Lediga jobb som Organisk kemist i Göteborg

Se lediga jobb som Organisk kemist i Göteborg. Genom att välja en specifik arbetsgivare kan du även välja att se alla jobb i Göteborg som finns hos arbetsgivaren.

Förste forskningsingenjör

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.För mer information,se Göteborgs universitet, lediga anställningar   https://web103.reachmee.com/ext/I005/... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.För mer information,se Göteborgs universitet, lediga anställningar

 

https://web103.reachmee.com/ext/I005/1035/job?site=6?=SE&validator=3038fcf1516ea1184a6da70a891f87da&job_id=33143

 Ansökan:  https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar

 

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Associate Principal Scientist - Medicinal Chemistry

Ansök    Feb 29    Astrazeneca AB    Organisk kemist
We are looking to hire an Associate Principal Scientist (APS) within our Medicinal Chemistry department in the therapeutic area of Respiratory & Immunology (R&I). In this position you will get the opportunity to lead research in a highly creative and collaborative discovery team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates. We are searching for a Medicinal Chemist with e... Visa mer
We are looking to hire an Associate Principal Scientist (APS) within our Medicinal Chemistry department in the therapeutic area of Respiratory & Immunology (R&I). In this position you will get the opportunity to lead research in a highly creative and collaborative discovery team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates.



We are searching for a Medicinal Chemist with extensive experience working with synthesis and design of small molecules and/or PROTACs. The discovery research within our department spans across small molecules, Proteolysis Targeting Chimeras (PROTACs), peptides and oligonucleotides. We embrace the diversity of talents and enable teams to grow and learn together to accomplish our collective goal to improve the quality of life for patients.



What you'll do?

As an APS in the Early R&I Medicinal Chemistry department you will play an important role in advancing drug discovery projects from target validation to preclinical phase. You will join a highly integrated discovery team leveraging innovative Medicinal Chemistry to invent novel medicines. Your focus will be on design, synthesis and characterization of drug molecules and you will be expected to lead by example with expertise and integrity, following the science and collaborating across discipline boundaries. You will ensure uptake of novel scientific developments into project teams and lead chemistry teams and compound design by generating creative and novel ideas for our molecules. You will also be expected to share scientific findings to a broader internal and external audience and to publish your results.



We are looking for a person with a strong scientific curiosity and a solid background in Organic and Medicinal Chemistry. You should be up-to-date with recent trends in Synthetic and Medicinal Chemistry and have a constant drive to develop and to implement new approaches. Excellent communication and leadership skills and a strong ability to collaborate across disciplines are important skills in this role: as an APS you will lead chemistry projects.

Main Duties and Responsibilities:

*

Support Early R&I drug discovery programs through design and synthesis of potential drug molecules
*

Provide state-of-the-art synthetic organic chemistry to projects at all stages of drug discovery delivering potential drug molecules and tool compounds
*

Collect, analyze and interpret project data. Propose hypotheses and plan how to test them
*

Collaborate and lead chemistry teams in the development, planning and prioritization of route design, sharing findings and jointly solving scientific questions in the projects
*

Drive R&I´s scientific reputation by presenting and publishing your results within the department, across AZ and externally
*

Lead chemistry programs and represent the medicinal chemistry discipline in cross functional teams
*

Follow safety requirements and all AZ corporate responsibility policies



Essential for the role

*

PhD in Organic Chemistry, Medicinal Chemistry or Biochemistry
*

>5y of professional experience as Medicinal Chemist in Pharmaceutical Industry, biotech or CRO
*

In-depth scientific knowledge and recent practical experience in the area of synthetic chemistry
*

Up-to-date with the application of modern purification and analytical techniques
*

A proven track record of delivery from own experimental and project work
*

Excellent communication, collaboration and leadership skills
*

Knowledge of the pharmaceutical drug discovery and development process



Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D sites. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,900 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.



What's next?

If you are interested, apply now! We welcome your application no later than March 31st, 2024. If you need additional information, please contact Lena Ripa at [email protected].



Where can I find out more?
Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Senior Research Scientist - Medicinal Chemistry

Ansök    Feb 28    Astrazeneca AB    Organisk kemist
Are you an experienced Organic Chemist who wants to expand Medicinal Chemistry skills? Can you envision your future in drug discovery, developing novel drug molecules? Then this is an outstanding opportunity for you! We are hiring a Senior Research Scientist in the therapeutic area of Respiratory & Immunology (R&I) at AstraZeneca BioPharmaceuticals R&D. This role is based at AstraZeneca's vibrant R&D site in Gothenburg, Sweden. What you'll do? As... Visa mer
Are you an experienced Organic Chemist who wants to expand Medicinal Chemistry skills? Can you envision your future in drug discovery, developing novel drug molecules? Then this is an outstanding opportunity for you!



We are hiring a Senior Research Scientist in the therapeutic area of Respiratory & Immunology (R&I) at AstraZeneca BioPharmaceuticals R&D. This role is based at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.



What you'll do?

As Senior Research Scientist in the Early R&I Medicinal Chemistry department you will play an important role in advancing drug discovery projects from target validation to preclinical phase. You will join a highly integrated discovery team leveraging innovative medicinal chemistry to invent novel medicines. Your focus will be on design and synthesis of drug molecules and you will be expected to lead by example and to follow the science and collaborate across scientific disciplines. You will ensure uptake of recent scientific developments into project teams and generate creative ideas in the design of novel molecules. You will also be expected to share scientific findings to a broader internal and external audience and to publish your results.



We are looking for a person who enjoys practical synthetic chemistry and has a strong background in Organic Chemistry. You should be up-to-date with recent trends in Organic Chemistry and have a problem-solving attitude and an interest to develop new skills in Medicinal Chemistry.


Main Duties and Responsibilities:

*

Support Early R&I's drug discovery programs through synthesis and design of potential drug molecules
*

Provide state-of-the-art synthetic organic chemistry to drug discovery projects, delivering high quality drug molecules
*

Collect, analyze and interpret project data. Propose hypotheses and plans how to test them
*

Collaborate with the chemistry team in the development, planning and prioritization of route design, share findings and jointly solve scientific questions in the projects
*

Follow safety requirements and all AZ corporate responsibility policies
*

Drive R&I´s scientific reputation by presenting and publishing your results within the department, across AZ and externally



Essential for the role

*

PhD in Organic Chemistry, Medicinal Chemistry or Chemical Biology
*

Strong synthetic chemistry knowledge
*

Ability to plan and perform work independently, including synthetic route design and problem solving
*

Excellent communication and collaboration skills
*

High self-motivation and capability of analyzing complex data



Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D sites. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,900 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.



What's next?

If you are interested, apply now! Please send in your application no later than March 31, 2024. If you have questions regarding the role, please contact Nils Pemberton via [email protected].



Where can I find out more?
Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Team Leader - Director, New Modalities Medicinal Chemistry

Ansök    Dec 18    Astrazeneca AB    Organisk kemist
AstraZeneca is committed to the development of the next generation of innovative medicines. We now seek to recruit a Director, New Modalities Medicinal Chemistry to the New Modalities Medicinal Chemistry team, which is part of the department of Medicinal Chemistry, Early Respiratory & Immunology (R&I) at AstraZeneca. The New Modalities team works in close collaboration with Computational Chemists, Analytical Chemists, Biologists, DMPK, Safety and Pharmace... Visa mer
AstraZeneca is committed to the development of the next generation of innovative medicines. We now seek to recruit a Director, New Modalities Medicinal Chemistry to the New Modalities Medicinal Chemistry team, which is part of the department of Medicinal Chemistry, Early Respiratory & Immunology (R&I) at AstraZeneca.

The New Modalities team works in close collaboration with Computational Chemists, Analytical Chemists, Biologists, DMPK, Safety and Pharmaceutical scientists - all joined up by the goal to discover synthetic therapeutics of the future.



This is a very exciting opportunity as it combines Medicinal Chemistry of peptides and oligonucleotides, the development of cell- and tissue targeting moieties and the development of diverse types of conjugates. This role is based at our vibrant R&D site in Gothenburg, Sweden.



What you'll do?
The Director, New Modalities Medicinal Chemistry leads a team of 10 PhDs who share a strong experience in peptides, oligonucleotides, targeting ligands and conjugation of diverse modalities. As an authority in the field of peptide and/or oligonucleotide drug discovery the successful candidate is expected to make significant contributions to early target validation and the design, optimization and delivery of drug molecules for AZ´s new modality portfolio.

In this role you will have a significant impact on multiple projects across and beyond the R&I New Modality portfolio. You will lead a multidisciplinary, highly collaborative and international team and represent the department in global scientific initiatives defining strategic direction and implementing new technologies in Medicinal Chemistry. The successful candidate will host MSc/PhD students and postdocs, work with multiple academic and industrial partners and publish/patent and regularly present at internal and external conferences.


Major Duties and Responsibilities:
* Impact on R&I´s project portfolio of synthetic New Modalities
* Co-lead drug discovery projects and collaborate in crossfunctional teams
* Generation/support of new target/project proposals
* Advise project teams and senior leaders around peptides, oligonucleotides and conjugates
* Lead, develop and mentor a team of New Modalities chemists
* Initiate and lead collaborations with external and internal partners
* Publish and present internally and externally
* Manage performance and career development of direct reports

Essential skills/experience:
* PhD in Organic Chemistry, Medicinal Chemistry, Biochemistry or Chemical Biology
* In-depth experience in design, synthesis and characterization of peptides and/or oligonucleotides
* Expertise in pharmaceutical drug discovery and development of new modalities drug candidates
* Extensive interdisciplinary knowledge of drug discovery
* Experience in modern analytical, biophysical, structural chemistry and computational techniques
* Excellent leadership and interpersonal skills
* Ability to prioritize workload and manage challenging staff situations
* Excellent written and verbal communication skills



Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. The Respiratory & Immunology (R&I) unit is one of AstraZeneca´s core therapy areas focused on the discovery and development of novel treatments for respiratory and immunological diseases.

What's next?
We would be delighted to receive your application until January 31st, 2024.
For more information about the position please contact: Dr. Werngard Czechtizky, Head of Medicinal Chemistry, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg at [email protected].


Where can you find out more about Gothenburg?
https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Senior Research Scientist - High-throughput synthesis

Ansök    Dec 7    Astrazeneca AB    Organisk kemist
Do you have organic synthesis expertise? Are you interested in becoming part of an impactful team passioned for science and technology, and focused on chemistry automation to accelerate drug discovery? Would you like to become part of a company where we are committed to lifelong learning, growth, and development? This might be your next challenge! We are looking for an Organic Chemist for a position as Senior Research Scientist - High-throughput synthesis... Visa mer
Do you have organic synthesis expertise? Are you interested in becoming part of an impactful team passioned for science and technology, and focused on chemistry automation to accelerate drug discovery? Would you like to become part of a company where we are committed to lifelong learning, growth, and development? This might be your next challenge!

We are looking for an Organic Chemist for a position as Senior Research Scientist - High-throughput synthesis who will play an important part in our interdisciplinary team, implementing state-of-the-art chemistry automation technologies for the high-throughput synthesis of new molecules for projects.

Join our team at AstraZeneca in Gothenburg, Sweden. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
This is an exciting role where you will utilise chemistry automation technologies to optimise and synthesise libraries of screening compounds (including traditional small molecules and small molecules degraders) on nanomol and micromol scale to progress projects. You will collaborate with experts in a variety of disciplines, including medicinal chemistry and artificial intelligence, to maximise the impact of our capabilities. You will contribute to the evaluation and development of automation-friendly synthetic methods to access optimal synthetic pathways for the synthesis of desired libraries and make a significant contribution to the team delivery.

You will have access to the best internal and external science and enhance business reputation internally and externally through peer-reviewed publications and oral/poster presentations.

Essential on the role:
You're a chemist with a track record of applying technology and innovative chemistry solutions, with resulting impact on project delivery. You also have:

* Ph.D. in organic chemistry, or a Master degree in chemistry with minimum 5 years' experience in synthetic organic chemistry
* Experience in planning and executing chemistry experiments in parallel (including automation) and adapting existing protocols to new applications
* Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification, and analytical chemistry
* Excellent knowledge of current chemical literature and technologies for driving project delivery
* Technology-first mindset
* Understanding of drug discovery


The successful candidate should encourage innovation and be motivated to work effectively in team having strong communication and collaboration skills. The ideal candidate should demonstrate ability to work across scientific fields, possess a curious mind and a long-term commitment to advancing chemistry automation as an innovative tool in drug discovery.

Why AstraZeneca Gothenburg?
With more than 2,800 employees from more than 70 different countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

So, what's next? If this sound like your next challenge - welcome to apply today!

Welcome with your application no later than January 8, 2024.

For more information about the position please contact Giulia Bergonzini, Director of Chemistry, at [email protected].

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Forskningsassistent för beräkningsbiologi

Ansök    Jan 11    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vet... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vetenskaper och molekylära livsvetenskaper. Vår forskning och utbildning fokuserar på en djup förståelse av kemiska och biologiska processer i celler och i miljön. Vi ansvarar för forskarutbildning inom ämnesområdet Naturvetenskap med inriktning mot kemi, biofysik, biologi och utbildningsvetenskap. Därtill är institutionen värd för utbildningsprogram i molekylärbiologi, genomik och systembiologi, kemi, organisk kemi och läkemedelskemi samt receptarieutbildningen.  Institutionen är en internationell miljö med tvärvetenskapliga samarbeten inom både forskning och utbildning, och bidrar starkt till Göteborgs universitets topprankning inom life science. Institutionens verksamhet bedrivs i Natrium, Medicinareberget i Göteborg.

Arbetsuppgifter 
Vi söker en forskningsssistent för att gå med i vår forskargrupp i tolv månader (https://dbojar.com/bojar-lab/). Genom att utveckla och tillämpa beräkningsmetoder som sträcker sig från bioinformatik till AI, kommer den framgångsrika kandidaten att flytta gränsen inom beräkningsglykobiologi och förbättra analysen av kolhydratrelaterade data, såsom glykomik eller glykanbindande data. Forskningsassistenten kommer att bidra till och förbättra vår kodbas i Python-paketet glycowork med öppen källkod. Exempel på uppgifter inkluderar nya och/eller förbättrade djupinlärningsmodeller för att förutsäga glykanegenskaper som protein-kolhydratbindning eller förbättrade algoritmer för att analysera glykanrelaterade systembiologiska data.

Kvalifikationer 
Krav utbildning, kunskaper och erfarenheter, personliga egenskaper

- Erfarenhet av att arbeta med Python

- Kandidatexamen inom beräkningsbiologi.

Meriterande utbildning, kunskaper och erfarenheter, personliga egenskaper

- Genomfört projekt i glykobiologi

- Demonstrerad erfarenhet av att använda GitHub

Anställning 
Anställningen är tidsbegränsad anställning på heltid under 360 dagar med placering vid institutionen för kemi och molekylärbiologi.

Kontaktuppgifter för anställningen 
Har du frågor om anställningen är du välkommen att kontakta Daniel Bojar, epost: [email protected]

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Ansökan 
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Din ansökan skall innehålla 


• Personligt brev
• CV
• Bevis på din kandidatexamen

Ansökan ska vara inkommen senast: 2024-02-01

 

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Chemistry & Material Specialist

Ansök    Aug 10    PulPac AB (publ)    Organisk kemist
Är du nyfiken på teknik som bidrar till en mer hållbar framtid? Vill du vara med och utforska möjligheterna med fiber som material tillsammans med engagerade kollegor? Hos oss får du chans att skapa något nytt i en miljö som präglas av engagemang, innovation och nyfikenhet. Har du goda kunskaper om cellulosafiber och ett intresse för problemlösning med hållbarhet i fokus - då är detta rätt roll för dig! Vad kan vi erbjuda dig? - En innovativ och familjär... Visa mer
Är du nyfiken på teknik som bidrar till en mer hållbar framtid? Vill du vara med och utforska möjligheterna med fiber som material tillsammans med engagerade kollegor? Hos oss får du chans att skapa något nytt i en miljö som präglas av engagemang, innovation och nyfikenhet. Har du goda kunskaper om cellulosafiber och ett intresse för problemlösning med hållbarhet i fokus - då är detta rätt roll för dig!

Vad kan vi erbjuda dig?

- En innovativ och familjär miljö där vi värnar om både varandra och vår planet

- En möjlighet att få utforska en unik teknik med potential att ersätta engångsplast på global skala

- En arbetsplats där vi har kul tillsammans, med allt ifrån kallbad och löpning till AW

Vårt Chemistry & Materials-team ansvarar för att driva utveckling inom Kemi och Material. Som Chemistry & Material Specialist med fiber som ditt expertområde kommer du bidra med din kunskap om fiberns fysikaliska och kemiska egenskaper samt hur materialet påverkas vid olika applicerings- och processtekniker. En viktig del av din roll kommer handla om att lösa processtekniska utmaningar för att uppnå optimala material- och barriäregenskaper på produkter av torrformad cellulosa. Tillsammans med dina kollegor ansvarar ni för tekniskt underlag, funktionalitet, dokumentation och relevanta resultat kopplat till försök i både lab-, pilot- och fabriksskala.

Kemi och Material är ett viktigt område för vår teknik där barriäregenskaper är en central del av produktens design och specifikation. Som en del av vår R&D-avdelning är du och dina kollegor med och skapar möjligheterna med torrformad cellulosa för att hjälpa våra kunder i övergången från plast till hållbarare alternativ.

I din roll kommer du bland annat att:

- Utforska och utvärdera olika materialval och dess användningsområden för PulPac’s teknik.

- Utveckla recept och lösningar för olika typer av funktionalitet i form av materialegenskaper och prestanda.

- Skapa teknisk dokumentation, dels som resultatunderlag för testkörningar, dels som underlag till patentansökningar.

- Utveckla torrformningsmässiga tekniska processer, både för industriell skala och för laboratoriemiljö.

- Bidra med din kunskap till resten av verksamheten.

Om dig
För att trivas i din roll som Chemistry & Material Specialist tror vi du är en positiv och kommunikativ person som drivs av ett nära samarbete med dina kollegor. Då du kommer arbeta i en aktiv miljö där riktning snabbt kan ändras, ser vi gärna att du är flexibel, har lätt för att ta egna initiativ och har en förmåga att skapa struktur omkring dig.

För att lyckas i din roll har du en ingenjörsexamen inom kemiteknik, gärna med inriktning mot process, samt ett par års erfarenhet av liknande arbete sedan tidigare, gärna från fiber-, massa-, process- eller barriärindustrin. PhD examen är meriterande. Vi ser gärna att du har arbetat med utveckling av tekniska processer och testning samt har en god dokumentationsförmåga.

Du behärskar både svenska och engelska flytande i tal och skrift. Eftersom resor kan förekomma i tjänsten så behöver du ha körkort.

Då urval sker löpande så önskar vi att få in din ansökan så snart som möjligt. Har du eventuella frågor eller funderingar kring tjänsten så är du välkommen att kontakta HR Linus Pihlsgård på 0766 523 362 eller [email protected].

Vi ser fram emot din ansökan!

Om PulPac
PulPac är ett R&D- och IP-bolag som utvecklar och säljer en banbrytande tillverkningsteknik för fiberbaserade förpackningar och engångsprodukter med hög prestanda och lågt pris. Genom att revolutionera tekniken för cellulosaformning gör vi det möjligt för våra kunder att ersätta engångsplast med ett hållbart och kostnadseffektivt alternativ. Vår marknad är global och vårt mål är att ersätta världens engångsplast genom att licensiera vår teknik till etablerade förpackningstillverkare.

https://www.youtube.com/watch?v=IKgfMxi8U0Y

https://www.pulpac.com/ Visa mindre

Associate Principal Scientist - Synthetic Medicinal Chemistry

Ansök    Sep 5    Astrazeneca AB    Organisk kemist
Are you an experienced organic chemist with profound interest in advanced synthetic chemistry and would like to be a leader of this area? Are you excited by challenging, creative chemistry and pioneering technology? Then you might be the one we are looking for! Join us and apply your expertise in a company that follows the science and turns ideas into life-changing medicines. At AstraZeneca, you will be empowered to be innovative and creative where diffe... Visa mer
Are you an experienced organic chemist with profound interest in advanced synthetic chemistry and would like to be a leader of this area? Are you excited by challenging, creative chemistry and pioneering technology? Then you might be the one we are looking for! Join us and apply your expertise in a company that follows the science and turns ideas into life-changing medicines.

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We now have an exciting opportunity for an Associate Principal Scientist within the Medicinal Chemistry department in the therapeutic area Cardiovascular, Renal and Metabolism (Early CVRM). In this role you are expected to lead science and collaborate with the global team of scientists dedicated to advancing the field of synthetic chemistry relevant to Medicinal Chemistry, including high throughput experimentation (HTE), green/sustainable chemistry, bio-catalysis, chemical biology and much more.

The use of innovative synthetic chemistry allows the development of efficient and sustainable processes by enabling efficient routes towards drug discovery compounds. We expect the successful candidate to have experience in a range of technologies such as photo/electrochemistry, C-H functionalization, and general knowledge on green and sustainable synthetic chemistry.

The role will be based at AstraZeneca's dynamic R&D site in Gothenburg, Sweden and be an integrated part of the chemistry community.

What you'll do

The role is primarily lab-based and focused on delivering synthetic chemistry to impact AstraZeneca's portfolio of drug projects. In a highly cross-disciplinary environment as part of an open-minded, creative team in Medicinal Chemistry you will seek out the most appropriate methods for carrying out experimental work to a high standard, including using relevant automation. You will provide leadership in synthesis, related workflows, and equipment and work collaboratively internally and globally to help to design, develop, and implement best practice. Through your synthetic chemistry skills you will be an integral member of the design teams and influence next generation molecules to be made in drug discovery projects.

You will be active in evaluating and implementing cutting edge technologies and workflows via external collaborations and internal science and technology projects and help build the strategic direction.

You will be an emerging leader within synthesis on the international arena and be supported to build your network and external profile further as you are expected to take part of external collaborations and publish scientific papers. There will be opportunities for mentorship and supervision of students and post-docs.

Essential for the role

We are looking for a person who is a passionate and excellent synthetic chemist and who has the ability to think innovatively, drive improvement and support development of co-workers.

To be successful in this role you need to be highly self-motivated and capable of analyzing complex data and to decide on next course of action. You also need to possess excellent teamwork skills and a demonstrated ability to work in cross-functional teams. It's important to have excellent communication and strategic influencing skills including scientific writing.

*

Experienced Ph.D. in Organic Chemistry with relevant multi-year industrial or academic experience, or equivalent.
*

Recent practical experience in organic synthesis in the pharmaceutical industry and/or academia including working with novel synthetic methodology; with the ability to plan, prioritize and perform work independently, including synthetic route design and problem-solving.
*

An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques.
*

Hands on experience in novel synthesis methodology.
*

Great awareness of recent literature as well as current developments and trends in organic synthesis.
*

Excellent English, both spoken and written.
*

A strong track-record in publications and conference presentations.

Desirable for the role

*

General knowledge of green chemistry principles, photo and /or electrochemistry.
*

Experience of supervising students and/or mentoring peers.

So, what's next?

Are you already imagining yourself joining our team? Excellent! We look forward to your application.

Welcome with your application no later than October 1st 2023. We will review the applications continuously so please apply at your earliest convenience.

For more information, please contact recruiting managers Olaf Panknin ([email protected]) or Magnus Johansson ([email protected])

Where can I find out more?

Global Gothenburg: Link

Our Gothenburg site: Link

AstraZeneca sustainability efforts: Link

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,800 employees from more than 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Visa mindre

Senior Research Scientist - Synthetic chemistry

Ansök    Okt 20    Astrazeneca AB    Organisk kemist
Are you a passionate Scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the opportunity to further exploit our drug discovery platforms? If yes, we have just the position for you at AstraZeneca, Discovery Sciences in Gothenburg, Sweden! We are currently recruiting a motivated Senior Research Scientist with recognized solid sup... Visa mer
Are you a passionate Scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the opportunity to further exploit our drug discovery platforms? If yes, we have just the position for you at AstraZeneca, Discovery Sciences in Gothenburg, Sweden!

We are currently recruiting a motivated Senior Research Scientist with recognized solid support synthesis expertise within the oligonucleotide or peptide chemistry field to join our Oligonucleotide Chemistry team within the Oligonucleotide Discovery Department, part of the Discovery Sciences R&D organization at AstraZeneca in Gothenburg, Sweden.

This is an opportunity for you to apply your expert synthetic organic chemistry knowledge to expand the use of oligonucleotides, and molecular conjugates thereof, in the treatment of diseases across therapy areas within AstraZeneca. In doing so you demonstrate a passion for driving scientific questions, combined with strong working ethics and the ability to work well within teams aiming to drive drug discovery projects forward.

The Oligonucleotide Chemistry team is working in close collaboration with other Scientists in Discovery Sciences, Medicinal Chemistry, Pharmacology, DMPK, Safety and Pharmaceutical sciences with a focus on the goal to design and develop the oligonucleotide therapeutics of the future. We offer a highly rewarding scientific environment, with the expectation to publish new findings.

What you will do
This role is a synthesis specialist role with a focus on developing oligonucleotide drugs and thereby supporting the AstraZeneca pipeline. You will also synthesize and purify high quality building blocks and compounds by applying cutting-edge technologies and methodologies to support project progression from pre-TSID to CDID according to agreed timelines, as well as applying purification and analytical sciences, troubleshoot challenges and make a significant contribution to the practical delivery of project compounds. You will work alongside other chemists in the team to support project priorities but should also be comfortable in supervising more junior colleagues. The role also includes development of new building blocks and linkers as well as setting up new techniques.

As a Senior Research Scientist you will propose experimental strategies and have the possibility to be creative in solving a wide range of synthetic challenges. You will plan, prioritize and perform your own work and actively collaborate with the project team by driving problem solving using literature and own knowledge. An important responsibility is to support oligonucleotide projects to ensure high scientific standards and quality of compounds to meet project objectives. You will build strong collaborative relationships within the team and in projects to ensure the smooth running of projects.


Essential for this role

*

A PhD in Organic Chemistry; post-doc is a plus.
*

Detailed knowledge of synthetic chemistry related to oligonucleotides, oligo building blocks and/or synthesis of advanced organic molecules. Knowledge in the area of oligonucleotide therapeutics, design and data analysis is a plus.
*

Ability to design and execute experiments autonomously.
*

Evidence of experimental impact by either peer-reviewed publications or external presentations.



The successful candidate will demonstrate a passion for driving scientific questions and is a scientifically critical individual capable of receiving and analysing input from multiple fields and deciding on focused course of action. You should also be able to work independently and have a positive, result-oriented, and problem-solving attitude. Excellent English is required, both spoken and written, and ability to operate effectively in a multi-disciplinary research environment. We also believe that you enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.

Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic science centres. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to develop a working environment that furthers collaboration, openness, and innovation. Therefore, we have built space for meetings, and socializing, where spontaneous meetings can give birth to new innovations.



Does this sound like your next challenge and a good workplace for you? Welcome to apply today!

We look forward to your application, but no later than November 3, 2023.

More information:
For more information about the position please contact Anders Dahlén at +46 31 706 4842 or [email protected]

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Principal Scientist - Oligonucleotide Chemistry

Ansök    Jul 13    Astrazeneca AB    Organisk kemist
Are you an experienced and passionate scientific specialist within Oligonucleotides and have a passion for research and development of Oligonucleotide Therapeutics? Do you wish to impact and flourish in an excellent team where you will have the opportunity to further exploit our drug discovery platforms? If yes, welcome to us at AstraZeneca! We are looking for a motivated Scientific Specialist (Principal Scientist, high expertise level) with enthusiasm, e... Visa mer
Are you an experienced and passionate scientific specialist within Oligonucleotides and have a passion for research and development of Oligonucleotide Therapeutics? Do you wish to impact and flourish in an excellent team where you will have the opportunity to further exploit our drug discovery platforms? If yes, welcome to us at AstraZeneca!

We are looking for a motivated Scientific Specialist (Principal Scientist, high expertise level) with enthusiasm, expertise and experience in Oligonucleotides to join the Oligonucleotide Chemistry team within the Oligonucleotide Discovery Department at AstraZeneca in Gothenburg, Sweden. The department is part of the broader Discovery Sciences R&D organization.

AstraZeneca is committed to the development of next generation innovative medicines and is focused on expanding the use of oligonucleotides and molecular conjugates thereof, in the treatment of diseases across therapy areas. As an expert and member of the Oligonucleotide Medicinal Chemistry team you will have a key role to influence the strategy as well as to develop and lead the science in the field to expand the use of therapeutic oligonucleotides in drug projects within AstraZeneca.

Join a place built on innovation and creativity where different views and perspectives are welcomed and valued.


What you will do:
This is a Senior Scientific role for a specialist within the field of Oligonucleotides, where you will work as an expert within oligonucleotide medicinal chemistry and contribute to shaping the future of our therapeutic oligonucleotide build, identifying opportunities to innovate in the interface between oligonucleotide chemistry and conjugation to other chemical modalities. You will be a role model and support scientists in oligonucleotide medicinal chemistry by advising and challenging them and providing expert knowledge and interpretation of complex data.

Recommend and champion new innovations that enable the Oligonucleotide Discovery department to meet its overall objectives, as well as influence across disciplines in the drug project core teams to ensure state of the art approaches in oligonucleotide medicinal chemistry are used to answer the scientific hypotheses. We also want you to demonstrate scientific leadership through high quality publications, conference presentations and by building networks with key opinion leaders and academic groups.

Essential in the role:
Our team is a collaborative group working together for a greater goal and by showing self-awareness of training needs, including leadership development, being a strong team member and an encouraging colleague, you will be successful in this role. Furthermore, you are a scientifically critical and curious individual who has the ability to operate effectively in a multi-disciplinary research environment and take own initiatives.

You also have:

* PhD in Organic Chemistry and a post-doc experience or minimum 5 years of professional experience in pharmaceutical industry or academia.
* Expert knowledge and significant experience in oligonucleotide medicinal chemistry including IP strategies.
* Great knowledge in biological processes enabling the design of effective oligonucleotide ligand conjugates.
* Substantial track record of innovation and milestone delivery in oligonucleotides drug discovery projects across phases.

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you improve your skills, abilities and contribution.

Why AstraZeneca?
With more than 2,800 employees from over 70 different countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next? If this sound like your next challenge and a good workplace for you - please apply today!

We look forward to your application and getting to know you better, but please remember to send it to us no later than August 13th, 2023.

For more information about the position please contact Anders Dahlén at +46 31 706 4842 or anders.dahlen(at)astrazeneca.com

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38

Note: Due to Swedish summer vacation period, the screening process may take a bit longer than usual. Please bear with us and we will get back to you as soon as possible when we are back in August. Visa mindre

Senior Research Scientist - Medicinal Chemistry

Ansök    Maj 15    Astrazeneca AB    Organisk kemist
Are you an experienced Organic Chemist who wants to expand Medicinal Chemistry skills? Can you envision your future in drug discovery, developing novel drug molecules? Then this is an outstanding opportunity for you! We are hiring a Senior Research Scientist in the therapeutic area of Respiratory & Immunology (R&I). This role is based at AstraZeneca's vibrant R&D site in Gothenburg, Sweden. What you'll do? As Senior Research Scientist in the Early R&... Visa mer
Are you an experienced Organic Chemist who wants to expand Medicinal Chemistry skills? Can you envision your future in drug discovery, developing novel drug molecules? Then this is an outstanding opportunity for you!

We are hiring a Senior Research Scientist in the therapeutic area of Respiratory & Immunology (R&I). This role is based at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.


What you'll do?

As Senior Research Scientist in the Early R&I Medicinal Chemistry department you will play an important role in advancing drug discovery projects from target validation to preclinical phase. You will join a highly integrated discovery team leveraging innovative medicinal chemistry to invent novel medicines. Your focus will be on design and synthesis of drug molecules and you will be expected to lead by example and to follow the science and collaborate across scientific disciplines. You will ensure uptake of recent scientific developments into project teams and generate creative ideas in the design of novel molecules. You will also be expected to share scientific findings to a broader internal and external audience and to publish your results.


We are looking for a person who enjoys practical synthetic chemistry and has a strong background in Organic Chemistry. You should be up-to-date with recent trends in Organic Chemistry and have a problem-solving attitude and an interest to develop new skills in Medicinal Chemistry.

Main Duties and Responsibilities

* Support Early R&I's drug discovery programs through synthesis and design of potential drug molecules
* Provide state-of-the-art synthetic organic chemistry to drug discovery projects, delivering high quality drug molecules
* Collect, analyze and interpret project data. Propose hypotheses and plans how to test them
* Collaborate with the chemistry team in the development, planning and prioritization of route design, share findings and jointly solve scientific questions in the projects
* Follow safety requirements and all AZ corporate responsibility policies
* Drive R&I´s scientific reputation by presenting and publishing your results within the department, across AZ and externally


Essential for the role
* PhD, or equivalent experience, in Organic Chemistry, Medicinal Chemistry or Chemical Biology
* Strong synthetic chemistry knowledge
* Ability to plan and perform work independently, including synthetic route design and problem solving
* Excellent communication and collaboration skills
* High self-motivation and capability of analyzing complex data



Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,900 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.



What's next?

If you are interested, apply now! Please send in your application no later than June 4, 2023. If you have questions regarding the role, please contact Nils Pemberton via [email protected].



Where can I find out more?
Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Doktorand i Organisk Kemi

Ansök    Jun 19    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska ve... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.
Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vetenskaper och molekylära livsvetenskaper. Från och med augusti 2023 finns vi i Natrium, en ny byggnad för naturvetenskap och life science med tillgång till moderna utbildnings- och forskningsfaciliteter. 

Doktorandtjänsten a?r knuten till den forskningsverksamhet som bedrivs i Carl-Johan Wallentins forskargrupp där ett generellt focus ligger på utveckling av nya katalytiska metoder för att generera molekylär komplexitet samt aktivera typisk inerta funktionaliteter. Mer specifikt inriktar vi oss på att använda katalytiska processer vilka drivs av synligt ljus. Projektet utgör ett samarbete mellan flertalet forskargrupper, och således kommer doktoranden få tillgång till världsledande expertis samt relevant utrustning vid flertalet lärosäten. Doktorandtjänsten kommer att omfatta metodutveckling inom området fotoredoxkatalys där interaktioner över vetenskapliga discipliner vilket möjliggör bedrivandet av forskning vid den absoluta fronten inom ämnesområdet.


Universitetsgemensam information om vad det innebär att vara doktorand vid Göteborgs universitet kan du finna på universitetets doktorandsidor. https://medarbetarportalen.gu.se/doktorand/    

Arbetsuppgifter   
Projektet kommer att vara syntesbaserat, vilket innebär att största delen av doktorandtiden kommer att vara laboratoriearbete. Det är därför viktigt att kandidaten kan uppvisa erfarenhet av laboratoriearbete i form av ett exjobb inom organisk syntes eller liknande och att kandidaten trivs med laborativt arbete.

Arbetet under doktorandtiden ska resultera i en skriven och försvarad doktorsavhandling som överensstämmer med reglerna för en avhandling vid Göteborgs Universitet.

Utbildning på forskarnivå omfattar fyra års heltidsstudier och leder fram till en doktorsexamen.?   

Inom ramen för din doktorandanställning kan du ha institutionstjänstgöring i en omfattning av max 20 % av heltid fördelat under hela utbildningstiden. Institutionstjänstgöring omfattar vanligtvis undervisning på grundnivå och avancerad nivå, men även forskning och administration kan ingå.    

Behörighet   
För tillträde till utbildning på forskarnivå krävs både grundläggande och särskild behörighet. Grundläggande behörighet till utbildning på forskarnivå har den som:


• avlagt examen på avancerad nivå;
• fullgjort kursfordringar om minst 240 högskolepoäng, varav minst 60 högskolepoäng på avancerad nivå, eller
• på annat sätt inom eller utom landet förvärvat motsvarande kunskaper.


Särskild behörighet har den som har:


• avlagt examen på avancerad nivå i relevant* naturvetenskapligt ämne, eller
• fullgjort kursfordringar om minst 60 högskolepoäng på avancerad nivå i relevanta* naturvetenskapliga ämnen, eller
• på något annat sätt inom eller utom landet förvärvat i huvudsak motsvarande kunskaper relevanta för den planerade utbildningen. *Relevant för den planerade utbildningen på forskarnivå

För särskild behörighet krävs också att sökande behärskar engelska i tal och skrift på en godtagbar nivå. Som riktmärke gäller 550 poäng på TOEFL-test (eller 213 poäng på TOEFL-CBT, eller 79 poäng på TOEFL-iBT). 

Bedömningsgrund   
Urval bland sökande som uppfyller krav på grundläggande och särskild behörighet baseras på förmågan att tillgodogöra sig utbildningen på forskarnivå. Vid bedömningen fästs särskild vikt vid dokumenterade kvalifikationer avseende:

*Erfarenhet av laborativt arbete

*Forskningsbakgrund

*Förmåga att uttrycka sig på engelska i tal och skrift  

Anställning   
Anställningsform: Tidsbegränsad anställning, fyra år

Omfattning: 100 %

Placering: Institutionen för Kemi och molekylärbiologi, Göteborg

Tillträde: Snarast enligt överenskommelse

Bestämmelser för anställning som doktorand återfinns i förordning SFS 1993:100. Som innehavare får enbart förordnas den som är antagen till utbildning på forskarnivå. Förutom skyldighet att ägna sig åt egen forskarutbildning kan innehavaren åläggas att fullgöra tjänstgöring som avser utbildning, forskning och administrativt arbete enligt särskilda bestämmelser i förordningen.

En ny anställning som doktorand gäller för högst ett år. Anställningen får förnyas med högst två år i taget. Den sammanlagda anställningstiden får dock inte vara längre än vad som motsvarar fyra års utbildning på forskarnivå på heltid.

Universitetet tillämpar lokalt avtal om lönesättning av doktorander.   

Kontaktuppgifter för anställningen   
Carl-Johan Wallentin: [email protected]  

Fackliga?organisationer   
Fackliga företrädare vid Göteborgs universitet hittar du här:   
https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande     

Ansökan   
Du söker anställningen via Göteborgs universitets rekryteringsportal, och där hittar du även den fullständiga annonsen. Du som sökande ansvarar för att ansökan är komplett i enlighet med den fullständiga annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Ansökan ska vara inkommen senast: 2023-09-30  

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Automated Chemistry Application Specialist

Ansök    Maj 12    Astrazeneca AB    Organisk kemist
Are you a trained organic chemist/synthesis chemist with practical experience of using lab automation technologies for setting up and running experiments and synthesizing new molecules? Are you interested in becoming part of an impactful team focusing on the autonomous synthesis of bioactive molecules at a company where we are committed to lifelong learning, growth, and development? This might be your next challenge! We are looking for an Organic Chemist ... Visa mer
Are you a trained organic chemist/synthesis chemist with practical experience of using lab automation technologies for setting up and running experiments and synthesizing new molecules? Are you interested in becoming part of an impactful team focusing on the autonomous synthesis of bioactive molecules at a company where we are committed to lifelong learning, growth, and development? This might be your next challenge!

We are looking for an Organic Chemist with extensive experience in applying laboratory automation technologies to the synthesis of new molecules to play a meaningful part in our iLAB team, focusing on building an industry-leading end-to-end chemistry automation platform. In this multidisciplinary, multinational team you can drive and advance our chemistry automation capabilities at AstraZeneca in Gothenburg, Sweden.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
In this exciting role, you will be responsible for the transfer of manually implemented compound synthesis to automation platforms. You will actively develop synthesis protocols for innovative chemistry transformations to be driven in a fully automated way. As well as be intimately involved in the build of a new end-to-end chemistry automation platform and work with colleagues on the design and implementation of novel automation workflows. You will also identify, test, and evaluate new devices. You will play an important role during factory and site acceptance test activities for the new platform and drive the use of these capabilities in AstraZeneca drug discovery projects.

During your work you will spend approximately 50% of your time in the laboratory investigating how manual syntheses must be modified to be driven in an automated way. You will transfer this knowledge to your colleagues to facilitate the automation of synthesis tasks requested by medicinal chemists from across the organization. During the other 50% of your time, you will work together with colleagues on the detailed specification for the future chemistry automation platform and function as an expert user of specific lab automation devices. As a Chemistry Automation Application Specialist, you will have access to the best internal and external science and be expected to enhance business reputation both internally and externally through peer-reviewed publications and oral/poster presentations.

Essential in the role:
You're a chemist with a track record of applying innovative chemistry and/or technology solutions, which result in impact on projects. You also have:

* Ph.D. in organic chemistry or a master's degree in chemistry with a minimum of five years industrial experience in synthetic organic chemistry.
* Experience in planning and executing chemistry experiments in parallel and adapting existing protocols to new applications
* Hands on experience with creating custom lab automation workflows and a strong interest in developing new technologies for organic synthesis.
* Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification, and analytical chemistry.
* Excellent knowledge of current chemical literature, chemical technologies, and innovations for driving project delivery.

We also believe that our new colleague is motivated to work effectively in a collaborative team and demonstrate ability to work across scientific fields to drive project success. The ideal candidate should have a scientific drive and a long-term commitment to advancing chemistry automation as an innovative tool in drug discovery.

Why AstraZeneca?
With more than 2,800 employees from over than 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next? If this sounds like your next challenge - apply today!

Welcome with your application but send it to us no later than 9th June, 2023.

For more information about the position please contact Dr Michael Kossenjans, Director Chemistry and Head of AZ Chemistry Automation at [email protected].

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html
This is our Discovery Sciences community: https://www.youtube.com/watch?v=pSu2Z7wpC_w Visa mindre

Senior Synthetic Chemist - Medicinal Chemistry

Ansök    Maj 15    Astrazeneca AB    Organisk kemist
Do you have a strong synthetic chemistry expertise? Would you like to use your expertise to develop drug conjugates containing small molecules, peptides, proteins or oligonucleotides in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the b... Visa mer
Do you have a strong synthetic chemistry expertise? Would you like to use your expertise to develop drug conjugates containing small molecules, peptides, proteins or oligonucleotides in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We now offer a unique opportunity for a senior scientist with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry in design of drug modalities and conjugates. As part of an open minded, creative and experienced team in New Modalities drug discovery, you will contribute with your high ambitions, collaborative attitude and enthusiasm to push the boundaries of science in the area of synthetic and medicinal chemistry. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden in the therapy area of Cardiovascular, Renal and Metabolism (CVRM).

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality and have expertise in small molecules, PROTACs, peptides, oligonucleotides, and drug conjugates. In recent years we have expanded our investments in targeted drug delivery requiring expertise in synthesis and design of various molecular conjugates.

We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to stay at the forefront of science.

What you'll do

The role is lab based and focused on synthetic chemistry of various modalities and drug conjugates. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation. The work is done in a highly cross disciplinary environment. In addition, you are expected to be part of external collaborations, publish scientific papers, present, and represent the department externally.

Essential for the role

We are looking for an ambitious team player that have expert knowledge in synthetic organic chemistry applied across multiple modalities and handling of complex molecules.

*

Ph. D. degree in Organic Chemistry, Medicinal Chemistry, Chemical Biology with emphasis on synthesis.
*

Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
*

Scientific creativity: ability to identify, develop and apply new technologies and ways of working
*

Great awareness of recent literature as well as current developments and trends in organic synthesis
*

Highly self-motivated and capable of analyzing complex data and deciding on focused course of action
*

Excellent teamwork, collaboration, networking and communication skills

Desirable for the role

*

Experience with oligonucleotide chemistry
*

Experience from developing new chemistry for conjugations of different modalities e.g. peptides, oligonucleotides, small molecules, proteins or antibodies

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information, please contact Associate Director, Ranganath Gopalakrishnan through +46-31-7761000

Welcome with your application no later than Jun 11th, 2023

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Meet Hasse, Chemist at AstraZeneca Gothenburg: https://www.youtube.com/watch?v=QulX8EotRSE&list=PLgfkdJlwmkT6h7sZKBXqs7Xj4PobD4RmR

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more. Visa mindre

APS or Senior Scientist - Oligonucleotide Conjugation Chemistry

Ansök    Maj 8    Astrazeneca AB    Organisk kemist
AstraZeneca R&D, Gothenburg, Sweden seek to recruit an Associate Principal Scientist (APS) or Senior Scientist, responsible for Oligonucleotide Conjugation Chemistry within the Medicinal Chemistry department of the therapeutic area Respiratory and Immunology (R&I). AstraZeneca is one of the world's most exciting biopharmaceutical companies. From scientists to sales, lab techs to legal, we're on a mission to turn science into life-changing medicines that ... Visa mer
AstraZeneca R&D, Gothenburg, Sweden seek to recruit an Associate Principal Scientist (APS) or Senior Scientist, responsible for Oligonucleotide Conjugation Chemistry within the Medicinal Chemistry department of the therapeutic area Respiratory and Immunology (R&I).

AstraZeneca is one of the world's most exciting biopharmaceutical companies. From scientists to sales, lab techs to legal, we're on a mission to turn science into life-changing medicines that improve patients' lives and benefit society. AstraZeneca is committed to the development of the next generation innovative medicines. The Department of Medicinal Chemistry in the therapeutic area of Respiratory & Immunology is focused on the delivery of Small Molecule (SM) and New Modalities (NM) clinical candidates. In this context, we are focused on increasing our capabilities around novel peptide and oligonucleotide-based molecules / conjugates for the treatment of respiratory and immunological diseases.



What you'll do
You will be part of a team of scientists dedicated to discovering drugs based on oligonucleotides. For this permanent position, you should have a strong background in the design, synthesis, bioconjugation, purification and characterization of novel oligonucleotides or other biologics conjugates (e. g. mRNA, antibodies). Your level of professional experience will be relevant for your initial career level (Associate Principal Scientist/Senior Scientist).


Major Duties and Responsibilities:
* Oligonucleotide conjugate design, synthesis and optimization
* Design and execution of various (bio)conjugation techniques to prepare novel oligonucleotide conjugates
* Contribution to identify novel delivery technology applicable to oligonucleotide therapeutics
* Effective collaboration with project team members and colleagues in other departments
* Driving internal / external scientific visibility through publications and scientific presentations



Essential for the role
* PhD in Bio-/Organic Chemistry/Chemical Biology
* Expertise in oligonucleotide and/or conjugation chemistry
* Knowledge of recent developments in (bio-)conjugation chemistry
* Strong scientific curiosity in novel technology and methods
* Excellent communication and collaboration skills
* Knowledge of tissue specific delivery of oligonucleotides is a bonus
* Experience in pharmaceutical drug discovery of oligo drug candidates is a plus


Why AstraZeneca?
There are many opportunities to develop yourself and your career. From our diverse portfolio and teamwork to our cutting-edge innovations - it's a place for lifelong learning. Ultimately, it's more than a job. We know that our work impacts people with serious conditions, many of whom have no other alternatives. That's what drives us - the potential to impact over one billion patients worldwide.



What's next?
For more information about the position please contact Felix Gnerlich, Team Leader, Medicinal Chemistry Oligonucleotides, by email: Felix.Gnerlich(@)astrazeneca.com or via LinkedIn. We welcome your application until May 30th, 2023.

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Senior Scientist Chemistry

Ansök    Maj 3    Hays AB    Organisk kemist
Research Scientist - On-DNA Synthesis - AstraZeneca - Gothenburg - 1-year Senior Research Scientist - On-DNA Synthesis at AstraZeneca Hays Life Sciences is currently looking for a senior research scientist for a 1 year consultant assignment with AstraZeneca. This is an exciting opportunity to join AstraZeneca's iLAB team in Gothenburg, focusing on the development and implementation of cutting-edge on-DNA chemistry techniques for DNA-encoded library... Visa mer
Research Scientist - On-DNA Synthesis - AstraZeneca - Gothenburg - 1-year

Senior Research Scientist - On-DNA Synthesis at AstraZeneca

Hays Life Sciences is currently looking for a senior research scientist for a 1 year consultant assignment with AstraZeneca.
This is an exciting opportunity to join AstraZeneca's iLAB team in Gothenburg, focusing on the development and implementation of cutting-edge on-DNA chemistry techniques for DNA-encoded library (DEL) synthesis.

Key Responsibilities:


* Design and synthesize on-DNA compounds, contributing to the continuous improvement of the DEL synthesis platform.
* Validate new building blocks and extend the implementation of synthesis automation.
* Contribute to the improvement of the building blocks database.
* Troubleshoot laboratory-based problems and contribute to the delivery of team goals.
* Enhance business reputation through peer-reviewed publications and oral/poster presentations.

Essential Requirements:


* Ph.D. in a relevant chemistry discipline, or a Master's degree in chemistry with a minimum of 5 years' experience in synthetic organic chemistry.
* Expertise in synthetic organic chemistry, retrosynthesis, compound route design, purification, and analysis. Knowledge of basic molecular biology techniques, e.g., gel electrophoresis, DNA ligation, PCR.
* Advanced knowledge of modern chemical literature, chemical technologies, and applying new ideas to project delivery.
* A track record of driving innovation in chemistry-related sciences.

Desirable Skills:


* Hands-on experience with on-DNA synthesis/DEL synthesis.

As an ideal candidate, you should be motivated to work effectively in hardworking teams and demonstrate the ability to work across scientific fields to achieve results. Strong communication skills, a scientific drive, and a high interest in working with organic chemistry and molecular biology techniques are essential.

Why join AstraZeneca in Gothenburg?


* Be part of a diverse and inclusive team of over 2,500 employees from over 50 different nationalities.
* Access to a wide range of professional development opportunities.
* Collaborative and innovative workspaces designed to encourage creativity and collaboration. Visa mindre

Associate Principal Scientist - Medicinal Chemistry

Ansök    Apr 5    Astrazeneca AB    Organisk kemist
We are looking to hire an Associate Principal Scientist (APS) within our Medicinal Chemistry department in the therapeutic area of Respiratory & Immunology (R&I). In this position you will get the opportunity to lead research in a highly creative and collaborative discovery team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates. We are searching for a Medicinal Chemist with ... Visa mer
We are looking to hire an Associate Principal Scientist (APS) within our Medicinal Chemistry department in the therapeutic area of Respiratory & Immunology (R&I). In this position you will get the opportunity to lead research in a highly creative and collaborative discovery team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates.



We are searching for a Medicinal Chemist with extensive experience working with synthesis and design of small molecules and/or Proteolysis Targeting Chimeras (PROTACs). The discovery research within our department spans across small molecules, PROTACs, peptides and oligonucleotides. We embrace the diversity of talents and allow the teams to grow and learn together to accomplish our collective goal to improve the quality of life for patients. This role is placed at our vibrant R&D site in Gothenburg, Sweden.



What you'll do

As an APS in the Early R&I Medicinal Chemistry department you will play an important role in advancing drug discovery projects from target validation to preclinical phase. You will join a highly integrated discovery team leveraging innovative Medicinal Chemistry to invent novel medicines. Your focus will be on design, synthesis and characterization of drug molecules and you will be expected to lead by example with expertise and integrity, following the science and collaborating across discipline boundaries. You will ensure uptake of novel scientific developments into project teams and lead chemistry activities and compound design by generating creative and novel ideas for our molecules. You will also be expected to share scientific findings to a broader internal and external audience and to publish your results.



We are looking for a person with a strong scientific curiosity and a solid background in Organic Chemistry. You should be up-to-date with recent trends in Synthetic and Medicinal Chemistry and have a constant drive to develop and to implement new approaches. Excellent communication and leadership skills and a strong ability to collaborate across disciplines are important skills in this role: as an APS you will be expected to lead chemistry projects.

Main Duties and Responsibilities

* Support Early R&I drug discovery programs through design and synthesis of potential drug molecules
* Provide state-of-the-art synthetic organic chemistry to projects at all stages of drug discovery delivering potential drug molecules and tool compounds
* Collect, analyze and interpret project data. Propose hypotheses and plan how to test them.
* Collaborate and lead chemistry teams in the development, planning and prioritization of route design, sharing findings and jointly solving scientific questions in the projects
* Drive R&I´s scientific reputation by presenting and publishing your results within the department, across AZ and externally
* Lead chemistry programs and represent the medicinal chemistry discipline in cross functional teams
* Follow safety requirements and all AZ corporate responsibility policies



Essential for the role
* PhD in synthetic Organic Chemistry, Medicinal Chemistry or Biochemistry
* >3y of professional experience as Medicinal Chemist in Pharmaceutical Industry, biotech or CRO
* In-depth scientific knowledge and recent practical experience in the area of synthetic chemistry
* Up-to-date with the application of modern purification and analytical techniques
* A proven track record of delivery from own experimental and project work
* Excellent communication, collaboration and leadership skills
* Knowledge of the pharmaceutical drug discovery and development process



What's next?
If you are interested, apply now! We welcome your application no later than May 5th, 2023. For more information, please contact hiring manager Annika Wellner; Annika.Wellner(@)astrazeneca.com.


Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Senior Scientist in Medicinal and Synthetic Chemistry

Ansök    Maj 3    Astrazeneca AB    Organisk kemist
Are you an experienced Synthetic Organic Chemist with interest to apply your skills in Medicinal Chemistry? Can you envision your future in drug discovery, creating and developing novel drug molecules? Do you have experience and desire to apply cutting-edge techniques and strategies to make the drugs of the future to help patients with unmet medical need? Then this is an outstanding opportunity for you! At AstraZeneca, we follow the science to explore and... Visa mer
Are you an experienced Synthetic Organic Chemist with interest to apply your skills in Medicinal Chemistry? Can you envision your future in drug discovery, creating and developing novel drug molecules? Do you have experience and desire to apply cutting-edge techniques and strategies to make the drugs of the future to help patients with unmet medical need? Then this is an outstanding opportunity for you!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

Our Early Cardiovascular, Renal and Metabolism (CVRM) Medicinal Chemistry Department is a critical player in the design and discovery of drug molecules. We are proud of our heritage of successful delivery of clinical candidates to human testing, leading to new medicines for patients. Here, we work agnostic to molecular modality and have expertise in small molecules, PROTACs, peptides, oligonucleotides, and drug conjugates.

We drive our pipeline and areas of scientific leadership internally and in partnership with world experts, which provides you as a scientist with the unique opportunity to stay at the forefront of science.

You will be based at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.



What you'll do

The role is lab based and focused on synthetic chemistry. You will actively contribute to AstraZeneca's portfolio of drug projects using your compound design, synthesis, data generation, and data interpretation skills.

There will also be opportunities to develop your medicinal chemistry and drug discovery knowledge together with the experts in the department.

All work is performed in a highly cross-disciplinary environment. In addition, you will be part of external collaborations, publish scientific papers, present, and represent the department externally.

As part of an open-minded, creative, and experienced team in drug discovery, you will contribute with your high ambitions, collaborative mentality, and passion to push the boundaries of science in the area of synthetic and medicinal chemistry.



Essential for the role

We are looking for an ambitious team player that has expert knowledge in synthetic organic chemistry. Basic knowledge of medicinal from drug discovery in an industrial setting,

*

Ph. D. degree in Organic Chemistry/Synthetic Chemistry/Medicinal Chemistry or Master of Science with a few years' experience in synthetic/medicinal chemistry.
*

Strong synthetic chemistry knowledge: ability to plan, prioritize and perform work independently, including synthetic route design and problem solving.
*

Scientific curiosity and creativity: ability to identify, develop and apply new technologies and ways of working.
*

Experience of developing new chemistry and methods, including high-throughput experimentation, is an advantage.
*

Great awareness of recent literature as well as current developments and trends in organic synthesis.
*

Highly self-motivated and capable of analyzing complex data and deciding on focused course of action.
*

Excellent teamwork, collaboration, networking, and communication skills.
*

Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents.



Why AstraZeneca

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe - with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures collaboration, openness and innovation. Therefore, we have created space for meetings, socializing, and relaxation, where spontaneous meetings can give birth to new innovations.

We offer competitive salaries and excellent benefits, such as extra paid Holiday, Private Medical Benefit, on site exercise, and much, much more.



So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information, please contact Director Rhona Cox by email [email protected]

Welcome with your application no later than 17th May 2023



Where can I find out more?

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38

Meet Hasse, Chemist at AstraZeneca Gothenburg: https://www.youtube.com/watch?v=QulX8EotRSE&list=PLgfkdJlwmkT6h7sZKBXqs7Xj4PobD4RmR

Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Associate Principal Scientist - Synthetic Chemistry

Ansök    Apr 5    Astrazeneca AB    Organisk kemist
Are you an experienced organic chemist with passion for High-Throughput Experimentation (HTE)? Are you excited by challenging, creative chemistry and state-of-the-art methodology and instrumentation? Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life-changing medicines. We have an opening for an Associate Principal Scientist - High-Throughput Experimentation in Synthetic Chemistry, and you will be ... Visa mer
Are you an experienced organic chemist with passion for High-Throughput Experimentation (HTE)? Are you excited by challenging, creative chemistry and state-of-the-art methodology and instrumentation? Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life-changing medicines.



We have an opening for an Associate Principal Scientist - High-Throughput Experimentation in Synthetic Chemistry, and you will be working within the department of Early Respiratory & Immunology (R&I) at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

AstraZeneca is a global, innovation-driven biopharmaceutical company focusing on the discovery, development, and delivery of life-saving medicines while taking sustainability and environmental footprint into consideration. Our team embraces the diversity of talented team members and has a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity.

What you'll do
In your role, as an Associate Principal Scientist - High-Throughput Experimentation in Synthetic Chemistry you will be an integrated part of the Chemistry Centre of Excellence. With your key expertise in a range of technologies such as modern organic chemistry, automation, and information handling you will collaborate with medicinal chemistry teams delivering efficient, sustainable and innovative routes to target molecules. You will be part of a global vibrant and growing group of scientists dedicated to HTE and will be joining a cutting-edge pharmaceutical lab with access to state-of-the-art HTE equipment and automation.

Main duties and responsibilities
* Lead HTE chemistry delivering innovative routes to AstraZeneca's portfolio of drug projects.
* Support full integration of HTE in medicinal chemistry projects including training of peers
* Outline strategic direction for HTE within the Chemistry Centre of Excellence in Gothenburg
* Develop and maintain a state-of-the-art HTE facility, develop best practices and establish external collaborations

Essential for the role
* PhD degree in Organic Chemistry or equivalent
* >3 years of relevant professional experience after PhD
* Recent practical experience in organic synthesis and HTE, including automation, relevant analytical techniques, statistical experimental design, and data workflows
* Excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques
* Awareness of recent literature, current developments and trends in organic synthesis
* Excellent collaboration and communication skills, including scientific writing



What's next?

We welcome your application (CV and Cover Letter) no later than April 30th, 2023. For more information, please contact Lena Ripa at: lena.e.ripa(@)astrazeneca.com



Here you can find out more about AstraZeneca and Gothenburg:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
AstraZeneca in Gothenburg: https://www.astrazeneca.com/our-science/gothenburg.html
Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Senior Research Scientist - Medicinal Chemistry

Ansök    Apr 5    Astrazeneca AB    Organisk kemist
We have a temporary opening for a Senior Research Scientist within our Medicinal Chemistry department in the therapeutic area of Respiratory & Immunology (R&I). You will get the opportunity to join a highly creative and collaborative discovery team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates. We are searching for a synthetic chemist interested in drug discovery researc... Visa mer
We have a temporary opening for a Senior Research Scientist within our Medicinal Chemistry department in the therapeutic area of Respiratory & Immunology (R&I). You will get the opportunity to join a highly creative and collaborative discovery team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates.



We are searching for a synthetic chemist interested in drug discovery research across small molecules or Proteolysis Targeting Chimeras (PROTACs). Our department embraces the diversity of talents and allows the teams to grow and learn together to accomplish our collective goal to improve the quality of life for patients.



What you'll do

As Senior Research Scientist in the Early R&I Medicinal Chemistry department you will play an important role in advancing drug discovery projects from target validation to preclinical phase. You will join a highly integrated discovery team leveraging innovative medicinal chemistry to invent novel medicines. Your focus will be on synthesis, characterization and design of drug molecules and you will be expected to lead by example with integrity and to follow the science and collaborate across boundaries. You will ensure uptake of recent scientific developments into project teams and generate creative ideas in the design of novel molecules. You will also be expected to share scientific findings to a broader internal and external audience and to publish your results.


We are looking for a person who enjoys synthetic chemistry and experimenting in the lab, with strong scientific curiosity and a solid background in Organic Chemistry. You should be up-to-date with recent trends in synthetic chemistry and have a continuous drive to develop skills in Medicinal Chemistry. We are looking forward to a candidate with excellent communication skills and a strong ability to collaborate across disciplines.

Main Duties and Responsibilities

* Support Early R&I's drug discovery programs through synthesis and design of potential drug molecules
* Provide state-of-the-art synthetic organic chemistry to drug discovery projects, delivering high quality drug molecules and tool compounds
* Collect, analyze and interprete project data. Propose molecules and plans how to test them.
* Collaborate with the chemistry team in the development, planning and prioritization of route design, share findings and jointly solve scientific questions in the projects
* Drive R&I´s scientific reputation by presenting / publishing within the department and across AZ
* Follow safety requirements and all AZ corporate responsibility policies


Essential for the role
* PhD, or equivalent experience, in Organic Chemistry, Medicinal Chemistry or Biochemistry
* In-depth scientific knowledge and recent practical experience in the area of synthetic chemistry
* Up-to-date with the application of modern purification and analytical techniques
* Excellent communication and collaboration skills
* Professional experience in the Pharmaceutical Industry is a benefit


Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,900 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.



Job Details

Type of contract: Temporary (1 year)
Location: Gothenburg, Sweden


What's next?

If you are interested, apply now! Please send in your application no later than April 30th, 2023. For more information, please contact hiring manager Annika Wellner; Annika.Wellner(@)astrazeneca.com Visa mindre

Associate Principal Scientist - HTE Synthetic Chemistry

Ansök    Mar 6    Astrazeneca AB    Organisk kemist
Are you an experienced organic chemist with experience from High-Throughput Experimentation (HTE) and would like to be a leader of this area? Are you excited by challenging, creative chemistry and state-of-the-art equipment? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life-changing medicines. AstraZeneca is a global, innovation-driven biopharmaceutical... Visa mer
Are you an experienced organic chemist with experience from High-Throughput Experimentation (HTE) and would like to be a leader of this area? Are you excited by challenging, creative chemistry and state-of-the-art equipment? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life-changing medicines.

AstraZeneca is a global, innovation-driven biopharmaceutical company where we focus on the discovery, development, and delivery of life-saving medicines to our patients while taking sustainability and environmental footprint into consideration. We are proud to be a great place to work and have a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected, and rewarded for their ideas and creativity.

We now have exciting opportunities for Associate Principal Scientist(s) that will be working with us in Gothenburg within the Medicinal Chemistry department of the therapeutic area Cardiovascular, Renal and Metabolism (CVRM) or in the Early Chemical Development department in Pharmaceutical Sciences. In this role you are expected to collaborate with the growing global group of scientists dedicated to synthetic High-Throughput Experimentation (HTE) chemistry.

The use of HTE within synthetic chemistry allows the development of efficient and sustainable processes by enabling innovative routes towards drug discovery compounds and in optimizing synthesis of API materials. The HTE scientists support drug projects in discovery and process development, with key expertise in a range of technologies, such as modern organic chemistry, automation, and information handling (recording of experiments and results).

The successful candidate(s) will be joining a cutting-edge pharmaceutical lab with access to gloveboxes and state-of-the-art HTE equipment. The roles will be based at AstraZeneca's dynamic R&D site in Gothenburg, Sweden and be an integrated part of the Chemistry Centre of Excellence.

What you'll do

The role is lab-based and focused on delivering synthetic chemistry to contribute to AstraZeneca's portfolio of drug projects. You will be a leader within HTE externally and in Gothenburg providing technical support and outline strategic direction in the area. You will provide leadership of the relevant HTE facility, workflows, and equipment and collaboratively help to design, develop, and implement best practice. You will be active in evaluating and implementing cutting edge technologies and workflows via external collaborations and internal science and technology projects.

In a highly cross-disciplinary environment you will seek out the most appropriate methods for carrying out experimental work to a high standard, including utilizing relevant automation. You are expected to be part of external collaborations and publish scientific papers and as part of an open-minded, creative team in HTE you are expected to coach and drive performance and development among your peers. You will contribute with your high ambitions, collaborative mentality, and passion to push the boundaries of science in the area of synthetic chemistry.

Essential for the role

We are looking for a person who has the ability to think innovatively and drive improvement, to support development of co-workers, and address issues when contributing to project strategies.

To be successful in this role you need to be highly self-motivated and capable of analyzing complex data and to decide on focused course of actions. You also need to possess excellent teamwork skills and a demonstrated ability to work in cross functional teams.

It's important to have excellent communication and strategic influencing skills including scientific writing.

*

Experienced Ph.D. in Organic Chemistry with relevant multi-year industrial experience, or equivalent.
*

Recent practical experience in organic synthesis and HTE experimentation in the pharmaceutical industry including working in glovebox, with the ability to plan, prioritize and perform work independently, including synthetic route design and problem-solving.
*

An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques.
*

Experience in statistical experimental design and data workflows relevant for HTE.
*

Great awareness of recent literature as well as current developments and trends in organic synthesis.
*

Excellent English both spoken and written.



Desirable for the role

*

Documented experience and skills in chemical process research and development or medicinal chemistry from industry.
*

General knowledge of green chemistry principles
*

Experience of supervising students and/or coaching peers.



So, what's next?

Are you already imagining yourself joining our team? Excellent! We look forward to your application.

Welcome with your application no later than April 2nd 2023.

For more information, please contact recruiting managers

Hans Emtenäs at [email protected] or Anneli Nordqvist [email protected] Visa mindre

Scientific Specialist - Oligonucleotide Chemistry

Ansök    Feb 14    Astrazeneca AB    Organisk kemist
Are you an experienced and passionate Senior Scientist with extensive expertise in Oligonucleotides and a passion for research and development of Oligonucleotide Therapeutics? Do you wish to impact and flourish in an excellent team where you will have the opportunity to further exploit our drug discovery platforms? If yes, welcome to us at AstraZeneca! We are looking for two motivated Scientific Specialists with enthusiasm, expertise and experience in Oli... Visa mer
Are you an experienced and passionate Senior Scientist with extensive expertise in Oligonucleotides and a passion for research and development of Oligonucleotide Therapeutics? Do you wish to impact and flourish in an excellent team where you will have the opportunity to further exploit our drug discovery platforms? If yes, welcome to us at AstraZeneca!

We are looking for two motivated Scientific Specialists with enthusiasm, expertise and experience in Oligonucleotides to join the Oligonucleotide Chemistry team within the Oligonucleotide Discovery Department at AstraZeneca in Gothenburg, Sweden. The department is part of the broader Discovery Sciences R&D organization.

AstraZeneca is committed to the development of next generation innovative medicines and is focused on expanding the use of oligonucleotides and molecular conjugates thereof, in the treatment of diseases across therapy areas. As an expert and member of the Oligonucleotide Medicinal Chemistry team you will have a key role to influence the strategy as well as to develop and lead the science in the field to expand the use of therapeutic oligonucleotides in drug projects within AstraZeneca.

Join a place built on innovation and creativity where different views and perspectives are welcomed and valued.

What you will do:
This is a senior scientific role for a specialist within the field of Oligonucleotides, where you will work as an expert within oligonucleotide medicinal chemistry and contribute to shaping the future of our therapeutic oligonucleotide build, identifying opportunities to innovate in the interface between oligonucleotide chemistry and conjugation to other chemical modalities. You will be a role model and support scientists in oligonucleotide medicinal chemistry by advising and challenging them and providing expert knowledge and interpretation of complex data.

Recommend and champion new innovations that enable the Oligonucleotide Discovery department to meet its overall objectives, as well as influence across disciplines in the drug project core teams to ensure state of the art approaches in oligonucleotide medicinal chemistry are used to answer the scientific hypotheses. We also want you to demonstrate scientific leadership through high quality publications, conference presentations and by building networks with key opinion leaders and academic groups.

Essential in the role:
Our team is a collaborative group working together for a greater goal and by showing self-awareness of training needs, including leadership development, being a strong team member and an encouraging colleague, you will be successful in this role. Furthermore, you are a scientifically critical and curious individual who has the ability to operate effectively in a multi-disciplinary research environment and take own initiatives.

We also believe you have:

* PhD in Organic Chemistry and a post-doc experience or minimum 5 years of professional experience in pharmaceutical industry or academia.
* Expert knowledge and significant experience in oligonucleotide medicinal chemistry including IP strategies.
* Great knowledge in biological processes enabling the design of effective oligonucleotide ligand conjugates.
* Substantial track record of innovation and milestone delivery in oligonucleotides drug discovery projects across phases.

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you improve your skills, abilities and contribution. Depending on your individual background and skills we will tailor the role to suit your profile the best way possible.

Why AstraZeneca?
Join the team that follows the science unlike anywhere else. This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs. With more than 2,800 employees from over 70 different countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next? If this sound like your next challenge and a good workplace for you - please apply today!

We look forward to your application and getting to know you better, but please remember to send it to us no later than March 12th, 2023.

For more information about the position please contact Anders Dahlén at +46 31 706 4842 or [email protected]

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Senior Scientist - Synthetic chemistry, Oligonucleotide field

Ansök    Feb 14    Astrazeneca AB    Organisk kemist
Are you a passionate scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the opportunity to further exploit our drug discovery platforms? If yes, we might have the position for you! Welcome to join the great Oligonucleotide Chemistry team as a motivated Senior Research Scientist at AstraZeneca in Gothenburg, Sweden. In this posi... Visa mer
Are you a passionate scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the opportunity to further exploit our drug discovery platforms? If yes, we might have the position for you!

Welcome to join the great Oligonucleotide Chemistry team as a motivated Senior Research Scientist at AstraZeneca in Gothenburg, Sweden. In this position, you will play an important part in our Oligonucleotide Discovery Department which is part of the broader Discovery Sciences R&D organization.

AstraZeneca is committed to the development of next generation innovative medicines and is focused on expanding the use of oligonucleotides and molecular conjugates thereof, in the treatment of diseases across therapy areas. As an specialist and member of the Oligonucleotide Medicinal Chemistry team you will have a key role to influence the strategy as well as to develop and lead the science in the field to expand the use of therapeutic oligonucleotides in drug projects within AstraZeneca.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
This role is a synthesis specialist role with the aim to develop novel oligonucleotide chemistry building blocks, oligonucleotides and oligo conjugates and thereby supporting the AstraZeneca pipeline. The Senior Research Scientist works alongside other chemists in the team to contribute to drug projects but should also be comfortable in supervising and mentoring more junior colleagues.

In the position you will also propose experimental strategies and have the possibility to be creative in solving a wide range of synthetic challenges. Plan, prioritize and perform own work and actively collaborate with the project team by driving problem solving using literature and own knowledge. Support oligonucleotide projects to ensure high scientific standards and quality of compounds to meet project objectives. Build strong collaborative relationships within the team and in projects to ensure the smooth running of projects.

We rely on you to have recognized synthesis expertise and experience. Knowledge within the oligonucleotide chemistry field is considered a plus including synthesis and purification of high quality building blocks and oligo compounds by applying innovative technologies and methodologies to support project progression according to agreed timelines. The SRS should also be able to apply analytical sciences, troubleshoot challenges and make a significant contribution to the practical delivery of project compounds.

Essentials for this role:

* Candidate should have a PhD in Organic Chemistry, post-doc is a plus.
* Detailed knowledge of synthetic chemistry related to oligonucleotides, oligo building blocks and/or synthesis of advanced organic molecules. Knowledge in the area of oligonucleotide therapeutics, design and data analysis is a plus.
* Ability to design and complete experiments independently.
* Evidence of experimental impact by either peer-reviewed publications or external presentations.

We believe that our new team member will share our passion for driving scientific questions and is a scientifically critical individual with curiosity to explore. You should have a positive, goal oriented and problem-solving attitude. Ability to enjoy working and effectively operate in a multi-disciplinary research environment is a must. We also believe that you enjoy teamwork, have a collaborative nature and is an encouraging colleague to all.

Why AstraZeneca?
With more than 2,800 employees from over 70 different countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life. Our belief powers us to push the boundaries. As we improve success rates, we keep moving forward. Celebrating both successes and failures along the way.

So, what's next? If this sound like the place and position for you - welcome to apply today!

We look forward to your application and getting to know you better, but please remember to send it to us no later than March 12th, 2023.

For more information about the position please contact Anders Dahlén at +46 31 706 4842 or [email protected]

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Senior Scientist - HTE Synthetic Chemistry

Ansök    Mar 6    Astrazeneca AB    Organisk kemist
Are you an experienced organic chemist and would like to become a leader in High-Throughput Experimentation (HTE)? Are you excited by challenging, creative chemistry and state-of-the-art methodology and equipment? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life-changing medicines. AstraZeneca is a global, innovation-driven biopharmaceutical company wh... Visa mer
Are you an experienced organic chemist and would like to become a leader in High-Throughput Experimentation (HTE)? Are you excited by challenging, creative chemistry and state-of-the-art methodology and equipment? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life-changing medicines.

AstraZeneca is a global, innovation-driven biopharmaceutical company where we focus on the discovery, development, and delivery of life-saving medicines to our patients while taking sustainability and environmental footprint into consideration. We are proud to be a great place to work and have a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected, and rewarded for their ideas and creativity.

We now have exciting opportunities for Senior Scientist(s) that will be working with us in Gothenburg within the Medicinal Chemistry department of the therapeutic area Cardiovascular, Renal and Metabolism (CVRM) or in the Early Chemical Development department in Pharmaceutical Sciences. In this role you are expected to collaborate with the global growing group of scientists dedicated to synthetic High-Throughput Experimentation (HTE) chemistry.

The use of HTE within synthetic chemistry allows the development of efficient and sustainable processes by enabling innovative routes towards drug discovery compounds and in optimizing synthesis of API materials. The HTE scientists support drug discovery projects in discovery and process development, with key expertise in a range of technologies such as modern organic chemistry, automation, and information handling (recording of experiments and results).

The successful candidate(s) will be joining a cutting-edge lab with access to state-of-the-art HTE equipment/automation. The roles will be based at AstraZeneca's dynamic R&D site in Gothenburg, Sweden and be an integrated part of the Chemistry Centre of Excellence.

What you'll do

The role is lab-based and focused on synthetic chemistry. You will actively contribute to AstraZeneca's portfolio of drug projects. In a highly cross-disciplinary environment you will seek out the most appropriate methods for carrying out experimental work to a high standard, including utilizing relevant automation. In addition, there will be the opportunity to be part of external collaborations and publish scientific papers.

As part of an open-minded, creative, and experienced team in HTE, you will contribute with your high ambitions, collaborative mentality and passion to push the boundaries of science in the area of synthetic chemistry.

Essential for the role

To be successful in this role you need to be highly self-motivated and capable of analyzing complex data and to decide on focused course of actions. You also need to possess excellent teamwork and collaboration skills and have an ability to communicate your work internally and externally in scientific papers and documents.

*

Ph. D. degree in Organic Chemistry or BSc/MSc with relevant industrial experience to an equivalent level.
*

An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques
*

Recent practical experience in the area of synthetic chemistry including state-of-the-art catalysis.

*

The ability to plan, prioritize and perform work independently, including synthetic route design and problem-solving.
*

Great awareness of recent literature as well as current developments and trends in organic synthesis.
*

Excellent English both spoken and written.



Desirable for the role

*

Experience from High-Throughput Experimentation in organic synthesis
*

General knowledge of green chemistry principles
*

Good understanding of reactions relevant to the pharmaceutical industry



So, what's next?

Are you already imagining yourself joining our team? Excellent! We look forward to your application.



Welcome with your application (CV and Cover Letter) no later than April 2nd, 2023.

For more information please contact recruiting managers
Hans Emtenäs at [email protected] or Anneli Nordqvist [email protected]


Where can I find out more?



www.astrazeneca.com



Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,800 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life. Visa mindre

Senior Scientist / APS - Peptide and Conjugation Chemistry

Ansök    Nov 15    Astrazeneca AB    Organisk kemist
AstraZeneca R&D, Gothenburg, Sweden seek to recruit a Senior Scientist or Associate Principal Scientist responsible for Peptide and Conjugation Chemistry within the Medicinal Chemistry department of the therapeutic area Respiratory and Immunology (R&I). AstraZeneca is one of the world's most exciting biopharmaceutical companies. From scientists to sales, lab techs to legal, we're on a mission to turn science into life-changing medicines that improve pat... Visa mer
AstraZeneca R&D, Gothenburg, Sweden seek to recruit a Senior Scientist or Associate Principal Scientist responsible for Peptide and Conjugation Chemistry within the Medicinal Chemistry department of the therapeutic area Respiratory and Immunology (R&I).

AstraZeneca is one of the world's most exciting biopharmaceutical companies. From scientists to sales, lab techs to legal, we're on a mission to turn science into life-changing medicines that improve patients' lives and benefit society. AstraZeneca is committed to the development of the next generation innovative medicines.


The Department of Medicinal Chemistry in the therapeutic area of Respiratory & Immunology is focused on the delivery of Small Molecule (SM) and New Modalities (NM) clinical candidates. In this context, we are focused on increasing our capabilities around novel peptide and oligonucleotide-based molecules / conjugates for the treatment of respiratory and immunological diseases.


What you'll do
You will be part of a team of scientists dedicated to discovering drugs based on peptide and oligonucleotide chemistry. For this permanent position, you should have a strong background in the design, synthesis, bioconjugation, purification and characterization of novel peptide-based molecules. Your level of professional experience will be relevant for your initial career level (Senior Scientist/Associate Principal Scientist).

Major Duties and Responsibilities:

*

Peptide design, synthesis and optimization
*

Design and execution of various (bio)conjugation techniques to prepare novel peptide-oligonucleotide conjugates
*

Contribution to identify novel delivery technology applicable to peptide and/or oligonucleotide therapeutics
*

Effective collaboration with project team members and colleagues in other departments
*

Driving internal / external scientific visibility through publications and scientific presentations


Essential for the role

*

PhD in Bio-/Organic Chemistry
*

Expertise in peptide and/or conjugation chemistry
*

Knowledge of recent developments in peptide and (bio-)conjugation chemistry
*

Strong scientific curiosity in novel technology and methods
*

Excellent communication and collaboration skills


Desirable for the role

*

Knowledge of tissue specific delivery of peptides and/or oligonucleotides is a bonus
*

Experience in pharmaceutical drug discovery of peptide drug candidates is a plus


Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.


What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! For more information about the position please contact Wu Su, Team Leader, New Modalities Medicinal Chemistry, by email: [email protected] or via LinkedIn. We welcome your application until December 9, 2022.

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Visa mindre

Senior Scientist - New Modality Clinical Formulation

Ansök    Jan 13    Astrazeneca AB    Organisk kemist
At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person. We continually push the boundaries of science to deliver medicines that tre... Visa mer
At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.


We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.



Pharmaceutical Sciences is a department within AstraZeneca Biopharmaceutical R&D. The Pharmaceutical Sciences' mission is to transform molecules into investigational medicines, meeting the unmet needs of future patients. Advanced Drug Delivery is a department in Pharmaceutical Sciences. Our portfolio of projects spans traditional small molecules, peptides oligonucleotides to RNA based therapeutics across AstraZeneca's therapy areas and our mission is to transform diverse modalities into investigational medicines.

We are now looking for a skilled and experienced Formulation Scientist to join us as Senior Scientist, in the New Modality Clinical Formulation team. The role sits within the ADD group at our vibrant R&D site in Gothenburg, Sweden. With more than 2 800 employees from over 70 different countries, our vibrant Gothenburg site is a truly inspiring place to work.



What You'll do

This is an exciting role where you will act as a key member of various project teams and provide your technical and scientific expertise into formulation design and development strategies within the new modality and advanced drug delivery portfolio of peptides, oligonucleotides and RNA based therapeutics, with emphasis on parental formulation development. You will be responsible for defining lead enabling formulations to ensure desired clinical performance from discovery to Phase II, including a strong contribution to CMC (Chemistry, Manufacturing, Control) aspects and deliveries. In addition, you will lead GxP/non-GxP drug product manufacturing and outsourcing activities and strategies. As such, we are looking for a candidate who has a strong understanding of biopharmaceutics, formulation, and drug delivery across various modalities and dosage forms. The role will be expected to work cross-functionally supporting drug projects from early to late clinical phase and be involved in science & technology initiatives.

We are looking for you, who together with your team will make a difference for patients' lives every day. This through your ability to independently lead and achieve set goals within budget, time and to the right quality.



Essential for the role

*

PhD degree in relevant field (such as Chemistry, Pharmaceutics, Chemical Engineering or Biotechnology) or MSc degree with +2 years of industrial experience within the field of Pharmaceutical/Biotechnology Science.
*

Hands-on experience of formulation development with biomolecules (e.g. RNA, proteins and peptides) and lipid nanoparticles for RNA delivery
*

Good understanding of formulation science, drug delivery and biopharmaceutics to enable mechanistic understanding of in vivo drug product performance.
*

Experience on clinical formulation development and design from the pharmaceutical industry, including knowledge of CMC deliveries and regulatory frameworks.
*

Knowledge of GxP manufacturing activities and strategies, including scale-up development, outsourcing, tech transfer, reviewing and approving documentation such as Manufacturing Methods and Master Batch Records.
*

Good understanding of the overall drug discovery and development process and an appreciation of how the Pharmaceutical Science field contributes to R&D.
*

Ability and desire/willingness to effectively communicate, network and build collaborative relationships with partners across disciplines and cultures, internally and externally and independently lead and influence projects.



If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be. With us there are many opportunities to develop yourself and your career. From our diverse portfolio and teamwork, to our cutting-edge innovations - it's a place for lifelong learning.



Are you ready to make a difference? Send in your application, and we'll make it happen together.

For more information about the position please contact Marianna Yanez Arteta, at [email protected]

We encourage you to send your application as soon as possible, but no later than 31st January.





Additional information

Our Gothenburg site

Life in Gothenburg Visa mindre

Biträdande forskare inom organisk kemi

Ansök    Jan 26    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vet... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vetenskaper och molekylära livsvetenskaper. Vår forskning och utbildning fokuserar på en djup förståelse av kemiska och biologiska processer i celler och i miljön. Vi tar oss an viktiga samhällsfrågor som till exempel antibiotikaresistens, cancer, hjärnsjukdomar, miljöproblem och klimatförändringar. På så sätt medverkar vi till att uppnå FN:s globala mål för hållbar utveckling inom områdena god hälsa och välbefinnande, hållbar energi för alla, hållbara städer och samhällen samt bekämpa klimatförändringar.

Institutionen är en internationell miljö med tvärvetenskapliga samarbeten inom både forskning och utbildning, och bidrar starkt till Göteborgs universitets topprankning inom life science. Institutionen ansvarar för forskarutbildning inom ämnesområdet Naturvetenskap med inriktning mot kemi, biofysik, biologi och utbildningsvetenskap. Därtill är institutionen värd för utbildningsprogram i molekylärbiologi, genomik och systembiologi, kemi, organisk kemi och läkemedelskemi samt receptarieutbildningen. Institutionen samverkar med olika samhällsaktörer som skolor, näringsliv och myndigheter. Institutionen för kemi och molekylärbiologi har runt 200 anställda. Vi finns i centrala lokaler både på Campus Johanneberg och på Campus Medicinareberget i Göteborg och vi flyttar till Natrium i augusti.

Projekt som bedrivs inom ramen för den verksamhet vilken leds av Carl Johan Wallentin fokuserar på utvecklandet av katalytiska metoder för bildandet av molekylär komplexitet. Dessa katalytiska processer drivs av låg-energi ljus och involverar bindningsbildande förlopp med radikal karaktär. Det specifika projektet som avses handhavas av denna anställning involverar utvecklandet av metoder som via syre-centrerade radikaler kan aktivera inerta molekylära funktioner, samt vidareförädla dessa högreaktiva intermediärer i komplexgenererande syntetiska processer.

Arbetsuppgifter 
Arbetsuppgifter inkluderar typisk experimentell verksamhet för syntetisk organisk kemi, vilket inkluderar att utföra och designa experimentella processer för produktion av olika substrat. Diverse kromatografiska samt spektroskopiska tekniker kommer att nyttjas i projektet. Även ansvar för underhåll av diverse appretur kommer att ingå i tjänsten.

Kvalifikationer 
Krav: För att vara berättigad till anställningen krävs en masterutbildning inom kemi med specialisering inom organisk kemi.Erfarenhet med metodutveckling inom ämnesområdet fotokatalys är ett krav för anställningen. 

Meriterande: Doktorsexamen inom ämnesområdet fotokatalys är starkt meriterande. 

Anställning 
Anställningen är ?en tidsbegränsad anställning under 6 månader med placering vid institutionen för kemi och molekylärbiologi.

Kontaktuppgifter för anställningen 
Har du frågor om anställningen är du välkommen att kontakta universitetslektor: Carl-Johan Wallentin, e-post: [email protected]

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Ansökan 
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. Ansökan skall innehålla:

- Personligt brev

-CV

-Betyg/certifikat

-Rekomendationsbrev

Ansökan ska vara inkommen senast: 2023-02-16

 

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Postdoktor i molekylära verktyg

Ansök    Nov 10    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Institutionen för neurovetenskap och fysiologi, söker nu en postdoktor, med placering vid Sektionen för fa... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Institutionen för neurovetenskap och fysiologi, söker nu en postdoktor, med placering vid Sektionen för farmakologi.

Den utlysta tjänsten syftar till att utveckla molekylära verktyg för att undersöka interaktioner mellan terapeutiska oligonukleotider och intracellulära proteiner och andra biomolekyler. Anställningen är i Pär Matssons forskargrupp vid Sektionen för farmakologi (https://www.gu.se/en/research/cellular-and-molecular-pharmacokinetics) och är ett nära samarbete med Morten Grøtli (Läkemedelskemi, Inst f kemi och molekylärbiologi; https://www.grotlilab.net ).

Projektet kommer utföras under gemensam handledning av forskningsledarna, och kandidaten kommer tillbringa tid i båda labben. Nära band till OligoNova Hub vid Göteborgs universitet (https://www.oligonova.org, en del av SciLifeLabs Drug Discovery and Development-plattform) ger tillgång till en dynamisk forskningsmiljö inom det spännande nya området design av terapeutiska oligonukleotider. Forskningsledarna har omfattande expertis inom cellulär farmakologi och läkemedelsdisposition, organisk syntes, läkemedels- och oligonukleotidkemi och utveckling av molekylära verktyg. Postdoktorstjänsten positionerar alltså kandidaten väl för att utveckla sitt eget forskningsprogram och för en framstående karriär inom akademi eller industri.

Ämne
Molekylära verktyg för att klarlägga terapeutiska oligonukleotiders interaktioner med cellulära proteiner.

Ämnesbeskrivning
Terapeutiska oligonukleotider är kemiskt modifierade RNA- eller DNA-baserade läkemedel som framkallar sin effekt genom komplementär bindning till nukleotidsekvenser i den sjukdomspåverkade cellen. Oligonukleotidbaserade läkemedel väntas leda till stora framsteg för behandling av sjukdomar som för närvarande saknar fungerande terapier.

De cellulära effekterna från terapeutiska oligonukleotider är starkt kopplade till interaktioner med cellulära proteiner, vilka bland annat påverkar det cellulära upptaget och den intracellulära fördelningen av den terapeutiska molekylen. Dessa interaktionsmönster och de bakomliggande molekylära mekanismerna är dock inte klarlagda.

Projektet syftar därför till att utveckla molekylära verktyg för att kartlägga och definiera hur olika kemiskt modifierade terapeutiska oligonukleotider binder till cellulära proteiner och andra biomolekyler, och hur dessa interaktionsmönster påverkar läkemedlens effektivitet och säkerhet.

Arbetsuppgifter
Kandidaten kommer att utveckla och tillämpa molekylära verktyg för att studera terapeutiska oligonukleotiders interaktioner med cellulära proteiner och andra biomolekyler. De utvecklade probsubstanserna kommer studeras i sjukdomsrelevanta cellmodeller med hjälp av imagingtekniker och masspektrometiska proteomikanalyser.

Behörighet
Behörighet för anställning som lärare regleras i Högskoleförordningen 4 Kap och Göteborgs universitets anställningsordning. 

Behörig att anställas som postdoktor är den som har avlagt doktorsexamen, konstnärlig doktorsexamen eller som har en utländsk examen som bedöms motsvara doktorsexamen. Detta behörighetskrav ska vara uppfyllt senast vid tidpunkten då anställningsbeslutet fattas. 

Behörig att anställas som postdoktor för denna utlysning är den som innehar doktorsexamen i organisk kemi, läkemedelskemi eller motsvarande.

Bedömningsgrund
Vi söker en mycket motiverad person med betydande erfarenhet och djup kunskap i syntetisk organisk kemi, visad genom högkvalitativa publikationer inom relevant område samt genomgången forskarutbildning i organisk kemi eller läkemedelskemi eller motsvarande.

Tidigare erfarenhet av läkemedelsdesign, nukleotidkemi, och/eller kemisk biologi är starkt meriterande. Sökande ska ha utmärkt generell forskningsförmåga, skrivförmåga, och förmåga att arbeta både självständigt och inom ett team. Flytande kunskaper i talad och skriftligt engelska är väsentligt.

Erfarenhet av experimentell bestämning av intracellulära molekylära interaktioner (genom imaging/mikroskopi, proteomik/CETSA, spektrofotometri, SPR eller liknande tekniker) är meriterande. Vi lägger stor vikt vid personlig lämplighet. 

Ansökningsförfarande
Ansökan ska innehålla doktorsexamen, personligt brev, meritförteckning, förteckning över vetenskapliga publikationer samt kontaktuppgifter för minst 2 referenser.

Anställning
Anställningen är en tidsbegränsad anställning i 2 år, 100% av heltid, med placering tills vidare vid Institutionen för neurovetenskap och fysiologi. Tillträde: snarast eller enligt överenskommelse. 

Kontaktuppgifter för anställningen
Har du frågor om anställningen är du välkommen att kontakta professor Pär Matsson, tfn: +46 31 786 49 32, e-post: [email protected]

Ansvarig chef är universitetslektor/sektionschef Michael Winder, tfn: +46 31 786 34 77, e-post: [email protected]

Ansökningshandlingar skickas inte till kontaktpersonerna.

Ansökan
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att registrera din ansökan elektroniskt via hemsidan: https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar

Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. 

Intyg om doktorsexaman bifogas med ansökan.

Ansökan ska vara inkommen senast: 2023-01-09


Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Senior Research Scientist - Medicinal Chemistry

Ansök    Nov 2    Astrazeneca AB    Organisk kemist
We have a temporary opening for a Senior Research Scientist within our Medicinal Chemistry department in the area of Respiratory & Immunology (R&I). You will get the opportunity to join a highly creative and collaborative discovery team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. We are sear... Visa mer
We have a temporary opening for a Senior Research Scientist within our Medicinal Chemistry department in the area of Respiratory & Immunology (R&I). You will get the opportunity to join a highly creative and collaborative discovery team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.


We are searching for an Organic/Medicinal chemist interested in drug discovery research across small molecules or Proteolysis Targeting Chimeras (PROTACs). Our department embraces the diversity of talents and allows the teams to grow and learn together to accomplish our collective goal to improve the quality of life for patients.


What you'll do:

As a Senior Research Scientist in the Early R&I Medicinal Chemistry department you will play an important role in advancing drug discovery projects from target validation to preclinical phase. You will join a highly integrated discovery team leveraging innovative medicinal chemistry to invent novel medicines. Your focus will be on synthesis, characterization and design of drug molecules and you will be expected to lead by example with integrity, to follow the science and collaborate across boundaries. You will ensure uptake of recent scientific developments into project teams and generate creative ideas in the design of novel molecules. You will also be expected to share scientific findings to a broader internal and external audience and to publish your results.


We are looking for a person with strong scientific curiosity and a solid background in Organic Chemistry. You should be up-to-date with recent trends in synthetic chemistry and have a continuous drive to develop skills in Medicinal Chemistry. We are looking forward to a candidate with excellent communication skills and a strong ability to collaborate across disciplines.

Main Duties and Responsibilities:

* Support Early R&I's drug discovery programs through design and synthesis of potential drug molecules
* Provide state-of-the-art synthetic organic chemistry to drug discovery projects, delivering high quality drug molecules and tool compounds
* Collect, analyze and interpret project data. Propose hypotheses and plans how to test them
* Collaborate with the chemistry team in the development, planning and prioritization of route design, share findings and jointly solve scientific questions in the projects
* Drive R&I´s scientific reputation by presenting and publishing your results within the department, across AZ and externally
* Follow safety requirements and all AZ corporate responsibility policies


Essential for the role:
* PhD in synthetic Organic Chemistry, Medicinal Chemistry or Biochemistry
* In-depth scientific knowledge and recent practical experience in the area of synthetic chemistry
* Up-to-date with the application of modern purification and analytical techniques
* A proven track record of delivery from own experimental work
* Excellent communication and collaboration skills
* Professional experience in the Pharmaceutical Industry is a benefit


Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,800 employees from over 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.


Job Details

Type of contract: Temporary (1 year)
Preferred start date: Q1 - Q2, 2023


What's next?
If you are ready to make a difference - apply today! Please send in your application no later than November 27, 2022. Visa mindre

Senior Research Scientist - Medicinal Chemistry

Ansök    Okt 26    Astrazeneca AB    Organisk kemist
Are you an experienced chemist ready to apply your skills in a diverse and dynamic company? If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be! We have an opening for a Senior Research Scientist within our Medicinal Chemistry department in the area of Respiratory & Immunology (R&I). This role is based at our vibrant R&D site in Gothenburg, Sweden. In this role you ... Visa mer
Are you an experienced chemist ready to apply your skills in a diverse and dynamic company? If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be!

We have an opening for a Senior Research Scientist within our Medicinal Chemistry department in the area of Respiratory & Immunology (R&I). This role is based at our vibrant R&D site in Gothenburg, Sweden. In this role you will have the opportunity to join a creative and collaborative team embedded in a science driven environment, leveraging innovative Organic and Medicinal Chemistry to invent novel drug candidates.

We are searching for an Organic/Medicinal chemist interested in discovery research across small molecules or Proteolysis Targeting Chimeras (PROTACs). Our department embraces the diversity of talents and allows the teams to grow and learn together to accomplish our collective goal to improve the quality of life for patients.


What you'll do
As a Senior Research Scientist in the Early R&I Medicinal Chemistry department you will play an important role in advancing drug discovery projects from target validation to preclinical phase. You will join a highly integrated drug discovery team leveraging innovative medicinal chemistry to invent novel medicines. Your focus will be on design, synthesis and characterization of drug molecules. You will be expected to lead by example with integrity, to follow the science and collaborate across disciplines. You will ensure uptake of novel scientific developments into project teams and lead compound design by generating creative and novel ideas for our molecules. You will also be expected to share scientific findings to a broader internal and external audience and to publish your results.

We are looking for a person with strong scientific curiosity and a solid background in Organic Chemistry. You should be up-to-date with recent trends in Synthetic Chemistry and have a constant drive to develop skills in Medicinal Chemistry. We are looking forward to a candidate with excellent communication and leadership skills and a strong ability to collaborate across disciplines.


Main Duties and Responsibilities:
* Support Early R&I drug discovery programs through design and synthesis of potential drug molecules
* Provide state-of-the-art synthetic organic chemistry to projects at all stages of drug discovery delivering high quality drug molecules and tool compounds
* Collect, analyze and interpret project data. Propose hypotheses and plans how to test them
* Collaborate with the chemistry team in the development, planning and prioritization of route design, sharing findings and jointly solving scientific questions in the projects
* Drive R&I´s scientific reputation by presenting and publishing your results within the department, across AZ and externally
* Follow safety requirements and all AZ corporate responsibility policies


Essential for the role
* PhD in synthetic Organic Chemistry, Medicinal Chemistry or Biochemistry
* In-depth scientific knowledge and recent practical experience in the area of synthetic chemistry
* Up-to-date with the application of modern purification and analytical techniques
* A proven track record of delivery from own experimental work
* Excellent communication and collaboration skills
* Professional experience in the Pharmaceutical Industry is a benefit


Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,800 employees from over 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

What's next?
If you are ready to make a difference - apply today! Please send in your application no later than November 20th, 2022.

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Senior Scientist, Large Scale Synthetic Chemistry

Ansök    Okt 10    Astrazeneca AB    Organisk kemist
Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the person we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines. The role We are seeking a new member to join our Large Scale Synthetic Chemistry ... Visa mer
Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the person we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines.



The role

We are seeking a new member to join our Large Scale Synthetic Chemistry team as a Senior Scientist. Working within our Early Chemical Development function you will be located at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.

Early Chemical Development (ECD) is a World-Class CMC department within Pharmaceutical Sciences whose responsibilities span from early engagement with Discovery Chemistry groups to manufacture of Phase II Clinical trial materials. Its key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large-Scale Laboratory (Kilo-Lab) Manufacturing, Process Chemistry, Process Engineering and Separation Science.

The Large Scale Synthetic Chemistry team sits within ECD and delivers high-quality API material in the range of 100-1000 g through development of excellent chemistry, innovative routes and creative solutions. The laboratory is the single company wide asset for large scale, non-GMP manufacturing of API for pre-clinical toxicology studies.



What you'll do

As a member of the Large Scale Synthetic Chemistry team, you will work closely with both medicinal chemists and process chemists to explore and develop safe, efficient and cost-effective synthesis routes to drug candidates.



Your main accountabilities/responsibilities:

*

With strong emphasis on safety you will explore and develop experimental strategies, troubleshoot problems and synthesize organic compounds in the range of 100-1000 grams.
*

Plan, prioritise and perform your own work and actively collaborate with the drug project synthesis teams.
*

Demonstrate expertise in synthetic and analytical chemistry, purification and crystallisation.
*

Provide rigorous documentation of experimental results in an electronic laboratory journal, and author development/campaign reports.
*

Publish novel work in peer reviewed journals.



Essential qualifications:

A Ph.D. or equivalent in organic chemistry, or extensive directly relevant experience is required. It is likely that you will have post-graduate research experience, preferably within route development and large-scale synthesis of complex organic molecules.

You will have excellent collaboration, communication, and planning skills with a strong sense of responsibility, teamwork and delivery focus.



Other qualifications:

*

Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
*

Ability to independently design, plan and execute multistep syntheses suitable for kilogram manufacture.
*

Able to identify, develop and apply new technologies and ways of working within large scale synthetic organic chemistry
*

Creativity in handling a wide range of synthetic challenges and a passion for complex problem solving.
*

Ability to coach peers to enhance individual and team performance and development
*

Curious and innovative mindset



So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Then you might be the one we are looking for! We would welcome with your application (CV and cover letter) no later than Nov 4, 2022.

For more information please contact the recruiting manager Hans Emtenäs, [email protected]



Where can I find out more?

Relocate to Gothenburg

AstraZeneca in Gothenburg

A life-changing day: Meet Hasse

Move to Gothenburg Visa mindre

Chemistry Automation Application Specialist

Ansök    Okt 13    Astrazeneca AB    Organisk kemist
Are you a trained Organic Chemist/Synthesis Chemist with practical experience of using lab automation technologies for setting up and running experiments and synthesizing new molecules? Are you interested in becoming part of a growing team focusing on the autonomous synthesis of bioactive molecules at a company where we are committed to lifelong learning, growth, and development? Welcome to AstraZeneca! We are seeking an Organic Chemist with extensive exp... Visa mer
Are you a trained Organic Chemist/Synthesis Chemist with practical experience of using lab automation technologies for setting up and running experiments and synthesizing new molecules? Are you interested in becoming part of a growing team focusing on the autonomous synthesis of bioactive molecules at a company where we are committed to lifelong learning, growth, and development? Welcome to AstraZeneca!

We are seeking an Organic Chemist with extensive experience in applying laboratory automation technologies to the synthesis of new molecules to play an important part in our iLAB team, focusing on building an industry-leading end-to-end chemistry automation platform. You will work as a Chemistry Automation Application Specialist and in this multidisciplinary, multinational team you can drive and advance our chemistry automation capabilities at AstraZeneca in Gothenburg, Sweden.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. With our ground-breaking pipeline comes a bright future - a secure job, exciting opportunities, and varied work. You will be valued. Not only for your unique contribution, skills, and background, but because we recognize people are our greatest asset.

What you will do:
In this exciting role you will be responsible for the transfer of manually executed compound synthesis to automation platforms. You will actively develop synthesis protocols for state-of-the-art chemistry transformations to be executed in a fully automated way. As well as intimately be involved in the build of a new end-to-end chemistry automation platform and work with colleagues on the design and implementation of novel automation workflows. You'll identify, test and evaluate new devices and play an important role during factory and site acceptance test activities for the new platform and drive the use of these capabilities in AstraZeneca drug discovery projects.

During your work you will spend approximately 50% of your time in the laboratory investigating how manual syntheses must be modified to be robustly executed in an automated way. You will transfer this knowledge to your colleagues in order to facilitate the automation of synthesis tasks requested by medicinal chemists from across the organization. During the other 50% of your time, you will work together with colleagues on the detailed specification for the future chemistry automation platform and function as an expert user of specific lab automation devices. As our new Chemistry Automation Application Specialist you will have access to the best internal and external science and be expected to enhance business reputation both internally and externally through peer-reviewed publications and oral/poster presentations

Essential in the role:
You're a chemist with a track record of applying innovative chemistry and/or technology solutions, which result in impact on projects. You also have:

* Ph.D. in organic chemistry or a master's degree in chemistry with a minimum of five years industrial experience in synthetic organic chemistry
* Hands on experience with creating custom lab automation workflows and a strong interest in developing new technologies for organic synthesis
* Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification and analytical chemistry
* Excellent knowledge of current chemical literature, chemical technologies and innovations for driving project delivery

Our new colleague should be motivated to work effectively in hardworking teams and demonstrate ability to work across scientific disciplines to drive project success. We also believe you have the ability to effectively communicate, have a high scientific drive and a long-term commitment to advancing chemistry automation as an innovative tool in drug discovery.

Desirable in the role:

* Experience in planning and executing chemistry experiments in parallel and adapting existing protocols to new applications (e.g., high throughput experimentation, batch-to-flow chemistry, or process scale-up).
* Experience of working in the pharmaceutical/agrochemistry/biotech industry in a discovery environment, including chemistry scale-up labs.
* Experienced with troubleshooting and basic maintenance of instruments (e.g liquid handlers, analytical equipment, flow chemistry reactors).
* Basic programming skills in e.g C#, Python.

Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world.

So, what's next? If this sounds like your next challenge - apply today! Welcome with your application but send it to us no later than November 13th, 2022.

For more information about the position please contact Dr Michael Kossenjans, Director Chemistry and Head of AZ Chemistry Automation.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Scientist, Large Scale Synthetic Chemistry

Ansök    Okt 10    Astrazeneca AB    Organisk kemist
Are you an organic chemist with experience in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines. The role We are seeking a new member to join our Large Scale Synthetic Chemistry team as a Scie... Visa mer
Are you an organic chemist with experience in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines.



The role

We are seeking a new member to join our Large Scale Synthetic Chemistry team as a Scientist. Working within our Early Chemical Development function you will be located at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.

Early Chemical Development (ECD) is a World-Class CMC department within Pharmaceutical Sciences whose responsibilities span from early engagement with Discovery Chemistry groups to manufacture of Phase II Clinical trial materials. Its key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large-Scale Laboratory (Kilo-Lab) Manufacturing, Process Chemistry, Process Engineering and Separation Science.

The Large Scale Synthetic Chemistry team sits within ECD and delivers high-quality API material in the range of 100-1000 g through development of excellent chemistry, innovative routes and creative solutions. The laboratory is the single company wide asset for large scale, non-GMP manufacturing of API for pre-clinical toxicology studies.



What you'll do

As a member of the Large Scale Synthetic Chemistry team, you will work closely with both medicinal chemists and process chemists to explore and develop safe, efficient and cost-effective synthesis routes to drug candidates.



Your main accountabilities/responsibilities:

*

With strong emphasis on safety aspects, explore and develop experimental strategies, troubleshoot problems and synthesize organic molecules in the range of 100-1000 grams
*

Plan and perform your own work and actively collaborate with the drug project synthesis teams.
*

Demonstrate good skills in synthetic and analytical chemistry, purification and crystallisation
*

Rigorously document experimental results in an electronic laboratory notebook, as well as support the writing of campaign and development reports.



Essential qualifications:

A Master of Science degree in Organic Chemistry or equivalent is required. It is likely that you have some experience of route development and large-scale synthesis of complex organic molecules gained in an industrial or academic environment.

You will have excellent collaboration, communication, and planning skills with a strong sense of responsibility, teamwork and delivery focus.

Other qualifications:

*

Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
*

Able to apply new technologies and ways of working within large scale synthetic organic chemistry
*

Ability to independently design, plan and execute multistep syntheses to be able to manufacture kilogram campaigns together with team members
*

Creativity in handling a wide range of synthetic challenges
*

Curious and innovative mindset
*

Passion for solving complex synthetic problems
*

Excellent English, both spoken and written



So, what's next?

If your passion is science & technology and you want to be part of a team that makes a positive impact on patients' lives, then there's no better place to be. With us there are many opportunities to develop yourself and your career. From our diverse portfolio and teamwork, to our cutting-edge innovations - it's a place for lifelong learning.

We would welcome with your application (CV and cover letter). We review applications on a continuous basis so please apply as soon as possible and no later than November 4 2022.

For more information please contact the recruiting manager Hans Emtenäs at [email protected]



Where can I find out more?

Relocate to Gothenburg

AstraZeneca in Gothenburg

A life-changing day: Meet Hasse

Move to Gothenburg Visa mindre

Forskare i nanoelektrokemi i celler och flughjärnor

Ansök    Aug 25    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Vid institutionen för kemi och molekylärbiologi bedrivs forskning och forskarutbildning inom ett brett omr... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Vid institutionen för kemi och molekylärbiologi bedrivs forskning och forskarutbildning inom ett brett område som sträcker sig hela vägen från atom- och molekylskala via celler till hela organismer. Mycket av de fenomen som studeras har en inverkan på vår naturliga miljö och levande system. Vi deltar i utbildning på grundläggande nivå inom programmen för kemi, molekylärbiologi, läkemedelskemi, biologi, marina vetenskaper och apotekarprogrammet. Vi letar efter en person som kan bidra till ett starkt forskningsprogram och tillföra mervärde till den pågående forskningen i Ewing-laboratoriet vid Göteborgs universitet. Arbetetets ämne är utveckling av nya elektrokemiska nano- och mikrometoder för att förstå vesikler och överföring i flughjärnan.

ARBETSUPPGIFTER

Arbetsuppgifterna innefattar huvudsakligen planering, design och genomförande av forskning för att utveckla och tillämpa snabbavsökningsvoltammetri i flughjärnan med optogenetisk stimulering, att utveckla nanotip-elektroder för att mäta koncentrationen av katekolaminer i encellig cytoplasma och överföring av molekyler mellan vesiklar.

KVALIFIKATIONER

Krav för tjänsten är en doktorsexamen i analytisk kemi krävs med minst två års erfarenhet efter doktorsexamen. Vi söker dig som har erfarenhet av elektrokemi, nanotip-kolelektroder, utveckling av kolnanoelektroder, snabbavsökning av cyklisk voltammetri och att arbeta med bananflugor. Eftersom det är en ettårig tjänst är erfarenhet inom alla dessa områden ett krav.

ANSTÄLLNING

Anställningen är?en tidsbegränsad anställning på heltid under ett år med placering vid Institutionen för kemi och molekylärbiologi. 

KONTAKTUPPGIFTER FÖR ANSTÄLLNINGEN

Har du frågor om anställningen är du välkommen att kontakta Professor Andrew Ewing, e-post: [email protected] 

FACKLIGA ORGANISATIONER

Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

ANSÖKAN

För att söka en anställning vid Göteborgs universitet måste du registrera ett konto i vårt rekryteringssystem. Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag 2022-09-15. Dina ansökningshandlingar ska innehålla: CV, personligt brev, och kontaktuppgifter till två referenser. 

Ansökan ska vara inkommen senast: 2022-09-15

 Lägg till att man ansöker via https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar.

 


Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Senior Scientist in Medicinal and Synthetic Chemistry

Ansök    Aug 17    Astrazeneca AB    Organisk kemist
Are you an experienced Synthetic Organic Chemist with interest to apply your skills in Medicinal Chemistry? Can you envision your future in drug discovery, creating and developing novel drug molecules? Do you have experience and desire to apply cutting-edge techniques and strategies to make the drugs of the future to help patients with unmet medical need? Then this is an outstanding opportunity for you! At AstraZeneca, we follow the science to explore and... Visa mer
Are you an experienced Synthetic Organic Chemist with interest to apply your skills in Medicinal Chemistry? Can you envision your future in drug discovery, creating and developing novel drug molecules? Do you have experience and desire to apply cutting-edge techniques and strategies to make the drugs of the future to help patients with unmet medical need? Then this is an outstanding opportunity for you!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

Our Early Cardiovascular, Renal and Metabolism (CVRM) Medicinal Chemistry Department is a critical player in the design and discovery of drug molecules. We are proud of our heritage of successful delivery of clinical candidates to human testing, leading to new medicines for patients. Here, we work agnostic to molecular modality and have expertise in small molecules, PROTACs, peptides, oligonucleotides, and drug conjugates.

We drive our pipeline and areas of scientific leadership internally and in partnership with world experts, which provides you as a scientist with the unique opportunity to stay at the forefront of science.

You will be based at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

What you'll do

The role is lab based and focused on synthetic chemistry. You will actively contribute to AstraZeneca's portfolio of drug projects using your compound design, synthesis, data generation, and data interpretation skills.

There will also be opportunities to develop your medicinal chemistry and drug discovery knowledge together with the experts in the department.

All work is performed in a highly cross-disciplinary environment. In addition, you will be part of external collaborations, publish scientific papers, present and represent the department externally.

As part of an open-minded, creative, and experienced team in drug discovery, you will contribute with your high ambitions, collaborative mentality and passion to push the boundaries of science in the area of synthetic and medicinal chemistry.

Essential for the role

We are looking for an ambitious team player that has expert knowledge in synthetic organic chemistry. Basic knowledge of medicinal from drug discovery in an industrial setting,

* Ph. D. degree in Organic Chemistry/Synthetic Chemistry/Medicinal Chemistry or Master of Science with a few years' experience in synthetic/medicinal chemistry.
* Strong synthetic chemistry knowledge: ability to plan, prioritize and perform work independently, including synthetic route design and problem solving.
* Scientific curiosity and creativity: ability to identify, develop and apply new technologies and ways of working.
* Experience of developing new chemistry and methods, including high-throughput experimentation, is an advantage.
* Great awareness of recent literature as well as current developments and trends in organic synthesis.
* Highly self-motivated and capable of analyzing complex data and deciding on focused course of action.
* Excellent teamwork, collaboration, networking, and communication skills.
* Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents.

Why AstraZeneca

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe - with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures collaboration, openness and innovation. Therefore, we have created space for meetings, socializing, and relaxation, where spontaneous meetings can give birth to new innovations.

We offer competitive salaries and excellent benefits, such as extra paid Holiday, Private Medical Benefit, on site exercise, and much, much more.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact Director Robert Sheppard through +46-31-7761000

Welcome with your application no later than 11th September , 2022

Where can I find out more?

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38

Meet Hasse, Chemist at AstraZeneca Gothenburg: https://www.youtube.com/watch?v=QulX8EotRSE&list=PLgfkdJlwmkT6h7sZKBXqs7Xj4PobD4RmR

Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Sr. Research Scientist/Assoc. Principle Scientist

Ansök    Aug 4    Astrazeneca AB    Organisk kemist
Senior Research Scientist or Associate Principle Scientist- Isotope Chemistry At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of pers... Visa mer
Senior Research Scientist or Associate Principle Scientist- Isotope Chemistry



At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.



Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API).



We are now looking for a Senior Research Scientist or an Associate Principle Scientist to join our Isotope Chemistry Team, part of Early Chemical Development, in Gothenburg.



The Isotope Chemistry Team delivers high-quality tritium, C-14, and stable isotope labeled compounds through the use of novel chemistry, innovative routes, and creative solutions. The laboratory is a companywide asset for the non-GMP manufacture of radiolabeled and stable isotope labeled compounds. It supports projects from target identification to single compound selection to clinical phases and post marketing support for all therapy areas in the portfolio.



The isotope chemistry team supports the projects with the highest priority and urgent needs in the AZ portfolio and has access to top-quality labs and equipment.



The role

As a member of the team, you will work closely with scientists in drug projects to develop safe, efficient, and cost-effective synthesis routes to labeled drug candidates and tool compounds.



Key Deliverables:

* With strong emphasis on safety, health, and environmental aspects, explore and develop experimental strategies, troubleshoot problems, and synthesize labeled organic molecules.
* Plan, prioritise, and perform own work and actively collaborate with the drug project teams.
* Demonstrate expertise in synthetic and analytical chemistry, as well as, purification techniques.
* Provide stringent documentation of experimental results in an electronic lab journal.
* Publish novel work in peer reviewed journals.



Experience

* A Ph.D. degree or equivalent in Organic Chemistry
* Strong collaborative and communication skills.
* Previous work with radioactivity is not required.



Key qualities:

* Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
* Ability to independently design, plan, and execute multistep syntheses
* Creativity in handling a wide range of synthetic challenges
* Ability to coach peers for improved individual and team performance and development
* A good communicator with experience in interacting effectively across disciplines
* Work collaboratively across boundaries
* Curious and innovative



Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.



Welcome with your application by the 25th of August.



Open date: 4/8/2022

Close date: 25/8/2022



Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ Visa mindre

Forskare inom stark exciton foton koppling

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska v... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vetenskaper och molekylära livsvetenskaper. Vår forskning och utbildning fokuserar på en djup förståelse av kemiska och biologiska processer i celler och i miljön.

Vi tar oss an viktiga samhällsfrågor som till exempel antibiotikaresistens, cancer, hjärnsjukdomar, miljöproblem och klimatförändringar. På så sätt medverkar vi till att uppnå FN:s globala mål för hållbar utveckling inom områdena god hälsa och välbefinnande, hållbar energi för alla, hållbara städer och samhällen samt bekämpa klimatförändringar.

Institutionen är en internationell miljö med tvärvetenskapliga samarbeten inom både forskning och utbildning, och bidrar starkt till Göteborgs universitets topprankning inom life science.

Institutionen ansvarar för forskarutbildning inom ämnesområdet Naturvetenskap med inriktning mot kemi, biofysik, biologi och utbildningsvetenskap. Därtill är institutionen värd för utbildningsprogram i molekylärbiologi, genomik och systembiologi, kemi, organisk kemi och läkemedelskemi samt receptarieutbildningen. Institutionen samverkar med olika samhällsaktörer som skolor, näringsliv och myndigheter. Institutionen för kemi och molekylärbiologi har runt 200 anställda. Vi finns i centrala lokaler både på Campus Johanneberg och på Campus Medicinareberget i Göteborg.

I gruppen för molekylära material bygger vi molekylära system som är gjorda så att de kan utföra en precist definierad funktion med utgångspunkt för användning inom materialkemi. Kompetensen i gruppen ligger både inom organisk syntes och optisk/elektrisk karakterisering av komplicerade molekylära material. Oftast använder vi organiska molekyler till våra studier, och även om dessa kan ensamma kan utföra en uppgift så ligger fokus på vad de syntetiserade materialen kan utföra tillsammans. Se vår hemsida för mer information (www.molecularmaterials.se).

Arbetsuppgifter 
Du kommer att bedriva forskning i gränslandet mellan kemi, fysik och materialvetenskap. Du kommer att arbeta inom ett projekt som handlar om att förstå vad som händer med molekyler som är starkt kopplade med ljus. Praktiska arbetsuppgifter kommer att vara fokuserade på att undersöka hur starkt foton-exciton kopplade system kan användas för att transportera energi i organiska material för användning inom organisk elektronik.

Kvalifikationer 
Krav för anställningen är svensk doktorsexamen inom kemi alternativt fysik eller har en utländsk examen som bedöms motsvara doktorsexamen inom kemi alternativt fysik. Expertis inom stark exciton-foton koppling genom användandet av organiska molekyler är ett krav. Att kunna uttrycka sig i skrift och text flytande på engelska är ett krav.

Meriterande är en stark publikationslista, där den sökande är förstaförfattare på artiklar publicerade i välrenommerade tidskrifter. Dessutom är erfarenhet av ämnena stark exciton-foton koppling och organisk elektronik starkt meriterande.

Anställning 
Anställningen är en tidsbegränsad anställning i sex månader på heltid (100%) med placering tills vidare vid Institutionen för kemi och molekylärbiologi i Göteborg. Tillträde i september.

Kontaktuppgifter för anställningen 
Har du frågor om anställningen är du välkommen att kontakta professor Karl Börjesson, [email protected].

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Ansökan 
För att söka en anställning vid Göteborgs universitet måste du registrera ett konto i vårt rekryteringssystem. Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. Ansökan skall innehålla:

- CV
- Personligt brev
- Forskningsartikel som behandlar ämnet stark exciton-foton koppling som du är förstaförfattare på


Ansökan ska vara inkommen senast: 2022-07-31


Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Senior Research Scientist - DNA encoded library synthesis

Ansök    Jun 30    Astrazeneca AB    Organisk kemist
Do you have hands-on experience and great knowledge with the synthesis of DNA encoded libraries? Are you interested in establishing and developing our new DEL synthesis lab at a company where we are committed to lifelong learning, growth and development? If yes, this might be the role for you! We are looking for a specialized Synthetic Chemist that will play an important part in our iLAB team, focusing on the synthesis of novel DNA encoded libraries (DEL)... Visa mer
Do you have hands-on experience and great knowledge with the synthesis of DNA encoded libraries? Are you interested in establishing and developing our new DEL synthesis lab at a company where we are committed to lifelong learning, growth and development? If yes, this might be the role for you!

We are looking for a specialized Synthetic Chemist that will play an important part in our iLAB team, focusing on the synthesis of novel DNA encoded libraries (DEL). You will have the opportunity to drive and influence the DEL synthesis capabilities in our newly created lab at AstraZeneca in Gothenburg, Sweden and contribute to the production of a proprietary compound collection based on DEL.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. With our ground-breaking pipeline comes a bright future - a secure job, exciting opportunities and varied work. You will be valued. Not only for your unique contribution, skills and background, but because we recognize people are our greatest asset. Here we are dedicated to being a Great Place to Work.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
This is an exciting role where you will contribute from an early stage to the development of the newly created DEL synthesis lab capabilities at AstraZeneca Gothenburg. You will design and synthesize DNA encoded libraries - and use and develop currently available chemistry automation for DEL synthesis. You will also contribute to the continuous improvement of the DEL synthesis platform by developing and applying new, groundbreaking synthetic approaches for on-DNA chemistry and by evaluating new technologies.

In your daily work you will troubleshoot laboratory-based problems and make a significant contribution to the delivery of the team. As a DEL Chemist, you will maintain access to the best internal and external science and enhance business reputation internally and externally through peer-reviewed publications and oral/poster presentations.

Essential in the role:
You're a chemist with a track record of applying innovative chemistry solutions, with resulting impact in project delivery. You also have:

* Ph.D. in a relevant chemistry field, or a Master degree in chemistry with minimum 5 years' experience in synthetic organic chemistry.
* Hands-on experience with on-DNA synthesis and/or synthesis of DNA encoded libraries.
* Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification and analytical sciences.
* Expertise in parallel chemistry.
* Knowledge of basic molecular biology techniques e.g gel electrophoresis, DNA ligation, PCR.
* Advanced knowledge of modern chemical literature, chemical technologies and applying new ideas to project delivery.
* A track record of driving innovation in chemistry related sciences.

The successful candidate should be motivated to work effectively in hardworking teams and demonstrate ability to work across scientific fields to get results. We also believe that our candidate have effective levels of communication, a scientific drive and a high interest in working with organic chemistry and molecular biology techniques.

Desirable in the role:

* Experience in the development of on-DNA chemistry.
* Experience in methods development.
* Experience with chemistry automation.
* Knowledge in designing high-throughput chemistry and/or library synthesis experiments using bespoke design software.
* Knowledge of medicinal chemistry.

We also believe that the successful candidate have a detailed understanding of the chemical sciences and how they contribute and influence drug discovery together with knowledge of the drug discovery process.

Why AstraZeneca Gothenburg?
With more than 2,400 employees from over 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next? If this sounds like your next challenge - apply today!

Welcome with your application, but send it to us no later than 15th August, 2022.

For more information about the position please contact Nidhal Selmi, Director of Chemistry - DNA-Encoded & Compound Collection Libraries - iLAB, at nidhal.selmi(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About iLAB - Innovation Lab: https://www.astrazeneca.com/r-d/our-technologies/ilab.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work. Visa mindre

Postdoktor i Naturproduktkemi och kemisk biologi

Ansök    Maj 25    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska v... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vetenskaper och molekylära livsvetenskaper. Vår forskning och utbildning fokuserar på en djup förståelse av kemiska och biologiska processer i celler och i miljön. Vi tar oss an viktiga samhällsfrågor som till exempel antibiotikaresistens, cancer, hjärnsjukdomar, miljöproblem och klimatförändringar. På så sätt medverkar vi till att uppnå FN:s globala mål för hållbar utveckling inom områdena god hälsa och välbefinnande, hållbar energi för alla, hållbara städer och samhällen samt bekämpa klimatförändringar. Institutionen är en internationell miljö med tvärvetenskapliga samarbeten inom både forskning och utbildning, och bidrar starkt till Göteborgs universitets topprankning inom life science. Institutionen ansvarar för forskarutbildning inom ämnesområdet Naturvetenskap med inriktning mot kemi, biofysik, biologi och utbildningsvetenskap. Därtill är institutionen värd för utbildningsprogram i molekylärbiologi, genomik och systembiologi, kemi, organisk kemi och läkemedelskemi samt receptarieutbildningen. Institutionen samverkar med olika samhällsaktörer som skolor, näringsliv och myndigheter. Institutionen för kemi och molekylärbiologi har runt 200 anställda. Vi finns i centrala lokaler både på Campus Johanneberg och på Campus Medicinareberget i Göteborg

Naturprodukter är en riklig källa för identifiering av bioaktiva föreningar och värdefulla läkemedelsmål. I det utlysta projektet siktar vi mot att syntisera produktbaserade verktygsföreningar från naturliga källor, för en ny målidentifieringsmetod som använder bioaktiva markörer. Projektet kommer att genomföras i nära samarbete med CytoLabs DFG Consortium i Tyskland.

Arbetsuppgifter 
Tjänsten inkluderar ledning av ett tvärvetenskapligt forskningsprojekt i gränslandet mellan semi- och totalsyntes av naturprodukter, design av bioaktiva verktygsföreningar och implementering av ett arbetsflöde för målidentifiering via MS/MS. Sökanden är tänkt att utföra kemisk syntes, biokemiskt arbete såväl som biologiska analyser för målidentifiering. Den sökande ska dokumentera forskningsresultat, skriva vetenskapliga publikationer och bidra till bidragsansökningar

Kvalifikationer 
Behörig att anställas som postdoktor är den som har svensk doktorsexamen eller har en utländsk examen som bedöms motsvara doktorsexamen. I första hand prioriteras dem som har avlagt examen högst tre år före ansökningstidens utgång samt inte tidigare varit anställd som postdoktor under mer än ett år inom samma eller närliggande ämnesområden vid Göteborgs universitet. Även den som har avlagt examen tidigare kan komma i fråga om särskilda skäl föreligger (t ex ledighet på grund av sjukdom, tjänstgöring inom totalförsvaret, förtroendeuppdrag inom fackliga organisationer och studentorganisationer eller föräldraledighet eller andra liknande omständigheter). För att kvalificera sig för denna tjänst bör den sökande ha en doktorsexamen i ett relevant ämne inom området kemi, läkemedelskemi eller kemisk biologi.

Vi söker en ambitiös, motiverad och mångsidig person med ett särskilt intresse för naturlig produktkemi och bioaktiva molekyler. Erfarenhet av totalsyntes och semisyntetisk modifiering av naturliga produkter krävs för tjänsten. Utmärkta kemikunskaper och praktiska laboratoriekunskaper, samt grundläggande kunskaper inom biologi krävs för att framgångsrikt kunna samarbeta med experter inom ämnet. Kandidaten ska kunna arbeta självständigt såväl som i grupp, och ha goda kunskaper (skrift och tal) i engelska. Tyska är ett plus då projektet kommer att genomföras i nära samarbete med CytoLabs DFG Consortium i Tyskland. Personen måste vara välstrukturerad och organiserad eftersom stora datamängder kommer att analyseras. Dessutom förväntas personen vara ansvarsfull och ha goda kommunikations- och samarbetsförmåga.

Anställning 
Anställningen är tidsbegränsad på 2 år på heltid (100%) med placering tillsvidare vid Institutionen för kemi och molekylärbiologi vid Göteborgs universitet. Start i oktober 2022.

Kontaktuppgifter för anställningen 
Har du frågor om anställningen är du välkommen att kontakta: Philipp Klahn, e-post: [email protected]

Fackliga?organisationer 
Fackliga företrädare vid Göteborgs universitet hittar du här:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Ansökan 
För att söka en anställning vid Göteborgs universitet måste du registrera ett konto i vårt rekryteringssystem. Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag 2022-06-16. Ansökan skall innehålla cv, personligt brev, examensbevis och kontaktuppgifter till referenser.

Ansökan ska vara inkommen senast: 2022-06-16


Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Researcher within strong exciton photon copuling

Ansök    Mar 24    Göteborgs Universitet    Organisk kemist
The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future. The Department of Chemistry and Molecular Biology conducts high-quality research an... Visa mer
The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Department of Chemistry and Molecular Biology conducts high-quality research and education in chemical sciences and molecular life sciences. Our research and education focuses on a deep understanding of chemical and biological processes in cells and in the environment.

We address important societal issues such as antibiotic resistance, cancer, brain diseases, environmental problems and climate change. In this way, we contribute to achieving the UN's global goals for sustainable development in the areas of good health and well-being, sustainable energy for all, sustainable cities and communities, and combating climate change.

The department is an international environment with interdisciplinary collaborations in both research and education, and contributes strongly to the University of Gothenburg's top ranking in life science.

The department is responsible for postgraduate education in the subject area Natural Sciences with a focus on chemistry, biophysics, biology and educational science. In addition, the department hosts educational programs in molecular biology, genomics and systems biology, chemistry, organic chemistry and pharmaceutical chemistry, as well as prescription education. The department collaborates with various societal actors such as schools, business and authorities. The Department of Chemistry and Molecular Biology has around 200 employees. We are located in central premises both on Campus Johanneberg and on Campus Medicinareberget in Gothenburg.


In the molecular materials research group we construct molecules or molecular based systems that perform highly specialized functions to be used within material sciences. The competence of the group involves both the synthesis of complex molecules and the photophysical/electrical characterization of these molecular based systems. Most often we are working with organic molecules and even though each molecule is able to perform a task on its own, our aim is not to use the single molecules, but ensembles of molecules to create materials for the future. For more information see www.molecularmaterials.se.

Duties 
You will pursue research at the cutting edge of chemistry, physics and materials science. The project that you will work within has the goal to explore the phenomena of strong exciton photon coupling using organic. Your specific work tasks will include writing a review article within the area of strong exciton-photon coupling using organic molecules. You will work independently within the context of the research group in molecular materials.

Qualifications 
To qualify as a researcher, the applicant must have completed a Swedish doctoral degree or must have a foreign degree corresponding to a Swedish doctoral degree in the areas of chemistry of physics. Being an expert within strong exciton-photon coupling using organic molecules is a demand. A high proficiency within the English language is also a demand. Having first author publications in well reputed journals is a merit. Having previously summarized the field of strong exciton-photon coupling using organic molecules is a merit. 

Employment 
Is a fixed term fulltime during  6 months at the Department of Chemistry and Molecularbiology.

Contact information for the post 
If you have any questions about the position, please contact Karl Börjesson e-mail: [email protected]

Unions 
Union representatives at the University of Gothenburg can be found here:?https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline 2022-04-14.  Your application must include cv, personal letter and Research article within the subject of strong exciton-photon coupling using organic molecules that you are first author on.

Applications must be received by: 2022-04-14


The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Tjänstebenämning

Ansök    Mar 24    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska v... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vetenskaper och molekylära livsvetenskaper. Vår forskning och utbildning fokuserar på en djup förståelse av kemiska och biologiska processer i celler och i miljön.

Vi tar oss an viktiga samhällsfrågor som till exempel antibiotikaresistens, cancer, hjärnsjukdomar, miljöproblem och klimatförändringar. På så sätt medverkar vi till att uppnå FN:s globala mål för hållbar utveckling inom områdena god hälsa och välbefinnande, hållbar energi för alla, hållbara städer och samhällen samt bekämpa klimatförändringar. Institutionen är en internationell miljö med tvärvetenskapliga samarbeten inom både forskning och utbildning, och bidrar starkt till Göteborgs universitets topprankning inom life science.

Institutionen ansvarar för forskarutbildning inom ämnesområdet Naturvetenskap med inriktning mot kemi, biofysik, biologi och utbildningsvetenskap. Därtill är institutionen värd för utbildningsprogram i molekylärbiologi, genomik och systembiologi, kemi, organisk kemi och läkemedelskemi samt receptarieutbildningen. Institutionen samverkar med olika samhällsaktörer som skolor, näringsliv och myndigheter. Institutionen för kemi och molekylärbiologi har runt 200 anställda. Vi finns i centrala lokaler både på Campus Johanneberg och på Campus Medicinareberget i Göteborg.

I gruppen för molekylära material bygger vi molekylära system som är gjorda så att de kan utföra en precist definierad funktion med utgångspunkt för användning inom materialkemi. Kompetensen i gruppen ligger både inom organisk syntes och optisk/elektrisk karakterisering av komplicerade molekylära material. Oftast använder vi organiska molekyler till våra studier, och även om dessa kan ensamma kan utföra en uppgift så ligger fokus på vad de syntetiserade materialen kan utföra tillsammans. Se vår hemsida för mer information (www.molecularmaterials.se).

Arbetsuppgifter

Du kommer att bedriva forskning i gränslandet mellan kemi, fysik och materialvetenskap. Du kommer att arbeta inom ett projekt som handlar om att förstå vad som händer med molekyler som är starkt kopplade med ljus. Praktiska arbetsuppgifter kommer att vara fokuserade på att skriva en sammanfattningsartikel inom ämnet stark foton-exciton koppling.

Kvalifikationer

Behörig att anställas som forskare är den som har svensk doktorsexamen eller har en utländsk examen som bedöms motsvara doktorsexamen inom kemi alternativt fysik. Expertis inom stark exciton-foton koppling genom användandet av organiska molekyler är ett krav. Att kunna uttrycka sig i skrift och text flytande på engelska är ett krav. Meriterande är en stark publikationslista, där den sökande är förstaförfattare på artiklar publicerade i välrenommerade tidskrifter. Dessutom är erfarenhet av summering av ämnet stark exciton-foton koppling starkt meriterande.

Ansökan

Lägg till att man ansöker via https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar

 


Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Forskare i nanoelektrokemi vid celler och vesiklar

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Vid institutionen för kemi och molekylärbiologi bedrivs forskning och forskarutbildning inom ett brett omr... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Vid institutionen för kemi och molekylärbiologi bedrivs forskning och forskarutbildning inom ett brett område som sträcker sig hela vägen från atom- och molekylskala via celler till hela organismer. Mycket av de fenomen som studeras har en inverkan på vår naturliga miljö och levande system. Vi deltar i utbildning på grundläggande nivå inom programmen för kemi, molekylärbiologi, läkemedelskemi, biologi, marina vetenskaper och apotekarprogrammet.

Arbetsuppgifterna

Arbetsuppgifterna innefattar huvudsakligen planering, design och genomförande av forskning för att syntetisera nya kemiska märkningssonder som kan användas både inom fluorescensmikroskopi och masspektrometri. Den framgångsrika sökanden kommer att sätta upp syntes och arbeta med att utveckla nya sondmolekyler med bor och en fluorescensmärkning i samma molekyl. Vi söker efter en person som kan bidra till ett starkt forskningsprogram och tillföra mervärde till den pågående forskningen i Ewing-laboratoriet vid Göteborgs universitet. Arbetetets ämne är kemisk syntes av nya märkningssonder för fluorescensmikroskopi och masspektrometriavbildning med NanoSIMS. Dessa märkningssonder är ämnet för forskning i gruppen Nhu Phan så detta kommer att vara ett samarbete

Krav utbildning, kunskaper och erfarenheter, personliga egenskaper

Krav för tjänsten är en doktorsexamen i organisk kemi med minst fem års erfarenhet efter doktorsexamen. Vi söker någon som har erfarenhet av syntes av bor och fluorinnehållande funktionella grupper för att vara detektoraktiva i NanoSIMS. Vi är också engagerade i grön eller miljövänlig kemi. Erfarenhet av effektiva och gröna syntesmetoder för att bygga ett bibliotek av fluor-/eller borinnehållande föreningar är avgörande för detta projekts framgång och alla sökande måste ha visat publicerad erfarenhet inom detta område för att anses vara berättigad.

Ansökan

Du ansöker via https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar

 


Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Senior Scientist Computational Chemistry

Ansök    Feb 9    Astrazeneca AB    Organisk kemist
Would you like to bring your expertise and passion for Computational Chemistry and Medicinal Chemistry to a company that push the boundaries to unlock the power of what science can do? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in ... Visa mer
Would you like to bring your expertise and passion for Computational Chemistry and Medicinal Chemistry to a company that push the boundaries to unlock the power of what science can do? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We now offer an exciting opportunity for a Computational Chemist to join the Medicinal Chemistry Department within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area, one of AstraZeneca´s core therapy areas. The Medicinal Chemistry Department within CVRM is a critical player in the discovery and design of our drug molecules and in identifying and validating novel biological targets. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

What you'll do

As a Computational Chemist you will have a profound impact on multiple projects across the CVRM portfolio covering many different modalities (small molecules, peptides, PROTACs, and RNAs). As part of our fantastic, fast-paced computational chemistry team you will operate in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK, Biophysics and Pharmaceutical Sciences departments. You will have a key role in modelling, analysis of large datasets, drug design and you will be a significant contributor to discovery project progression. You will also be involved in building and driving our future design capabilities to tackle difficult targets and implementation of Augmented Drug Design across our portfolio. You will join a great team of highly-skilled and experienced computational chemists mastering all contemporary design capabilities like MD, FEP, ML and AI.

* You will simultaneously impact multiple discovery projects by efficiently and pro-actively applying a wide variety of computer-aided drug design approaches
* You will be expected to plan, write and publish high quality scientific papers

Essential for the role

In this key role you will bring your solid computational chemistry experience to the drug discovery project portfolio. We are looking for a drug hunter with a PhD (or equivalent experience) in computational chemistry. You have a high degree of independence and a proven record of excellence in a number of computer-aided drug design techniques. You also have:

* Solid knowledge of computer-aided drug design and modern medicinal chemistry.
* Expertise in using standard computational chemistry software.
* Ideally having industry experience in drug design.
* Expertise in biophysics, structural modeling and methods to study protein dynamics.
* Knowledge in scientific computing, and programming skills (e.g. Python) is an advantage.
* Expertise in machine-learning methods is a plus.
* Excellent communication skills in English is required.

If you have the ability to influence both people and science and thrive on team work in a multidisciplinary environment, you will fit right in at AstraZeneca!

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information, please contact recruiting manager Dr. Anders Hogner, [email protected] +46-31-7761000

Welcome with your application no later than March 9, 2022.

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Meet Hasse, Chemist at AstraZeneca Gothenburg: https://www.youtube.com/watch?v=QulX8EotRSE&list=PLgfkdJlwmkT6h7sZKBXqs7Xj4PobD4RmR

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more. Visa mindre

Associate Principal Scientist, focus on chemistry outsourcing

Ansök    Mar 11    Astrazeneca AB    Organisk kemist
Are you an enthusiastic scientist with experience in the field of chemistry outsourcing, looking to develop yourself and work with a great team of scientists? At AstraZeneca, we turn ideas into life changing medicines. Working here means thinking big and working together to deliver impact from our contributions that make the impossible a reality. We have an exciting opportunity in our Discovery Sciences unit for an Associate Principal Scientist. This role... Visa mer
Are you an enthusiastic scientist with experience in the field of chemistry outsourcing, looking to develop yourself and work with a great team of scientists? At AstraZeneca, we turn ideas into life changing medicines. Working here means thinking big and working together to deliver impact from our contributions that make the impossible a reality.

We have an exciting opportunity in our Discovery Sciences unit for an Associate Principal Scientist. This role, in the Compound Synthesis and Management group, provides leadership of synthetic chemistry outsourcing to AstraZeneca's BioPharmaceuticals R&D portfolio of drug discovery projects. The position will be placed at our vibrant AstraZeneca R&D site in Gothenburg, Sweden.

As our new Associate Principal Scientist, you will collaborate with chemistry teams and external companies to ensure high quality supply of compounds from strategic partnerships and fee-for-service contracts, spanning all phases of drug discovery. You will have a passion for scientific innovation and delivery, developing science strategy and shaping the future of the BioPharmaceuticals R&D chemistry capability - building trusting relationships with internal and external scientific colleagues.

We value our differences because we recognize that a team is at its most creative when it is made up of people who think differently from one another, in an environment where different views and perspectives are welcomed and valued. This is how we foster continuous innovation, constant learning and growth for us as individuals and for our patients.

What you'll do:
Lead the external sourcing of small molecules, oligonucleotides and peptides for BioPharmaceuticals R&D. Collaborate with Therapeutic Areas, Discovery Sciences, and external partners to establish priorities, provide expert insight to compound outsourcing, manage expectations and communicate progress. Other accountabilities:

* Collaborate with Therapeutic Areas, Discovery Sciences and enabling functions to establish and lead strategy developments.
* Develop yourself together with your colleagues to maximise individual and team contributions.
* Enhance the external science and technology reputation of AstraZeneca chemistry through peer-reviewed publication, external presentation of innovative results and involvement in external scientific communities.

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues and other leaders, will ensure you maximise your skills, abilities and contribution.

Essential in this role:

* Expertise in synthetic organic chemistry, with experience of establishing and leading diverse chemistry operations with CROs.
* Collaborative science lead with the skills and behaviors to develop trusted, interdisciplinary partnerships that ensure alignment of priorities and inspire the delivery of ambitious goals.
* Engaging, scientific leadership with great communication skills and a passion for project delivery and personal development.
* Ph.D. or a B.Sc./M.Sc. Degree (or equivalent) in a related scientific discipline with a minimum of 3 years of experience in a drug discovery unit or pharmaceutical company.

An active network of external contacts and experience of developing outsourcing strategy is a great plus.

Why AstraZeneca?
Ultimately, it's more than a job. We know that our work impacts people with serious conditions, many of whom have no other alternatives. That's what drives us - the potential to impact over one billion patients worldwide.

So, what's next? If you're passionate about the possibilities of science to make a difference, welcome to join us!

We look forward to get to know you and invite you to submit your application as soon as possible, but no later than the 27th March.

For more information about the position please contact Clive Green, Executive Director Compound Synthesis and Management, at [email protected].

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Forskare inom kovalenta organiska ramverk i form av filmer

Ansök    Mar 10    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska v... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 56 000 studenter och 6 600 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Institutionen för kemi och molekylärbiologi bedriver högkvalitativ forskning och utbildning inom kemiska vetenskaper och molekylära livsvetenskaper. Vår forskning och utbildning fokuserar på en djup förståelse av kemiska och biologiska processer i celler och i miljön. Vi tar oss an viktiga samhällsfrågor som till exempel antibiotikaresistens, cancer, hjärnsjukdomar, miljöproblem och klimatförändringar. På så sätt medverkar vi till att uppnå FN:s globala mål för hållbar utveckling inom områdena god hälsa och välbefinnande, hållbar energi för alla, hållbara städer och samhällen samt bekämpa klimatförändringar. Institutionen är en internationell miljö med tvärvetenskapliga samarbeten inom både forskning och utbildning, och bidrar starkt till Göteborgs universitets topprankning inom life science.

Institutionen ansvarar för forskarutbildning inom ämnesområdet Naturvetenskap med inriktning mot kemi, biofysik, biologi och utbildningsvetenskap. Därtill är institutionen värd för utbildningsprogram i molekylärbiologi, genomik och systembiologi, kemi, organisk kemi och läkemedelskemi samt receptarieutbildningen. Institutionen samverkar med olika samhällsaktörer som skolor, näringsliv och myndigheter. Institutionen för kemi och molekylärbiologi har runt 200 anställda. Vi finns i centrala lokaler både på Campus Johanneberg och på Campus Medicinareberget i Göteborg.

Arbetsuppgifter
I gruppen för molekylära material bygger vi molekylära system som är gjorda så att de kan utföra en precist definierad funktion med utgångspunkt för användning inom materialkemi. Kompetensen i gruppen ligger både inom organisk syntes och optisk/elektrisk karakterisering av komplicerade molekylära material. Oftast använder vi organiska molekyler till våra studier, och även om dessa kan ensamma kan utföra en uppgift så ligger fokus på vad de syntetiserade materialen kan utföra tillsammans. Se vår hemsida för mer information (www.molecularmaterials.se)

Nanostrukturerade material tillverkade av högt kontrollerade syntetiska och supramolekylära kemiska reaktioner blir allt viktigare för att lösa utmaningarna med energilagring och ren luft. Ett kommande material som redan har visat en hög potential i många av dessa aspekter är kovalenta organiska ramverk (COF), som är en metallfri utveckling från metall organiska ramverk. Börjesson-gruppen har utvecklat en ny metod för att syntetisera smidiga, självbärande, kristallina kovalenta organiska ramverk. Som forskare kommer du att utnyttja den utvecklade metoden, göra den perfekt och hitta nya applikationer inom COF-membran. Du kommer att arbeta självständigt såväl som i ett team, specialiserat på COF.

Kvalifikationer
Behörig att anställas som forskare är den som har svensk doktorsexamen eller har en utländsk examen som bedöms motsvara doktorsexamen inom kemi alternativt fysik. Expertis inom 3D kovalenta organiska ramverk i form av tunna filmer är ett krav. Expertis visas enklast med en artikel publicerad i en välrenommerad tidskrift (välrenommerad=ett högre impact factor än 10) som förstaförfattare i ämnet. Att kunna uttrycka sig i skrift och text flytande på engelska är ett krav. Meriterande är en stark publikationslista, där den sökande är förstaförfattare på artiklar publicerade i välrenommerade tidskrifter. Dessutom är erfarenhet av ytkemimätmetoder såsom AFM, XRD, QCM, etc starkt meriterande.

Anställning
Anställningen är en tidsbegränsad anställning på heltid, under 18 månader med placering vid Institutionen för Kemi och Molekylärbiologi.

Kontaktuppgifter för anställningen
Har du frågor om anställningen är du välkommen att kontakta professor: Karl Börjesson, e-post: [email protected]

Fackliga organisationer
Fackliga företrädare vid Göteborgs universitet hittar du här: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Ansökan
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag 2022-03-31

Ansökan skall innehålla:

- Personligt brev
- CV
- Publikation inom ämnet som förstaförfattare

Ansökan ska vara inkommen senast: 2022-03-31

Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten. 

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

 


Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Forskare, Core Facilities

Ansök    Jan 12    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 53 300 studenter och 6 500 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. OligoNova Hub är en nationell forskningsinfrastruktur som tillhandahåller stöd för svenska akademiska fors... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 53 300 studenter och 6 500 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

OligoNova Hub är en nationell forskningsinfrastruktur som tillhandahåller stöd för svenska akademiska forskare att omvandla idéer och upptäckter till nya, oligonukleotidbaserade läkemedel. OligoNova Hub är lokaliserad vid Göteborgs universitet och är också en del av Science for Life Laboratory (http://www.scilifelab.se) läkemedelsutvecklingsplattform (SciLifeLab-DDD), en nationell resurs bestående av cirka 40 högmotiverade forskare, flertalet med erfarenhet från industriell läkemedelsutveckling.

Göteborgs universitet rekryterar nu motiverade och engagerade forskare till enheten för oligonukleotidkemi vid OligoNova Hub och SciLifeLab-DDD. Framgångsrika kandidater har betydande erfarenhet av kemisk syntes, rening och/eller analys av oligonukleotidläkemedel eller liknande molekyler, och god förmåga att arbeta som en del av ett integrerat team på flera parallella projekt. Detta är en spännande möjlighet att bidra till ett dynamiskt och tvärvetenskapligt team som utvecklar innovativa tekniker för kemisk syntes och konjugering av oligonukleotider för läkemedelsprojekt.

Arbetsuppgifter
Som forskare i OligoNova Hubs kemiteam kommer dina huvudsakliga uppgifter att vara att leverera innovativa oligonukleotider till läkemedelsutvecklingsprojekt vid OligoNova Hub.

Du ingår i teamet som ansvarar för design, syntes, rening och analys av oligonukleotider, kemiskt modifierade nukleosidbyggstenar och oligonukleotidkonjugat till OligoNova Hubs läkemedelsprojekt. Framgångsrika kandidater bör därför ha praktisk kunskap om kemiska struktursökningsverktyg, syntestekniker, renings- och analysinstrumentering och –metoder, relaterade till kemiskt modifierade nukleosider, oligonukleotider och konjugat.

Huvudsakliga uppgifter:


• Leverera nya och skräddarsydda oligonukleotidprodukter enligt projektens behov och tidsplaner.
• Utföra syntes av oligonukleotider med hjälp av automatiserad syntesutrustning.
• Syntetisera och karakterisera skräddarsydda fosforamiditmonomerer samt småmolekyler för konjugering till oligonukleotider.
• Ansvara för kemisk laboratorieutrustning och inköp och handhavande av reagens.
• Utföra postsyntetiska konjugeringar.
• Rena intermediärer och slutprodukter.
• Ansvara för drift av analys- och reningsutrustning, inklusive HPLC, LC-MS, UV-Vis, NMR-instrumentering.
• Identifiera strategier för syntes av modifierade oligonukleotider och deras konjugat.
• Utvärdera och utöka nya kemier och bidra till innovationer för att uppnå nya produktfördelar.
• Organisera, registrera, utvärdera och sammanfatta experimentellt arbete och resultat, samt rapportera till en teamledare, interna teammedlemmar och till externa projektägare.
• Sammanställa skriftliga rapporter (på engelska) av projektmetoder och resultat.

Kvalifikationer

• Doktorsexamen i organisk kemi, läkemedelskemi eller motsvarande är ett krav; särskilt meriterande är praktisk erfarenhet av syntes och rening/analys av oligonukleotider, nukleotidbyggblock och/eller småmolekyler (särskilt RNA-riktade).
• Måste tala och skriva engelska flytande. Engelska är det huvudsakliga språket för intern och extern projektrapportering.
• Måste ha fördjupade kunskaper i strategier, tekniker och reaktioner för organisk syntes, samt praktisk erfarenhet av rening och analytiska karakteriseringsmetoder såsom NMR, MS, UV-vis, och fluorescensspektroskopi, HPLC, gelelektrofores.
• Måste ha dokumenterad förmåga att självständigt utforma och utföra experiment och tolka resultat.
• God problemlösningsförmåga är nödvändig, liksom utmärkt samarbetsförmåga, drivkraft och förmåga att arbeta väl i ett tvärvetenskapligt team.

Ytterligare kvalifikationer:

Erfarenhet inom kombinationer av följande områden är meriterande:


• Erfarenhet av automatiserad oligonukleotidsyntes genom fosforamiditkemi.
• Erfarenhet av nukleosid/nukleotidkemi och syntes av nukleosidbyggstenar för efterföljande fastfassyntes av oligonukleotider.
• Erfarenhet av biokonjugeringskemiska tekniker, särskilt konjugering av oligonukleotider och/eller syntes av organiska molekyler för efterföljande konjugering.
• Erfarenhet av rening, analys och karaktärisering av oligonukleotider och/eller andra biomolekyler.
• Erfarenhet av att utveckla processer för syntes och rening av stora makromolekyler.
• Erfarenhet av läkemedelsutvecklingsprocessen, särskilt relaterat till terapeutiska oligonukleotider.
• Kunskaper inom området terapeutiska oligonukleotider, inklusive design och syntes därav.

 

För övrig information och för att söka anställningen se den fullständiga annonsen på www.gu.se. 


Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Sr Synthetic Chemist in discovery of oligonucleotide conjugates

Ansök    Nov 25    Astrazeneca AB    Organisk kemist
Are you an experienced Synthetic Organic Chemist with deep knowledge of Medicinal Chemistry? Can you envision applying your skills into drug discovery, to develop novel drug conjugates between various modalities such as small molecules or peptides linked to oligonucleotides. Then this is an outstanding opportunity for you! At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamles... Visa mer
Are you an experienced Synthetic Organic Chemist with deep knowledge of Medicinal Chemistry? Can you envision applying your skills into drug discovery, to develop novel drug conjugates between various modalities such as small molecules or peptides linked to oligonucleotides. Then this is an outstanding opportunity for you!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

Our Early Cardiovascular, Renal and Metabolism (CVRM) Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. Here, we work agnostic to molecular modality and have expertise in small molecules, PROTACs, peptides, oligonucleotides and drug conjugates. We drive our pipeline and areas of scientific leadership internally and in partnership with world experts which provides you as a scientist with the unique opportunity to stay at the fore-front of science.

You will be based at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

What you'll do

The role is lab based and focused on synthetic chemistry of various modalities across projects, including conjugates of therapeutical oligonucleotides. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation.

All work is done in a highly cross disciplinary environment. In addition, you will be part of external collaborations, publish scientific papers, present and represent the department externally.

As part of an open minded, creative and experienced team in drug discovery, you will contribute with your high ambitions, collaborative mentality and passion to push the boundaries of science in the area of synthetic and medicinal chemistry.

Essential for the role

We are looking for ambitious colleagues who have expert knowledge in synthetic organic chemistry applied across multiple modalities and handling of complex molecules.

*

Ph. D. degree in Organic Chemistry, Medicinal Chemistry or Chemical Biology with emphasis on synthesis.
*

Strong synthetic chemistry knowledge: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
*

Scientific curiosity and creativity: ability to identify, develop and apply new technologies and ways of working
*

Experience from developing new chemistry for conjugations of different modalities e.g. peptides, oligonucleotides, small molecules is an advantage
*

Great awareness of recent literature as well as current developments and trends in organic synthesis
*

Highly self-motivated and capable of analyzing complex data and deciding on focused course of action
*

Excellent teamwork, collaboration, networking and communication skills
*

Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents

Desirable for the role

*

Experience of oligonucleotide chemistry

Why AstraZeneca

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe - with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations.

We offer competitive salaries and excellent benefits, such as extra paid Holiday, Private Medical Benefit, on site exercise and much, much more.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact Associate Director Ranganath Gopalakrishnan or Director Laurent Knerr through +46-31-7761000

Welcome with your application no later than January 9th, 2022

We will review applications continuously, however the application period is extended due to the upcoming Holiday season, which may delay our communication.

Where can I find out more?

Our Gothenburg site: https://www.facebook.com/astrazenecacareers/videos/astrazeneca-gothenburg/10156331412734784/

Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38

Life in Gothenburg: https://www.movetogothenburg.com/

Meet Hasse, Chemist at AstraZeneca Gothenburg: https://www.youtube.com/watch?v=QulX8EotRSE&list=PLgfkdJlwmkT6h7sZKBXqs7Xj4PobD4RmR Visa mindre

Senior Research Scientist - Oligonucleotide Chemistry

Ansök    Feb 2    Astrazeneca AB    Organisk kemist
Are you a Senior Research Scientist with a passion for and expertise of synthetic chemistry related to oligonucleotides? Do you want to join a growing team where you have the opportunity to further exploit our drug discovery platforms? If yes, this might be the opening for you! We are looking for two Senior Research Scientists to join our great Oligonucleotide Chemistry team within the Oligonucleotide Discovery Department in Gothenburg, Sweden. You will a... Visa mer
Are you a Senior Research Scientist with a passion for and expertise of synthetic chemistry related to oligonucleotides? Do you want to join a growing team where you have the opportunity to further exploit our drug discovery platforms? If yes, this might be the opening for you!

We are looking for two Senior Research Scientists to join our great Oligonucleotide Chemistry team within the Oligonucleotide Discovery Department in Gothenburg, Sweden. You will apply expert knowledge and synthesis skills in the Oligonucleotide field to expand the use of oligonucleotides, and molecular conjugates thereof, in the treatment of diseases across therapy areas within AstraZeneca. In doing so you demonstrate a passion for driving scientific questions, combined with strong team working ethics, to drug discovery projects.

The Oligo Chemistry team is working in close collaboration with scientists in other functions with a focus on the goal to design and develop the oligo therapeutics of the future. We offer a highly rewarding scientific environment and with an expectation to publish new findings.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

What you will do:
This role is a synthesis specialist role in oligonucleotide chemistry with a focus on developing oligonucleotide drugs and thereby supporting the AstraZeneca pipeline. You should be able to apply purification and analytical sciences, propose experimental strategies, troubleshoot problems and make a significant contribution to the practical delivery of project compounds. As well as synthesize and purify high quality building blocks and compounds by applying cutting-edge technologies and methodologies to support project progression from according to agreed timelines.

The Senior Research Scientist work alongside other chemists in the team to support project priorities but should also be comfortable in supervising more junior scientists. The role includes development of new building blocks and linkers as well as setting up new techniques. You will support oligonucleotide projects to ensure high scientific standards and quality of compounds to meet project objectives and support publication opportunities in the field of oligonucleotides.

Essential in the role:

* Candidate should have a PhD in Organic Chemistry, post-doc is a plus.
* Detailed knowledge of synthetic chemistry related to oligonucleotides, oligo building blocks and/or synthesis of advanced organic molecules. Knowledge in the area of oligonucleotide therapeutics, design and data analysis is a plus.
* Ability to design and execute experiments autonomously.
* Evidence of experimental impact by either peer-reviewed publications or external presentations.

We also believe that our new colleagues are individuals who thinks outside the box and find innovative scientific approaches. You hold enthusiasm and curiosity towards scientific questions and have a scientifically critical mindset capable of receiving and analyzing input from multiple disciplines. You can work in an independent and goal-oriented way, but you also enjoy team work and collaboration with ability to communicate in a global setting with cross-functional groups.

Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

So, what's next? If you want to join our Oligo journey - welcome to apply today!

We look forward to get to know you better. Send in your application as soon as possible, but no later than 27th February, 2022.

For more information about the position please contact Anders Dahlén at +46 31 706 4842 or [email protected]

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Principal Scientist, Computational Chemistry

Ansök    Okt 5    Astrazeneca AB    Organisk kemist
Would you like to bring your expertise and passion for Computational Chemistry and Medicinal Chemistry to a company that push the boundaries to unlock the power of what science can do? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in ... Visa mer
Would you like to bring your expertise and passion for Computational Chemistry and Medicinal Chemistry to a company that push the boundaries to unlock the power of what science can do? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We now offer an exciting opportunity for an experienced Computational Chemist to join the Medicinal Chemistry Department within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area, one of AstraZeneca´s core therapy areas. The Medicinal Chemistry Department within CVRM is a critical player in the discovery and design of our drug molecules and in identifying and validating novel biological targets. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden or Cambridge, UK and comes with and comes with competitive salary and benefits.

What you'll do

As a Computational Chemist you will have a profound impact on multiple projects across the CVRM portfolio covering many different modalities (small molecules, peptides, PROTACs, and oligonucleotides). As part of our fantastic, fast-paced computational chemistry team you will operate in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK, Biophysics and Pharmaceutical Sciences departments. You will have a key role in modelling, analysis of large datasets, drug design and you will be a significant contributor to discovery project progression. You will also be involved in building and driving our future design capabilities to tackle difficult targets and implementation of Augmented Drug Design across our portfolio. You will join a great team of highly-skilled and experienced computational chemists mastering all contemporary design areas like MD, FEP, ML and AI.

* You will simultaneously impact multiple discovery projects by efficiently and pro-actively applying a wide variety of computer-aided drug design approaches
* With your solid experience and excellent knowledge of modern computational chemistry you will identify and drive our future design capabilities
* You will be expected to plan, write and publish high quality scientific papers



Essential for the role

In this key role you will bring your solid computational chemistry experience to the drug discovery project portfolio. We are looking for a drug hunter with a PhD (or equivalent experience) in computational chemistry and industry experience from drug design, biophysics or related field. You have a high degree of independence and a proven record of excellence in a number of computer-aided drug design techniques to assist in target identification and advancement of discovery programs. In addition you will have:

* Solid knowledge of computer-aided drug design and modern medicinal chemistry.
* Expertise in using standard computational chemistry software.
* Ideally experience of computational chemistry applied to new modalities (e.g. peptides, PROTACs or oligonucleotides).
* Expertise in biophysics, structural modeling and methods to study protein dynamics.
* Knowledge in scientific computing, and programming skills (e.g. Python) is an advantage.
* Expertise in machine-learning methods is a plus.
* Excellent communication skills in English is required.

If you have the ability to influence both people and science and thrive on team work in a multidisciplinary environment, you will fit right in at AstraZeneca!

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact recruiting manager Dr. Anders Hogner, [email protected].

Welcome with your application no later than November 4th, 2021, 2021

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-company/our-locations/gothenburg.html

Our Cambridge site: https://www.astrazeneca.com/our-company/our-locations/cambridge.html#modal-generic

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Why AstraZeneca?

AstraZeneca is a global, innovation-driven biopharmaceutical company proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity. Visa mindre

Forskare i kemi med inriktning mot modellering

Ansök    Sep 24    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 53 300 studenter och 6 500 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.   Arbetsuppgifter Med stöd från Mistra, annonserar Institutionen för kemi och molekylärbiologi en postdoc... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 53 300 studenter och 6 500 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

 

Arbetsuppgifter
Med stöd från Mistra, annonserar Institutionen för kemi och molekylärbiologi en postdoc-tjänst under två år med fokus på att undersöka metall/metalloxid nanopartiklars interaktion med organiska molekyler i joniska vattenlösningar genom att använda simulerings metoder såsom molekylär dynamik (MD), Monte Carlo (MC) och analytisk teori.

Nanopartiklar i naturliga vattensystem såsom sjöar, floder och havsvatten kan vara giftiga för levande organismer. Emellertid är toxiciteten av nanopartiklar i hög grad relaterad till deras tillstånd i vilket de existerar d.v.s. som fria partiklar, eller i form av aggregat. Nanopartiklar som ingå i vattensystem eller i biologiska system kan omvandlas till komplexa aggregat på grund av förändringar i sina ytegenskaper (ytladdning, potentiella) eller genom adsorption av organiskt material.

Tillståndsförändringar kan leda till förändringar i reaktivitet av nanopartiklarna, därför är det av yttersta vikt att förstå de grundläggande mekanismerna bakom sådana förändringar. Omvandlingar av nanopartiklar i komplexa miljöer såsom naturliga vattensystem och i biologiska system styrs av invecklade relationer interaktionskrafter som verkar på nano- samt meso-skalor.

Modelleringen av transformation i sådana komplexa system, kräver simulerings metodologi av varierande komplexitet. Projektet kommer att inleds med modellering av ytladdningen och gräns potential (zetapotential) av nakna liksom belagda nanopartiklar i jonisk vattenlösning och biologiska system. Korrigerad Debye-Hückel (CDH) teori, klassisk ytkomplexering och molekylära dynamiken (MD) simuleringar kommer att användas.

Information som erhålls från dessa undersökningar kommer vidare att användas för att modellera bildandet av organiska corona på partikelytan och vidare till aggregering. Användning av Monte Carlo (MC) simuleringar tillsammans med klassisk DLVO teori kommer att undersökas. Resultaten av simuleringarna kommer att jämföras med de relevanta försöksdata som erhållits av andra grupper i en nära samverkan.

Forskningsprojektet kommer att utföras i nära samarbete mellan olika grupper i ”Mistra Environmental Nanosafety” konsortium (https://www.mistraenvironmentalnanosafety.org/) som finansieras av Mistra. Grupper från olika discipliner som fysik, kemi, biologi, medicin och samhällsvetenskap samarbetar i detta konsortium på problemet med Nanosafety.

Kvalifikationer
Behörig att anställas som postdoktor är den som har svensk doktorsexamen eller har en utländsk examen som bedöms motsvara doktorsexamen. I första hand bör den komma i fråga som har avlagt examen högst tre år före ansökningstidens utgång samt inte tidigare varit anställd som postdoktor under mer än ett år inom samma eller närliggande ämnesområden vid Göteborgs universitet. Även den som har avlagt examen tidigare kan komma i fråga om särskilda skäl föreligger (t ex ledighet på grund av sjukdom, tjänstgöring inom totalförsvaret, förtroendeuppdrag inom fackliga organisationer och studentorganisationer eller föräldraledighet eller andra liknande omständigheter).

Eftersom projektet är främst baserad på att använda teoretiska verktyg så som molekyldynamik (MD), Monte Carlo (MC) simuleringar och analytisk teori är det nödvändigt att ha kunskaper och erfarenheter inom dessa simuleringsmetoder. Kunskap om modellering av ytan och gräns kemi av nanopartiklar i joniska lösningar är meriterande.

Modelleringsarbetet kommer att ske i nära samarbete med andra grupper i konsortium som använder experimentella metoder är det mycket viktigt att kandidat ska vara van med samarbete med olika grupper och personer.

Ansökan
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag. Ansökan ska innehålla:

- Ett personligt brev med motivering till varför du söker tjänsten
- CV som inkluderar vetenskapliga publikationer
- Kopia på examensbevis
- Två personliga referenser (namn, telefonnr, relation)

Ansök här:
https://web103.reachmee.com/ext/I005/1035/job?site=6?=SE&validator=3038fcf1516ea1184a6da70a891f87da&job_id=21969


 


Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Postdoc Fellow: Drug Discovery

Ansök    Okt 19    Astrazeneca AB    Organisk kemist
Postdoc Fellow: Methyltransferases for biocatalytic applications in drug discovery Location: Gothenburg, Sweden Innovate to change the world! Do you have expertise in biocatalysis and a passion for innovation? Would you like to apply your expertise to impact sustainable drug discovery in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you! AstraZeneca is a global, scienc... Visa mer
Postdoc Fellow: Methyltransferases for biocatalytic applications in drug discovery



Location: Gothenburg, Sweden



Innovate to change the world!



Do you have expertise in biocatalysis and a passion for innovation? Would you like to apply your expertise to impact sustainable drug discovery in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!



AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. A place for bold disruptors shifting from academia to industry, this is where you can think differently to cut through the noise, add value, and bring fresh thinking to our teams and projects. Collaborating across functions and international boarders, you'll share knowledge and combine strengths to take your skills, and our science, to the next level.



About the Postdoc Programme



We're currently looking for hardworking scientists to join our innovative academic-style Postdoc program. This position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, where you will be in a global pharmaceutical environment, contributing to live projects right from the beginning. You'll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in our ground-breaking laboratories. This an exciting and newly expanding programme spanning a range of therapeutic areas across a wide range of fields.



About the Opportunity



Part of Discovery Sciences, you will have the advantage of working within the "iLAB"; a vibrant, energetic and diverse group passionate about integrating chemical technologies and automation to challenging strategic medicinal chemistry problems. You will have the support of the UK-based enzyme engineering team and the broader biocatalysis community within AstraZeneca.



This is an excellent opportunity to broaden your skills in biocatalysis and organic chemistry in a highly creative drug discovery environment. Mentored by Professor Bernhard Hauer, University of Stuttgart and guided and coached by AstraZeneca scientists in Gothenburg, Sweden and Cambridge, UK- it is an outstanding opportunity to innovate at the interface of small molecule synthesis and chemical biology/ medicinal chemistry in an industrial setting.



The project strives to -

* Develop synthetic methodologies using novel biocatalytic systems with utility in drug and drug intermediate synthesis
* Build and develop high throughput methodologies for biocatalytic reaction screening and optimisation
* Work collaboratively with scientists from across multiple disciplines both internally and externally with the capacity to manage and perform research independently
* Communicate results both within AstraZeneca via global working groups, externally at scientific meetings and through high impact publications



Essential Education and Experience

* PhD in biocatalysis or synthetic organic chemistry
* Solid experience in biocatalysis, small-molecule analysis, purification and structural elucidation techniques
* In-depth knowledge and understanding of late stage functionalisation, particularly C-H activation chemistry
* Strong organizational, communication and interpersonal skills
* An outstanding track record of research, proven by high impact publications in peer reviewed journals, patents and/or presentations at scientific meetings
* Proven ability to work in multidisciplinary teams with good collaboration and communication skills



Desirable Qualifications

* Protein engineering experience
* Interest in automation/ high-throughput experimentation/ high- throughput analysis
* Previous Post doc experience in a relevant area would be advantageous
* Interest in drug discovery and development



This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based.



Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.



Advert Opens: 19 October 2021

Advert Closes: 28 November 2021



Where can I find out more?



AstraZeneca's Postdoc Programme: https://careers.astrazeneca.com/postdocs-astrazeneca

Life at AstraZeneca: https://careers.astrazeneca.com/life-at-astrazeneca

Sustainability at AstraZeneca: https://www.astrazeneca.com/sustainability.html Visa mindre

Doktorand inom struktur-aktivitetsrelationsstudier

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 53 300 studenter och 6 500 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Tietze´s lab är en del av Wallenbergs center för molekylär och translationell medicin och tillhör institut... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 53 300 studenter och 6 500 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Tietze´s lab är en del av Wallenbergs center för molekylär och translationell medicin och tillhör institutionen för Kemi och Molekylärbiologi vid Naturvetenskapliga fakulteten vid Göteborgs Universitet. Vårt peptidkemiteam tillhör organkemi och läkemedelskemi-divisionen, vi fokuserar på bioinspirerad kemisk framtagande av peptid-baserade molekyler/material för läkemedelsframtagning och diagnostik. Målet med min forskning är att studera hydrofoba peptider/efterhärmade peptider i.e. transmembranpeptider/proteiner och venom-utvunna cysteinrika peptider. Vi utvecklar nya konjugeringsmetoder, utforskar SAR egenskaper av nya bioaktiva peptider och utvecklr peptid-baserade nanosensorer.

Arbetsuppgifter
Huvudsyftet med detta projekt är att belysa verkningsmekanismen för nya naturligt härledda bioaktiva cykliska peptider. Detta projekt är mycket tvärvetenskapligt och kombinerar peptidsyntes (manuell och automatiserad), peptidcyklisering, bioaktivitetsanalys samt peptiddesign.

Metoder:


• Fastfas och manuell peptidsyntes
• Peptidcykliseringstekniker
• Analytisk och preparativ HPLC, masspektrometri (ESI), NMR, LC-MS-analys
• Bioaktivitetsanalys
• Aminosyraanalys

Ämnesområde: peptidkemi / karakterisering / bioaktivitet / interaktionsstudier / strukturbestämning

Behörighet
Grundläggande behörighet till utbildning på forskarnivå har den som:
1. avlagt examen på avancerad nivå, eller
2. fullgjort kursfordringar om minst 240 högskolepoäng, varav minst 60 högskolepoäng på avancerad nivå, eller
3. på annat sätt inom eller utom landet förvärvat motsvarande kunskaper.

Särskild behörighet:
1. avlagt examen på avancerad nivå i relevant* naturvetenskapligt ämne, eller
2. fullgjort kursfordringar om minst 60 högskolepoäng på avancerad nivå i relevanta* naturvetenskapliga ämnen, eller
3. på något annat sätt inom eller utom landet förvärvat i huvudsak motsvarande kunskaper relevanta för den planerade utbildningen.* Relevant för den planerade utbildningen på forskarnivå

Bedömningsgrund
Den sökande måste ha en bakgrund inom organisk eller medicinsk kemi. Erfarenhet av peptidkemi, cykliseringsteknik, peptidanalys (RP-HPLC, LC-MS) och bioaktivitetsanalyser är fördelaktig. Den framgångsrika sökanden förväntas planera, genomföra och analysera experiment på ett självständigt sätt och aktivt bidra vetenskapligt till gruppen. Kandidater måste ha utmärkta muntliga och skriftliga kommunikationsförmåga på engelska

De specifika behörighetskraven inkluderar också ett godtagbart kommando för talad och skriftlig engelska. Riktlinjer för bedömning av kunskaper i engelska kan innehålla minst 550 på TOEFL-testet (eller 213 på TOEFL-CBT eller 79 på TOEFL-iBT).

Detta projekt kräver av kandidaten att arbeta effektivt med andra i grupp, visa utmärkt muntlig och skriftlig kommunikation, starka organisatoriska och interpersonella färdigheter. Den sökande ska ha en examen eller magisterexamen i kemi, biomolekylär teknik, biokemi, bioteknik eller farmaci. Vi söker högt motiverade studenter som vill fortsätta sin karriär inom naturvetenskap med ett konkurrenskraftigt CV (Examensarbete: "sehr gut" i det tyska poängsystemet, "utmärkt"), regelbunden studieperiod och förmåga att utföra självständigt arbete. Den sökande ska ha en integrerande och samarbetsvillig personlighet med entusiasm för att aktivt delta i tvärvetenskapliga nätverk med mycket god kommunikations- och skrivförmåga (engelska). Anställningen är begränsad (tillfällig), heltid och placeras vid Institutionen för Kemi och Molekylärbiologi.

Anställning
Anställningsform: Tidsbegränsad anställning, fyra år

Omfattning: 100 %

Placering: Inst. för Kemi och molekylärbiologi, Göteborg

Tillträde: Snarast enl överenskommelse

Bestämmelser för anställning som doktorand återfinns i förordning SFS 1998:80.

GU tillämpar lokalt avtal om lönesättning av doktorander.

Tillsättningsförfarande
Registrera din ansökan elektroniskt www.gu.se/ledigaanstallningar.

Kontaktuppgifter för anställningen
Alesia A. Tietze, Associate Professor, email: [email protected]

Ansökan
Du hittar fullständig annons och ansöker om att till att bli antagen till forskarstudier via Göteborgs universitets rekryteringsportal, www.gu.se/ledigaanstallningar genom att klicka på knappen ”Ansök”. Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag.
Ansökan ska vara inkommen senast: 2021-05-24

 


Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Senior Synthetic Chemist-Medicinal Chemistry of drug conjugates

Ansök    Jun 10    Astrazeneca AB    Organisk kemist
Would you like to apply your strong synthetic chemistry expertise in conjugation chemistry in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. We n... Visa mer
Would you like to apply your strong synthetic chemistry expertise in conjugation chemistry in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We now offer a exciting opportunity for a senior scientist with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry in design of drug conjugates. As part of an open minded, creative and experienced team in New Modalities drug discovery, you will contribute with your high ambitions, collaborative mindset and enthusiasm to push the boundaries of science in the area of synthetic and medicinal chemistry. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden in the therapy area of Cardiovascular, Renal and Metabolism (CVRM).

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality and have expertise in small molecules, PROTACs, peptides, oligonucleotides and drug conjugates. In recent years we have expanded our investments in targeted drug delivery requiring expertise in synthesis and design of various molecular conjugates.

We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to stay at the fore-front of science.

What you'll do

The role is lab based and focused on synthetic chemistry of various modalities and drug conjugates. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation. The work is done in a highly cross disciplinary environment. In addition, you are expected to be part of external collaborations, publish scientific papers, present and represent the department externally.

Essential for the role

We are looking for an ambitious team player that have expert knowledge in synthetic organic chemistry applied to conjugation chemistry and handling of complex molecules.

* Ph. D. degree in Organic Chemistry, Medicinal Chemistry or Chemical Biology with emphasis on synthesis.
* Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
* Scientific creativity: ability to identify, develop and apply new technologies and ways of working
* Experience from developing new chemistry for conjugations of peptides, oligonucleotides, small molecules, proteins or antibodies is a plus.
* Great awareness of recent literature as well as current developments and trends in organic synthesis
* Highly self-motivated and capable of analyzing complex data and deciding on focused course of action
* Excellent teamwork, collaboration, networking and communication skills
* Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact Team Leader Ranganath Gopalakrishnan or Associate Director Laurent Knerr through +46-31-7761000

Welcome with your application no later than July 25th, 2021

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Meet Hasse, Chemist at AstraZeneca Gothenburg: https://www.youtube.com/watch?v=QulX8EotRSE&list=PLgfkdJlwmkT6h7sZKBXqs7Xj4PobD4RmR



Why AstraZeneca?

AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail. Visa mindre

PostDoc Fellow - Synthetic Chemist, Oligonucleotides

Ansök    Apr 29    Astrazeneca AB    Organisk kemist
Are you a hardworking Synthetic Chemist with a great passion for science? Would you like to apply your expertise in synthetic chemistry to develop innovative oligonucleotide therapeutics and make an impact on drug discovery sciences? We invite you to join AstraZeneca in Gothenburg as our next PostDoc Fellow! We are searching for an engaged and talented Synthetic Chemist to join our Oligonucleotide Chemistry Team within the Discovery Sciences department at... Visa mer
Are you a hardworking Synthetic Chemist with a great passion for science? Would you like to apply your expertise in synthetic chemistry to develop innovative oligonucleotide therapeutics and make an impact on drug discovery sciences? We invite you to join AstraZeneca in Gothenburg as our next PostDoc Fellow!

We are searching for an engaged and talented Synthetic Chemist to join our Oligonucleotide Chemistry Team within the Discovery Sciences department at AstraZeneca in Gothenburg, Sweden as our new PostDoc. In a collaborative environment, you will get the opportunity to apply your expertise in synthetic chemistry to contribute and play a meaningful role in advancing the oligonucleotide therapeutic field. This is a temporary position of 2 years, with chance to extend +1 year of temporary employment.

We have been curious about oligonucleotides as a new modality since 2012 and our scientific interest has only grown. Therefore, we are now poised to exploit on the wealth of expertise from across our R&D units and through a new matrix organization to deliver a proprietary Oligonucleotide Therapeutics Platform in-house. We offer a highly rewarding scientific environment along with an inclusive, dynamic and team focused atmosphere - with a goal to design and develop the oligonucleotide therapeutics of the future.

What you will do:
You will drive projects from the start with the focus on developing new chemistries to synthesize innovative conjugated oligonucleotide therapeutics. Your main research project will focus on exploring linker chemistry and conjugation strategy to efficiently attach oligonucleotides to ligands and understand the impact of the linker properties on oligonucleotide delivery. As an expert in synthetic chemistry, you will apply your expertise in compound purification and characterization, propose experimental strategies and troubleshoot challenges to succeed in your role. You will also be involved in oligonucleotide synthesis process in close collaboration with the team and other groups at AstraZeneca.

This position offers the opportunity not only to be creative in solving a wide range of synthetic challenges but also to learn advanced techniques and participate in biological evaluation of the synthesized compounds through active collaboration with multiple specialists across AstraZeneca functions. This strong network of professionals will help to ensure a high impact publication track record. Therefore, the position offers the ability to maintain a competitive research output.

Essential in the role:
The successful candidate should have an extensive passion for driving scientific questions, can work independently and have a result oriented, problem-solving and positive attitude. Excellent English is required, both spoken and written, and ability to operate effectively in a multi-disciplinary research environment. We also believe that you enjoy teamwork, have a collaborative nature and be an encouraging colleague to all.

As well as:

* PhD in Organic Chemistry.
* Advanced and up to date knowledge in synthetic strategies, techniques and reactions.

Desirable in the role:

* Knowledge in the area of oligonucleotide therapeutics including design and synthesis.
* Scientific excellence as shown by previous work, publication list or references from scientific mentors.

Why AstraZeneca?
It's a place to think differently - to find new ways of handling and treating diseases. We are trusted and empowered to explore. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be. To read more about our AstraZeneca site in Gothenburg, see the additional information below.

What's next? We look forward to finding out more about you. Welcome to send in your application as soon as possible but no later than 31st May, 2021.

More information:
For more information about the position please contact Annabelle Biscans, Associate Principal Scientist, Oligonucleotide Chemistry Team at [email protected].

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Team Leader Medicinal Chemistry - New Modalities Chemistry

Ansök    Mar 1    Astrazeneca AB    Organisk kemist
Would you like to lead an experienced Medicinal Chemistry team focusing on New Modalities in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in ... Visa mer
Would you like to lead an experienced Medicinal Chemistry team focusing on New Modalities in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We are now looking for a new Medicinal Chemistry team leader to lead our expanding New Modalities chemistry team working on peptides, drug conjugates and optimization of small molecule ligands for targeted drug delivery. We offer an exciting opportunity for a strong medicinal chemist with great leadership skills and experience in drug discovery and medicinal chemistry, from design and synthesis of new candidate drugs.

As part of an creative and dedicated team, you will contribute with your high ambitions, collaborative mindset and enthusiasm to push the boundaries of science in the area of medicinal and synthetic chemistry. You will influence the direction of strategy and take a responsible role of the operational aspects within the department. The positions are placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. We follow the science and turn ideas into life changing medicines for patients suffering from Heart Failure, Diabetes and Chronic Kidney Disease. We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to stay at the fore-front of science.

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules to identify and validate novel biological targets. To realize our ambitions, we stay agnostic to molecular modality and you will be able to lead a team and work with experts around you in small molecules, peptides, RNA and drug conjugates.

What you'll do

In this role you will lead a team of creative, openminded and experienced Medicinal Chemists in the area of New Modalities Chemistry. As team leader you will be accountable for your team's delivery and personal development of your team members. You will also lead Medicinal Chemistry in projects across various phases in discovery and contribute to the scientific direction of research programs across the portfolio.

As a representative of the department leadership you are expected to be up to date with the latest scientific development in your area of expertise and contribute to the strategic direction. You will ensure an openness and curiosity to quickly adopt to new opportunities.

As both an opportunity and expectation, you will build on your scientific reputation and represent the department through publications, presentations and leveraging your collaborative networks.

Essential for the role

This role requires a Ph. D. degree in a relevant scientific discipline of Synthetic Chemistry or Medicinal Chemistry with 5+ years post-doctoral research experience in drug discovery, preferentially from an industrial setting. Prior experience and proven ability to lead and deliver medicinal chemistry programs of discovery projects is a must. Experience from New Modalities chemistry such as peptides, RNA or drug conjugates is strongly preferred.

You are internationally recognized within the field of Medicinal Chemistry applied to drug discovery through your publication record, conference disclosures and external network.

With your excellent interpersonal, communication and collaboration skills you will have the ability to operate effectively in a multidisciplinary matrix research environment, providing leadership and insight in drug discovery. Key qualities:

* Track record of leadership with strong social and interpersonal skills and an ability to develop high performing teams with various cultural and diversity aspects.
* A demonstrated record of leading through others, people development and performance management.
* Experience and a good understanding of when to use various chemical modalities in drug discovery, various hit finding strategies, multi-parameter optimization, synthetic route development and IP strategies
* A genuine openness to novel scientific approaches and eagerness to drive projects with the most relevant drug modalities
* Strong influencing skills and a developed strategic thinking which can be exemplified
* Sound knowledge of related disciplines including DMPK, safety, bioscience, pharmaceutical development and early clinical development
* Excellent written and verbal communication skills, including ability to present to senior leaders. Excellent English.

So, what's next?

Are you already imagining yourself joining us? Good, because we can't wait to hear from you!

For more information about the position please contact hiring manager Malin Lemurell, +46-31-776 10 00

Welcome with your application no later than March 22, 2021

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link Visa mindre

Synthetic Chemist - Expert on DNA encoded library synthesis

Ansök    Mar 3    Astrazeneca AB    Organisk kemist
Do you have hands-on experience and great knowledge with synthesis of DNA encoded libraries? Are you interested to establish and develop our new DEL synthesis lab at a company where we are committed to lifelong learning, growth and development? Welcome to AstraZeneca! We are seeking a specialized Synthetic Chemist that will play an important part in our iLAB (Innovation Lab) team, focusing on the synthesis of novel DNA encoded libraries (DEL). You have th... Visa mer
Do you have hands-on experience and great knowledge with synthesis of DNA encoded libraries? Are you interested to establish and develop our new DEL synthesis lab at a company where we are committed to lifelong learning, growth and development? Welcome to AstraZeneca!

We are seeking a specialized Synthetic Chemist that will play an important part in our iLAB (Innovation Lab) team, focusing on the synthesis of novel DNA encoded libraries (DEL). You have the opportunity to drive and establish the DEL synthesis capabilities in a new lab at AstraZeneca in Gothenburg and contribute to the production of a proprietary compound collection based on DEL.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. With our ground-breaking pipeline comes a bright future - a secure job, exciting opportunities and varied work. You will be valued. Not only for your unique contribution, skills and background, but because we recognize people are our greatest asset. Here we are dedicated to being a Great Place to Work.

What you will do:
This is an exciting role where you will drive the set up and development of the new DEL synthesis lab capabilities at AstraZeneca Gothenburg. You will design and synthesize DNA encoded libraries - and use and develop currently available chemistry automation for DEL synthesis. You will also contribute to the continuous improvement of the DEL synthesis platform by developing and applying new , cutting edge synthetic approaches for on-DNA chemistry and by evaluating new technologies.

In your daily work you will troubleshoot laboratory-based problems and make a significant contribution to the delivery of the team. As DEL Chemist, you will maintain access to the best internal and external science and enhance business reputation internally and externally through peer-reviewed publications and oral/poster presentations.

Essential on the role:
You're a chemist with a track record of applying innovative chemistry solutions, with resulting impact in project delivery. You also have:

* Ph.D. in a relevant chemistry discipline, or a Master degree in chemistry with minimum 5 years' experience in synthetic organic chemistry
* Hands-on experience with on-DNA synthesis and/or synthesis of DNA encoded libraries.
* Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification and analytical sciences.
* Expertise in parallel chemistry
* Knowledge of basic molecular biology techniques e.g gel electrophoresis, DNA ligation, PCR.
* Advanced knowledge of modern chemical literature, chemical technologies and applying new ideas to project delivery.
* A track record of driving innovation in chemistry related sciences.


The successful candidate should be motivated to work effectively in hardworking teams and demonstrate ability to work across scientific fields to get results. We also believe that our candidate have effective levels of communication, a scientific drive and a high interest in working with organic chemistry and molecular biology techniques.

Desirable in the role:

* Experience in the development of on-DNA chemistry.
* Experience in methods development.
* Experience with chemistry automation.
* Knowledge in designing high-throughput chemistry and/or library synthesis experiments using bespoke design software.
* Knowledge of medicinal chemistry

We also believe that the successful candidate have a detailed understanding of the chemical sciences and how they contribute and influence drug discovery together with knowledge of the drug discovery process.

Why AstraZeneca Gothenburg?
Our spectacular campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from over 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. The site itself is designed with collaboration in mind: from the Coffee Lab to the gym, we have built a series of environments where innovation can happen.

Does this sound like your next challenge? Apply today!

Welcome with your application, but send it to us no later than 4th April, 2021.

For more information about the position please contact Nidhal Selmi, Compound Collection Enhancement programme manager - iLAB, at [email protected].

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html
About iLAB - Innovation Lab: https://www.astrazeneca.com/r-d/our-technologies/ilab.html Visa mindre

Team Leader Medicinal Chemistry

Ansök    Mar 1    Astrazeneca AB    Organisk kemist
Are you a passionate Medicinal Chemist with strong leadership skills? Would you like to lead a dedicated and experienced team in a company that push the boundaries of science and collaborate with diverse minds? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inc... Visa mer
Are you a passionate Medicinal Chemist with strong leadership skills? Would you like to lead a dedicated and experienced team in a company that push the boundaries of science and collaborate with diverse minds? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We are now looking for a new Medicinal Chemistry team leader and offer an exciting opportunity for you with great leadership skills and experience in drug discovery and medicinal chemistry, from design and synthesis of new candidate drugs. The team will primarily drive chemistry in small molecule drug discovery programs, but we truly believe in innovations across modalities and work flexible to support our portfolio across small molecules and New Modalites.

As part of an creative and dedicated team, you will contribute with your high ambitions, collaborative mindset and enthusiasm to push the boundaries of science in the area of medicinal and synthetic chemistry. You will influence the direction of strategy and take a responsible role of the operational aspects within the department. The positions are placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. We follow the science and turn ideas into life changing medicines for patients suffering from Heart Failure, Diabetes and Chronic Kidney Disease. We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to stay at the fore-front of science.

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules to identify and validate novel biological targets. To realize our ambitions, we stay agnostic to molecular modality and emphasize a strong science driven culture.

What you'll do

In this role you will lead a team of creative, openminded and experienced Medicinal Chemists in drug design and synthesis. As team leader you will be accountable for your team's delivery and personal development of your team members. You will also lead Medicinal Chemistry in projects across various phases in discovery and contribute to the scientific direction of research programs across the portfolio.

As a representative of the department leadership you are expected to be up to date with the latest scientific development in your area of expertise and contribute to the strategic direction. You will ensure an openness and curiosity to quickly adopt to new opportunities.

You are also expected to build on your scientific reputation and represent the department through publications, presentations and leveraging your collaborative networks.

Essential for the role

This role requires a Ph. D. degree in a relevant scientific discipline of Synthetic Chemistry or Medicinal Chemistry, with 5+ years post-doctoral research experience in drug discovery, preferentially from an industrial setting. The role requires the ability to lead the chemistry program of drug discovery projects and we look for prior experience and a strong track record of delivery. Strong leadership skills is a must.

You are recognized internationally within the field of Medicinal Chemistry and Synthetic Chemistry applied to drug discovery through your publication record, conference disclosures and external network.

With your excellent interpersonal, communication and collaboration skills you will have the ability to operate effectively in a multidisciplinary matrix research environment, providing leadership and insight in drug discovery. Key qualities:

* Track record of leadership with strong social and interpersonal skills and an ability to develop high performing teams with various cultural and diversity aspects.
* A demonstrated record of leading through others, people development and performance management.
* Experience and a good understanding of when to use various chemical modalities in drug discovery, various hit finding strategies, multi-parameter optimization, synthetic route development and IP strategies
* A genuine openness to novel scientific approaches and eagerness to drive projects with the most relevant drug modalities
* Strong influencing skills and a developed strategic thinking which can be exemplified
* Sound knowledge of related disciplines including DMPK, safety, bioscience, pharmaceutical development and early clinical development
* Excellent written and verbal communication skills, including ability to present to senior leaders. Excellent English.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact hiring manager Malin Lemurell, +46-31-776 10 00

Welcome with your application no later than March 22, 2021

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link Visa mindre

Senior Synthetic Chemists in Medicinal Chemistry

Ansök    Jan 24    Astrazeneca AB    Organisk kemist
Would you like to apply your synthetic chemistry expertise in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! AstraZeneca now offer several exciting opportunities for senior scientists with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry into desig... Visa mer
Would you like to apply your synthetic chemistry expertise in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

AstraZeneca now offer several exciting opportunities for senior scientists with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry into design and synthesis of new candidate drugs. We are further expanding our teams to support both classical small molecules projects and New Modalities chemistry working on drug conjugates and targeted drug delivery. As part of an open minded, creative and experienced team, you will contribute with your high ambitions, collaborative mindset and enthusiasm to push the boundaries of science in the area of synthetic and medicinal chemistry. The positions are placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. We follow the science and turn ideas into life changing medicines for patients suffering from Heart Failure, Diabetes and Chronic Kidney Disease. We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to stay at the fore-front of science.

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules to identify and validate novel biological targets. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality which opens opportunities for creative synthetic chemists.

What you'll do

The role is lab based and focused in the area of medicinal chemistry with emphasis on synthetic chemistry. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation. The work is done in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, Discovery Sciences, DMPK and Pharmaceutical Sciences departments.

There will also be opportunities to develop medicinal chemistry and drug discovery knowledge together with the experts in the department. In addition, you are expected to be part of external collaborations, publish scientific papers, present and represent the department externally.

Depending on your previous experience you will be focusing on small molecules or new modalities chemistry, drug conjugates and targeted drug delivery.

Essential for the role

We are looking for an ambitious team player that have expert knowledge in synthetic organic chemistry. Basic knowledge in medicinal from drug discovery in an industrial setting.

* Ph. D. degree in Organic Chemistry or Medicinal Chemistry with focus on the synthetic chemistry component. Relevant post-doctoral experience in academic or industrial setting is preferred.
* Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
* Scientific creativity: ability to identify, develop and apply new technologies and ways of working
* Experience from New Modalities chemistry such as conjugations of peptides, RNA or small molecules is seen as an advantage for one of the positions, but not a prerequisite.
* Great awareness of recent literature within synthesis/medicinal chemistry as well as current developments and trends in organic synthesis
* Highly self-motivated and capable of receiving and analyzing input from complex data and deciding on focused course of action
* Excellent teamwork, collaboration, networking and communication skills
* Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact Associate Director Laurent Knerr or Principal Scientist Magnus Johansson through +46-31-7761000

Welcome with your application no later than February 25, 2021

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link

Meet Hasse, Chemist at AstraZeneca Gothenburg: Link

Why AstraZeneca?



Our Gothenburg site is one of AstraZeneca's three strategic science centres. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail. Visa mindre

Associate Principal Scientist - Oligonucleotide Chemistry

Ansök    Jan 21    Astrazeneca AB    Organisk kemist
Are you a motivated scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the possibility to further exploit our drug discovery platforms? If yes, we have the position for you at AstraZeneca, Discovery Sciences in Gothenburg, Sweden! We are seeking for an Associate Principal Scientist to join our Oligonucleotide Chemistry team wit... Visa mer
Are you a motivated scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the possibility to further exploit our drug discovery platforms? If yes, we have the position for you at AstraZeneca, Discovery Sciences in Gothenburg, Sweden!

We are seeking for an Associate Principal Scientist to join our Oligonucleotide Chemistry team within the Oligonucleotide Discovery Department, part of the Discovery Sciences R&D organization at AstraZeneca in Gothenburg, Sweden.

You will apply cutting-edge expert knowledge and skills in the field of oligonucleotides, including oligonucleotide design and synthesis of oligo-related building blocks, to expand the use of oligonucleotide therapeutic, and molecular conjugates thereof, in the treatment of diseases across therapy areas within AstraZeneca. In doing so you demonstrate a passion for driving scientific questions, combined with strong working ethics and the ability to work well within teams aiming to drive drug discovery projects forward.

The Oligonucleotide Chemistry team is working in close collaboration with other Scientists in Discovery Sciences, Medicinal Chemistry, Pharmacology, DMPK, Safety and Pharmaceutical sciences with a focus on the goal to design and develop the oligonucleotide therapeutics of the future. We offer a highly rewarding scientific environment with the expectation that you drive AZ scientific reputation by identifying and progressing publication opportunities in the field of oligonucleotides internally, across AZ and/or together with external partners.

What you will do:
As Associate Principal Scientist we rely on you to have recognized synthetic organic chemistry expertise within the oligonucleotide chemistry field and to function as a scientific specialist within the team. Focus will be put on effective delivery to drug discovery projects including internal laboratory work and collaborations with external services and partners.

The APS provides support, supervision and mentorship to junior scientists. Ensures that methods are run professionally and develops and guides the setup of new techniques. As well as recommend, gain dedication to, initiate, lead and champion new innovations and investments that aids the department to meet its overall objectives. You will build strong collaborative relationships with the project investigators, key stakeholders and cross functional project scientists to ensure the smooth running and execution of projects.

Additional accountabilities:

* Apply cutting-edge technologies and methodologies to establish a state-of-the-art oligonucleotide chemistry platform including laboratory capabilities.
* Contribute to the strategy for the ongoing development of oligonucleotides, and conjugates thereof, and their application to relevant disease areas.
* Directly impact on oligonucleotide projects to ensure high scientific standards and quality of compound design to meet project objectives.

Essentials for the role:

* Candidate should have a PhD in Synthetic Organic Chemistry, post-doc is a plus.
* Advanced and up to date knowledge about synthetic strategies, techniques and reactions.
* Knowledge in the area of oligonucleotide therapeutics including design and synthesis thereof.
* Strong evidence of experimental impact through a track record of High-Impact and High-Quality publications and external presentations.
* Several years of shown experience in drug discovery and/or early development or in a leading academic institution.

The successful candidate is a scientifically critical individual capable of receiving and analyzing input from multiple fields and deciding on focused course of action. Excellent English is required, both spoken and written, and have the ability to operate effectively in a multi-disciplinary research environment. We also believe that you should show self-awareness of training needs, including leadership development, be a strong team player and an encouraging colleague to all.

Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic science centres. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to develop a working environment that furthers collaboration, openness and innovation. Therefore, we have built space for meetings, and socializing, where spontaneous meetings can give birth to new innovations.

Does this sound like a position for you? Welcome to apply today!

We look forward to your application, but no later than 21st February, 2021.

More information:
For more information about the position please contact Anders Dahlén at +46 31 706 4842 or [email protected]

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Senior Scientist - Synthetic chemistry & Oligonucleotides

Ansök    Jan 21    Astrazeneca AB    Organisk kemist
Are you a passionate Scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the opportunity to further exploit our drug discovery platforms? If yes, we have just the position for you at AstraZeneca, Discovery Sciences in Gothenburg, Sweden! We are currently recruiting a motivated Senior Research Scientist to join our Oligonucleoti... Visa mer
Are you a passionate Scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the opportunity to further exploit our drug discovery platforms? If yes, we have just the position for you at AstraZeneca, Discovery Sciences in Gothenburg, Sweden!

We are currently recruiting a motivated Senior Research Scientist to join our Oligonucleotide Chemistry team within the Oligonucleotide Discovery Department, part of the Discovery Sciences R&D organization at AstraZeneca in Gothenburg, Sweden.

You will apply expert synthetic organic chemistry knowledge to expand the use of oligonucleotides, and molecular conjugates thereof, in the treatment of diseases across therapy areas within AstraZeneca. In doing so you demonstrate a passion for driving scientific questions, combined with strong working ethics and the ability to work well within teams aiming to drive drug discovery projects forward.

The Oligonucleotide Chemistry team is working in close collaboration with other Scientists in Discovery Sciences, Medicinal Chemistry, Pharmacology, DMPK, Safety and Pharmaceutical sciences with a focus on the goal to design and develop the oligonucleotide therapeutics of the future. We offer a highly rewarding scientific environment, with the expectation to publish new findings.

What you will do:
This role is a synthesis specialist role with the aim to develop novel oligonucleotide chemistry building blocks and thereby supporting the AstraZeneca pipeline. The Senior Research Scientist works alongside other chemists in the team to support project priorities but should also be comfortable in supervising and mentoring more junior colleagues.

In the position you will also propose experimental strategies and have the possibility to be creative in solving a wide range of synthetic challenges. Plan, prioritize and perform own work and actively collaborate with the project team by driving problem solving using literature and own knowledge. Support oligonucleotide projects to ensure high scientific standards and quality of compounds to meet project objectives. Build strong collaborative relationships within the team and in projects to ensure the smooth running of projects.

We rely on you to have recognized synthesis expertise and experience, and knowledge within the oligonucleotide chemistry field is considered as a plus. The SRS should also be able to synthesize and purify high quality building blocks and compounds by applying cutting-edge technologies and methodologies to support project progression from according to agreed timelines, as well as applying purification and analytical sciences, troubleshoot challenges and make a significant contribution to the practical delivery of project compounds.

Essentials for this role:

* Candidate should have a PhD in Organic Chemistry, post-doc is a plus.
* Detailed knowledge of synthetic chemistry related to oligonucleotides, oligo building blocks and/or synthesis of advanced organic molecules. Knowledge in the area of oligonucleotide therapeutics, design and data analysis is a plus.
* Ability to design and execute experiments autonomously.
* Evidence of experimental impact by either peer-reviewed publications or external presentations.

The successful candidate will demonstrate a passion for driving scientific questions and is a scientifically critical individual capable of receiving and analyzing input from multiple fields and deciding on focused course of action. You should also be able to work independently and have a positive, result-oriented and problem-solving attitude. Excellent English is required, both spoken and written, and ability to operate effectively in a multi-disciplinary research environment. We also believe that you enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.

Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic science centres. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to develop a working environment that furthers collaboration, openness and innovation. Therefore, we have built space for meetings, and socializing, where spontaneous meetings can give birth to new innovations.

Does this sound like your next challenge and a good workplace for you? Welcome to apply today!

We look forward to your application, but no later than 21st February, 2021.

More information:
For more information about the position please contact Anders Dahlén at +46 31 706 4842 or [email protected]

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Doktorand i Läkemedelskemi

Ansök    Dec 18    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 38 000 studenter och 6 000 medarb... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 38 000 studenter och 6 000 medarbetare gör universitetet till en stor och inspirerande arbetsplats. 

Morten Grøtlis forskning fokuserar på användningen av syntetisk organisk kemi för att producera nya substanser för studier i cellbiologi och medicin. Sådana föreningar är intressanta både som potentiella läkemedel och som experimentella verktyg för att förstå den fysiologiska rollen för målproteiner. Kemisk modifiering av proteiner ger kraftfulla verktyg för funktionella studier av enskilda proteiner i komplexa biologiska system. Modifiering av naturliga proteiner i provrör och biologiska sammanhang genom platsspecifika och målselektiva metoder är dock fortfarande utmanande.

Institutionen för Kemi och Molekylärbiologi inbjuder nu sökande till en doktorandanställning med fokus på att utveckla nya kemiska strategier för in vitro biokonjugering av kinaser. Doktoranden kommer att designa, syntetisera och utvärdera molekyler för specifik märkning av endogena kinaser i olika biologiska miljöer.

Resultaten av dessa studier kommer att ge en ny teknik för märkning av kinaser och kan ge ny insikt i signaltransduktionen, vilket i slutändan leder till nya terapeutiska mål och förbättrad sjukdomshantering.

Arbetsuppgifter
Doktoranden förväntas bedriva avancerad forskning inom ämnet syntesbaserad läkemedelskemi under handledning. I tjänsten ingår även skrivande av forskningsrapporter och vetenskapliga artiklar för internationella tidskrifter och presentationen av vetenskapliga resultat på konferenser. Doktoranden bör därför ha goda färdigheter i engelska. Doktoranden kommer att fördjupa sin kunskap inom syntesbaserad läkemedelskemi och kemisk biologi genom att gå relevanta kurser.

Behörighet
Grundläggande behörighet till utbildning på forskarnivå har den som:
1. avlagt examen på avancerad nivå, eller
2. fullgjort kursfordringar om minst 240 högskolepoäng, varav minst 60 högskolepoäng på avancerad nivå, eller
3. på annat sätt inom eller utom landet förvärvat motsvarande kunskaper.

Särskild behörighet:
1. avlagt examen på avancerad nivå i relevant* naturvetenskapligt ämne, eller
2. fullgjort kursfordringar om minst 60 högskolepoäng på avancerad nivå i relevanta* naturvetenskapliga ämnen, eller
3. på något annat sätt inom eller utom landet förvärvat i huvudsak motsvarande kunskaper relevanta för den planerade utbildningen.* Relevant för den planerade utbildningen på forskarnivå

Bedömningsgrund
Vi söker en duktig och motiverad individ med en stark bakgrund inom organisk syntes, som vill investera tid och energi för att stilla sin nyfikenhet på design, syntes och utvärdering av bioaktiva föreningar. Ett genuint intresse av att arbeta på ett tvärvetenskapligt sätt kommer att vara avgörande. Utbildning i ett relevant ämne utöver organisk syntes/syntesbaserad läkemedelskemi kommer att vara en fördel. God förmåga att muntligt och skriftligt kommunicera på engelska är ett krav.

Urval bland sökande som uppfyller krav på grundläggande och särskild behörighet baseras på förmågan att tillgodogöra sig utbildningen på forskarnivå. Vid bedömningen fästs särskild vikt vid dokumenterade kvalifikationer avseende:

- specifika kunskaper och färdigheter inom ämnesområdet

- erfarenhet av vetenskaplig teori och relevanta forskningsmetoder

- vetenskaplig analys och presentation styrkt genom uppsats, examensarbete, vetenskapliga publikationer eller liknande.

Anställning
Anställningsform: Tidsbegränsad anställning, fyra år

Omfattning: 100 %

Placering: Inst. för Kemi och molekylärbiologi, Göteborg

Tillträde: Snarast enligt överenskommelse

Bestämmelser för anställning som doktorand återfinns i förordning SFS 1998:80.

Universitetet tillämpar lokalt avtal om lönesättning av doktorander.

Tillsättningsförfarande
Registrera din ansökan elektroniskt www.gu.se/ledigaanstallningar.

Kontaktuppgifter för anställningen
Morten Grøtli, E-mail: [email protected]

http://grotlilab.net/

Ansökan
Du hittar fullständig annons och ansöker om att till att bli antagen till forskarstudier via Göteborgs universitets rekryteringsportal, www.gu.se/ledigaanstallningar genom att klicka på knappen ”Ansök”. Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag.
Ansökan ska vara inkommen senast: 2021-02-15

 


Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Senior Scientist, Large Scale Synthetic Chemistry

Ansök    Dec 15    Astrazeneca AB    Organisk kemist
Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines. We are now looking to recruit a Senior Scientist focused on large scale synthetic chemis... Visa mer
Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines.

We are now looking to recruit a Senior Scientist focused on large scale synthetic chemistry to join the Early Chemical Development (ECD) function within Pharmaceutical Sciences at AstraZeneca. The position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) across all the AstraZeneca therapy areas.

The ECD team is responsible for developing manufacturing routes and processes as well as delivering batches of drug substance for all projects in the late discovery and early development portfolio.

The Large Scale Synthetic Chemistry team in Gothenburg delivers high-quality API batches in the range of 100-1000 g through development of great chemistry, innovative routes and creative solutions. The laboratory is the single company wide asset for large scale, non-GMP manufacturing of API for pre-clinical toxicology studies for all therapy areas.

We support the projects with the highest priority, most technically challenging chemistry in the AstraZeneca early phase portfolio and have access to top-quality labs and equipment, including e.g. reactors up to 100L, flow- and high-pressure reactors, and a wide range of modern analytical instruments.

Main Duties and Responsibilities

As a member of the Large Scale Synthetic Chemistry team, you will work closely with both medicinal chemists in drug development projects and process chemists to explore and develop safe, efficient and cost-effective synthesis routes to produce drug candidates. Key deliverables are:

* With strong emphasis on SHE aspects, explore and develop experimental strategies, troubleshoot problems and synthesize organic molecules in the range of 100-1000 grams
* Plan, prioritise and perform own work and actively collaborate with the drug project synthesis teams.
* Demonstrate expertise in synthetic and analytical chemistry, purification and crystallisation
* Provide stringent documentation of experimental results in an electronic labjournal, as well as writing up campaign and development reports.
* Publish novel work in peer reviewed journals

Essential for the role

* Ph.D. degree or equivalent in Organic Chemistry
* Post-graduate research experience, preferably from work with route development and large-scale synthesis of complex organic molecules
* Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
* Able to identify, develop and apply new technologies and ways of working within large scale synthetic organic chemistry
* Ability to independently design, plan and execute multistep syntheses to be able to manufacture kilogram campaigns together with team members
* Creativity in handling a wide range of synthetic challenges
* Ability to coach peers for enhanced individual and team performance and development
* Strong collaborative and communication skills with experience of interacting effectively and work collaboratively across interfaces of disciplines
* Curious and innovative mindset
* Passion for solving complex synthetic problems and demonstrate proof of concept for new route



Are you ready to bring new ideas and fresh thinking to the table? Then you might be the one we are looking for!

We encourage you to send your application as soon as possible, since interviews will be held continuously, but no later than February 1st, 2021.

For more information please contact recruiting manager Hans Emtenäs at [email protected]

Learn more about AstraZeneca Gothenburg: https://www.astrazeneca.com/our-science/gothenburg.html Visa mindre

Doktorand i Läkemedelskemi

Ansök    Dec 18    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.   Morten Grøtlis forskning fokuserar på användningen av syntetisk organisk kemi för att producera nya sub... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

 

Morten Grøtlis forskning fokuserar på användningen av syntetisk organisk kemi för att producera nya substanser för studier i cellbiologi och medicin. Sådana föreningar är intressanta både som potentiella läkemedel och som experimentella verktyg för att förstå den fysiologiska rollen för målproteiner. Institutionen för kemi och molekylärbiologi inbjuder nu sökande till en doktorandtjänst med fokus på design, syntes och evaluering av kinasinhibitorer. Projektet utgör ett samarbete mellan forskargrupper vid Göteborgs universitet samt Universitetet i Cambridge, UK, och således kommer doktoranden att få tillgång till världsledande expertis vid båda lärosätena. Doktorandtjänsten kommer att fokusera på utveckling av kinasinhibitorer där samarbete mellan olika vetenskapliga discipliner och mellan flera forskargrupper vid två lärosäten möjliggör bedrivandet av forskning vid den absoluta fronten inom ämnesområdet.

Arbetsuppgifter
Doktoranden förväntas bedriva avancerad forskning inom ämnet syntesbaserad läkemedelskemi under handledning. I tjänsten ingår även skrivande av forskningsrapporter och vetenskapliga artiklar för internationella tidskrifter och presentationen av vetenskapliga resultat på konferenser. Doktoranden bör därför ha goda färdigheter i engelska. Doktoranden kommer att fördjupa sin kunskap inom syntesbaserad läkemedelskemi och kemisk biologi genom att gå relevanta kurser. Dessutom kommer kandidaten att arbeta nära andra som evaluerar syntetiserade inhibitorer och som gör strukturbiologisk analys av enzym-inhibitorkomplex. Det är därför viktigt att doktoranden har en stark vilja att samarbeta med andra.  

Tjänsten är menad att leda till en doktorsexamen och doktorandens huvuduppgift är att arbeta på sina doktorandstudier, som inkluderar både deltagande i forskning och forskarutbildningskurser. Undervisning och annat avdelningsarbete kan tilldelas (upp till maximalt 20%). Anställningen är begränsad till fyra år på heltid eller upp till fem år när andra uppgifter deltid ingår.

Behörighet
Grundläggande behörighet till utbildning på forskarnivå har den som:
1. avlagt examen på avancerad nivå, eller
2. fullgjort kursfordringar om minst 240 högskolepoäng, varav minst 60 högskolepoäng på avancerad nivå, eller
3. på annat sätt inom eller utom landet förvärvat motsvarande kunskaper.

Särskild behörighet:
1. avlagt examen på avancerad nivå i relevant naturvetenskapligt ämne, eller
2. fullgjort kursfordringar om minst 60 högskolepoäng på avancerad nivå i relevanta naturvetenskapliga ämnen, eller
3. på något annat sätt inom eller utom landet förvärvat i huvudsak motsvarande kunskaper relevanta för den planerade utbildningen.

Bedömningsgrund
Vi söker en duktig och motiverad individ med en stark bakgrund inom organisk syntes, som vill investera tid och energi för att stilla sin nyfikenhet på design, syntes och utvärdering av bioaktiva föreningar. Ett genuint intresse av att arbeta på ett tvärvetenskapligt sätt kommer att vara avgörande. Utbildning i ett relevant ämne utöver organisk syntes/syntesbaserad läkemedelskemi kommer att vara en fördel. God förmåga att muntligt och skriftligt kommunicera på engelska är ett krav.

 Vid bedömningen fästs särskild vikt vid dokumenterade kvalifikationer avseende:

- specifika kunskaper och färdigheter inom ämnesområdet

- erfarenhet av vetenskaplig teori och relevanta forskningsmetoder

- vetenskaplig analys och presentation styrkt genom uppsats, examensarbete, vetenskapliga publikationer eller liknande.

Anställning
Anställningsform: Tidsbegränsad anställning, fyra år

Omfattning: 100 %

Placering: Inst. för Kemi och molekylärbiologi, Göteborg

Tillträde: Snarast enligt överenskommelse

Bestämmelser för anställning som doktorand återfinns i förordning SFS 1998:80.

Universitetet tillämpar lokalt avtal om lönesättning av doktorander.

Tillsättningsförfarande
Registrera din ansökan elektroniskt www.gu.se/ledigaanstallningar.

Kontaktuppgifter för anställningen
Morten Grøtli, E-mail: [email protected]

Ansökan
Du hittar fullständig annons och ansöker om att till att bli antagen till forskarstudier via Göteborgs universitets rekryteringsportal, www.gu.se/ledigaanstallningar genom att klicka på knappen ”Ansök”. Du som sökande ansvarar för att ansökan är komplett och att den är universitetet tillhanda senast sista ansökningsdag.
Ansökan ska vara inkommen senast: 2021-02-15

 


Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Senior Research Scientist - Synthetic/Medicinal Chemistry

Ansök    Nov 18    Astrazeneca AB    Organisk kemist
AstraZeneca is one of the world's most exciting biopharmaceutical companies. We're on a mission to turn ideas into life-changing medicines that improve patients' lives and benefit society. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. Now we are hiring a Senior Research Scientist with focus on Synthetic Medicinal Chemistry in the area of Research and Early ... Visa mer
AstraZeneca is one of the world's most exciting biopharmaceutical companies. We're on a mission to turn ideas into life-changing medicines that improve patients' lives and benefit society. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world.

Now we are hiring a Senior Research Scientist with focus on Synthetic Medicinal Chemistry in the area of Research and Early Development in Respiratory & Immunology within AZ´s BioPharmaceutical R&D - right in the middle of AstraZeneca's vibrant R&D site in Sweden.

The Medicinal Chemistry team in Early R&I is focused on driving discovery research to deliver world-class medicines with an emphasis on small to large sized synthetically accessible molecules. The team operates in a cross-disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK and Pharmaceutical Science departments to advance the R&I project pipeline.

The successful candidate will join a highly collaborative discovery team leveraging innovative medicinal chemistry to invent novel medicines. The position includes synthesis, purification and characterization of lead molecules from target validation to lead optimization phase including compound design and medicinal chemistry aspects. The candidate will ensure uptake of novel scientific developments in the area of synthetic organic chemistry into AstraZeneca´s medicinal chemistry project teams and influence compound design by generating ideas for novel molecules from recent progress in synthetic organic chemistry. Embedded in a strongly science driven environment, this position certainly includes opportunities to share scientific findings and publish novel science.

We are looking for an ambitious team player with a strong scientific background in organic chemistry including excellent verbal and written communication skills and the ability to engage and collaborate across boundaries. We rely on a person with a problem-solving attitude and delivery focus, and a strong interest to continuously develop new skills in medicinal chemistry.



Major Duties and Responsibilities

* Provide state-of-the-art synthetic organic chemistry to projects at all stages of drug discovery, delivering high quality drug molecules and tool compounds
* Apply synthetic chemistry with an idea generation mindset, efficiently troubleshooting problems and maintaining a clear focus and impact on project progression
* Provide a significant level of expertise in synthetic chemistry methodology, purification and analytical sciences to efficiently deliver high quality compounds within agreed timelines
* Collaborate with the project chemistry team in the development, planning and prioritization of compound synthesis, route design and problem solving
* Provide quality input into compound design and medicinal chemistry optimization
* Follow safety requirements and all AZ corporate responsibility policies
* Drive Early R&Is; scientific reputation by identifying and contributing to publication opportunities internally, across AZ and/or together with external partners

Essential Requirements

We search for a creative scientist with a strong synthetic background and the desire to rapidly develop as a medicinal chemist.

* PhD in synthetic organic chemistry, medicinal chemistry or biochemistry
* Postdoctoral and/or industrial experience is a plus
* In-depth scientific knowledge in the area of modern synthetic chemistry
* Up-to-date with the application of modern purification and analytical techniques
* A proven track record of delivery from own experimental work
* Excellent communication and collaboration skills
* Basic knowledge of the pharmaceutical drug discovery and development process is a plus.



We welcome your application until January 10th, 2021!

Our R&D site has around 2500 employees and a very high share of scientists with very diverse origin with respect to scientific expertise and nationalities. Please look at the following two webpages to get an impression of AZ´s R&D site in Sweden and the beautiful Swedish environment in and around Gothenburg:



Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ Visa mindre

Senior Expert in Medicinal Chemistry, Targeted Drug Delivery

Ansök    Okt 5    Astrazeneca AB    Organisk kemist
Are you a medicinal chemist with experience from targeted drug delivery such as identifying receptor ligands and conjugation chemistry to enable drug conjugates to oligonucleotides or small molecules? Would you like to combine your technical expertise with your strategic leadership skills in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and... Visa mer
Are you a medicinal chemist with experience from targeted drug delivery such as identifying receptor ligands and conjugation chemistry to enable drug conjugates to oligonucleotides or small molecules? Would you like to combine your technical expertise with your strategic leadership skills in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next generation innovative medicines and are currently expanding our teams focused on RNA therapeutics and Targeted Drug Delivery for the treatment of diseases across our therapy area.

As part of this expansion, we are now recruiting a scientific leader with passion, expertise and experience in Tissue Targeted Drug Delivery and New Modalities Chemistry. You will have a key role in leading the scientific strategy while working in close collaboration with colleagues from multiple disciplines with expertise in the area of drug conjugates and discovery of novel targeting ligands. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. Together we push the boundaries of science for patients suffering from Heart Failure, Diabetes or Chronic Kidney Disease. The Medicinal Chemistry Department within Early CVRM is a critical player in the discovery and design of our drug molecules and in identifying and validating novel biological targets. We are agnostic to molecular modality and utilizes an array of therapeutic approaches. We drive our scientific leadership through partnerships and alliances with world specialists which will give you the opportunity to access the most advanced knowledge and tools to stay at the forefront of scientific research. You will be part of a stimulating and collaborative environment where scientific questions are addressed in an innovative and sustainable way.

What you'll do

This is a senior scientific role on Principal Scientist level where you will be an authority in the area of drug conjugates and receptor mediated up-take to specific tissues and cells to impact our future portfolio and drug discovery programs across disciplines, both internally and through collaborations. As a member of the Medicinal Chemistry New Modalities team you will lead and influence the strategy for how we integrate various modalities such as antibodies, peptides, small molecules and oligonucleotide based therapeutics. You will be leading the chemistry and have impact across multiple projects. You will be a strategic leader, seeing the opportunities to innovate at the interface and through combination of various chemical modalities. It will further require an understanding of the therapeutic needs of the CVRM therapy area across disease areas.

As Scientific Leader you will provide a clear communication, ownership of the operational aspects, provide strong influence and ensure an openness and curiosity to innovate. You are expected to build networks with key opinion leaders and academic groups and might evaluate and manage external collaborations and in-licensing opportunities.

Essential for the role

This role requires a Ph. D. degree in Synthetic Chemistry or Medicinal Chemistry, with 10+ years post-doctoral research experience in drug discovery, preferentially from an industrial setting. You are recognized internationally within the field of Targeted Drug Delivery and Drug Conjugates applied to drug discovery as evidenced by your external disclosures and publication record. With your excellent interpersonal, communication and collaboration skills you will have the ability to operate effectively in a multidisciplinary matrix research environment, providing leadership and insight in drug discovery. Prior experience and proven track record of delivery is a must. Key qualities are:

* Expert knowledge with proven track record of design and synthesis of drug conjugates
* Substantial track record of innovation and milestone delivery in drug discovery projects across both early and late discovery phase.
* Strong knowledge in biological processes and experience of when to use various chemical modalities in drug discovery
* Sound knowledge of related pharmaceutical industry disciplines
* Strong influencing skills in order to build capabilities and implement improvements based on new data and learnings in our targeted drug delivery capabilities across disciplines
* Excellent written and verbal communication skills, including ability to present to senior leaders. Excellent English.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

Welcome with your application no later than November 8th, 2020

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link

Meet Hasse, Chemist at AstraZeneca Gothenburg: Link Visa mindre

Postdoktor i triplet-triplet annihilering foton upkonvertering.

Ansök    Okt 29    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Vid institutionen för kemi och molekylärbiologi bedrivs forskning och forskarutbildning inom ett brett omr... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Vid institutionen för kemi och molekylärbiologi bedrivs forskning och forskarutbildning inom ett brett område som sträcker sig hela vägen från atom- och molekylskala via celler till hela organismer. Mycket av de fenomen som studeras har en inverkan på vår naturliga miljö och levande system. Vi deltar i utbildning på grundläggande nivå inom programmen för kemi, molekylärbiologi, läkemedelskemi, biologi, marina vetenskaper och apotekarprogrammet.

I gruppen för molekylära material bygger vi molekylära system som är gjorda så att de kan utföra en precist definierad funktion med utgångspunkt för användning inom materialkemi. Kompetensen i gruppen ligger både inom organisk syntes och optisk/elektrisk karakterisering av komplicerade molekylära material. Oftast använder vi organiska molekyler till våra studier, och även om dessa kan ensamma kan utföra en uppgift så ligger fokus på vad de syntetiserade materialen kan utföra tillsammans.

Arbetsuppgifter
Forskaren skall kunna utföra avancerade optiska spektroskopiska undersökningar med både steady-state och tidsupplösta spektrometrar. Kännedom om LabView programmering är också en viktig del av arbetet eftersom mycket av utrustningen styrs av hemgjorda program. Vidare förväntas forskaren kunna syntetisera halvledande nanokristaller (kvant-prickar) samt hjälpa till vid vetenskaplig publicering.

Kvalifikationer
Du som söker skall ha en Doktorsexamen i kemi eller materialvetenskap. Erfarenhet av att utföra avancerade optiska spektroskopiska undersökningar med både steady-state och tidsupplösta spektrometrar är ett krav. Kännedom och erfarenhet av LabView programmering är också ett krav. Vidare förväntas forskaren kunna syntetisera halvledande nanokristaller (kvant-prickar) samt hjälpa till vid vetenskaplig publicering. Det senare kravet skall vara dokumenterat genom publicering som förstaförfattare av vetenskapliga artiklar i högimpaktsjournaler. Förmåga att arbeta i grupp är meriterande och skall styrkas genom rekommendationsbrev från tidigare arbetsgivare.

Anställning
Anställningen är tidsbegränsad anställning på heltid 100% under 6 månader med placering vid Institutionen för Kemi och Molekylärbiologi. 

Kontaktuppgifter för anställningen
Har du frågor om anställningen är du välkommen att kontakta Karl Börjesson. e-post: [email protected]

Fackliga organisationer
Fackliga företrädare vid Göteborgs universitet hittar du här: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Ansökan
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enligt annonsen och skall innehålla CV, Publikationslista och rekomendationsbrev. Din ansökan skall vara universitetet tillhanda senast sista ansökningsdag 2020-11-20.

Ansökan ska vara inkommen senast:2020-11-20

 Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

 


Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Principal Scientist, New Modality Chemistry expert

Ansök    Maj 27    Astrazeneca AB    Organisk kemist
Would you like to combine your drug conjugate chemistry expertise with your strategic leadership skills in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next ... Visa mer
Would you like to combine your drug conjugate chemistry expertise with your strategic leadership skills in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next generation innovative medicines and are currently expanding our teams focused on RNA therapeutics and Targeted Drug Delivery for the treatment of diseases across our therapy areas.

As part of this expansion, we are now recruiting a scientific leader with passion, expertise and experience in Drug Discovery of New Modalities Chemistry. You will have a key role in leading strategy and working in close collaboration with colleagues in the area of drug conjugates and tissue targeting drug discovery. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. Together we push the boundaries of science to turn ideas into medicines for patients suffering from Heart Failure, Diabetes or Chronic Kidney Disease.

The Medicinal Chemistry Department within Early CVRM is a critical player in the discovery and design of our drug molecules and in identifying and validating novel biological targets. We are agnostic to molecular modality and utilizes an array of therapeutic approaches. We drive our scientific leadership through partnerships and alliances with world specialists which will give you the opportunity to access the most advanced knowledge and tools to stay at the forefront of scientific research. You will be part of a stimulating and collaborative environment where scientific questions are addressed in an innovative and sustainable way.

What you'll do

This is a senior scientific role where you will be an authority in the area of drug conjugates to impact our future portfolio and drug discovery programs across disciplines, both internally and through collaborations. As a member of the Medicinal Chemistry New Modalities team you will lead and influence the direction of strategy for how we integrate various modalities such as antibodies, peptides, small molecules and oligonucleotide based therapeutics including drug delivery to the tissue or cell of therapeutic relevance.

In this role you will be leading the chemistry and impact across multiple projects. You will be a strategic leader, seeing the opportunities to innovate in the interface and through combination of various chemical modalities. It will further require an understanding of the therapeutic needs of the CVRM therapy area.

As Scientific Leader you will provide a clear communication, ownership of the operational aspects, provide strong influence and ensure an openness and curiosity to innovate. You are expected to build networks with key opinion leaders and academic groups and might evaluate and manage external collaborations and in-licensing opportunities

Essential for the role

This role requires a Ph. D. degree in Drug Conjugate Chemistry or Medicinal Chemistry related to New Modalities, with 10+ years post-doctoral research experience in drug discovery, preferentially from an industrial setting. You will be recognized internationally within the field of New Modalities and Drug Conjugates applied to drug discovery as evidenced by your external disclosures and publication record.

With your excellent interpersonal, communication and collaboration skills you will have the ability to operate effectively in a multidisciplinary matrix research environment, providing leadership and insight in drug discovery. Prior experience and proven track record of delivery is a must.

* Expert knowledge with proven track record of design and synthesis of drug conjugates
* Substantial track record of innovation and milestone delivery in drug discovery projects across both early and late discovery phase and into clinical testing.
* Strong knowledge in biological processes and experience of when to use various chemical modalities in drug discovery
* Strong influencing skills in order to build capabilities and implement improvements in New Modalities chemistry and drug discovery across disciplines. Sound knowledge of related pharmaceutical disciplines
* Excellent written and verbal communication skills, including ability to present to senior leaders. Excellent English.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact hiring manager Malin Lemurell, +46-31-776 10 00

Welcome with your application no later than July 24, 2020

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link

Meet Hasse, Chemist at AstraZeneca Gothenburg: Link Visa mindre

Principal Scientist, New Modality Chemistry expert

Ansök    Jun 29    Astrazeneca AB    Organisk kemist
Would you like to combine your drug conjugate chemistry expertise with your strategic leadership skills in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next ... Visa mer
Would you like to combine your drug conjugate chemistry expertise with your strategic leadership skills in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next generation innovative medicines and are currently expanding our teams focused on RNA therapeutics and Targeted Drug Delivery for the treatment of diseases across our therapy areas.

As part of this expansion, we are now recruiting a scientific leader with passion, expertise and experience in Drug Discovery of New Modalities Chemistry. You will have a key role in leading strategy and working in close collaboration with colleagues in the area of drug conjugates and tissue targeting drug discovery. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. Together we push the boundaries of science to turn ideas into medicines for patients suffering from Heart Failure, Diabetes or Chronic Kidney Disease.

The Medicinal Chemistry Department within Early CVRM is a critical player in the discovery and design of our drug molecules and in identifying and validating novel biological targets. We are agnostic to molecular modality and utilizes an array of therapeutic approaches. We drive our scientific leadership through partnerships and alliances with world specialists which will give you the opportunity to access the most advanced knowledge and tools to stay at the forefront of scientific research. You will be part of a stimulating and collaborative environment where scientific questions are addressed in an innovative and sustainable way.

What you'll do

This is a senior scientific role where you will be an authority in the area of drug conjugates to impact our future portfolio and drug discovery programs across disciplines, both internally and through collaborations. As a member of the Medicinal Chemistry New Modalities team you will lead and influence the direction of strategy for how we integrate various modalities such as antibodies, peptides, small molecules and oligonucleotide based therapeutics including drug delivery to the tissue or cell of therapeutic relevance.

In this role you will be leading the chemistry and impact across multiple projects. You will be a strategic leader, seeing the opportunities to innovate in the interface and through combination of various chemical modalities. It will further require an understanding of the therapeutic needs of the CVRM therapy area.

As Scientific Leader you will provide a clear communication, ownership of the operational aspects, provide strong influence and ensure an openness and curiosity to innovate. You are expected to build networks with key opinion leaders and academic groups and might evaluate and manage external collaborations and in-licensing opportunities

Essential for the role

This role requires a Ph. D. degree in Drug Conjugate Chemistry or Medicinal Chemistry related to New Modalities, with 10+ years post-doctoral research experience in drug discovery, preferentially from an industrial setting. You will be recognized internationally within the field of New Modalities and Drug Conjugates applied to drug discovery as evidenced by your external disclosures and publication record.

With your excellent interpersonal, communication and collaboration skills you will have the ability to operate effectively in a multidisciplinary matrix research environment, providing leadership and insight in drug discovery. Prior experience and proven track record of delivery is a must.

* Expert knowledge with proven track record of design and synthesis of drug conjugates
* Substantial track record of innovation and milestone delivery in drug discovery projects across both early and late discovery phase and into clinical testing.
* Strong knowledge in biological processes and experience of when to use various chemical modalities in drug discovery
* Strong influencing skills in order to build capabilities and implement improvements in New Modalities chemistry and drug discovery across disciplines. Sound knowledge of related pharmaceutical disciplines
* Excellent written and verbal communication skills, including ability to present to senior leaders. Excellent English.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact hiring manager Malin Lemurell, +46-31-776 10 00

Welcome with your application no later than July 24, 2020



Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link

Meet Hasse, Chemist at AstraZeneca Gothenburg: Link Visa mindre

Scientist Organic Chemistry at AstraZeneca Gothenburg

Ansök    Jun 30    Randstad AB    Organisk kemist
Job description On behalf of AstraZeneca, we at Randstad Life Sciences are now looking for a research scientist for a consultant role.    At AstraZeneca they believe in the potential of people and you’ll develop beyond what you thought possible. They make the most of your skills and passion by actively supporting you to see what you can achieve, no matter where you start with them.  AstraZeneca is now looking for a consultant in a role as an Organic Synthe... Visa mer
Job description
On behalf of AstraZeneca, we at Randstad Life Sciences are now looking for a research scientist for a consultant role. 
 
At AstraZeneca they believe in the potential of people and you’ll develop beyond what you thought possible. They make the most of your skills and passion by actively supporting you to see what you can achieve, no matter where you start with them.  AstraZeneca is now looking for a consultant in a role as an Organic Synthesis Research Scientist within Discovery Sciences. This role will be based in their research laboratories in Gothenburg, Sweden.

In your role as a research scientist you will be part of the iLAB team which focuses on the exploration and implementation of new synthetic methodologies and automation technologies and their application in drug discovery. Your role will be to work in a team focused on the synthesis and purification of PROTACs (PROteolysis TArgeting Chimeras) molecules for application across several exciting medicinal chemistry projects. You will be responsible for the synthesis and isolation of these compounds, ready for purification and testing. After a thorough introduction you will use various types of conventional and automated laboratory equipment for your daily tasks. 

If you are a highly motivated person looking to develop your chemistry experience in a fast-paced and dynamic team, then you are our kind of person.

Responsibilities


Carry out small scale organic synthesis reactions and purification
Collect and weigh out chemicals and reagents from local storage 
Plan, prioritise and perform given tasks
Actively collaborate with colleagues to allow timely delivery of screening compounds to projects
Ensure that all safety guidelines are always followed strictly and maintain a clean and orderly environment
Record all data and results in specified forms with accuracy


Qualifications


Minimum a degree in chemistry with some post-degree experience of laboratory based organic synthesis
Ability to prioritise and perform tasks independently and to work under pressure
Work effectively in teams 
Ability to learn and adopt new chemical technologies and automation instrumentation
Very good knowledge of MS Office (Excel, Word, PowerPoint)
Excellent verbal and written communication skills in English


Application
2020-07-12, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information, please contact Sara Kuikka, consultant manager [email protected] 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre

2 Doktorandtjänster i organisk kemi

Ansök    Apr 27    Göteborgs Universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 38 000 studenter och 6 000 medarb... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 38 000 studenter och 6 000 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Doktorandtjänsten är knuten till den forskningsverksamhet som bedrivs i Henrik Sundéns forskargrupp där ett generellt focus ligger på utveckling av nya katalytiska metoder för skapandet av kemiska bindningar. Mer specifikt inriktar vi oss på att använda organiska småmolekyler, karbener, som katalysatorer för att skapa komplexa molekyler från enkla beståndsdelar. Vi har även visat att karbener i kombination med luftens syre kan användas för att ersätta annars resursintensiva oxidations reaktioner. Doktorandtjänsten kommer således att omfatta metodutveckling inom carbenkatalys för skapandet av kol-kol bindningar och utvecklandet av nya oxidationsreaktioner.

Arbetsuppgifter
Projektet kommer att vara syntesbaserat dvs att största delen av doktorandtiden kommer att vara laboratoriearbete. Det är därför viktigt att kandidaten kan uppvisa erfarenhet av laboratoriearbete i form av ett exjobb inom organisk syntes eller liknande och att kandidaten trivs med laborativt arbete.

Arbetet under doktorandtiden ska resultera i en skriven och försvarad doktorsavhandling som överensstämmer med reglerna för en avhandling vid Göteborgs Universitet. https://medarbetarportalen.gu.se/digitalAssets/1694/1694635_doktorandregler--180701.pdf

Utöver det vetenskapliga arbetet ska en doktorand deltaga i:

Gruppaktiviteter såsom gruppmöten, litteratur presentationer mm.

Institutionstjänstgöring. Innefattar, utbildning, underhåll av instrument och administration.

Doktorandkurser. Kurser motsvarande 60 hp måste vara registrerade för att få ut examen.

Presentera forsknings resultat iv vetenskapliga konferenser.

Utöver detta ska en licentiat uppsats/halvtids seminarium presenteras inom två år.

Behörighet
För tillträde till utbildning på forskarnivå krävs både grundläggande och särskild behörighet.

Grundläggande behörighet till utbildning på forskarnivå har den som:
1. avlagt examen på avancerad nivå, eller
2. fullgjort kursfordringar om minst 240 högskolepoäng, varav minst 60 högskolepoäng på avancerad nivå, eller
3. på annat sätt inom eller utom landet förvärvat motsvarande kunskaper.

Särskild behörighet:
1. avlagt examen på avancerad nivå i relevant* naturvetenskapligt ämne, eller
2. fullgjort kursfordringar om minst 60 högskolepoäng på avancerad nivå i relevanta* naturvetenskapliga ämnen, eller
3. på något annat sätt inom eller utom landet förvärvat i huvudsak motsvarande kunskaper relevanta för den planerade utbildningen.* Relevant för den planerade utbildningen på forskarnivå

Bedömningsgrund
Urval bland sökande som uppfyller krav på grundläggande och särskild behörighet baseras på förmågan att tillgodogöra sig utbildningen på forskarnivå. Vid bedömningen fästs särskild vikt vid dokumenterade kvalifikationer avseende:

Dokumenterat laborativt arbete

Forskningsbakgrund. Examensarbete i organisk syntes eller liknande.

Fördjupad kunskap inom organisk syntes. Tex. i form av masterskurser i avancerad organisk syntes och NMR spektroskopi.

Förmåga att uttrycka sig på engelska i tal och skrift

Anställning
Anställningsform: Tidsbegränsad anställning, fyra år

Omfattning: 100 %

Placering: Inst. för Kemi och molekylärbiologi, Göteborg

Tillträde: Snarast enligt överenskommelse

Bestämmelser för anställning som doktorand återfinns i förordning SFS 1998:80.

Universitetet tillämpar lokalt avtal om lönesättning av doktorander.

Tillsättningsförfarande
Registrera din ansökan elektroniskt www.gu.se/ledigaanstallningar.

Kontaktuppgifter för anställningen
[email protected]

Ansökan
Du hittar fullständig annons och ansöker om att till att bli antagen till forskarstudier via Göteborgs universitets rekryteringsportal, www.gu.se/ledigaanstallningar genom att klicka på knappen ”Ansök”. Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag.
Ansökan ska vara inkommen senast: 2020-06-08

 


Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Senior Synthetic Chemist, New Modalities Chemistry

Ansök    Maj 27    Astrazeneca AB    Organisk kemist
Are you a synthetic chemist with expertise in conjugation chemistry and targeted drug delivery? Would you like to apply your expertise in a company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases! Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to ... Visa mer
Are you a synthetic chemist with expertise in conjugation chemistry and targeted drug delivery? Would you like to apply your expertise in a company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next generation innovative medicines and are currently expanding our teams focused on RNA therapeutics and Targeted Drug Delivery for the treatment of diseases across our therapy areas.

As part of this expansion, we are now recruiting a a skilled senior scientist with great passion in synthetic organic chemistry and a special interest in bridging chemistry across various modalities in the area of drug conjugates and targeted drug delivery. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. Together we push the boundaries of science to develop medicines that makes a true difference for patients suffering from Heart Failure, Diabetes or Chronic Kidney Disease.

The CVRM Medicinal Chemistry Department is an essential player in the discovery and design of drug molecules to identify and validate novel biological targets. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality.

What you'll do

As a Senior Synthetic chemist, you will be part of an open minded, creative and experienced team where you will contribute with your high ambitions, collaborative attitude and enthusiasm to be part of design and synthesis of new candidate drugs. This is a lab-based role focused on medicinal chemistry with emphasis on synthetic chemistry of specific tissue targeting ligands and drug conjugates. You will actively contribute to AstraZeneca drug projects by compound design and synthesis, data generation and data interpretation. The work is done in a cross disciplinary environment in close collaboration with scientists from other functions like Bioscience, Discovery Sciences, DMPK, Pharmaceutical Sciences.

You are encouraged to be part of external collaborations, publish scientific papers, present and represent the department at scientific conferences.

Essential for the role

* Ph. D. degree in Organic Chemistry/Synthetic Chemistry/Drug Conjugate Chemistry or Medicinal Chemistry related to New Modalities. 2+ year relevant post-doctoral experience in academic or industrial setting is preferred
* Expert knowledge in synthetic organic chemistry
* Experience of different modalities chemistry such a small molecules, peptides, RNA or drug conjugates is seen as an advantage
* Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
* Scientific creativity: ability to identify, develop and apply new technologies and ways of working
* Great awareness of recent literature within synthesis/medicinal chemistry as well as current developments and trends in organic synthesis
* Highly self-motivated and capable of receiving and analyzing input from complex data and deciding on focused course of action
* Excellent teamwork, collaboration, networking and communication skills
* Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents
* Basic knowledge in medicinal chemistry or experience from drug discovery in an industrial setting is a plus but not essential.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact Laurent Knerr, +46-31-776 10 00

Welcome with your application no later than June 17, 2020

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link

Meet Hasse, Chemist at AstraZeneca Gothenburg: Link

Why AstraZeneca?



Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail. Visa mindre

Postdoktor inom optisk spektroskopi av organiska molekyler

Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Vid institutionen för kemi och molekylärbiologi bedrivs forskning och forskarutbildning inom ett brett omr... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 49 000 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Vid institutionen för kemi och molekylärbiologi bedrivs forskning och forskarutbildning inom ett brett område som sträcker sig hela vägen från atom- och molekylskala via celler till hela organismer. Mycket av de fenomen som studeras har en inverkan på vår naturliga miljö och levande system. Vi deltar i utbildning på grundläggande nivå inom programmen för kemi, molekylärbiologi, läkemedelskemi, biologi, marina vetenskaper och apotekarprogrammet.

I gruppen för molekylära material bygger vi molekylära system som är gjorda så att de kan utföra en precist definierad funktion med utgångspunkt för användning inom materialkemi. Kompetensen i gruppen ligger både inom organisk syntes och optisk/elektrisk karakterisering av komplicerade molekylära material. Oftast använder vi organiska molekyler till våra studier, och även om dessa kan ensamma kan utföra en uppgift så ligger fokus på vad de syntetiserade materialen kan utföra tillsammans. Se vår hemsida för mer information (www.molecularmaterials.se).

Arbetsuppgifter
Du kommer att bedriva forskning i gränslandet mellan kemi, fysik och materialvetenskap. Du kommer att arbeta med projekt som handlar om att förstå vad som händer med molekyler som är starkt kopplade med ljus, och inom projekt där triplet-triplet annihilering användas för att slå samman två fotoner till en. Praktiska arbetsuppgifter kommer att vara fokuserade på substrat tillverkning och testning, vilket oftast inbegriper optisk spektroskopi. Du kommer att arbeta självständigt inom en grupp fokuserad på molekylära material.

Kvalifikationer
Behörig att anställas som forskare är den som har svensk doktorsexamen eller har en utländsk examen som bedöms motsvara doktorsexamen inom kemi alternativt fysik. Expertis inom optisk spektroskopi (både i jämvikt och tidsupplöst) av organistiska molekyler är ett krav. Att kunna uttrycka sig i skrift och text flytande på engelska är ett krav. Meriterande är en stark publikationslista, där den sökande är förstaförfattare på artiklar publicerade i välrenommerade tidskrifter. Dessutom är erfarenhet av simuleringar och passningar av spektroskopi data, samt inom fälten ”stark exciton-foton koppling” och ”triplet-triplet annihilering foton uppkonvertering”.

Anställning
Anställningen är en tidsbegränsad anställning på 24 månader med placering vid Institutionen för Kemi och Molekylärbiologi. Tillträde: Augusti 2020

Kontaktuppgifter för anställningen
Har du frågor om anställningen är du välkommen att kontakta  Karl Börjesson e-post: [email protected]

Fackliga organisationer
Fackliga företrädare vid Göteborgs universitet hittar du här: http://www.gu.se/omuniversitetet/aktuellt/lediga-jobb/fackliga-kontaktpersoner

Ansökan
Du söker anställningen via Göteborgs universitets rekryteringsportal genom att klicka på knappen "Ansök". Du som sökande ansvarar för att ansökan är komplett i enlighet med annonsen och att den är universitetet tillhanda senast sista ansökningsdag 2020-04-23.

Ansökan ska vara inkommen senast: 2020-04-23

 Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten.

Universitetet tillämpar individuell lönesättning.

Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut.

 


Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Professor i läkemedelskemi

Ansök    Nov 29    Göteborgs universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 47 500 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Vid institutionen för kemi och molekylärbiologi bedrivs undervisning, forskning och forskarutbildning inom... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 47 500 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Vid institutionen för kemi och molekylärbiologi bedrivs undervisning, forskning och forskarutbildning inom ett brett område som sträcker sig hela vägen från atom- och molekylskala via celler till hela organismer. Mycket av de fenomen som studeras har en inverkan på vår naturliga miljö och levande system. Vi deltar i utbildning på grundläggande nivå inom programmen för kemi, molekylärbiologi, läkemedelskemi, biologi och marina vetenskaper samt på receptarie- och apotekarprogrammet. Mer information om oss finns på https://cmb.gu.se.

Forskargrupperna i läkemedelskemi vid Göteborgs universitet bedriver en internationellt mycket aktiv och framgångsrik forskning inom syntes och karakterisering av föreningar med potentiell biologisk aktivitet. Verksamheten är samlokaliserad med forskargrupperna i organisk kemi och tillsammans har de god tillgång till en omfattande instrumentpark i moderna labblokaler. Anställningen som professor avser forskning och utbildning inom läkemedelskemi vilket innebär en långsiktig förstärkning av den pågående verksamheten inom området.

I nuvarande utlysning söker vi kandidater med omfattande kompetens och mycket starka meriter inom läkemedelskemi. Grundförutsättningen är att anställningen kommer att förses med ett generöst stödpaket av finansiering för doktorander och medel för driftskostnader.

Göteborgs universitet kraftsamlar inom Life Science-området och ett modernt forsknings- och undervisningshus planeras stå färdigt till år 2021. Huset som samlar delar av den Naturvetenskapliga fakulteten, byggs i direkt anslutning till den medicinska fakulteten Sahlgrenska akademin och Sahlgrenska universitetssjukhuset. I direkt närhet finns Sahlgrenskas Core facilities som samlar viktig infrastruktur samt Svenskt NMR centrum med 900, 800 och flera 600 MHz instrument. Vi har också omfattande samarbeten med AstraZencea R&D i Mölndal.

Ämne
Läkemedelskemi

Ämnesbeskrivning
Forskningen inom ramen för anställningen ska komplettera och stärka existerande verksamhet vid institutionen för kemi och molekylärbiologi. Det innebär att forskningsaktiviteterna i läkemedelskemi ska inriktas mot design och syntes av bioaktiva föreningar.

Arbetsuppgifter
I arbetsuppgifterna ingår att skapa ett framgångsrikt forskningsprogram samt etablera och leda en självständig forskargrupp inom experimentell läkemedelskemi eller kemisk biologi, där syntes av bioaktiva föreningar skall utgöra en betydande del. För detta förväntas att du aktivt söker forskningsmedel från nationella och internationella forskningsfinansiärer.

I arbetsuppgifterna ingår också att planera och genomföra undervisning inom läkemedelskemi på alla utbildningsnivåer. Undervisningen omfattar föreläsningar, övningar och examinationer inom flera kurser. Handledning av doktorander samt kandidat- och mastersarbeten ingår också. Även viss undervisning inom organisk kemi kan komma att ingå.

Anställningen kan komma att innefatta ledningsuppdrag och administrativa uppdrag såväl inom som utom institutionen samt på receptarie- och apotekareprogrammen. Samverkan med det omgivande samhället ingår också i arbetsuppgifterna.

Du som saknar högskolepedagogisk utbildning förväntas genomgå sådan inom två år från anställningens tillträde. Du förväntas kunna undervisa på svenska inom två år.

Fullständig annons
För fullständig annons där detaljerade arbetsuppgifter, behörighetskrav, bedömningsgrunder, praktisk information och krav på ansökans innehåll framgår hänvisas till https://www.gu.se/omuniversitetet/aktuellt/lediga-jobb/Lediga_anstallningar-detaljsida/?id=1253

Anställning
Anställningsform: Tillsvidareanställning
Omfattning: 100%
Placering: Institutionen för kemi och molekylärbiologi, Göteborg
Tillträde: Snarast enligt överenskommelse

Kontaktuppgifter för anställningen
Markus Tamas, prefekt vid Institutionen för kemi och molekylärbiologi 
+46 31 786 9022 
[email protected]

Ansökan ska vara inkommen senast: 15 januari 2020

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Professor i läkemedelskemi

Ansök    Jan 15    Göteborgs universitet    Organisk kemist
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 47 500 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Vid institutionen för kemi och molekylärbiologi bedrivs undervisning, forskning och forskarutbildning inom... Visa mer
Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 47 500 studenter och 6 400 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid.

Vid institutionen för kemi och molekylärbiologi bedrivs undervisning, forskning och forskarutbildning inom ett brett område som sträcker sig hela vägen från atom- och molekylskala via celler till hela organismer. Mycket av de fenomen som studeras har en inverkan på vår naturliga miljö och levande system. Vi deltar i utbildning på grundläggande nivå inom programmen för kemi, molekylärbiologi, läkemedelskemi, biologi och marina vetenskaper samt på receptarie- och apotekarprogrammet. Mer information om oss finns på https://cmb.gu.se.

Forskargrupperna i läkemedelskemi vid Göteborgs universitet bedriver en internationellt mycket aktiv och framgångsrik forskning inom syntes och karakterisering av föreningar med potentiell biologisk aktivitet. Verksamheten är samlokaliserad med forskargrupperna i organisk kemi och tillsammans har de god tillgång till en omfattande instrumentpark i moderna labblokaler. Anställningen som professor avser forskning och utbildning inom läkemedelskemi vilket innebär en långsiktig förstärkning av den pågående verksamheten inom området.

I nuvarande utlysning söker vi kandidater med omfattande kompetens och mycket starka meriter inom läkemedelskemi. Grundförutsättningen är att anställningen kommer att förses med ett generöst stödpaket av finansiering för doktorander och medel för driftskostnader.

Göteborgs universitet kraftsamlar inom Life Science-området och ett modernt forsknings- och undervisningshus planeras stå färdigt till år 2021. Huset som samlar delar av den Naturvetenskapliga fakulteten, byggs i direkt anslutning till den medicinska fakulteten Sahlgrenska akademin och Sahlgrenska universitetssjukhuset. I direkt närhet finns Sahlgrenskas Core facilities som samlar viktig infrastruktur samt Svenskt NMR centrum med 900, 800 och flera 600 MHz instrument. Vi har också omfattande samarbeten med AstraZencea R&D i Mölndal.

Ämne
Läkemedelskemi

Ämnesbeskrivning
Forskningen inom ramen för anställningen ska komplettera och stärka existerande verksamhet vid institutionen för kemi och molekylärbiologi. Det innebär att forskningsaktiviteterna i läkemedelskemi ska inriktas mot design och syntes av bioaktiva föreningar.

Arbetsuppgifter
I arbetsuppgifterna ingår att skapa ett framgångsrikt forskningsprogram samt etablera och leda en självständig forskargrupp inom experimentell läkemedelskemi eller kemisk biologi, där syntes av bioaktiva föreningar skall utgöra en betydande del. För detta förväntas att du aktivt söker forskningsmedel från nationella och internationella forskningsfinansiärer.

I arbetsuppgifterna ingår också att planera och genomföra undervisning inom läkemedelskemi på alla utbildningsnivåer. Undervisningen omfattar föreläsningar, övningar och examinationer inom flera kurser. Handledning av doktorander samt kandidat- och mastersarbeten ingår också. Även viss undervisning inom organisk kemi kan komma att ingå.

Anställningen kan komma att innefatta ledningsuppdrag och administrativa uppdrag såväl inom som utom institutionen samt på receptarie- och apotekareprogrammen. Samverkan med det omgivande samhället ingår också i arbetsuppgifterna.

Du som saknar högskolepedagogisk utbildning förväntas genomgå sådan inom två år från anställningens tillträde. Du förväntas kunna undervisa på svenska inom två år.

Fullständig annons
För fullständig annons där detaljerade arbetsuppgifter, behörighetskrav, bedömningsgrunder, praktisk information och krav på ansökans innehåll framgår hänvisas till https://www.gu.se/omuniversitetet/aktuellt/lediga-jobb/Lediga_anstallningar-detaljsida/?id=1253

Anställning
Anställningsform: Tillsvidareanställning
Omfattning: 100%
Placering: Institutionen för kemi och molekylärbiologi, Göteborg
Tillträde: Snarast enligt överenskommelse

Kontaktuppgifter för anställningen
Markus Tamas, prefekt vid Institutionen för kemi och molekylärbiologi 
+46 31 786 9022 
[email protected]

Ansökan ska vara inkommen senast: 15 januari 2020

Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser. Visa mindre

Forskare i atmosfärvetenskap

The University of Gothenburg tackles society’s challenges with diverse knowledge. 47 500 students and 6 400 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future. The atmospheric science group carries out research activities ranging from fundamen... Visa mer
The University of Gothenburg tackles society’s challenges with diverse knowledge. 47 500 students and 6 400 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The atmospheric science group carries out research activities ranging from fundamental studies of chemical reactions on the molecular level, to field studies of atmospheric processes and their importance to climate, air quality and sustainable development.The atmosphere is a complex mixture of interacting gases, aerosol and cloud particles. Phenomena at the gas-particle interface are receiving increased attention because of their importance for the behavior of the atmosphere. Interface processes alter the chemical composition of the atmosphere. They also impact the formation and growth of aerosol and cloud particles, and consequently affect the energy budget and dynamics of the atmosphere. Here, we focus on the detailed description of these interface processes, and in particular the behavior of water and organic material. The overall aim is to develop a molecular-level understanding of key processes in the atmosphere. A specific goal is to characterize trace gas interactions with condensed organic phases that serve as proxies for the organic aerosols found in the atmosphere. Our approach to achieve these goals is to perform large scale molecular dynamics simulations. The project is closely linked to ongoing experimental studies using the environmental molecular beam method, and together the studies provides unique information about the dynamics and kinetics on organic surfaces.

Job assignments
The research activities involve the use of large-scale molecular dynamics simulations to describe surface processes of relevance to atmospheric organic aerosol. The theoretical studies will be carried out in close connect to ongoing experimental work within the research group, with emphasis on environmental molecular beam experiments. In addition to work in Sweden the applicant is expected to participate in our international collaboration projects, and to present results from the project in scientific publications and at international conferences.

Qualifications
A completed Swedish doctoral degree in natural science or a foreign degree corresponding to a Swedish doctoral degree. Demonstrated experience in molecular dynamics simulations of surface processes on organic aerosol. Previous experience in using molecular dynamic simulations to describe and interpret results obtained in environmental molecular beam experiments with water and organic compounds.

Employment
Fixed term during a year, full time, 100 % at the Department of Chemistry and molecularbiology

For further information regarding the position
Prof. Jan Pettersson, Atmospheric Science, Department of Chemistry and Molecular Biology, University of Gothenburg. Phone: +46 76622 9072. E-mail: [email protected]

Unions
Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date: February 27, 2020 

 The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

 


In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies. Visa mindre

Postdoctoral stipend within Organic synthesis

Chemistry and Chemical Engineering is the largest department at Chalmers with research ranging from the most fundamental level to a level close to application in industry and society. The research activities reach from DNA-research and biomaterials to high temperature corrosion, catalysis and recycling. The Department is also heavily committed to teaching at the undergraduate, graduate, as well as postgraduate level in these areas. Health, natural resour... Visa mer
Chemistry and Chemical Engineering is the largest department at Chalmers with research ranging from the most fundamental level to a level close to application in industry and society. The research activities reach from DNA-research and biomaterials to high temperature corrosion, catalysis and recycling. The Department is also heavily committed to teaching at the undergraduate, graduate, as well as postgraduate level in these areas.

Health, natural resources, sustainable energy and materials are some of our lead words and our vision is “Through curiosity and knowledge towards a sustainable world”.

We have approximately 300 employees, divided into four research and one administrative division. We are situated at campus Johanneberg in the middle of Gothenburg.


Information about the project
The postdoc stipend is part of a research program aiming at the development of smart self-assembly materials. The aim for this recruitment is to synthesize and characterize composite fibers for activation of small molecules such as hydrogen and carbon dioxide. Activation of small molecules is an important task as they could lead to applications within areas such as hydrogen storage and artificial photosynthesis. The research focus will be on the synthesis of organic molecules that are capable of self-assembly into fibers or gels and applications of these molecules for the above mentioned aim.

The candidate will be working within the Division of Organic chemistry which is a part of the Department of Chemistry and Chemical engineering at Chalmers University of technology. The department has all the necessary synthetic equipment and analytical tools to carry out the intended program. In addition, Chalmers has two research facilities, Chalmers materials analysis laboratory and (CMAL) and Chalmers mass spectrometry infrastructure (CMSI) that have state of the art collection of instrumentation and technical support that can assist the project.

Major responsibilities
The main focus of the project is organic synthesis of small molecules, and their characterization by e.g. NMR but simpler rheological characterization will also be part of the project. The fibers will be analyzed with electron microscopes and other suitable analytical techniques. This gives an excellent opportunity for the candidate to both develop their synthetic skills and learn new techniques and procedures.

Position summary
Full-time temporary employment. The position is limited to a maximum of two years (1+1).

Qualifications
We are looking for a PhD with extensive experience in organic synthesis. The position is highly synthesis oriented and experience with inert techniques such as Schlenk line and/or glovebox are going to be important as some of the reactions involves handling of sensitive reagents. Additional selection criteria include experience from, working with frustrated Lewis pairs or supramolecular chemistry. The successful candidate should be a highly motivated, quality conscious individual with a PhD in fields related to synthetic organic chemistry. You should find it motivating working both alone as in close collaboration with others. As Chalmers is a highly international environment, proficiency in written and spoken English is necessary. As this is a stipend position the PhD exam cannot be older than 2 years due to tax reasons.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Our offer to you
Chalmers offers a cultivating and inspiring working environment in the dynamic city of Gothenburg. 
Read more about working at Chalmers and our benefits for employees.

Application procedure
The application should be marked with Ref 20190412 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document as: CV, Surname, Ref. number) including:
• CV, include complete list of publications
• Previous teaching and pedagogical experiences
• Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)
1-3 pages where you:
• Introduce yourself
• Describe your previous research fields and main research results
• Describe your future goals and future research focus

Other documents:
• Attested copies of completed education, grades and other certificates.

Application deadline: 8 September 2019

For questions, please contact:
Henrik Sundén, [email protected]

*** Chalmers declines to consider all offers of further announcement publishing or other types of support for the recruiting process in connection with this position. *** Visa mindre

Synthetic Chemist

Ansök    Nov 6    AstraZeneca    Organisk kemist
Would you like to apply your synthetic chemistry expertise in a global company where we work together across boundaries to make the impossible a reality? AstraZeneca now offer an exciting opportunity for a senior scientist with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry into design and synthesis of new candidate drugs. As part of an open minded, creative and experienced ... Visa mer
Would you like to apply your synthetic chemistry expertise in a global company where we work together across boundaries to make the impossible a reality?

AstraZeneca now offer an exciting opportunity for a senior scientist with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry into design and synthesis of new candidate drugs. As part of an open minded, creative and experienced team, you will contribute with your high ambitions, collaborative mindset and enthusiasm to push the boundaries of science in the area of synthetic and medicinal chemistry. The positions are placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. We follow the science and turn ideas into life changing medicines for patients suffering from Heart Failure, Diabetes and Chronic Kidney Disease. We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to access the most advanced knowledge and opportunities to stay at the fore-front of science.

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules to identify and validate novel biological targets. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality and we are now further expanding our team working on targeted protein degradation and PROTAC's with this position in synthetic chemistry.

Main duties and responsibilities

The role is lab based and focused in the area of medicinal chemistry with emphasis on synthetic chemistry and in particular PROTACs synthesis and design. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation. The work is done in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, Discovery Sciences, DMPK and Pharmaceutical Sciences departments. There will also be opportunities to develop medicinal chemistry and drug discovery knowledge together with the experts in the department. In addition, you are expected to be part of external collaborations, publish scientific papers, present and represent the department at conferences etc.

Requirements

We are looking for an ambitious team player that have expert knowledge in synthetic organic chemistry. Basic knowledge in medicinal from drug discovery in an industrial setting

* Ph. D. degree in Organic Chemistry/Synthetic Chemistry/Medicinal Chemistry or Master of Science with a few years' experience in synthetic/medicinal chemistry.
* Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
* Scientific creativity: ability to identify, develop and apply new technologies and ways of working
* Great awareness of recent literature within synthesis/medicinal chemistry as well as current developments and trends in organic synthesis
* Highly self-motivated and capable of receiving and analyzing input from complex data and deciding on focused course of action
* Excellent teamwork, collaboration, networking and communication skills
* Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents

If you are interested, apply now!

For more information about the position please contact recruiting manager Dr. Daniel Pettersen,

Welcome with your application no later than December 8th, 2019.

Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Sweden and the wonderful city of Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/



AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

Senior Scientist, Large Scale Synthetic Chemistry

Ansök    Nov 13    AstraZeneca    Organisk kemist
Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that are following the science and turn ideas into life changing medicines. We are now looking to recruit a Senior Scientist focused on large scale syntheti... Visa mer
Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that are following the science and turn ideas into life changing medicines.



We are now looking to recruit a Senior Scientist focused on large scale synthetic chemistry to join the Early Chemical Development (ECD) function within Pharmaceutical Sciences at AstraZeneca. The position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.



Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) across all the AstraZeneca therapy areas.

The ECD team is responsible for developing manufacturing routes and processes as well as delivering batches of drug substance for all projects in the late discovery and early development portfolio.



The Large Scale Synthetic Chemistry team in Gothenburg delivers high-quality API batches in the range of 100-1000 g through development of great chemistry, innovative routes and creative solutions. The laboratory is the single company wide asset for large scale, non-GMP manufacturing of API for pre-clinical toxicology studies for all therapy areas.

We support the projects with the highest priority, most technically challenging chemistry in the AstraZeneca early phase portfolio and have access to top-quality labs and equipment, including e.g. reactors up to 100L, flow- and high-pressure reactors, and a wide range of modern analytical instruments.



Main Duties and Responsibilities



As a member of the Large Scale Synthetic Chemistry team, you will work closely with both medicinal chemists in drug development projects and process chemists to explore and develop safe, efficient and cost-effective synthesis routes to produce drug candidates. Key deliverables are:

*

With strong emphasis on SHE aspects, explore and develop experimental strategies, troubleshoot problems and synthesize organic molecules in the range of 100-1000 grams
*

Plan, prioritise and perform own work and actively collaborate with the drug project synthesis teams.
*

Demonstrate expertise in synthetic and analytical chemistry, purification and crystallisation
*

Provide stringent documentation of experimental results in an electronic labjournal, as well as writing up campaign and development reports.
*

Publish novel work in peer reviewed journals



Essential requirements

*

Ph.D. degree or equivalent in Organic Chemistry
*

Post-graduate research experience, preferably from work with route development and large-scale synthesis of complex organic molecules
*

Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
*

Able to identify, develop and apply new technologies and ways of working within large scale synthetic organic chemistry
*

Ability to independently design, plan and execute multistep syntheses to be able to manufacture kilogram campaigns together with team members
*

Creativity in handling a wide range of synthetic challenges
*

Ability to coach peers for enhanced individual and team performance and development
*

Strong collaborative and communication skills with experience of interacting effectively and work collaboratively across interfaces of disciplines
*

Curious and innovative mindset
*

Passion for solving complex synthetic problems and demonstrate proof of concept for new route



Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have seats available and we hope one is yours.



For more information please contact recruiting manager Hans Emtenäs at



We encourage you to send your application as soon as possible, since interviews will be held continuously, but no later than January 6, 2020.



Learn more about AstraZeneca Gothenburg: https://www.astrazeneca.com/our-science/gothenburg.html

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

Computational / Medicinal Chemist

Ansök    Jun 5    AstraZeneca    Organisk kemist
Are you a skilled Chemist with fruitful experience computer-aided drug design? Do you want to drive the application of AI to new discoveries? Can you imagine yourself contributing to finding life changing drugs? We are looking for a new colleague to join our Molecular AI team. We will make sure that your scientific experience combined with your high ambition and enthusiasm gives you a superb opportunity to influence the development of AstraZeneca's future... Visa mer
Are you a skilled Chemist with fruitful experience computer-aided drug design? Do you want to drive the application of AI to new discoveries? Can you imagine yourself contributing to finding life changing drugs?

We are looking for a new colleague to join our Molecular AI team. We will make sure that your scientific experience combined with your high ambition and enthusiasm gives you a superb opportunity to influence the development of AstraZeneca's future in applying AI to drug discovery projects. Are you ready to join us?

Main Responsibilities

You will have a profound impact on multiple projects across AstraZeneca with a focus on applying Artificial Intelligence to discover new drugs. This will involve:

* Apply a variety of machine learning and artificial intelligence approaches in drug discovery projects, for instance deep learning based molecular de novo generation and synthesis prediction.
* Be responsible for training computational and medicinal chemists in applying ML/AI based tool in drug design
* Identify and drive areas of scientific improvements for applying AI in the field of drug design
* Drive and develop academic collaborations to access the forefront of AI based drug design
* Plan, write and publish high quality scientific papers
* Actively participate in mentoring the cohort of Postdocs, PhD students and Master Thesis students in the team

Essential Requirements

We believe that you have a true passion for computational drug design and the application of AI to drug design. You have a degree in chemistry, computer science or another similar discipline - complemented by experience from molecule design in drug development projects. Your collaboration skills will be of essential importance.

* In-depth scientific knowledge in drug design - confirmed by track record of project deliveries, publications and external presentations
* Excellent written and verbal communication skills
* An ambition to transform the drug design process with AI
* Experience in applying computational tools for drug design



If you are interested, apply now!

For more information about the role please contact Ola Engkvist, +46 31 706 5978.

Welcome with your application no later than June 26th, 2019.



At AstraZeneca we'll make the most of your skills and passion by actively supporting you. To do this, we've built an extraordinary international working environment with outstanding opportunities for collaboration and innovation. If you're encouraged to make a difference and ready to discover what you can do - join us.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre

Associate Principal Scientist - PROTAC Medicinal Chemistry

Ansök    Jun 19    AstraZeneca    Organisk kemist
Are you a skilled Synthetic Chemist with experience of working with PROTACs? Are you ready to bring new ideas and fresh thinking to the table? At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and cu... Visa mer
Are you a skilled Synthetic Chemist with experience of working with PROTACs? Are you ready to bring new ideas and fresh thinking to the table?

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

This APS position is placed in the Department of Medicinal Chemistry of Respiratory, Inflammation & Autoimmunity (RIA) - right in the middle of AstraZeneca's vibrant R&D site in Sweden hosting around 2500 employees with a great diversity of scientific expertise and nationalities.

RIA´s Medicinal Chemistry department is working across small to large sized synthetically accessible therapeutic modalities. This includes small molecules, peptides, oligonucleotides and conjugates. We are currently further expanding our portfolio in the area of Proteolysis Targeting Chimeras (PROTACs). To advance the RIA project pipeline, a newly formed PROTAC team operates in a cross-disciplinary therapeutic area environment in close collaboration with biologists, DMPK and safety experts as well as pharmaceutical scientists.

You will join highly integrated project teams focused on the discovery of PROTAC based drugs. The position includes the identification and optimization of PROTACs up to clinical candidate stage. As a RIA authority in the field of PROTACs you contribute to specific RIA projects - as chemistry lead in a drug discovery project, including management of external resources and collaborations.

We are looking for a person with a strong scientific background in Medicinal Chemistry and previous experience in working on PROTACs. You have excellent verbal and written communication skills and the ability to engage and collaborate across boundaries. We believe that you are person with a problem-solving attitude and delivery focus, and a strong interest to continuously develop new skills in Medicinal Chemistry. Embedded in a strongly science driven environment, this position certainly includes opportunities to share scientific findings at conferences and publish novel science.



Main Duties and Responsibilities

* Design, synthesis and optimization of novel PROTACs up to clinical candidates
* Representation of Medicinal Chemistry as chemistry lead in respiratory project teams
* High level Medicinal Chemistry expertise to efficiently deliver within agreed timelines
* Proactively influence uptake of PROTACs as modalities into RIA portfolio where suited
* Efficient collaboration with biologists, DMPK and safety experts and pharmaceutical scientists
* Collaboration with academic partners and CROs
* Support extension of AstraZeneca´s scientific expertise with respect to the application of PROTACs for respiratory disease (inhalation, lung distribution and delivery aspects for PROTACs)
* Drive RIA´s scientific reputation by contributing conference presentations and publications together with internal and external partners



Essential Requirements

* PhD in Organic Chemistry or Medicinal Chemistry; post-doctoral experience is a plus
* Professional experience in Medicinal Chemistry and PROTACs, either in the Pharmaceutical Industry or in academia
* In-depth scientific knowledge of recent developments in PROTAC Medicinal Chemistry and modern synthetic methods
* A proven track record of delivery from own experimental work
* Excellent communication, influencing and collaboration skills
* Knowledge of the pharmaceutical drug discovery and development process



Are you ready to make a difference? Send in your application, and we'll make it happen together.



For more information about the position please contact:

Lena Ripa, RIA Medicinal Chemistry, at Lena.



Welcome with your application no later than July 7th, 2019!



Our Location

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre

(Associate) Principal Scientist - Oligonucleotide Design

Ansök    Maj 20    AstraZeneca    Organisk kemist
Are you ready for an exciting career in a company where absolutely everyone can thrive? Are you an experienced scientist, specialized in Oligonucleotide Design? Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours. Our Mission AstraZeneca is committed to the development of the next generation innovative respiratory medicines. The New Modalities (NMs) Chemistry team in RIA leads the... Visa mer
Are you ready for an exciting career in a company where absolutely everyone can thrive? Are you an experienced scientist, specialized in Oligonucleotide Design? Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

Our Mission

AstraZeneca is committed to the development of the next generation innovative respiratory medicines. The New Modalities (NMs) Chemistry team in RIA leads the efforts focused on expanding the use of novel peptide and oligonucleotide-based modalities and molecular conjugates in the treatment of respiratory diseases. The New Modalities team achieves this in close collaboration with computational chemists as well as scientists in the Bioscience, Translational Science & Bioinformatics, DMPK and Pharmaceutical Sciences departments - all joined by the goal to discover the respiratory medicines of the future.

As an Associate Principal Scientist/Principal Scientist in the Computational Chemistry team, you are surrounded by computational chemists specialized in the design of both SMs and NMs based therapeutics. As a RIA authority in the field of oligonucleotide design, you contribute as an active project team member to the selection and design of new oligonucleotides to specific RIA projects, in close collaboration with colleagues in other departments. In addition, you will influence the selection of portfolio targets by highlighting opportunities for therapeutic application of oligonucleotides. Overall, you will be part of RIA oligonucleotide projects from target selection to identification of clinical candidates.

Main Duties and Responsibilities

We expect you to have excellent interpersonal skills necessary for working in our multidisciplinary environment and to act as mentor for more junior colleagues.

Furthermore, you have an excellent scientific background with strong written and oral communication skills supplemented by an ability to engage and collaborate across boundaries with a proactive attitude and a clear delivery focus.

You will get the opportunity to:

* Lead oligonucleotide/sequence design in individual project teams as active project team member
* Actively impact RIA´s target portfolio by suggesting options for oligonucleotides for both target validation and therapeutic use, leveraging state of the art oligonucleotide design
* Collaborate seamlessly with RIA´s bioinformatics experts
* Contribute to internal projects and collaborations with external partner organizations
* Analysis of mRNA/microRNA target sites for ASOs/siRNAs/antimiRs to support generation of RNAi oligonucleotide libraries
* Identify suitable mRNA sequence regions for RNAi (UTRs, coding regions)
* Identify and correlate sequence and potency parameters for optimization
* Project specific display of sequence alignments and potency data
* Drive RIA IMED scientific reputation by identifying and progressing publication opportunities internally, across AZ and/or together with external partners
* Contribute to conference and project presentations internally and externally

Essential Requirements

* PhD in bioorganic, bioinformatics or computational chemistry
* In-depth knowledge of recent developments in oligonucleotide drug discovery
* Robust understanding of mechanism of action of oligonucleotide therapeutics (alternative splicing, steric blocking of protein translation, RNAaseH activity, RISC loading, splice switching, immune stimulation)
* Expertise in conformational/secondary/tertiary structure analysis of mRNA
* Expert user of ASO modeling software for e.g. prediction of ASO-target binding energies
* Basic knowledge in prediction of potential off-target interaction and toxicity

Desirable Requirements

* PostDoc experience and professional experience in drug discovery of oligonucleotide drug candidates

More information

For more information about the position please contact Dr. Werngard Czechtizky, Head of Medicinal Chemistry, IMED RIA, at or via LinkedIn.

Please send your application no later than June 15th, 2019.



Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.



Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ Visa mindre

Associate Principal Scientist - PROTAC Medicinal Chemistry

Ansök    Maj 17    AstraZeneca    Organisk kemist
Are you a skilled Synthetic Chemist with experience of working with PROTACs? Are you ready to bring new ideas and fresh thinking to the table? At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and cu... Visa mer
Are you a skilled Synthetic Chemist with experience of working with PROTACs? Are you ready to bring new ideas and fresh thinking to the table?

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

This APS position is placed in the Department of Medicinal Chemistry of Respiratory, Inflammation & Autoimmunity (RIA) - right in the middle of AstraZeneca's vibrant R&D site in Sweden hosting around 2500 employees with a great diversity of scientific expertise and nationalities.

RIA´s Medicinal Chemistry department is working across small to large sized synthetically accessible therapeutic modalities. This includes small molecules, peptides, oligonucleotides and conjugates. We are currently further expanding our portfolio in the area of Proteolysis Targeting Chimeras (PROTACs). To advance the RIA project pipeline, a newly formed PROTAC team operates in a cross-disciplinary therapeutic area environment in close collaboration with biologists, DMPK and safety experts as well as pharmaceutical scientists.

You will join highly integrated project teams focused on the discovery of PROTAC based drugs. The position includes the identification and optimization of PROTACs up to clinical candidate stage. As a RIA authority in the field of PROTACs you contribute to specific RIA projects - as chemistry lead in a drug discovery project, including management of external resources and collaborations.

We are looking for a person with a strong scientific background in Medicinal Chemistry and previous experience in working on PROTACs. You have excellent verbal and written communication skills and the ability to engage and collaborate across boundaries. We believe that you are person with a problem-solving attitude and delivery focus, and a strong interest to continuously develop new skills in Medicinal Chemistry. Embedded in a strongly science driven environment, this position certainly includes opportunities to share scientific findings at conferences and publish novel science.



Main Duties and Responsibilities

* Design, synthesis and optimization of novel PROTACs up to clinical candidates
* Representation of Medicinal Chemistry as chemistry lead in respiratory project teams
* High level Medicinal Chemistry expertise to efficiently deliver within agreed timelines
* Proactively influence uptake of PROTACs as modalities into RIA portfolio where suited
* Efficient collaboration with biologists, DMPK and safety experts and pharmaceutical scientists
* Collaboration with academic partners and CROs
* Support extension of AstraZeneca´s scientific expertise with respect to the application of PROTACs for respiratory disease (inhalation, lung distribution and delivery aspects for PROTACs)
* Drive RIA´s scientific reputation by contributing conference presentations and publications together with internal and external partners



Essential Requirements

* PhD in Organic Chemistry or Medicinal Chemistry; post-doctoral experience is a plus
* Professional experience in Medicinal Chemistry and PROTACs, either in the Pharmaceutical Industry or in academia
* In-depth scientific knowledge of recent developments in PROTAC Medicinal Chemistry and modern synthetic methods
* A proven track record of delivery from own experimental work
* Excellent communication, influencing and collaboration skills
* Knowledge of the pharmaceutical drug discovery and development process



Are you ready to make a difference? Send in your application, and we'll make it happen together.

For more information about the position please contact:

Lena Ripa, RIA Medicinal Chemistry, at

Welcome with your application no later than June 15th, 2019!



Our Location

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Visa mindre

Senior Scientist - Synthetic / Medicinal Chemistry

Ansök    Maj 17    AstraZeneca    Organisk kemist
Are you a skilled Synthetic Chemist dedicated to use your scientific skills to make a difference? Do you enjoy a collaborative and creative working atmosphere? Would you like to join a company where absolutely everyone can thrive? At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible ... Visa mer
Are you a skilled Synthetic Chemist dedicated to use your scientific skills to make a difference? Do you enjoy a collaborative and creative working atmosphere? Would you like to join a company where absolutely everyone can thrive?

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

This position is placed in the department of Medicinal Chemistry of Respiratory, Inflammation & Autoimmunity (RIA) - right in the middle of AstraZeneca's vibrant R&D site in Sweden.

RIA´s Medicinal Chemistry team is focused on driving discovery research to deliver world-class medicines with an emphasis on small to large sized synthetically accessible molecules. This includes classical small molecules, peptides, oligonucleotides - and Proteolysis Targeting Chimeras (PROTACs). Right now, we are further expanding our portfolio in the PROTAC area. Our team operates in a cross-disciplinary environment in close collaboration with biologists, DMPK experts and Pharmaceutical Scientists to advance the RIA project pipeline.

You will join a highly integrated discovery team leveraging innovative Medicinal Chemistry to invent novel medicines. Your focus will be on synthesis, purification and characterization of lead molecules from target validation to lead optimization - certainly including compound design and Medicinal Chemistry aspects with a focus on PROTACs. You will ensure uptake of novel scientific developments in synthetic Organic Chemistry into project teams and influence compound design by generating completely novel ideas for our molecules.

We are looking for a person with a strong scientific background in Organic Chemistry including excellent verbal and written communication skills and the ability to engage and collaborate across boundaries. We see you as a person with a problem-solving attitude and delivery focus, as well as a strong interest to continuously develop new skills in Medicinal Chemistry. Embedded in a strongly science driven environment, this position certainly includes opportunities to share scientific findings and publish novel science.



Main Duties and Responsibilities

* Actively contribute to RIA´s PROTAC portfolio projects with compound design and synthesis
* Provide state-of-the-art Synthetic Chemistry to projects at all stages of drug discovery
* Deliver high quality drug molecules and tool compounds
* Apply synthetic skills with an idea generation mindset, learning to efficiently troubleshoot Medicinal Chemistry problems while maintaining a clear focus and impact on project progression
* Continuously expand expertise in PROTAC Medicinal Chemistry aspects
* Drive RIA´s scientific reputation by identifying and contributing to publication opportunities internally, across AZ and/or together with external partners
* Follow safety requirements and all AZ corporate responsibility policies



Essential Requirements

You are a creative scientist with a strong synthetic background and the desire to rapidly develop as Medicinal Chemist. We believe that being successful in this position requires:

* PhD in Organic Chemistry, Medicinal Chemistry or Biochemistry
* Excellent skills in Organic Synthesis
* Up-to-date with modern purification and analytical techniques
* Excellent communication and collaboration skills



Desirable Requirements

* Postdoctoral and/or industrial experience is a plus
* PROTAC experience is a significant plus
* Basic knowledge of drug discovery in the pharmaceutical industry is a plus



Are you ready to make a difference? Send in your application, and we'll make it happen together.

For more information about the position please contact:

Lena Ripa, RIA Medicinal Chemistry, at



Welcome with your application no later than June 15th, 2019!



Our Location

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.



Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ Visa mindre