical modelling
*

Experience with tools for reproducible research such as git, conda, Snakemake or Nextflow
*

Excellent English, spoken and in writing



To be successful, we expect you to demonstrate a passion for driving scientific questions and being capable of receiving and analysing input from multiple fields and deciding on focused course of action. You have a consistent track record of delivering analytical solutions for business or academic needs. You are able to work independently and have a positive, result-oriented and problem-solving attitude. We also believe that you enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.


Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity


So, what's next!
Does this sound like your next position? Apply now!

We will continuously review applications and look forward to your application no later than August 11, 2024.

For more information about the position please contact hiring manager Fredrik Karlsson at [email protected]


Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Visa mindre

AstraZeneca is a global, science-led biopharmaceutical business whose innovative medicines are used by millions of patients worldwide. We are committed to making a meaningful difference to patient health through great medicines that bring benefit for patients and add value for our stakeholders and society.



We are seeking an experienced Automation Software Engineer / Application Specialist to join our multidisciplinary Chemistry Automation team at the AstraZeneca site in Gothenburg, Sweden. With your expertise and skills, you will play a vital role in advancing our automated compound synthesis platform. The ideal candidate will have a strong background in working with hard- and/or software of laboratory automation technologies used in pharmaceutical research, a good understanding of the scientific disciplines needed in drug discovery and a proven record of successfully implementing, operating, and troubleshooting automation software.



What you will do

You will join and support the Chemistry Automation team (iLAB) within the Compound Synthesis & Management department which overall is focusing on making and processing chemical compounds using innovative science and technology that accelerates the discovery of novel medicines to impact patients' lives. The department has no less ambition than to be a pioneer and industry leader in the application of laboratory automation technologies for both the synthesis of chemical compounds and their subsequent processing into the drug discovery workflow. In this team you will be able to use your experience and skills to ensure that Chemistry Automation in combination with AI will contribute significantly to the aimed accelerated discovery of novel medicines.



Key responsibilities:

*

Collaborate in a multidisciplinary team of synthetic and analytical chemists, automation engineers, and software developers, to create a world-leading autonomous chemical synthesis laboratory.
*

Work with automation workcell software and equipment to design and implement complex device integrations, as well as troubleshoot and optimize existing automation protocols in chemical drug discovery.
*

Evaluate and carry out critical analysis of new software and other tools or technologies, to improve the quality and efficiency of automated laboratory processes.
*

Travel to external partners to participate in regular update meetings and factory acceptance tests.



Required qualifications

*

Degree in a science or engineering field with minimum of 3 years of experience in developing software for automated laboratories in a life sciences field.

*

Highly proficient in C# or other programming languages and frameworks (e.g .NET, Python, Java etc.)
*

Experience of integrating software with laboratory instruments, robots, or automation workcells.
*

Excellent communication skills to be able to both convey complex technical descripts to non-experts and understand vice-versa.



Beneficial qualifications

*

Knowledge of object-oriented programming; software architecture and design patterns, including cloud-based platforms.
*

Experience with programming standards or paradigms such as RestFUL APIs, SOAP, OPC UA, JSON, XML, etc.
*

Experience with scheduling, orchestrator, or LIMS software (e.g., HighRes Cellario, Biosero Green Button Go, Titian Mosaic, Thermo Fisher SampleManager, etc.).
*

Knowledge of the pharmaceutical industry and drug discovery process.



Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we can grow our pipeline and positively impact the lives of billions of patients worldwide. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.


So, what is next? If this sounds like the job and place for you - apply today!

You are welcome with your application but send it to us no later than August 8, 2024.

For more information about the position please contact Dr Michael Kossenjans, Director Chemistry and Head of AZ Chemistry Automation at [email protected].

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Are you a curious Scientist who wants to join a team working with outstanding science that have a direct impact for patients? Do you also want to contribute to our larger purpose with great colleagues by your side working in a collaborative, global environment? If yes, welcome to join AstraZeneca!



We are now looking for a Translational Scientist to join our Precision Medicine Discovery and Development team. This role is based at our site in Gothenburg, Sweden.

The Early Respiratory and Immunology (Early R&I) Translational Science and Experimental Medicine (TSEM) department is a fast-paced environment, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and to close the gap between bench science and bedside clinical practice.



A key role of Precision Medicine Discovery and Development is to lead the development of precision medicine in immunological and respiratory diseases, driving patient stratification and delivering translational clinical validation, underpinned by the understanding of disease relevant pathways and drivers.



What you'll do?
The Translational Scientist is accountable as member of the Translational Science team for the development and optimisation of molecular biology techniques and biomarker assays to enable precision medicine and target validation strategies. Continuous collaboration with Translational Science Leads, Bioscience, and Biomarker Discovery colleagues will be essential to qualify relevant experimental techniques, disease models and biomarkers according to projects requirements. This is a laboratory role, requiring flexibility to ensure all experimental aspects of the projects are supported according to timelines.



This is a key scientific laboratory role, where you will be focusing on:



* Enabling precision medicine strategies to select the patients most likely to benefit from our medicines by developing biomarker assays and analysing biomarkers in experimental medicine cohorts
* Building mechanistic understanding of targets and diseases through setting up and execution of novel molecular biology techniques
* Establishing and using advanced human disease models to deliver human target validation data and early target engagement assessments
* Identifying Proof of Mechanism (PoM) biomarkers to demonstrate target engagement in clinical studies

Essential for the role:
* Bachelor's degree with a strong experimental drive and background in relevant scientific field
* Experience in a pharmaceutical or biotechnology industry setting
* Broad understanding of relevant technologies and methodologies along with excellent laboratory skills and ability to experimentally address key scientific questions
* Experience in setting up novel molecular biology techniques
* Experience in working with human biological samples
* Understanding of the Immunology and/ or Respiratory therapy area and disease biology, including related molecular pathways and mechanisms
* Skilled in hypothesis forming and testing
* Skilled in data analysis, interpretation and archiving
* Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects
* Proven written, oral, presentation and interpersonal skills



Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we're proud to have an outstanding workplace culture that encourages innovation, entrepreneurship, and collaboration through scientific research. Employees are empowered to express diverse perspectives and are made to feel valued, energised and rewarded for their ideas and creativity.



What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application (including CV and cover letter), no later than June 19, 2024. Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Vid Institutionen för neurovetenskap och fysiologi vid Sahlgrenska akademin bedrivs omfattande forskning och undervisning över stora kunskapsområden - från molekyl till människa. Verksamheten utgörs av fem sektioner; farmakologi, fysiologi, hälsa och rehabilitering, klinisk neurovetenskap samt psykiatri och neurokemi.

Institutionen för neurovetenskap och fysiologi, söker nu en forskningsassistent, med placering vid Sektionen för fysiologi. 

Du kommer att undersöka de molekylära mekanismerna bakom typ 2-diabetes med det långsiktiga målet att finna nya antidiabetiska läkemedel.

Arbetsuppgifter

Du kommer använda en rad cellfysiologiska och cellbiologiska tekniker samt qPCR och transfektionssystem. Utöver de fysiologiska studierna kommer du arbeta nära experter inom RNA-sekvensering för att studera de associerade genexpressionsförändringarna. Möjligheten att koppla singelcellgenuttryck med funktionella data är ett spännande område som inte har utforskats till sin fulla potential, vilket ger en möjlighet att göra en verklig skillnad för framtida medicinsk forskning.

Kvalifikationer

Läkarexamen eller examen från biomedicinsk utbildning är ett krav. Tidigare erfarenhet inom experimentell diabetesforskning är meriterande. God kommunikationsförmåga på engelska i både tal och skrift är ett krav. Vi värdesätter att du är ansvarstagande och kan arbeta självständigt samt har en organisatorisk förmåga. Vi lägger stor vikt vid personlig lämplighet. 

Anställning

Anställningen är en tidsbegränsad anställning i 5 månader, 100% av heltid, med placering tills vidare vid Institutionen för neurovetenskap och fysiologi. Tillträde: snarast eller enligt överenskommelse. 

Kontaktuppgifter för anställningen

Har du frågor om anställningen är du välkommen att kontakta professor Anders Rosengren, tfn: 031 786 10 00, e-post: [email protected]

Ansvarig chef är universitetslektor/sektionschef Lars-Gunnar Pettersson, tfn: 031 786 35 07, e-post: [email protected]

Ansökningshandlingar skickas inte till kontaktpersonerna.

Fackliga organisationer

Fackliga företrädare vid Göteborgs universitet hittar du här: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Ansökan

Du söker anställningen via Göteborgs universitets rekryteringsportal genom att registrera din ansökan elektroniskt via hemsidan: https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar 

Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag.

Ansökan ska vara inkommen senast: 2024-06-14

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

AstraZeneca Biopharmaceuticals Medical (BPM) ensures the best patient outcomes by providing healthcare decision-makers around the world with the evidence and confidence they need on AstraZeneca's therapies and support our internal stakeholders with medical insight and expertise. BPM aims to lead AstraZeneca in achieving scientific leadership, being a great place to work, and keeping patients at the core of everything we do.

Epidemiologists at AstraZeneca are integral throughout the lifecycle of a drug, from drug discovery and development to commercialization of pharmaceuticals. Major activities include design, initiation, management, conduct, analysis, and reporting of epidemiological studies, including observational and interventional studies as well as critical appraisal of relevant epidemiological literature and development of medical evidence plans to fill critical knowledge gaps.

We are now looking for an Epidemiologist to join our team working in Cardiovascular, Renal and Metabolism (CVRM) Evidence Strategy at any of our vibrant sites in Gothenburg, Sweden or Gaithersburg, US.



What You'll do

The role is both strategic as well as scientific and involves shaping and executing evidence plans aligned with global strategy. As you will act as the scientific study leader, in the design, execution, analysis, interpretation, and communication of assigned studies, you will benefit of good experience of applying research methodologies and with focus on epidemiology and observational research studies. The role also includes engagement in other activities, such as active contribution to the development of strategic evidence plans and scientific leadership to other study teams and the functional team. The role requires collaboration with diverse internal and external stakeholder groups to ensure delivery of scientifically rigorous, timely, and impactful evidence. In the role, you consult with more senior staff as necessary to provide specialist guidance and direction to project teams, senior leaders, and other colleagues to ensure optimal management of high-impact project opportunities and risks.



When working on evidence strategy and observational research at AstraZeneca, you are also expected to promote good research practices and represent AstraZeneca' position when interacting with external experts, collaborative groups, and contract research organizations; and maintain functional skill set by keeping up to date on epidemiological advances.



Essential for the role

*

Ph.D. or equivalent in epidemiology or related health science field and experience in the health care environment. Alternatively, an MSc or MPH with substantial experience in the health care environment or equivalent
*

5 years of experience in the pharmaceutical industry or in closely related epidemiological research
*

Excellent knowledge in epidemiological methodology and ability to apply it within the pharmaceutical industry at an international level

*

Experience in utilizing secondary data and conducting primary data collection studies
*

Experience managing complex strategic medical evidence plans
*

Sustained productivity in epidemiological research as manifested by successful design, execution, and publication of original epidemiological research relevant to drug discovery and development (e.g., drug safety) or commercialization, in peer-reviewed journals
*

Emerging recognition by the external scientific communities as an expert in the application of epidemiology to areas relevant to drug development and commercialization
*

Ability to effectively engage and consult with recognized key external scientific experts
*

Ability to work in different roles in teams as well as work independently in a proactive manner
*

Ability to provide critical appraisal to study designs and published studies
*

Excellent communication skills and cultural sensitivity



Desirable for the role

*

Ability to apply advanced and novel epidemiological theory and techniques into projects, including interventional studies such as pragmatic trials, throughout the pharmaceutical development and product life cycle
*

Good disease area knowledge and knowledge of drug development and life cycle management
*

High degree of conceptual thinking skills
*

Ability to access external resources and work effectively with External Experts, Collaborative Groups and Contract Research Organizations as necessary
*

Ability to effectively represent the Company to external stakeholders, including regulatory authorities and key scientific opinion leaders
*

Ability to effectively engage with a wide variety of technical and business experts
*

Ability to present advanced epidemiological topics at Professional and Scientific meetings
*

Excellent understanding of overall business strategy and its link to the various disease areas
*

Ability to make complex judgments, develop innovative solutions, and apply comprehensive cross-functional and industry understanding to individual projects and programs



So, what's next?

Are you already imagining yourself joining us? Welcome with your application, no later than May 31, 2024. Interviews may be held on a continuous basis. For more information about the position please contact Karolina Andersson Sundell, hiring manager, at [email protected] Visa mindre

Join our BioPharmaceuticals Medical team, where we strive to provide healthcare decision-makers around the world with the evidence and confidence they need on AstraZeneca therapies. We are looking for an Evidence Delivery Associate Director to lead or support the operational planning, delivery, oversight, and budget management of company sponsored research. This is a great opportunity to shape the future of healthcare and be part of changing the practice of medicine forever!



As Evidence Delivery Associate Director you will be based in our strategic R&D site in Gothenburg. Sweden and be a vital part of our BioPharmaceuticals Medical (BPM) Global Evidence Portfolio Delivery organization. BPM is accountable for the operational delivery of global strategic studies required to generate the evidence to build the confidence on AstraZeneca therapies required by Global Product Teams and Global Medical Teams. We aim to lead AstraZeneca in achieving scientific leadership, being a great place to work, and keeping patients at the core of everything we do.



What you will do

You will lead or support the operational planning, delivery, oversight and budget management of company sponsored research. The majority of the evidence delivered is conducted by one of our preferred CRO partners. The studies may be interventional or observational, including both primary data collection or secondary data collection. You may also help to coordinate the efforts of extended team members, notably the scientific study leader (epidemiologist for observational studies, Medical Affairs Leader for interventional studies). As Evidence Delivery Associate Director you may own specific areas or deliverables within a study, or in some cases, assume the accountabilities of a team leader for study delivery. One important task will be leading delivery through oversight of our preferred CRO or a third party vendor. In addition, you will support BPM Evidence's continuous improvement by developing expertise in a specific area of study delivery, serving as a point of contact for best practice, and contributing to the development and maintenance of guidance documents and training materials.



As Evidence Delivery Associate Director your focus will be to lead and project manage Company Sponsored Observational and Interventional Research studies. Independent of the study type, key accountabilities of the Evidence Delivery Associate Director will be:

*

Management of study Governance processes
*

Management of internal and external stakeholders
*

Project Management of accountable study areas and oversight of CRO/Vendors to deliver according to cost, time and quality
*

Finance Management support
*

Support of study Risk Management and Quality Management activities
*

Study compliance



Essential Skills/Experience

*

Bachelor's degree required preferably in medical or biological science or equivalent by experience
*

Extensive pharmaceutical industry/CRO experience within clinical study/research project delivery, drug development process and relevant guidelines, for example GCP/ICH, for a specific therapeutic and geographical area
*

Project Management qualification or demonstration of project management skills including scope, budget, timeline, resource management and use of associated tools
*

Scientific awareness and extensive knowledge of observational study guidelines and SOPs
*

Extensive knowledge of early and late-stage Pharmaceutical Development
*

Ability to effectively work with Clinical Research Organisations/External Providers
*

Proven ability to interact widely and effectively within the company across regions, functions and cultures
*

Persuasive communicator in English with a proven ability to work collaboratively in a multi-cultural environment
*

Open to periods of travel



Why AstraZeneca?

At AstraZeneca, we are at the forefront of medical innovation. We use our unique position as medical leaders across our enterprise and the healthcare ecosystem to shape the future of Healthcare. We provide medical leadership across the whole product lifecycle - from advising on Research & Development investment decisions, to leading pre-launch scientific efforts and accelerating evidence-based healthcare changes in the real world. We are networkers and influencers by nature. In our role as scientific ambassadors, we thrive on working with people internally and externally.



When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.



Ready to make a difference? Apply now to join AstraZeneca and our BPM team as an Evidence Delivery Associate Director! Welcome with your CV and cover letter, no later than 23 May, 2024.

For more information, please contact recruiting manager Magnus Mattsson (BPM Evidence Delivery Senior Director CVRM) at [email protected] Visa mindre

Are you an experienced scientist ready to apply your skills in a diverse and dynamic company? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now!

Our team is growing and we are now looking to recruit a Senior Scientist experienced in histology with a background in image analysis and ideally experience with pathological assessment of immune-mediated diseases. If you have a drive for innovation and idea generation as well as excellent laboratory skills, this is a great opportunity to join the Bioscience In Vivo Department within Early Respiratory and Immunology. The role is located at our vibrant R&D site in Gothenburg, Sweden.

Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases such as asthma, COPD, IPF, IBD, RA and SLE.

The successful candidate will join a highly motivated team that works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics to support discovery projects and to drive new exciting research. Are you ready to join us?

What you'll do?
As a Senior Scientist you will be a vital member of the department and in various working teams to progress our respiratory and immunological drug discovery projects. You will actively take part in scientific discussions, gain input from others and be involved in multiple project meetings to present and discuss experimental plans and data.

This is a partly lab-based role where you will be actively involved in experimental phase of histological analyses, with responsibility to coordinate, perform and evaluate experiments as well as drive the establishment of new techniques. Characterization and validation of target expression and subsequent evaluation of engagement of the target by drug treatment in both patient and in vivo tissue samples will be key areas of your daily work. You will independently assess and report data with a clear understanding of its reliability, interpretation of findings and draw appropriate conclusions with input from others.

We are looking for a great teammate with strong background in histology and related image analysis techniques with a specific focus on autoimmune and autoinflammatory diseases, ideally complemented by some experience in pathology and pre-clinical drug discovery processes.

Essential for the role

*

PhD in a relevant field (area of Bioscience/Immunology) ideally complemented with experience of working in a drug discovery environment
*

Strong experimental histology skills in performing immunohistochemistry, istochemistry, in situ hybridization (including RNAscope) with automated machines (e.g. Ventana Discovery Ultra and Leica Bond)
*

Experience with immune cell identification and characterization (cluster of differentiation antigens, transcription factors, cytokines, etc)"
*

Knowledge in histology scoring and histomorphometry
*

Proven knowledge and experience in image analysis platforms (e.g. Visiopharm and Halo)
*

Understanding of statistical methods, quality control and data reporting/archiving
*

Be respectful, communicate openly and show effective collaborative behavior to obtain high quality study results
*

Excellent written and oral communication skills, including presentation skills. You are organized and incorporate the views of others in your communication and collaboration



Desirable for the role

*

Knowledge of immune-mediated diseases, with a specific focus on gut, skin, joint, liver and/or kidney immunity including target and mechanism knowledge and basic understanding of pharmacokinetics
*

Some experience in pathology
*

Good understanding of pharmacology, physiology and immunology
*

Familiarity with deep learning image analysis methods, e.g. image segmentation and classification
*

Practical experience with a scripting language (Phyton, R) modelling tools
*

Knowledge in advanced histological techniques such as spatial transcriptomics, hyperplex staining and tissue optical clearing



Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until May 10, 2024.

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Visa mindre

Are you an experienced scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!

Our team is growing, and we are now looking for a motivated individual with experience in Biologics and/or small molecule drug development and PKPD, to join us as a DMPK Project Leader, from candidate selection to registration and beyond. This position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress.

Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.

What you'll do?
With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area as a subject matter expert. In the DMPK project lead role you will work collaboratively with project representatives from other disciplines. These may include biology, safety , clinical pharmacology, pharmaceutical sciences, antibody Discovery/Protein Engineering and medicinal chemistry, where your task is to influence candidate profiling by providing the necessary DMPK support for clinical investigations.

It is your responsibility to ensure delivery of all DMPK related activities throughout the value chain in accordance with regulatory requirements. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction and emerging clinical experience.

You will work as the development DMPK representative on project teams from candidate selection to registration and beyond. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex nonclinical and clinical data.

Main duties and responsibilities;

*

Communicate scientific progresses both externally and internally
*

Deliver DMPK input and data to projects within agreed timelines and to the right quality
*

Responsible for delivering and produce the nonclinical pharmacokinetic documentation to support clinical progression
*

Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy
*

Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
*

Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
*

Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
*

Prepare clear presentations related to the above for internal governance bodies



Your level of professional experience will be relevant for your initial career level (Associate Principal Scientist or Principal Scientist).



?Essential for the role

*

PhD or equivalent experience in a relevant field
*

Expert in DMPK sciences with profound knowledge of drug discovery and development processes
*

Broad experience in biologics drug development (PK & Bioanalysis)
*

Have PK modelling skills, experience of human PK and dose prediction, as well as an understanding of disease biology and PKPD
*

Experience with regulatory submissions for biologics and/or small molecules
*

Knowledge of all DMPK assays including the use of in silico tools for PK prediction
*

Experience in project leadership
*

Collaborative mindset
*

Team player
*

Proactive in providing expert support to project team and excellent communication skills



Work policy
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until May 31, 2024. For more information about the position, please contact recruiting manager Lassina Badolo at [email protected]

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Visa mindre

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We do this with integrity even in the most difficult situations because we are committed to doing the right thing.

Patient Safety Biopharma at AstraZeneca is now looking for a Director, Principal Patient Safety Scientist

The core purpose of AstraZeneca Patient Safety is to add value to AstraZeneca products, provide clear science-based guidance for investigators and prescribers to safeguard patients as well as the success of our business. Patient Safety covers the entire clinical life cycle of a drug from first time into man to withdrawal of a product from the market

What you'll do
The Principal Patient Safety Scientist is a global role providing expertise to multiple and/or single but complex products in different stages of development within the therapy areas of Respiratory & Immunology and Cardiovascular, Renal & Metabolism. The role holder provides oversight of safety documents and deliverables for these projects in collaboration with the Global Safety Physician (GSP) and other Patient Safety Scientists.

In this exciting and challenging role, you will work collaboratively with other Patient Safety Scientists and physicians to shape the culture of the safety team and the wider PSTA function. You will facilitate collaboration with colleagues from across AstraZeneca and externally, including counterparts within Clinical Project Teams, Global Regulatory Affairs, and Global Commercial teams.

Your main accountabilities / responsibilities:
Leads the strategy for proactive pharmacovigilance and risk management planning of complex or multiple products, including preparation of the safety aspects of Global Risk Management Plans in partnership with the Global Safety Physician (GSP) and others as appropriate.

* Leads safety strategy for multiple or complex periodic regulatory documents according to the agreed process and timelines.
* Leads safety strategy for regulatory submissions of new products, formulations or indications (NDA/BLA, MAA), in partnership with the GSP and other functional experts.
* Performs duties as a Safety Strategy and Management Team (SSaMT) Leader for complex and/or multiple products.
* As a Safety expert leads presentation of complex issues to Safety Information Review Committee (SIRC).
* Has the ability to lead cross-functional process improvement or other initiatives on behalf of the Patient Safety organization.
* Leads negotiations and provides expertise to the Patient Safety component of contracts/agreements with third parties to ensure quality and integrity of agreements.
* Takes accountability and leads resolution of complex safety issues and mediates cross-functional agreement.
* Has the ability to participate in due diligence activities.
* As a safety expert provides training and mentorship to new GSPs and Patient Safety Scientists in processes and systems.

Essential for the role

* BSc in sciences/pharmacy/nursing or related field
* 7+ years of relevant experience
* Advanced Patient Safety and/or Clinical/Drug Development experience of leading safety &/or scientific activities, across at least 4 of the following areas:

* Clinical drug development (Early and/or Late Phase: develop program level safety strategy, including proactive risk identification & mitigation planning)
* Post-Marketing Surveillance (including signal detection & evaluation)
* MAA/BLA submissions (setting strategy; preparation and authoring of the safety related aspects of the Common Technical Document)
* Periodic Safety Reports (establish and lead strategy, preparation and authoring)
* Risk Management Plans (establish and lead strategy, preparation and authoring)

* Governance board interactions and communication across a range of activities
* Advanced knowledge of PV regulations
* Demonstrated ability to handle more than one complex project simultaneously, prioritizing well and recognizing key issues
* Ability to work effectively in an advanced matrix structure
* Proficient in written and verbal English

Desirable for the role

* MSc or PhD in relevant scientific field preferred
* Strong network and reputation within the business and industry
* Extensive knowledge of the latest technical and regulatory expectations

Why AstraZeneca
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

So, what's next?
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours. Welcome with your application!

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn
https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook
https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram
https://www.instagram.com/astrazeneca_careers/?hl=en Visa mindre

Quality Assurance Specialist

Quality Assurance Specialist / AstraZeneca / 12 months / Hays Life Science / Göteborg, Sweden



Hays Life Science is now looking for two new consultants to become Quality Assurance Specialists in Göteborg, Sweden.



AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies.



At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. The arena Are you interested in a challenging opportunity within the Development Quality function in one of the world's leading pharmaceutical companies. The Development Quality function is responsible for quality oversight of the pharmaceutical development activities in AstraZeneca.



We are now looking for a Quality Advisor with GMP focus to our Gothenburg team. AstraZeneca's pharmaceutical development organizations manage all facets of the process of turning a molecule into a medicine which can be safely and effectively used by patients. The Quality Advisor role has a broad range of responsibilities to ensure all internal and external requirements are fulfilled for the AstraZeneca projects in the development phase. The role As a Quality Advisor, you will work with early product development manufacturing and packaging teams and be responsible for Development Quality release of externally manufactured Drug Product and Investigational Medicinal Product for clinical trials. You are expected to assure that activities and processes across the development chain are delivered to appropriate standards to meet regulatory expectations and assure product integrity and acceptability. You will develop and maintain a knowledge of the quality regulations and guidelines applicable to your area and a deep scientific understanding of the products that you are supporting. In your role you will have interactions with internal and external stakeholders.



Typical Accountabilities:



* Responsible for quality Release of manufactured Drug Product, Investigational Medicinal Product for clinical trials

* Providing quality input to Manufacturing, Packaging, Labelling & Distribution activities

* Providing proactive quality advice to support the development, implementation and continuous improvement of GMP quality systems across the Clinical Supply functions and support implementation of agreed global standards

* Support the pharmaceutical development functions with investigations of deviations, changes and other quality and compliance decisions in the development projects

* Provide appropriate Quality Assurance input to business improvement projects

* Operate as part of a global organisation with an integrated mindset to create an organisation with common processes and ways of working. Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Vid Institutionen för neurovetenskap och fysiologi vid Sahlgrenska akademin bedrivs omfattande forskning och undervisning över stora kunskapsområden från molekyl till människa. Verksamheten utgörs av fem sektioner; farmakologi, fysiologi, hälsa och rehabilitering, klinisk neurovetenskap samt psykiatri och neurokemi.

Institutionen för neurovetenskap och fysiologi, söker nu en postdoktor, med placering vid Sektionen för klinisk neurovetenskap för arbete med ett registerbaserat projekt. Projektet har anslag från Vetenskapsrådet och ska de kommande åren använda stora datamängder för att studera långtidsutfall vid epilepsi.

Forskargruppen är baserad vid Institutionen för neurovetenskap och fysiologi och tillhör därutöver Wallenbergscentrum för molekylär och translationell medicin (www.wcmtm.gu.se), vilket medför goda möjligheter för karriärutveckling och nätverksbyggande.

Ämne
Epilepsi

Ämnesbeskrivning
Epilepsi kan vara medfött, men också uppstå mitt i livet efter någon form av hjärnskada eller hjärnsjukdom. Syftet med gruppens forskning är att förbättra sjukvården av personer med förvärvad epilepsi, hitta sätt att tidigt detektera förvärvad epilepsi och optimera behandling. Epilepsi behandlas ofta med läkemedel, men att välja rätt läkemedel för rätt patient är svårt. Vi använder stora registermaterial för att försöka studera vilka epilepsiläkemedel som passar bäst för vilken patient utifrån individuella karakteristika som ålder, kön, samsjuklighet. Vi har också egna kliniska studier där vi letar biomarkörer (blodprover, neurofysiologiska undersökningar eller avbildning) för svårbehandlad epilepsi eller läkemedelsbiverkningar.

Arbetsuppgifter
Vi arbetar i flera projekt med data från nationella register och studerar riskfaktorer för, prognos vid och behandling av olika epilepsier. Ett stort fokus är för närvarande farmakoepidemiologi, att med hjälp av läkemedelsregisterdata följa epilepsibehandling i olika patientgrupper. Vidare genomför vi biomarkörstudier där vi samlar in biologiskt material eller undersökningsresultat i klinisk verksamhet och försöker korrelera dessa till kliniskt förlopp – exempelvis epileptiska anfall eller läkemedelsbiverkningar.

Vi söker nu en postdoktor för arbete med vårt projekt om stora datamängder i vilket vi vill bygga upp en stor databas för farmakoepidemiologiska studier. Arbetet förutsätter förtrogenhet med statistiska metoder och programmeringsspråk som används för att hantera stora datamängder, exempelvis R eller Python. Det finns möjlighet att inom ramen för gruppens forskning också utveckla egna forskningslinjer inom epilepsi. Postdoktorn förväntas också bidra till den akademiska miljön i gruppen och det finns stora möjligheter att handleda doktorander och studenter.

Behörighet
Behörighet för anställning som lärare regleras i Högskoleförordningen 4 Kap och Göteborgs universitets anställningsordning. 

Behörig att anställas som postdoktor är den som har avlagt doktorsexamen, konstnärlig doktorsexamen eller som har en utländsk examen som bedöms motsvara doktorsexamen. Detta behörighetskrav ska vara uppfyllt senast vid tidpunkten då anställningsbeslutet fattas.

I första hand bör den komma i fråga som har avlagt examen högst tre år före ansökningstidens utgång. Även den som avlagt examen tidigare bör komma i fråga i första hand, om det finns särskilda skäl. Med särskilda skäl avses ledighet på grund av sjukdom, föräldraledighet, förtroendeuppdrag inom fackliga organisationer, tjänstgöring inom totalförsvaret, eller andra liknande omständigheter samt klinisk tjänstgöring eller för ämnesområdet relevant tjänstgöring/uppdrag. 

Behörig att anställas som postdoktor för denna utlysning är den som innehar doktorsexamen i det medicinska fältet eller datavetenskap/statistik.

Bedömningsgrund
Kvalifikationskrav: relevant doktorsavhandling inom antingen datavetenskap/statistik eller det medicinska fältet, såsom biomedicin, bioinformatik, eller motsvarande. Goda kunskaper i engelska.

Följande är meriterande: Erfarenhet av att hantera stora datamängder. Erfarenhet av epidemiologi. Kunskap om epilepsi. Erfarenhet av registerforskning. Tidigare klinisk forskning.

Vi lägger stor vikt vid personlig lämplighet. 

Anställning
Anställningen är en tidsbegränsad anställning i 2 år, 100% av heltid, med placering tills vidare vid Institutionen för neurovetenskap och fysiologi. Tillträde: snarast eller enligt överenskommelse. 

Kontaktuppgifter för anställningen
Har du frågor om anställningen är du välkommen att kontakta professor Johan Zelano, tfn: +46 31 342 90 62, epost: [email protected]

Ansvarig chef är professor/sektionschef Katharina Stibrant Sunnerhagen, tfn: +46 709 52 00 23, e-post: [email protected]

Ansökningshandlingar skickas inte till kontaktpersonerna.

Ansökan
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att registrera din ansökan elektroniskt via hemsidan: https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar

Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Intyg om doktorsexamen bifogas med ansökan.

Ansökan ska vara inkommen senast: 2024-04-30

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.

The Institute is composed of the following four departments:


• The Department of Infectious Diseases
• The Department of Microbiology and Immunology
• The Department of Medical Biochemistry and Cell Biology
• The Department of Laboratory Medicine

At present, the institute has about 340 employees and approximately 450 million SEK in total assets

Duties 
The researcher will be engaged in projects focused on mechanisms that regulate initiation, growth and survival of Non-Small-Cell-Lung-Cancer ALK positive cancers and their microenvironment. The fellow will use a broad range of approaches, such as genetics, cell biology and in vivo modeling to understand/reveal upstream/downstream targets of ALK both during novel developmental processes and disease. The fellow will be involved in mouse and cell culture models of NSCLC ALK positive cancer to validate novel therapeutic strategies. Signaling pathways will be further investigated in these models with consideration of their pathological relevance.

Qualifications 
Doctoral degree in a relevant subject area. Methods used require knowledge in genetics, cell biology, biochemistry, and histology in/or mouse and cell culture systems. Accustomed to treating mice with medical inhibitors, screening, live imaging, knowledge of ultrasound imaging, MRI, biochemical analyzes and cell culture model systems are meritorious. Laboratory knowledge and documented training for rodents and xenograft experience is a plus.

Employment 
The employment is limited (temporary) for 6 months and full time 100% with placement at the Institute of biomedicine. First day of employment as agreed.

Contact information for the post 
If you have any questions about the position, please contact Professor Bengt Hallberg, phone +460 (0)70 566 5742, mail [email protected]

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. 

Applications must be received by: 2024-02-15

The application should contain proof of completed PhD.

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.

The Institute is composed of the following four departments:


• The Department of Infectious Diseases
• The Department of Microbiology and Immunology
• The Department of Medical Biochemistry and Cell Biology
• The Department of Laboratory Medicine

At present, the institute has about 340 employees and approximately 450 million SEK in total assets.

A position within the research group led by Professor Joakim Larsson, Department of Infectious Diseases, Institute for Biomedicine, Sahlgrenska academy at the University of Gothenburg, Sweden. The focus of the research group is on antibiotic resistance, particularly the role of the external environment. The group consists of 1 professor, 1 associate professors, 7 postdoctoral fellows/researchers, 2 PhD students, 2 technicians as well as student on different levels. (https://www.gu.se/en/biomedicine/about-us/department-of-infectious-diseases/joakim-larsson-group). Larsson also leads the Centre of Antibiotic Resistance Research in Gothenburg (CARe; www.gu.se/en/care) with ca 150 active researchers. The group has extensive collaboration with other universities, nationally and internationally. The research is interdisciplinary and has significant funding through e.g. the Swedish Research Councils VR and Formas, JPIAMR and regional health care (ALF-VGR).

Duties 
The researcher will be responsible for developing and refining functional metagenomics as a tool for large-scale screening of bacterial genes for functionality, in particular antibiotic resistance. The work involves both planning, execution of the analyses and writing of scientific articles.

Qualifications 
PhD in a relevant subject. International postdoc experience. Extensive experience of bacterial genomics and metagenomics, including both in the laboratory and with bioinformatic analyses using relevant tools and programming languages (Python, R), cloning, functional metagenomics, experience of antibiotic resistance research, experience of environmental dimensions of antibiotic resistance research, good publication record with relevant articles in relation to the time passed since the applicant´s PhD exam. Excellent ability to communicate science in English, both orally and in written text.

Employment 
The employment is full time and temporary, 11 months, with placement at the Institute of Biomedicine. First day of employment: May 12.

Contact information for the post 
If you have any questions about the position, please contact Professor Joakim Larsson. E-mail: [email protected]

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. 

Applications must be received by: 2024-02-05

The application should contain:


• Proof of completed PhD

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Unlock the power of science and make a difference in patients' lives! Join our R&D team in Gothenburg as a Biosampling Business Area Leader and be part of an environment built on lifelong learning.

Human Biological Samples (HBS) are fundamental to medical research in the discovery, development and implementation of new treatments and diagnostics. They are ethically sensitive materials and underpin the delivery of every clinical trial in AstraZeneca.

As a key leadership role within the Precision Medicine and Biosamples (PMB) function, the Biosamples Business Area Leader (BBAL) is responsible for the clinical sampling strategy and Human Biological Samples (HBS) risks for a specific therapy area. Are you ready to lead a team of clinical sampling experts and drive continuous improvement through talent management?

In this role, you will be the single point of contact for a therapy area, working in partnership with TA leaders to achieve clinical, translational, and precision medicine aims. You will maintain oversight of clinical sampling delivery at a TA level, provide HBS expertise, monitor compliance with AstraZeneca policies, and lead performance management within your team.

Typical accountabilities:

* Maintains an oversight of clinical sampling delivery at a TA level, including risk logs, and leads the resolution of escalated issues in a timely, accurate and compliant manner.
* Accountable for in scope clinical study deliveries within the TA, to agreed time and quality, and for reporting of relevant metrics to senior leadership.
* Provides HBS expertise for the TA, driving cross TA continuous improvement and learnings
* Monitors and ensure compliance with all AstraZeneca Policies and Standards and immediately address instances of non-compliance. Delivers ethical and compliant management of Budget, Safety, Health and Environment within their team and on behalf of the PMB Function as required
* Attract, recruit, and retain top talent and technical expertise in their team. Lead performance management and personal development of group members through coaching, mentoring, and motivating. Ensures delivery of team objectives in line with business objectives.
* Works with PMB BPOs to ensure efficient deployment of resource including prioritisation
* Works with HBS external alliance teams to ensure that laboratory testing carried out on behalf of the TA is compliant, high quality and matches the intended use.

Essential for the role

* Higher degree (or relevant experience) in a scientific area
* Proven experience of the clinical development process
* Strong ability to work collaboratively in a cross-functional setting
* Experience of leading and managing a team
* A confident team player who is assertive but willing to listen and learn from others

Desirable for the role

* Operational deployment of clinical laboratory testing in clinical trials across both early and late development
* Experience in more than one company
* Process ownership and process optimization
* Prior experience in a similar role

Why AstraZeneca?
Embrace new and varied opportunities to develop and learn! Our commitment to making a difference is built around our passion for science. We fuse data and technology with the latest scientific innovations to achieve breakthroughs that positively impact billions of patients worldwide.

We are an equal opportunity employer that values diversity. We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or disability status.

So, what's next!
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.We are looking for a highly motivated, academically excellent and proactive associate researcher with a strong background in exosome biology and inflammation to study the connection between the immune system and brain health and further develop this research area in the Härtlova laboratory at the Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg.

Duties 
The employee will join an exciting project that characterizes the inflammatory pathways involved in the activation of the immune system in infection and neurodegenerative diseases. The employee will isolate outer membrane vesicles from different tissues and characterize their immunostimulatory potential and correlation to neuroinflammation and neurodegeneration. The successful employee is given the opportunity to develop their research career in a laboratory with a strong focus on education and mentorship.

Qualifications 
Applicants must have a strong background in innate immunity, inflammation or host-pathogen interactions. A broad base of expertise, including molecular and cellular biology (qRT-PCR), biochemistry (immunoprecipitation, Western blotting), immunological analyzes (ELISA, flow cytometry), exosome isolation is highly desirable. Applicants must have a strong desire to develop a successful and highly productive research career in immunological research, excellent general research skills, a strong methodological background, excellent writing skills and the ability to work both independently and within a team. Fluent proficiency in spoken and written English is essential.

Employment 
The employment is limited (temporary) for 5 months and full-time with placement at the Institute of Biomedicine. First day of employment as agreed.

Contact information for the post 
If you have any questions about the position, please contact Senior Lecturer Anetta Härtlova, mail  [email protected]

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. 

Applications must be received by: 2024-01-31

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.ansöker via https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar

 https://web103.reachmee.com/ext/I005/1035/job?site=6?=SE&validator=3038fcf1516ea1184a6da70a891f87da&job_id=32563

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.På institutionen för biomedicin bedrivs forskning och undervisning inom prekliniska och kliniska medicinska ämnen. Institutionen är indelad i följande fyra avdelningar: infektionssjukdomar, mikrobiologi och immunologi, medicinsk kemi och cellbiologi samt laboratoriemedicin. För närvarande har institutionen cirka 340 medarbetare och cirka 450 MSEK i omsättning.

På Avdelningen för mikrobiologi och immunologi på Göteborgs universitet pågår forskning med syfte att utveckla nya vacciner mot bakteriella tarminfektioner och för att studera det immunologiska svaret efter vaccination. Vi söker nu en biträdande forskare till dessa vaccinprojekt.

Arbetsuppgifter 
Arbetet innefattar framför allt immunologiska men också bakteriologiska, biokemiska och molekylärbiologiska analyser. I arbetsuppgifterna ingår även odling av smittfarliga bakterier och tester på dessa; isolering, odling och infrysning av immunceller; etablering och validering av nya analysmetoder; dataanalys och organisation av provsamlingar och resultat.

Kvalifikationer 
Vi söker en person med masterexamen i biologi, biomedicin eller med motsvarande utbildning. Kunskaper inom immunologi och erfarenhet av immunologiska analyser inom klinisk laboratorieverksamhet och/eller kliniska studier är viktiga meriter. Eftersom arbetet kommer att involvera hantering av humant blod och serum; ELISA-tekniker; isolering och odling av lymfocyter; odling och arbete med smittfarliga bakterier och mikroskopi bör du ha praktisk erfarenhet av dessa metoder. Erfarenhet av andra antikroppsmetoder, gelelektrofores, isolering av DNA och RNA, PCR och qPCR, liksom datasammanställning och -analys med Prism och Xcel är additionella meriter. Du är noggrann och bra på att planera och dokumentera ditt arbete. Du är flexibel och inte rädd för att lära dig nya metoder och tekniker. Vi fäster stor vikt vid dina personliga egenskaper, ditt intresse för forskning och din vilja att lära och utvecklas. Goda kunskaper i engelska är en förutsättning för arbetet. Goda kunskaper i svenska är önskvärda.

Anställning 
Anställningen är ett vikariat, 6 månader, med omfattning 100% och placering tills vidare vid institutionen för biomedicin. Tillträde enligt överenskommelse.

Kontaktuppgifter för anställningen 
Har du frågor om anställningen är du välkommen att kontakta professor Jan Holmgren, tele: 031-7866201, mail [email protected]

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Ansökan 
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Ansökan ska vara inkommen senast: 2024-01-09

 

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Research and Development (R&D) Graduate programme - Bioscience - Sweden

Location: Gothenburg, (Sweden)




Be empowered to be innovative and creative where difference is valued

If you have a Bioscience/Life science-based bachelor's or master's degree and a desire to explore your scientific potential within a global biopharmaceutical organisation, our Research and Development (R&D) Bioscience Graduate Programme could be a springboard to your future career. You'll gain invaluable insight, exposure, and opportunities across our diverse, R&D organisation. We'll accelerate your learning and help you achieve your potential as a research scientist.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines for some of the world's most serious diseases.

We are a company that genuinely follows the science and values individuals at all levels, you'll be backed and encouraged to speak up, ask questions, and continuously learn and explore.

At AstraZeneca, we unlock the power of what science can do by empowering you to explore, every day we work towards our ultimate aim - treating, preventing, modifying and even curing complex diseases.

What is the R&D Graduate programme?

Starting in September 2024, the programme lasts two years, consisting of three individual eight-month placements. Each placement will provide you with insights into drug discovery and development and the opportunity to expand your knowledge of our therapy areas.

The programme's variety and flexibility provide a unique exposure to develop your skills and interest in Bioscience research and other scientific disciplines, research areas and stages of the drug discovery process. As well as helping you broaden your scientific knowledge, we'll support you in developing the professional skills required to fulfil your career potential.

You'll gain an invaluable blend of on-the-job experience and training and enjoy guidance and advice from a huge support network, including a mentor and dedicated programme management team. We'll also encourage you to grow your network with experts and leaders across the business and leading academic and biotech research institutions. Together, we'll help accelerate your development and knowledge!

Applicants to our Bioscience programme should have a knowledge of the biology, biochemistry and pharmacology applied in drug discovery. They should have strong drive to make a difference and a passion for research as well as an understanding of the techniques used to identify and validate new targets, assessing the efficacy and safety of compounds and progressing these towards the clinic. You will have a wide variety of placements to choose from which will allow you to hone your current skills as well as develop new ones.

The majority of placements are wet lab based, although there will also be opportunities to gain experience outside of the lab with computational/bioinformatics projects or working with our early clinical and regulatory affairs groups. Graduates are expected to complete at least one lab-based placement related to their discipline during the course of the programme.

We offer broad placement opportunities, but these will vary by the site you are applying to and the departments and therapy areas which are based there.

You will be based at the site of application throughout the duration of the 2 years, we do not offer international placements on this programme.

Essential for the role:

*

A 2:1 (UK) or local equivalent bachelor's degree, or a Master's level qualification, in any life science or chemistry related subject awarded in 2023 or due to be awarded before September 2024.
*

Passionate about working in drug discovery and committed to pushing the boundaries of science to deliver life changing medicines and transform the lives of patients.
*

Proactive problem solving and critical thinking skills.
*

Excellent planning, organisational and time management skills.
*

Team-focused, with a partnership approach to achieving success.

Where can I find out more?

*

Learn more on our Careers Page
*

LinkedIn
*

Facebook
*

Instagram
*

Relocate to Gothenburg

What next?

Are you ready to bring your skills, drive and curiosity to our projects? Good, because we'd love to hear from you! Click the link to apply, and we will be in touch once the advert closes. After you submit your application, you will be asked to complete an online assessment (SHL). If shortlisted, you will then be invited to a full day virtual assessment day in March 2024.


Advert opens: Monday 4 December 2023
Advert closes: end of Sunday 14 January 2024 Visa mindre

We are now looking for an Associate Director Integrated Bioanalysis - Proteomics to be part of the Integrated Bioanalysis (iBA) Global Team. The iBA group within Clinical Pharmacology and Safety Sciences (CPSS) provides broad discovery, preclinical, and clinical support including life cycle management across all therapeutic areas enabling pipeline delivery, decision making, innovation and advancement to improve the lives of patients through life-changing medicines. You will be located at our vibrant research hub in Gothenburg, Sweden where you will work alongside a team of experienced bioanalytical scientists supporting projects across our portfolio. You will also be working closely with discovery scientists across CPSS and partner line to maximise internal knowledge exchange and collaboration. This is an exciting opportunity with an immediate and lasting impact on our diverse pipeline.



What you'll do

In this role you will be responsible for advancing the utilisation and application of arrange of -omic technics with a specific focus on using mass spectrometry applications such as proteomics, metabolomics and lipidomic applications in discovery and early development. You will be expected to contribute to the development of advanced bioanalytical techniques across all aspect of AZ portfolio within Oncology and Biopharma.

You will be responsible for assay development, optimization, qualification, execution, and transfer of high complexity assays using state-of-art instrumentation to support pre-clinical and clinical studies. You will also contribute to tech-transfer to established CRO partners and may be called upon to review data to ensure assays are fit for purpose including troubleshooting and data analysis. You will furthermore be expected to provide scientific leadership to junior staff and to develop strong intra and inter-departmental collaborations.

You will need to use your experience and proven track record of experimental design to support delivery of robust bioanalytical data. You will also be called upon to interpret data and provide scientific insight. As a Subject Matter Expert, you will work closely with AstraZeneca laboratory groups within iBA and our vendor partners to ensure appropriate -omics methods are established and you will be responsible for enhancing the iBA reputation for scientific excellence by presenting at internal and external meetings, and publishing manuscripts.

You will be working with a dynamic team in a matrixed environment and will need to manage stakeholder expectations, give input to project strategy and delivery while being the main interface with experienced and highly skilled bioanalytical scientist colleagues or our partnered labs.



Essential for the role:

*

PhD in analytical chemistry, biochemistry, genomics molecular biology or related discipline with at least 7 years of post-PhD experience.

*

Proven experience as a Subject Matter Expert in an array of proteomics techniques including the development broad spectrum and targeted proteomics strategies.
*

Experience in both hypothesis generation and targeted analyses approached to using proteomics to resolve to perform pathway analysis or biomarker strategies.

*

Employ a metabolomic/proteomics discovery platform to enable discovery and validation of metabolomic/lipidomic/proteomics biomarkers.

*

Experience using a broad array of proteomics platforms including but not limited to high resolution mass spectrometry (HRMS, ToF or Orbitrap), QqQ instruments and ligand binding based technology platforms.
*

Hands-on experience with chromatographic separation, characterization, and quantification of various analytes by LCMS or protein array platforms.
*

Proficiency with mass spectrometry and other protein array software, data analysis software (Spotfire, MATLAB, R, JMP, etc.) word processing, and graphical computer programs
*

Experience of working with high-quality, timely documentation in electronic laboratory notebooks and technical reports which support regulatory filings.
*

Ability to present data / strategy to scientists and management in internally.
*

Background in pharmaceutical clinical trial research.
*

A proven publication and presentation record.



To be successful in your role you need to have excellent organizational, documentation and technical writing skills. You have an ability to collaborate effectively to ensure productive interactions with all stakeholder groups. You show strong accountability and you have the ability to handle multiple projects and / or tasks concurrently in a fast-paced environment. You have exceptional verbal and written communication skills and an ability to develop, coach and mentor.



Desirable for the role:

*

Experience with a broad array of multi-omic techniques including but not limited to RNA seq, cell- painting or genomics applications.
*

Experience across a range of technology platforms including but not limited to LBA, Wester-blot, and PCR.
*

Experienced in regulated bioanalysis for a range of drug modalities.



Why AstraZeneca in Gothenburg?

At AstraZeneca's Biopharmaceuticals R&D division, we are committed to making a difference. We have built our business around our passion for science. It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before.

With more than 2,800 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthroughs come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

If this sounds like the job and place for you to make a change - apply today and come join our exciting journey! Welcome with your application no later than 15th of December, 2023. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.

The Institute is composed of the following four departments:


• The Department of Infectious Diseases
• The Department of Microbiology and Immunology
• The Department of Medical Biochemistry and Cell Biology
• The Department of Laboratory Medicine

At present, the institute has about 340 employees and approximately 450 million SEK in total assets.

The overall aim of the project is to increase our understanding of the molecular basis of the  upstream/downstream targets of Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kinase.

Duties 
The researcher will be engaged in projects focused on mechanisms that regulate initiation, growth and survival ALK positive neuroblastom and their microenvironment. The researcher will use a broad range of approaches, such as genetics, cell biology and in vivo modeling to understand/reveal upstream/downstream targets of ALK both during novel developmental processes and disease. The researcher will be involved in mouse and cell culture models of ALK positive neuroblastoma to validate novel therapeutic strategies. Signaling pathways will be further investigated in these models with consideration of their pathological relevance.

Qualifications 
A completed doctoral degree is compulsory. The doctoral thesis shall be in a relevant area according to the specific position stated here. Method employed in the project require knowledge in genetics, cell biology, biochemistry, advanced microscopy and cell culture systems.

Employment 
The employment is limited (temporary) for 11 months and full time 100% with placement at the Institute of biomedicine. First day of employment as agreed.

Contact information for the post 
If you have any questions about the position, please contact professor phone: 0046-(0)31-786-3815, mail: [email protected]

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. 

Applications must be received by: 2023-11-29

The application should contain proof of completed PhD.

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. The Institute is composed of the following four departments:


• The Department of Infectious Diseases
• The Department of Microbiology and Immunology
• The Department of Medical Biochemistry and Cell Biology
• The Department of Laboratory Medicine

At present, the institute has about 340 employees and approximately 450 million SEK in total assets.

 

Duties 
Participation in ongoing preclinical and clinical studies on mechanisms of action and effects of the protein Antisecretory Factor. Mainly histological and immunohistochemical studies on localization and expression of AF, and evaluation of cellular and clinical effects caused by AF-treatment.

Education, examination and administration of the course Functional Histology, Programme in Medicine, Sahlgrenska Academy, GU. Course development, especially concerning development of new web based methods in the teaching of histology.

Education, examination and administration of the course Biomedicine for PhD students, Programme  Medicine, Sahlgrenska Academy, with emphasis on histology and basal anatomy.

 

Qualifications 
PhD exam in relevant subject. Good knowledge of Swedish. High academic competence and thorough experience of teaching and examination in histology. Good practical and theoretical knowledge of histological and histochemical methods.

 

Employment 
The employment is limited (temporary) for 11 months and part time 50% with placement at the Institute of biomedicine. First day of employment as agreed.

 

Contact information for the post 
For further information regarding the position please contact Professor Bengt Hallberg. Tel: +46 31 7863815. E-mail:
[email protected]

 

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

 

Application 
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. 

Applications must be received by: 2023-10-15.

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Hays Life Science is now looking for a Quality Assurance Advisor for a 12-month assignment at our client AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The arena
Are you interested in a challenging opportunity within the Development Quality function in one of the world's leading pharmaceutical companies?

The Development Quality function is responsible for quality oversight of the pharmaceutical development activities in AstraZeneca. We are now looking for a Quality Advisor with GMP focus to our Gothenburg team. AstraZeneca's pharmaceutical development organizations manage all facets of the process of turning a molecule into a medicine which can be safely and effectively used by patients. The Quality Advisor role has a broad range of responsibilities to ensure all internal and external requirements are fulfilled for the AstraZeneca projects in the development phase.

The role
This is a 12 months assignment. As a Quality Advisor, you will work with early product development manufacturing and packaging teams and be responsible for Development Quality release of externally manufactured Drug Product and Investigational Medicinal Product for clinical trials. You are expected to assure that activities and processes across the development chain are delivered to appropriate standards to meet regulatory expectations and assure product integrity and acceptability.

You will develop and maintain a knowledge of the quality regulations and guidelines applicable to your area and a deep scientific understanding of the products that you are supporting. In your role you will have interactions with internal and external stakeholders.

Typical Accountabilities:
* Responsible for quality Release of manufactured Drug Product, Investigational Medicinal Product for clinical trials
* Providing quality input to Manufacturing, Packaging, Labelling & Distribution activities
* Providing proactive quality advice to support the development, implementation and continuous improvement of GMP quality systems across the Clinical Supply functions and support implementation of agreed global standards
* Support the pharmaceutical development functions with investigations of deviations, changes and other quality and compliance decisions in the development projects
* Provide appropriate Quality Assurance input to business improvement projects
* Operate as part of a global organisation with an integrated mindset to create an organisation with common processes and ways of working.

Minimum requirements - Education and Experience
* Degree in pharmacy or engineering (specializing in Pharmaceuticals) with at least 3 years' experience of working within a pharmaceutical GMP environment
* Broad understanding of Quality Systems and GMP and related activities to Investigational Medicinal Product (IMP)
* Comprehensive understanding of the pharmaceutical/drug development process
* Good communicator with experience of interacting effectively across interfaces
* Understanding of Project Management processes
* Fluent in written and spoken English

Preferred requirements
* Experience preferably within a pharmaceutical manufacturing organization
* Good team working and networking skills
* Capable of making effective decisions
* Demonstrate drive and energy in the role to make a difference
* Demonstrate a high degree of personal credibility Visa mindre

Are you ready for an opportunity to join New Modalities and Parenteral Development in a management role with a focus on leading a team that develops deep BioPharmaceutics understanding of our drug products? Then this role might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working as an Associate Director means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Pharmaceutical Technology and Development (PT&D) is the bridge between brilliant science and innovative medicines that help millions of people. We work across the entire value chain, designing and delivering the active ingredients, formulations and combination products required to support new medicines - from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Within our Product Development organization, we have formed a new BioPharmaceutics Science unit that unites our late-stage BioPharmaceutics expertise in modelling and simulation, advanced in-vitro methods and regulatory advocacy to provide a vibrant scientific environment and the critical mass needed to generate significant business impact. We are currently looking for the right candidate to be an Associate Director within the BioPharmaceutics science unit, leading an experienced team and supporting projects across both our Oral Product Development and New Modalities and Parenteral Development departments. This is the perfect time to progress your career and influence the evolution of this key capability.

We are seeking a candidate with significant scientific experience, from a BioPharmaceutics background, who can lead both individuals and projects and enable them to develop and grow. We work in cross-skilled project teams across all delivery routes, from oral to IV, providing a rich opportunity to deploy your technical and leadership skills. The role is based in Gothenburg, Sweden with an expectation to be on site close to the team, and is part of a global group operating across Sweden and the UK.



What you'll do

As an NMPD Associate Director, you will be a member of the NMPD Extended Leadership team and help shape and implement key aspects of our strategy, with a focus on BioPharmaceutics.

You will:

* Lead, mentor and coach a team of experienced BioPharmacists that are advanced practitioners in our key capabilities.
* Contribute to the definition of our BioPharmaceutics strategy and enable its effective execution through close collaboration with scientific and line leaders.
* Assist the team with prioritization, stakeholder management, customer interactions and relationships with external collaborators.
* Lead capability build in relevant areas of research and contribute as a valued discussion partner during the different development stages of both drug product and innovation projects.
* Contribute to and review regulatory submissions.
* Drive improvement initiatives for the function, both local and global.



Essential requirements

* Educational background at research level (PhD), or MSc in a relevant subject area, and with scientific experience relevant to the position.
* Detailed knowledge of BioPharmaceutics with a track record of its application to product development including in-vitro tools, digital modelling (PBBM) and regulatory aspects.
* A keen interest in developing both people and organizational effectiveness with significant experience in people leadership and lean working.
* Excellent interpersonal skills and the ability to engage and collaborate seamlessly across boundaries with a problem-solving attitude and focus on delivery.
* Effective influencing and prioritization skills to ensure effective resource management and project delivery to deadlines.



Desirable requirements

* Good awareness of quality systems and their role in successful product registration.
* Excellent scientific leadership skills, delivering robust scientific contributions to projects with evidence of applying risk-based and value driven approaches for successful delivery.
* Effective communication and stakeholder management, with the ability to discuss complex ideas in a simple, easy to understand, manner.
* Leadership experience of motivating and empowering diverse teams within an inclusive culture when faced with a volatile environment.
* Strong understanding of lean principles and the ability to drive continuous improvement.



Why AstraZeneca?

At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.



So, what's next?

We welcome your application no later than 15th October, 2023. Visa mindre

Do you have knowledge in regulatory/pharmacovigilance and partnership issues ? Do you have a "can do" attitude and an innovative approach and want to contribute to ensure good relationships across Patient Safety and related functions within Astra Zeneca and Alexion? Then this unique role with a broad spectrum of responsibilities might be the one for you!

At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Ensuring AstraZeneca comply with Pharmacovigilance regulations is key and in our team we make sure to make this a reality.

To meet our business priorities and address resource demands, we are now looking for you who wants to join our Global PS Operations, Technology & Analytics group in Patient Safety, CMO as an Associate Director in the ICSR Process & Partnership team.

We are responsible for the management of assigned AstraZeneca projects, processes and partnerships including implementation, communication, compliance, performance, vendor oversight and inspection readiness within the ICSR area. We ensure good relationships across Patient Safety in CMO and other relevant areas of AZ to execute the delivery of the processes and partnership strategy, priorities, alongside governance and management of the current procedural documents and partnerships

What you'll do
As an Associate Director you will be working with Directors and Associate Directors in PV Processes, Partnerships and Contracts area, taking responsibility for the management of ICSR process and vendor oversight in AstraZeneca, covering processes and partnerships including implementation, communication, compliance, performance and inspection readiness. You will be accountable to develop relationships across Patient Safety in CMO and other relevant areas of AZ to execute the delivery of the processes and partnership strategy, priorities, alongside governance and management of the current procedural documents and partnerships.

Here you will have a great opportunity to use your deep understanding of regulatory and pharmacovigilance processes and regulations providing process or compliance support to safety and regulatory teams and submissions as well as to develop and maintain a vision and strategy for nominated pharmacovigilance or regulatory processes. In addition you will:

* Identify opportunities for and drives the enhancement of existing processes and partnerships through knowledge of internal and external environment
* Working with the PV Process, Partnership and Patient Safety and Regulatory experts, develop, establish, monitor, report and assess global KPIs related to safety and regulatory data reporting
* Utilise safety and regulatory knowledge to maintain and support the global inspection readiness strategy
* Manages relationships/partnerships/alliances external to the AZ CMO function that are essential to delivering AstraZeneca's pharmacovigilance and regulatory LTO responsibilities
* Identify opportunities for and drives the enhancement of existing processes and partnerships through knowledge of internal and external environment
* Working with the PV Process, Partnership and Patient Safety and Regulatory experts, develop, establish, monitor, report and assess global KPIs related to safety and regulatory data reporting.
* Utilise safety and regulatory knowledge to maintain and support the global inspection readiness strategy.
* Manages relationships/partnerships/alliances external to the AZ CMO function that are essential to delivering AstraZeneca's pharmacovigilance and regulatory LTO responsibilities
* Provide support and oversight to the outsourcing partner(s) to facilitate compliance with regulatory and legal requirements and maintaining inspection

With this in mind, we are looking for you that have a proven ability to work across cultures using your strong negotiation, conflict management and interpersonal skills to influence whilst maintaining independent and objective view.

Essential for the role

* A science/pharmacy/nursing degree, with at least 5 years relevant experience (pharmaceutical, regulatory, safety and partnership)
* Experience in working cross-functionally
* Leadership skills, including proven leadership of project teams experience
* Thorough scientific knowledge sufficient to understand all aspects of regulatory/pharmacovigilance and partnership issues
* Thorough knowledge of the drug development process

Desirable for the role

* Knowledge of new and developing regulatory and pharmacovigilance expectations
* Knowledge of existing AstraZeneca external alliances and collaborative projects
* Experience of working with third party suppliers
* Experience in safety database functionalities

Why AstraZeneca?
Our purpose is ambitious and so is our approach. Becoming a more agile and innovative company means building a dynamic, inspiring culture where we celebrate forward thinking and act with a sense of urgency. We are ambitious, take informed risks and learn from both success and failure. We are curious, creative and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. Are you ready to move forward in your career?

Join us and be part of an outstanding place to work; an environment that energizes and empowers each of us to achieve our personal and organisational goals!

So, what's next!
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. We welcome you with your application, no later than, 27 September, 2023. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The position is located at the Sahlgrenska Center for Cancer Research, University of Gothenburg, in close proximity to the Sahlgrenska university hospital. The center is part of a strategic research effort within the Sahlgrenska academy focused on cancer and consists of 27 research groups. These groups have a wide range of research activities spanning from basic cancer research to clinical projects with a translational approach.

Subject area 
Targeted cancer therapy 

Subject area description 
A post doc position is available within the research area of targeted cancer therapy. The position is located in Göran Stenman’s research group at the Sahlgrenska Center for Cancer Research. The main aim of the project is to develop new therapy for glandular cancers with tumor type-specific genomic aberrations for which there are currently no treatment. The project includes large-scale drug screening and validation of pharmaceutical substances in in vitro models such as 2D and 3D cultures of primary tumor cells and in the extension in vivo in patient-derived xenograft models. The project aims to develop targeted therapy that can be combined with for example chemo- or radiation therapy. The work is carried out in close collaboration with national and international partners within academia and the health care system. Further information about the research group is available online at: https://www.gu.se/en/research/goran-stenman 

Duties 
You will plan, design and carry out research with the aim of developing new molecular treatment for glandular cancers. The work includes for example culture of human primary/short-term cultured tumor cells, pharmaceutical treatment/screening, proliferation/apoptosis/sphere assays, method optimization, bioinformatics/statistics, quantitative PCR, RNA-seq and western blot analysis. The position also includes project management, supervision, and written and oral reporting of research data.

Eligibility 
The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg. 

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. 

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.   

Assessment criteria 
We are looking for a curious, ambitious and driven scientist who can easily work with others. A suitable background is a PhD degree within biomedicine or a closely related field such as molecular biology or biochemistry. Experience with culturing human tumor cells is a merit as well as documented hands-on experience with bioinformatics, biostatistics, cell-based assay optimization, and combination treatments. Excellent organizational and communication skills in written and spoken English is a demand, as is the ability to deliver on deadlines. We are looking for an enthusiastic scientist who wants to take part in developing new cancer treatment in a research team and who is also motivated by working independently. The applicant should have a documented competence of independent research work.

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.

Employment 
The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed.

Contact information 
If you have any questions about the position, please contact Göran Stenman, professor, Phone: +46 31 786 6734, e-mail: [email protected]

 

Application 

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

The application should contain:


• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publications
• Proof of completed PhD
• Contact details of two references

Applications must be received by: 2023-08-21.? ? 

Information for International Applicants 

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: 

https://www.gu.se/en/about-the-university/welcome-services 
https://www.movetogothenburg.com/ 

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Do you have expertise in mathematical modelling and/or pharmacokinetics (PK) and pharmacodynamics (PD) and its application in drug discovery? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for to be part of the development of future treatment within respiratory and immunology.


We are now looking for a highly skilled and motivated modelling and simulation scientist with expertise in mathematical modelling preferably applied in the field of pharmacokinetics-pharmacodynamics (PKPD) to join our drug metabolism and pharmacokinetics department within early Respiratory and Immunology (R&I) at AstraZeneca's world-class R&D centre in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress.


At AstraZeneca we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity toward delivering candidate drugs into late-stage development.


What you'll do
You have a true passion for science and will support our portfolio within the R&I therapeutic area. We believe that you have solid, hands-on experience of PKPD modeling and that you will be able to provide expert advice and interpretation of complex drug discovery data. You will deliver translational quantitative/PKPD input for a broad range of drug modalities from target identification to life-cycle management as an Associate Principal Scientist (APS) or Principal Scientist (PS), depending on your background, experience and skills.

Main Duties and Responsibilities include:
* Identify the appropriate models and conduct analysis/modelling of PKPD data from various sources (from internal lab or external sources). Such models could be e.g. traditional PKPD modelling, non-linear mixed effects modelling or quantitative systems pharmacology to deliver the PKPD insights to influence critical decisions in drug discovery and development
* Inform and influence the design of studies, with PKPD in mind to answer relevant pharmacological questions and report results to project teams and internal governance bodies
* Contribute towards defining safety margins by means of PKPD assessments of efficacy and safety risks in collaboration with other functions
* Predict human pharmacokinetics, efficacious exposure and dosing regimen. This is done in close collaboration with other functions (bio scientists, safety scientists, clinical pharmacologist and clinical pharmacometricians)
* Communicate scientific progress to internal and external stakeholders
* Deliver input and data to projects within agreed timelines and to the right quality that supports/influences compound profiling, project progression and project strategy
* Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
* Prepare clear presentations related to the above for internal governance bodies



Essential for the role
The successful candidate is expected to have a solid PKPD understanding and hands on experience of mathematical modelling (e.g. empirical PKPD models, in vitro-in vivo translation, non-linear mixed effects models, quantitative systems pharmacology (QSP) models).
* PhD or equivalent in relevant field, with a focus on mathematical modelling of PKPD data, ideally in a preclinical/translational setting with a profound knowledge of drug discovery and development processes
* Specialist in PK and PKPD data analysis, interpretation, and reporting, including hands-on experience with modelling software (e.g. Phoenix WinNonlin, Matlab, Monolix, R, NONMEM, or similar)
* Proven scientific leadership and ability to mentor junior colleagues
* Experience in project leadership and collaborative mindset
* Scientific leadership evidenced by a publication track record and ability to independently lead the drafting and review of publication manuscripts
* Excellent interpersonal skills, and ability to work in cross-functional teams as well as independently
* Proactive and excellent communication skills
* Experience in defining quantitative modelling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, peptides, proteins, antibodies)



Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.



What's next?
This is an exciting opportunity for a talented modeller to join a strong team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the wonderful city of Gothenburg, Sweden.
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until September 8, 2023.
For more information about the position, please contact recruiting manager Nina Lawrence at [email protected] Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Institutionen för kliniska vetenskaper är jämte fem andra institutioner en del av Sahlgrenska akademin. Här bedrivs forskning och utbildning som sätter människans hälsa och livskvalitet i fokus. Institutionen för kliniska vetenskaper är organiserad i fyra sektioner och 16 olika ämnesområden. Genom ett berikande samarbete med sjukvården och Sahlgrenska Universitetssjukhuset har vi utvecklat samprojekt och mötesplatser som gynnar både vården och forskningen.

Avdelningen för pediatrik är ett av ämnesområdena inom institutionen för kliniska vetenskaper vid Sahlgrenska Akademin. Vi söker en biträdande forskare för en tidsbegränsad anställning, 11 månader lång tjänst inom translationell barncancerforskning. Forskargruppen arbetar i gränslandet mellan klinisk barnonkologi och grundforskning. Arbetet präglas av ett tätt samarbete mellan läkare och labforskare inom gruppen, men också med framstående kollegor i närliggande forskargrupper. Forskningen kommer att bedrivas på Sahlgrenska Center for Cancer Research, Medicinaregatan. 

Arbetsuppgifter 
Huvuduppgiften är att bedriva forskning självständigt, men genom ett nära samarbete med kollegor av olika yrkesgrupper. Projektets målsättning är att testa potentialen för patientspecifik analys av cirkulerande tumör-DNA som markör för behandlingssvar och återfall vid tumörer hos barn. Du kommer att designa och genomföra experiment, sammanställa och tolka data, och presentera resultaten inom och utanför forskargruppen. Denna anställning fokuserar på den experimentella sidan av projektet, och du kommer inte att träffa patienter.  

Kvalifikationer 
För anställningen krävs mastersexamen i relevant område för tjänsten. Tidigare erfarenhet inom forskning gällande solida tumörer hos barn är ett plus, liksom erfarenhet av forskning innefattande cirkulerande tumör-DNA. 

Anställning 
Anställningen är tidsbegränsad 11 månader på heltid med placering vid institutionen för kliniska vetenskaper, avdelningen för pediatrik. Tillträde: Enligt överenskommelse 

Kontaktuppgifter för anställningen 
Upplysningar om anställningen lämnas av docent, Martin Dalin, tfn;+46 709-220310 eller e-post; [email protected]

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande  

Ansökan 
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Ansökan ska vara inkommen senast: 2023-07-21

 

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Vid Institutionen för neurovetenskap och fysiologi vid Sahlgrenska akademin bedrivs omfattande forskning och undervisning över stora kunskapsområden från molekyl till människa. Verksamheten utgörs av fem sektioner; farmakologi, fysiologi, hälsa och rehabilitering, klinisk neurovetenskap samt psykiatri och neurokemi.

Institutionen för neurovetenskap och fysiologi, söker nu en talangfull och motiverad postdoktor, med placering vid Sektionen för fysiologi.

Kandidaten ska undersöka molekylära mekanismer för hjärnskador och utveckling av hjärnskadeskyddande behandling. Kandidaten kommer att spela en nyckelroll i ett translationellt forskningsprojekt i framkanten av forskningsområdet perinatal neurovetenskap. 

Projektet ingår i en parkopplad postdoktor-utlysning, där två forskningsledare tillsammans anställer en preklinisk och en kliniskt orienterad postdoktor i syfte att stärka kopplingarna mellan experimentell och klinisk forskning. För detta projekt rekryteras postdoktorerna till forskargrupperna som leds av Prof. Henrik Hagberg och Prof. Carina Mallard och som ingår i Centrum för perinatal medicin och hälsa vid Sahlgrenska akademin, Göteborgs universitet. Centrumet tillhandahåller utmärkt experimentell infrastruktur och omfattande internationella forskningssamarbeten. Projektet finansieras av Wallenberg Center for Molecular and Translational Medicine (WCMTM) vid Göteborgs universitet (https://www.gu.se/en/molecular-translational-medicine) och postdoktorerna kommer att ingå i ett stort vetenskapligt nätverk av unga forskare inom det molekylära medicinområdet vid Wallenberg Centers över hela Sverige.

Ämne
Perinatal neurovetenskap

Ämnesbeskrivning
Komplikationer som uppstår under graviditet, förlossning eller den neonatala perioden kan ha livslånga effekter på individen. Mer än 50% av spädbarn som föds för tidigt kommer att lida av cerebral pares, kognitiv funktionsnedsättning eller beteendestörningar inklusive autismspektrumstörningar och minst 40% av fullgångna spädbarn med hypoxisk-ischemisk encefalopati kommer att utveckla allvarliga neurologiska handikapp. Detta understryker det akuta behovet av mer kunskap om de bakomliggande mekanismerna för att utveckla nya behandlings- och förebyggande strategier. 

Arbetsuppgifter
Kandidaten kommer att karakterisera de molekylära mekanismerna som styr mitokondriell funktion i relation till aktivering av inflammasomen efter perinatal hjärnskada.

Kandidaten kommer att använda experimentella modeller i nyfödda möss och arbeta med material från en preklinisk smågrismodell. Väl etablerade molekylära tekniker kommer att kombineras med avancerade tekniker för analys av mitokondriell funktion och morfologi, spatial transkriptomi och cryoEM för att identifiera patofysiologiska mekanismer bakom perinatal hjärnskada.

Behörighet
Behörighet för anställning som lärare regleras i Högskoleförordningen 4 Kap och Göteborgs universitets anställningsordning. 

Behörig att anställas som postdoktor för denna utlysning är den som innehar doktorsexamen i medicinsk vetenskap, bioteknologi eller biomedicin. 

Bedömningsgrund
Sökande förväntas ha en stark bakgrund med vetenskaplig produktivitet med publikationer som första författare i internationellt kända tidskrifter. Den idealiska kandidaten har experimentell erfarenhet av djurstudier samt stor erfarenhet av att arbeta med molekylära tekniker. Tidigare forskningsarbete inom område relaterade till den omogna hjärnan är meriterande.

Den framgångsrika sökande förväntas planera, genomföra och analysera experiment på ett självständigt sätt och att aktivt bidra vetenskapligt till gruppen. Kandidater måste ha utmärkt muntlig och skriftlig kommunikationsförmåga på engelska. Vi lägger stor vikt vid personlig lämplighet. 

Anställning
Anställningen är en tidsbegränsad anställning i 2 år, 100% av heltid, med placering tills vidare vid Institutionen för neurovetenskap och fysiologi. Tillträde: snarast eller enligt överenskommelse. 

Kontaktuppgifter för anställningen
Har du frågor om anställningen är du välkommen att kontakta professor Carina Mallard, tfn: +46 705 63 10 04, epost: [email protected]

Ansvarig chef är professor/biträdande sektionschef Holger Nilsson, tfn: +46 31 786 35 18, e-post: [email protected]

Ansökningshandlingar skickas inte till kontaktpersonerna.

Fackliga organisationer
Fackliga företrädare vid Göteborgs universitet hittar du här: ?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Ansökan
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att registrera din ansökan elektroniskt via hemsidan: https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar 

Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen ”Ansök”. tillhanda senast sista ansökningsdag. 

Intyg om doktorsexamen bifogas med ansökan.

Ansökan ska vara inkommen senast: 2023-06-30

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Do you have expertise in and a passion for Integrated Bioanalysis? Are you ready to work at the scientific forefront, where innovations and an entrepreneurial spirit are the norm? Good, then this role might be for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.



The role
As part of the Integrated Bioanalysis (iBA) Global Team, you will be responsible for leading the design and implementation of robust bioanalytical strategies, including but not limited to, endpoints such as PK/CK, immunogenicity and biomarkers when required to support the AstraZeneca pipeline. Working with a dynamic team in a matrixed environment you will need to manage stakeholder expectations, input to project strategy and delivery while being the main collaborator with experienced and highly skilled bioanalytical scientist colleagues or our partnered labs. You will have the opportunity to have an immediate and lasting impact to our diverse pipeline.



The iBA group within Clinical Pharmacology and Safety Sciences provides broad discovery, preclinical, and clinical support including life cycle management across all therapeutic areas enabling pipeline delivery, decision making, innovation and advancement to improve the lives of patients through life-changing medicines.



What you'll do
This role will be located in Gothenburg, Sweden, where you will work alongside TA leads and stakeholders. In this non-laboratory-based role and you will be highly visible and able to use scientific knowledge and expertise while working with a range of collaborators and cross functional groups. You will need to use your experience and proven track record in designing, developing and delivering robust bioanalytical strategies and scientific oversight and delivery. You will also work with regulatory agencies and Health Authorities across a range of countries and geographies to mitigate risk, submit regulatory documents and respond to Health Authority questions. As a Subject Matter Expert, you will be responsible for improving the iBA reputation for scientific excellence by presenting at internal and external meetings, and publishing manuscripts.



The successful candidate will work closely with AstraZeneca laboratory groups within iBA and our vendor partners to ensure appropriate bioanalytical and platform strategies, scientific oversight and delivery of our cell and gene therapy pipeline while fostering an environment of scientific knowledge exchange. They will also interact with stakeholders and cross functional project teams.



Essential for the role:

*

PhD in immunology, molecular biology or related studies with significant relevant experience with a strong track record in regulated bioanalysis in a pharmaceutical or CRO setting.
*

Proven experience as a Subject matter Expert in regulated bioanalysis for PK/CK, PD and immunogenicity assessments and experienced as a bioanalytical lead in diverse project teams, defining, leading and implementing robust bioanalytical strategy to advance the portfolio.
*

Worked collaboratively with business partners, providing solutions to challenges and mitigating risk.
*

Skilled in use of bioanalytical methods in drug development such as ligand binding assays, LC-MS and molecular assays and supervising assay transfer, scientific quality and study conduct at CRO partners.
*

Deep understanding of global regulatory expectations and guidance with significant contributions to regulatory submission documentation such as INDs, CTAs, IBs, ISI and/or NDAs/BLAs.
*

Ability to balance multiple projects and / or tasks concurrently in a fast-paced environment and associated interpretation of integrated and complicated datasets.

Desirable for the role:

*

Matrix or line management experience.
*

Ability to develop, coach and mentor.
*

Proven publication and presentation record.
*

Outstanding verbal and written communication skills.

So, what's next
Are you already imagining yourself joining our team - good, because we can't wait to hear from you!





Additional information
Our Company Values & Behaviors underpin everything we do so please take a moment to familiarize yourself with them. You may also want to check out our new R&D Video showing how we turn Science into Medicines.

Where can I find out more
Our Social Media, Follow AstraZeneca on:

LinkedIn: https://www.linkedin.com/company/1603/

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Vid Institutionen för neurovetenskap och fysiologi vid Sahlgrenska akademin bedrivs omfattande forskning och undervisning över stora kunskapsområden - från molekyl till människa. Verksamheten utgörs av fem sektioner; farmakologi, fysiologi, hälsa och rehabilitering, klinisk neurovetenskap samt psykiatri och neurokemi.

Institutionen för neurovetenskap och fysiologi, söker nu en forskare, med placering vid Sektionen för fysiologi. 

En forskningsgrupp som studerar perinatala hjärnskador med inriktning mot autism vid Institutionen för neurovetenskap och fysiologi, Sektionen för fysiologi, Göteborgs universitet, utlyser en anställning som forskare i anatomisk neuroinflammation och neuroprotektion. Forskningen fokuserar på att studera neuropatologi i den omogna hjärnan som relaterar till specifika mekanismer och autistiskt beteende. Ett huvudsyfte är att finna nya biomarkörer för autism för barn som föds för tidigt och drabbas av neonatala infektioner.

Arbetsuppgifter

Arbetsuppgifterna omfattar kirurgiska ingrepp och metoder för att undersöka autistiskt beteende i heldjursmodeller med immunologisk påverkan.

Histologiska och immunohistologiska metoder, avancerad 3D mikroskopering (stereologi) och molekylärbiologi hos nyfödda möss utgör dessutom en betydande del av arbetet.

I tjänsten ingår även studenthandledning och undervisning, framför allt i cirkulationsfysiologi, och i begränsad omfattning, vissa administrativa arbetsuppgifter.

Kvalifikationer

Sökande måste ha fullgjort doktorsexamen i medicinsk vetenskap, bioteknik eller biomedicin.

Den ideala kandidaten har medicinsk grundutbildning och doktorsexamen i medicinsk vetenskap med teoretisk bakgrund i neurovetenskap och perinatal cirkulationsfysiologi. Kandidaten måste ha goda erfarenheter i immunohistokemi, analys av mikroskopiska bilder inklusive 3D rekonstruktion (stereologi) samt stor erfarenhet av avel och arbete med nyfödda transgena möss.

Tidigare forskningsarbete om inflammation i den omogna hjärnan, inklusive publikationer inom området, och handledning av doktorander är meriterande. Goda samarbets- och kommunikativa färdigheter är ett krav. Vi lägger stor vikt vid personlig lämplighet.

Anställning

Anställningen är en tidsbegränsad anställning i 6 månader, 100% av heltid, med placering tills vidare vid Institutionen för neurovetenskap och fysiologi. Tillträde: snarast eller enligt överenskommelse. 

Kontaktuppgifter för anställningen

Har du frågor om anställningen är du välkommen att kontakta professor Carina Mallard, tfn: +46 705 63 10 04, e-post: [email protected]

Ansvarig chef är professor/biträdande sektionschef Holger Nilsson, tfn: +46 31 786 35 18, e-post: [email protected]

Ansökningshandlingar skickas inte till kontaktpersonerna.

Fackliga organisationer

Fackliga företrädare vid Göteborgs universitet hittar du här: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Ansökan

Du söker anställningen via Göteborgs universitets rekryteringsportal genom att registrera din ansökan elektroniskt via hemsidan: https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar 

Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag.

Intyg om doktorsexamen bifogas med ansökan.

Ansökan ska vara inkommen senast: 2023-06-15

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The position is located at the Sahlgrenska Center for Cancer Research, University of Gothenburg, in close proximity to the Sahlgrenska university hospital. The center is part of a strategic research effort within the Sahlgrenska academy focused on cancer and consists of 25 research groups. These groups have a wide range of research activities spanning from basic cancer research to clinical projects with a translational approach

Subject area 
Targeted cancer therapy

Subject area description 
A post doc position is available within the research area of targeted cancer therapy. The position is located in Göran Stenman’s research group at the Sahlgrenska Center for Cancer Research. The main aim of the project is to develop new therapy for glandular cancers with tumor type-specific genomic aberrations for which there are currently no treatment. The project includes large-scale drug screening and validation of pharmaceutical substances in in vitro models such as 2D and 3D cultures of primary tumor cells and in the extension in vivo in patient-derived xenograft models. The project aims to develop targeted therapy that can be combined with for example chemo- or radiation therapy. The work is carried out in close collaboration with national and international partners within academia and the health care system. Further information about the research group is available online at: https://www.gu.se/en/research/goran-stenman 

Duties 
You will plan, design and carry out research with the aim of developing new molecular treatment for glandular cancers. The work includes for example culture of human primary/short-term cultured tumor cells in 2D and 3D models, pharmaceutical treatment/screening, proliferation/apoptosis/sphere assays, quantitative PCR, RNA-seq and western blot analysis. The position also includes project management, supervision, and written and oral reporting of research data.

Eligibility 
The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg. 

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. 

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.  

Assessment criteria 
We are looking for a curious, ambitious and driven scientist who can easily work with others and is percipient. A suitable background is a PhD degree within biomedicine or a closely related field such as molecular biology or biochemistry. Experience with culturing human tumor cells is a merit as well as hands-on experience with gene expression analyses such as RNA-seq, qPCR and western blot. Excellent organizational and communication skills in written and spoken English is a demand, as is the ability to deliver on deadlines. We are looking for an enthusiastic scientist who wants to take part in developing new cancer treatment in a research team and who is also motivated by working independently. The applicant should have a documented competence of independent research work.

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance. 

Employment 
The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed.

Selection process 
How to apply: https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply

Contact information 
If you have any questions about the position, please contact Göran Stenman, professor. Phone: +46 31-786 6734, e-mail: [email protected]

 

Application 

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

The application should contain:


• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publications
• Proof of completed PhD
• Contact details of two references

Applications must be received by: 2023-05-16

Information for International Applicants 

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: 

https://www.gu.se/en/about-the-university/welcome-services 
https://www.movetogothenburg.com/ 

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Would you like to make use your scientific expertise and skills to guide inhaled drug product design and development strategies? Join us at AstraZeneca, a place built on innovation and creativity.



We are now looking for a talented and motivated Biopharmaceutics Scientist / post-doc with a background in pharmaceutics, analytical chemistry, biomedicine or biomedical engineering for an exciting 2-year research projects in the Inhalation Product Development unit in Gothenburg, Sweden.



What you'll do

The project is a collaboration with the University of Louvain on studying the fate of novel inhaled protein therapeutics in the lung. You will work in a project team on studying how different formulation approaches can be used to avoid clearance mechanism in the lung, aiming to develop concepts for improved inhaled therapies for patients suffering from respiratory disease, and reaching other patient groups that benefit from systemic delivery of non-small molecules via the lung. The work will involve a range of in vitro experimental approaches including protein labelling, manufacture of experimental inhaled formulations, bio-relevant in vitro characterization including microscopic techniques and support to in vivo studies with delivery aspects. The work should result in a scientific publications.



AstraZeneca is a global, innovation-driven biopharmaceutical company where we turn ideas into life changing medicines and strive to meet the unmet needs of patients worldwide. We are proud to be a great place to work and have a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity.



Pharmaceutical Technology & Development (PT&D) is a global function tasked with design, development, commercialization and support of AstraZeneca's medicines and reports to the EVP of Operations. Inhalation Product Development (IPD) in Gothenburg sits within PT&D and is responsible for the development of inhalation products including combinations. Inhalation Product Development delivers the therapies of the future through scientific leadership in drug delivery, formulation and manufacturing the final drug product.



The role is a 2-year fixed term contract. For a successful candidate with PhD, the role will be regarded as a post-doc position.



Minimum Requirements

* MSc degree in a relevant discipline (such as biomedical engineering, pharmaceutics, biomedicine, analytical chemistry).
* Minimally 2 years of lab-based work experience in a relevant field (see above).
* Strong verbal and written communication skills.
* Ability and inclination to work collaboratively in a team.
* Documented independence in problem solving.



Preferred Requirements

* Track record of preparing scientific publications and presentations.
* Previous experience with aerosol delivery and characterisation.
* Previous experience of protein analysis (SEC, MFI, DLS, PAGE etc).
* Previous experience with microscopic techniques.
* Previous experience with image analysis.



Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There's no better place to make a difference to medicine, patients, and society.



Our Gothenburg site is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've built a series of environments where innovation can happen.



We offer competitive salaries and excellent benefits, such as extra paid Holiday, Private Medical Benefit, on-site Work Out and much, much more.



So, what's next!

If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us! We welcome your application no later than June 7th, 2023.



Screening of applications will be done during the application period.



Where can I find out more?



Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Patient Safety at AstraZeneca is now looking for Pharmacovigilance Scientists to join our Patient Safety Vaccines & Immune Therapies team.

The current positions are within the therapy areas of Vaccines & Immune Therapies. The core purpose of AstraZeneca Patient Safety is to add value to AstraZeneca products, provide clear science based guidance for investigators and prescribers to safeguard patients as well as the success of our business. Patient Safety covers the entire clinical life cycle of a drug from first time into man to withdrawal of a product from the market.

What you'll do
As a Pharmacovigilance Scientist, you work with Patient Safety Physicians and other PV Scientist(s) with review, analysis and interpretation of safety data obtained from patients who have been administered the assigned medicinal products in clinical development programs and/or from marketed use. You provide authoring and pharmacovigilance input to safety documents and regulatory reports and lead internal and external meetings to present safety data and analyses. You evaluate the clinical implications of safety data from pre-clinical studies, clinical studies, literature and other information sources to establish the safety profile of drugs and manage the risk to patients.

Essential for the role

*

Previous working experience from drug development and/or pharmacovigilance activities in a Pharmaceutical company, Academic research or Health Authority environment
*

Knowledge of pharmacovigilance regulations
*

You have a life sciences/pharmacy/nursing degree with proven analytical skills and understanding of scientific methodology.
*

You are curious and want to take the opportunity to learn, grow and develop from a wide range of experiences and have good attention to details.
*

You have a flexible, team orientated attitude with solid leadership skills and you are fluent in written and spoken English

We think you are looking for a position where you truly can make an impact and have the opportunity to collaborate across global boundaries. This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

Location: Gothenburg

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?
Our purpose is ambitious and so is our approach. Becoming a more agile and innovative company means building a dynamic, inspiring culture where we celebrate forward thinking and act with a sense of urgency. We are ambitious, take informed risks and learn from both success and failure. We are curious, creative and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. Are you ready to move forward in your career?

So, what's next!
We would like to know more about you. If you are interested, apply now!


Find out more:

The Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.html

LinkedIn:
https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook:
https://www.facebook.com/astrazenecacareers/ Visa mindre