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Do you want to expand your knowledge of the non-clinical safety assessment of the next generation of cell therapies and regenerative medicines? AstraZeneca is looking to build their capabilities in this area to complement the outstanding reputation we have in the development of advanced therapeutic medicines.

We are now looking for a Senior Scientist to join our CVRM Safety Group in Clinical Pharmacology and Safety Sciences (CPSS). The position will be based in Gothenburg, Sweden where we are significantly investing in the Lab4Life design of our R&D building. This will create the collaborative environment across our disciplines to drive the innovation required for 21st century pharmaceutical research.

In the role as Senior Scientist - Stem Cell Therapy Safety, you will need experience in the field of stem cell biology/regenerative medicine and therapeutic approaches - ideally within the discipline of cardiovascular therapeutic safety assessment. You will be responsible for investigating improved ways to assess the safety of AstraZeneca's regenerative medicine portfolio, including; cardiac cell regenerative therapies and cellular delivery systems, plus other such novel modalities that are rapidly changing the therapeutic landscape.

Main duties and responsibilities

One of your key research activities will be the development of new in vitro models to predict and assess the toxicity, immunogenicity and tumorigenicity of cell and regenerative medicine modalities. You will also gain wider experience of the general toxicological assessment of novel therapeutics and work closely with scientists from every part of Clinical Pharmacology and Safety Sciences and beyond. You will support pioneering therapeutics by discovering and applying fundamental biological principles to help answer the critical questions the field faces today.

You will identify and solve problems, championing science and technology innovations to develop our strategic capabilities and collaborate with leading academics, publish in high quality journals and actively contribute to scientific discipline networks. By driving innovation, helping to secure intellectual property, and contributing to presentations and publications you will develop your own and AstraZeneca's scientific position.

Essential requirements

* PhD or equivalent scientific qualification in stem cellular biology or a related subject
* Preferably with significant post-doctoral practical experience of cell therapies and/or safety assessment
* Demonstrated ability to work in multi-disciplinary teams with effective communication skills: including presenting, manuscript preparation, influencing and relationship building
* Excellent publication record
* Ability to comply with Good Laboratory Science standards, Safety, Health and Environment standards and other relevant external regulation.

If this sounds like the job for you - apply today!

We look forward to your application no later than the 1st March, 2020.

More information
For more information about the position, please contact hiring manager Mick Fellows at Visa mindre

Are you a quantitatively-minded scientist looking to apply bioinformatics and machine learning to design antisense oligo nucleotides in drug discovery? Would you like an exciting new challenge in a company that follows the science and turn ideas into life changing medicines? Then why not join our Quantitative Biology team in Gothenburg, Sweden!

We are now recruiting a Senior Bioinformatician in Quantitative Biology to join the Discovery Sciences organization in Gothenburg, Sweden.

Discovery Sciences work with all AstraZeneca's therapy areas to deliver candidate drugs into late-stage clinical development. The Quantitative Biology team is a multi-disciplinary team of data scientists with the purpose of providing quantitative insights to biology. We do so by improving the biological understanding of the target and its engagement, including supporting the identification of molecular mechanisms of action, building a platform for antisense oligonucleotide design providing image and data analysis solutions to high dimensional datasets, and by enhancing AstraZeneca's ability to prioritize target selection and portfolio projects based on probability of technical success.

As a Senior Bioinformatician your main responsibilities will involve:

* Using bioinformatics and machine learning you will collaborate with antisense oligonucleotide drug discovery projects to identify and deliver antisense oligonucleotide sequence designs
* Developing or internalizing appropriate algorithms, techniques and datasets to advance our ability to rapidly discover antisense oligonucleotide candidate drugs
* Building knowledge of and creating data analysis capabilities, typically on complex, high-dimensional -omics data to identify biologically induced effects of antisense oligonucleotides
* Contributing to and leading local and global projects for NGS applied in antisense oligonucleotide projects
* Ensuring that results are scientifically robust and documented

Essential Requirements

* PhD, or equivalent, in bioinformatics, mathematics, computer science, statistics, engineering or the life sciences
* Expertise in one or more of the core competency areas: DNA sequence analysis, next generation sequencing analysis, multivariate and/or high dimensional data analysis (-omics), ontologies, data management, machine learning, statistical modelling,
* Experience with relevant software tools such as R, Python, Shiny, Spotfire, Java, C/C++, /No/RDF, JavaScript
* Basic understanding of molecular biology, cell biology, and human physiology
* Excellent English, spoken and in writing

If you are interested - apply now!

Welcome with your application no later than February 28th, 2020.

More information
For more information about the position please reach out to contact person Fredrik Karlsson at Fredrik.h.karlsson(at)astrazeneca.com. Visa mindre

Do you want to make a difference for millions of patients by applying your expertise in a global company that follows the science and turn ideas into life changing medicines? At AstraZeneca, science is at the core of everything we do. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

AstraZeneca is now recruiting a Clinical Program Director (CPD) to join Early Respiratory, Inflammation and Autoimmune (RIA) Clinical Development. The position is located at either of AstraZeneca's vibrant R&D sites in Gothenburg, Sweden or Cambridge, UK.

Early RIA clinical development is a dedicated clinical scientific resource for AstraZeneca's early development portfolio (phase I to IIb), which provides a translational medicine capability to rapidly understand the disease target and the potential of our candidate drugs in humans. You will work where science meet patients and you will be joining at an exciting time of respiratory drug discovery and development, where we have a number of innovative assets in the pipeline.

The Clinical Program Director is a senior clinical program leader ensuring that each assigned clinical program is delivered to time, quality and cost. The role provides strategic input and final feasibility view into design of the clinical program and plays a key role in the work required to determine possible program design options, mainly in early clinical development programs. The focus is across the program level collaborating with the Development Operations (Dev Ops) organization, Program Team counterparts, and all other functions that are key to the development of a compound.



Main Duties and Responsibilities

* Translating science into crisp and robust clinical development plans, including operational design options for assigned program.
* In collaboration with Clinical Scientific Lead (Medical Director or Director of Clinical Science) accountable for the clinical program strategy, including innovative approaches to delivery, e.g., new delivery platforms and technology to ensure patient engagement, recruitment and retention.
* Program team leadership to achieve and maintain a high performing clinical team and to deliver excellence in clinical program management to maximize team performance and drive delivery
* Leadership and oversight of program strategy activities within each assigned program.
* Providing strategic and operational input to cross-functional program development plans and accountable for cross-functional leadership roles as delegated from the Project Team, e.g., leadership of cross-functional development team activities.
* Development and management of contingency risk plans within each assigned clinical program to ensure delivery to quality, budget and timelines, including management of issue escalation and resolution.
* Ensure consistent quality practices in alignment with highest ethical standards, GCP, ICH Guidelines, compliance with internal SOPs, local regulations and laws, etc.
* Contribute to scientific interpretation of clinical data.
* Ensuring timely compliance with company-wide governance controls.



Essential Requirements

* Bachelor of Science/Arts degree in related discipline, preferably in medical or biological science. Advanced degree is preferred.
* At least 12 years global drug development experience demonstrated in a variety of related roles.
* Leadership and strategic influencing skills with ability to influence broadly within and outside the organisation, motivate program team members, and build cross-functional program teams.
* Proven ability to develop clinical programs to meet business goals and to assess business risk versus potential value; ability to understand global business requirements.
* Experience of clinical program management and use of project management techniques in complex projects, including resourcing and financial management.
* Experience in clinical trial methodology with ability to deliver differentiated options based on sound knowledge of operational delivery.
* Extensive and proven experience in driving operational delivery to timelines, cost and quality.
* Proven experience of leading delivery through collaboration within globally matrix teams, including internal organization and external providers.
* Experience in selection and oversight of external providers and development/review of contracts.
* Strong collaborative communication skills including ability to engage with diverse client base and manage through conflict.
* Strategic skills including high level of creativity, innovation, and solution focused problem solving with ability to manage effectively through ambiguity
* Willingness to travel



If you are interested, apply now!

For more information about the position, please contact Sara Samuelsson at sara.samuelsson(@)astrazeneca.com

Welcome with your application no later than March 1, 2020

For more information about life in Gothenburg visit www.movetogothenburg.com Visa mindre

Are you a scientist with an interest in the development of novel treatments for patients with respiratory, inflammation and autoimmunity diseases? Are you open for an opportunity to apply your expertise in immunology in a company that is accelerating innovative science and turns ideas into life changing medicines? Welcome to join us on our journey to ease the lives of patients with respiratory and autoimmune diseases!

At AstraZeneca, we are now looking to strengthen our Respiratory, Inflammation and Autoimmunity (RIA) Safety department with an experienced Principal Scientist Immunotoxicology. This position will be based at one of our three strategic R&D sites in Gothenburg (Sweden), Cambridge (UK) or Gaithersburg, MD (US).

The Respiratory, Inflammation and Autoimmunity (RIA) Safety department is a leading safety organization that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel treatments for patients with respiratory, inflammation and autoimmunity diseases. We are a diverse international department across Sweden, UK and US that comprises project toxicologists, discovery safety specialists, respiratory safety experts, experimental scientists, a.o.

As part of Clinical Pharmacology & Safety Sciences (CPSS), which contains all non-clinical safety functions that support the entire AstraZeneca Portfolio, we have a strong focus on talent development. You will be able to make a difference in drug development by deploying and developing your skills, competences and scientific leadership, working together with experts in investigative toxicology, drug discovery and development, cell biology, predictive safety science, pharmacology, and regulatory toxicology.

The role

As a Principal Scientist Immunotoxicology, you will combine expertise in immunology and drug safety with experience in drug development. You should hold strong communication skills with the ability to influence across geographical and organizational dimensions and have the drive to contribute to our team culture - in which trust, cooperative support, diversity and inclusion enable engaged and motivated colleagues to deliver and develop.

Your main responsibilities will involve:

* Developing and implementing a comprehensive immunotoxicology strategy for drug discovery and development programs and diverse drug modalities across our Respiratory, Inflammation and Autoimmunity (RIA) portfolio, and align and contribute to the global immunotoxicology strategy across our therapeutic areas.
* Design platform- and project-specific in vitro and in vivo strategies to predict, assess and mitigate modality-, target- and drug-related immune-safety risks and execute through internal and external experimental capabilities.
* Integrate disease-specific immune dysfunction context to drive patient-centric risk assessment approaches.
* Engage with internal and external world-leading experts to develop, refine and implement innovative experimental strategies and apply to assess and/or provide mechanistic understanding of immune-safety issues.
* Develop innovative research proposals to pursue cutting edge science and technologies in order to optimize and influence immune-safety assessment of novel therapies in the RIA space.
* Operate and communicate with stakeholders across international boundaries and across R&D functions to provide insight and judgement on immunotoxicology aspects to enable successful candidate selection and clinical development of projects in the RIA portfolio.
* Contribute to development and delivery of the department strategy.

Essential Requirements:

* A PhD education in Immunology, Lung disease biology, Toxicology or a relevant life-science subject.
* Experience working within a pharmaceutical or biotech company, with a primary focus on immunology, respiratory or toxicology science and with knowledge and experience of drug development. Alternatively, experience working in a senior role at a leading academic research institution (or contract research organization) with experience of collaborating with pharmaceutical companies, with a primary focus on immunotoxicology and/or respiratory science.
* A strong scientific track record in the field.
* Demonstrated ability to translate complex research questions into innovative experimental strategies to inform translational understanding of pharmaceuticals.
* Eagerness for scientific excellence, investigation of mechanisms of toxicity and translation of insights to risk assessment.
* Specific experience with inhaled pharmaceuticals, immunogenicity, drug hypersensitivity and/or lung immunology is an advantage.

If this sounds like the opportunity for you - apply today!

We look forward to your application no later than 8th March 2020.

More information
For more information about the position please contact Hiring Manager Jorrit Hornberg, Global Head of RIA Safety, at Visa mindre

At AstraZeneca we use scientific excellence as the foundation to drive success of our drug discovery pipeline. Such excellence stems from strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery. Right now, we have an opportunity available for a highly motivated Senior Research Scientist to join the Protein Expression Team within Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D in Gothenburg, Sweden. Is this your next challenge?

Leading from the bench, you will apply proven skills in molecular biology, recombinant protein expression, a passion for investigating scientific questions, combined with strong team working ethics, to drug discovery projects. You will join our team whose remit is to support drug discovery projects globally with delivery of impactful recombinant protein reagents used for disease target identification and validation right through to clinical candidate evaluation.

As part of a team within the Discovery Sciences organisation, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate.

Main Duties & Responsibilities

This is a lab-based role, generating bespoke protein reagents to support projects in all phases of the discovery process. The role involves application of leading molecular biology techniques to design expression constructs, make DNA constructs for protein expression, producing recombinant proteins that impact projects, as well as troubleshooting. In addition, you will be required to make a significant contribution to the development and application of novel science to advance our capabilities in the production of molecular biology tools used in early drug discovery.

Essential Requirements

* Ph. D in Molecular Biology, Biotechnology, Cell Biology, Biochemistry or a related discipline, or 5 years of relevant working experience within Biotechnology
* Substantial expertise in molecular biology using a variety of techniques (Golden Gate, Gibson assembly or similar techniques)
* Experience in design of DNA constructs for recombinant protein production is essential
* Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines
* Proven ability in providing technical leadership and guidance to others
* Maintain an awareness of relevant scientific and technical advances to help identify opportunities for capability development

Desirable Requirements

* Experience in design of DNA constructs for other applications such as cell line generation for assay is highly desirable
* Experience in use of automation equipment such as liquid handling platforms is desirable
* Experience in cell culture and recombinant protein expression is desirable
* Good understanding of drug discovery and how to contribute with scientific expertise within own area of expertise to drive project progression
* Scientific visibility and leadership through project contributions, internal presentations and external publications
* Excellent problem-solving skills, not limited to own area of expertise
* Clear and firm decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
* Track-record in publishing scientific manuscripts in peer-reviewed journals, and presenting at external conferences

Apply today and come join AstraZeneca and our great place to work!

We look forward to your application no later than the 2nd March, 2020.

More information
For further details around this position you are welcome to contact the recruiting manager Robert Roth (phone +46725826411; email: ).

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Our entire business is transforming at pace. We're on a journey to become a data-led enterprise from IT through to R&D. We've come so far, but in many ways we're just getting started…



There's no better place, or time, to join. We're investing like never before in our people, in growth, and in new techniques and technologies. There are opportunities at every turn, with a variety and breadth that is uncommon to find.



Scientists at AstraZeneca are working every day to turn science fiction into science fact. Our dream - to develop innovative, targeted medicines for every patient that needs them - and to match those treatments to patients most likely to benefit from them - is now becoming a reality. This approach, known as Precision Medicine, is based on those individual characteristics that make some patients respond to treatment better than others. We use this knowledge to develop diagnostic tests that doctors can use to help prescribe the best treatment for each patient. Indeed, it's now become common practice for patients with cancer to be offered such diagnostic tests before their treatment plan is agreed



The Diagnostic Science group within Precision Medicine transform data and innovative technologies into future diagnostic options to match patients' needs. Two areas of focus within this group are Diagnostic Data and AI technologies and next generation medicines and early detection.



We are seeking a Radiomics Scientist - Biomedical Imaging to join the group.



The role:



In this role you will use your expertise in machine learning to develop innovative quantitative imaging approaches for improving prognosis, diagnosis and prediction of treatment response across therapeutic areas (Oncology, Respiratory, Cardiovascular) and imaging modalities (digital pathology, CT and PET). You will be leading projects from prototyping through delivering clinical trial ready solutions. To achieve this, you will scout technologies and work in a highly multidisciplinary environment with diagnostic experts, clinicians, statisticians and IT professionals. This is an opportunity to transform data and innovative technologies into future diagnostic options to match patients´ needs.



Typical Accountabilities, what you will be doing:

* You will lead the development of radiomic approaches that can be implemented in AstraZeneca clinical trials
* Identify key opportunities where machine learning can create more value from biomedical images (e.g. virtual biopsy or delta radiomics approaches)
* You'll prototype and validate models in collaboration with internal or external partners.
* Build a radiomics workflow (incl. segmentation, feature extraction and modelling) to standardize image pre-processing and effectively analyse imaging data and enable integration with omics and clinical data
* You will identify and engage with external collaborators to develop applications for clinical trial deployment and regulatory approval.
* Report and present results internally and externally.



Education, Qualifications, Skills and Experience

Essential:

* PhD degree in Machine Learning, Biomedical Image Analysis, Computer Vision or similar.
* Experience in applying deep learning to analyse pathology, CT or PET images evidenced by publications.
* A passion to apply machine learning to tackle difficult problems in precision medicine.





Desirable:

* Successful development of imaging solutions in a clinical environment
* Experience deploying applications in the cloud.
* Knowledge of regulations and standards in clinical research.





Role can be considered at career levels E - G depending on the suitability and experience of the successful candidate.



Next steps, if you feel you are suitable for the position please apply.



Location: Cambridge, UK or Gothenburg or Stockholm, Sweden

Salary: Competitive + Excellent Benefits

Closing Date: Friday 20th October 2019 Visa mindre

Are you a medical doctor with passion for science? Would you like to apply your expertise to impact exciting science into life changing medicines? Then AstraZeneca might be of interest to you!

Patient Safety at AstraZeneca is now looking for Safety Physicians to join our team in Gothenburg, Sweden. We are offering opportunities at different levels (e.g. Safety Physicians, Senior Safety Physicians and Principal Safety Physicians) depending on your expertise and previous experience.

The core purpose of AstraZeneca Patient Safety is to add value to AstraZeneca products, provide clear science-based guidance for investigators and prescribers to safeguard patients as well as the success of our business. Patient Safety covers the entire clinical life cycle of a drug from first time into man to withdrawal of a product from the market.

What's in it for you? You will get the opportunity to engage with key internal and external stakeholders to provide scientific leadership and channeling our scientific capabilities to make a positive impact on changing patients' lives. You will get a broad global exposure to other functions involved in the R&D process within AstraZeneca, as well as an overview of how strategic direction is set within the Clinical function and how decisions are made during drug development. Your work will be integrated with cross-functional teams in Clinical Development using your expertise to put a wide variety of issues into a clinical context to make informed decisions.

You will be responsible for providing medical expertise regarding the safety profile of the product(s) and the disease area while representing the patient and Health Authority perspective. This involves working closely together with global colleagues both from within the Patient Safety Department as well as other groups in AZ. Your key tasks will include using medical judgment to understand case histories, reviewing safety data in various formats to determine any findings of potential importance, helping identify, communicate and manage safety risks and providing a Patient Safety position in meetings and documents.

Who are you? You who will accept the challenge has a Medical Degree, experience from clinical practice and preferably also experience from pharmaceutical industry R&D work. PhD degree is meriting. You have a broad understanding about Health Authority regulations and Good Clinical Practice Standards and if you have experience from working with safety evaluation and risk management - that's great! At AstraZeneca you will fit right in if you thrive on team work, networking, communication and the ability to influence both people and science.

This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

We would like to know more about you. If you are interested, apply now!

For more information about the position please contact Kristina Johnsson (CVRM) at kristina.m.johnsson(at)astrazeneca.com or Per Arkhammar (RIA) at per.arkhammar1(at)astrazeneca.com
We encourage you to send your application as soon as possible, since interviews will be held continuously, but no later than March 8, 2020.

More information:

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Culture and atmosphere of the site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Life in Gothenburg and Sweden: https://www.movetogothenburg.com/ Visa mindre

AstraZeneca is a global, science-driven biopharmaceutical company with a pipeline of exciting new medicines with an array of modalities. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients.

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult Situations because we are committed to doing the right thing.

Our Development Quality team ensures the delivery of safe, effective and compliant medicines to patients participating in global clinical studies. We set standards and apply scientific and Quality expertise to our exciting drug pharmaceutical development portfolio and help maintain our reputation and license to operate. We also play an important part in the commercialisation of new medicines, working closely with our colleagues in Operations. Development Quality is a Global group, with teams located in Macclesfield, (UK), Gothenburg (Sweden), Durham (North Carolina, US), Gaithersburg (US), Redwood City (US) and Bad Homburg (Germany).

We are now looking for a Business Process Owner for our processes, to strengthen our Development Quality team!

The role will be accountable for the portfolio of DevQ Business Process, ensuring the the effectiveness and transparency of our processes. Besides being a process owner, you will also coach and advise other process owner and ensure continuous learning across all processes. Besides being a process owner, you are representing DevQ as a Lead Quality Advisor. As Lead Quality advisor, you are the prime source of Product Quality and GMP advice and Leadership to Drug Project, Supply Chain and improvement project teams, or functions, across Development. Ensuring, and Quality is built into products and processes right through the Development Quality Value chain to commercialisation.

Main duties and responsibilities

- Have a clear understanding between the relationship between operational requirements of a business corporate strategy and customer satisfaction
- Coach and advisor for defining a portfolio of process improvement in the organisation
- Recognise opportunities for improvement in respect to process portfolio management
- Accountable for deployment of AstraZeneca Business Process Framework standard and mentor all process owners
- Facilitate the business area leadership team in the identification and remove barriers
- Ensure risks of the process portfolio management are identified and mitigated

- Develop solutions to a diverse range of problems that require complex judgements, using highly developed levels of conceptual thought, strategic vision and analysis
- Operate confidently as part of a global organisation with an integrated mindset to create an organisation with common processes and ways of working
- Drives, role models and supports a strong lean culture that promotes standardisation, simplification and continuous improvement

Essential Requirements

*

Appropriate scientific degree with extensive experience (5-10 years) and with a reputation of working within a pharmaceutical GMP environment, preferably within a pharmaceutical development organisation
*

Proven and strong experience in Business Process Management
*

Strong engagement, communication and stakeholder management skills, including excellent presentation and influencing skills
*

Good knowledge and insight in IT systems
*

Problem-solving attitude, preferable LeanSix Sigma certification

To succeed in this role, you need to have excellent team working and networking skills and encourages team effectiveness. You are a good communicator with experience of interacting effectively across interfaces. You enjoy building excellent relationships both internally and with external suppliers or service providers. As a person, you demonstrate independent judgement and uses risk management in complex situations, and you demonstrate drive and energy in the role to make a difference.

We would like to know more about you. If you are interested, apply now!
Welcome with your application no later than February 16, 2020. For more information about the position, please contact Hiring Manager Anders Karlsson, at anders.karlsson1(at)astrazeneca.com Visa mindre

Do you have expertise in molecular biology and share our passion for exploring scientific questions? Great - we have an opportunity available for a highly motivated Research Scientist to join the Protein Expression Team within the Discovery Sciences Innovative Medicine (IMED) Biotech Unit in Gothenburg, Sweden.

Welcome to apply today and join AstraZeneca on our journey using excellence as the foundation to drive success of our drug discovery pipeline!

Leading from the bench, you will apply proven skills in molecular biology, recombinant protein production, a passion for investigating scientific questions, combined with strong team working ethics, to drug discovery projects. You will join our team whose remit is to support IMED projects globally with delivery of impactful recombinant protein reagents used for disease target identification and validation right through to clinical candidate evaluation.

As part of a team within the Discovery Sciences organisation, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate.

Main Duties & Responsibilities

This is a lab-based role, generating bespoke molecular biology and protein reagents to support projects in all phases of the discovery process. The role involves application of leading molecular biology techniques to design and make expression constructs, producing recombinant proteins that impact projects, as well as troubleshooting.

Essential Requirements:

* BSc/MSc in Molecular Biology, Biotechnology, Biochemistry or a related discipline
* Substantial expertise in molecular biology using a variety of techniques (Golden Gate, Gibson assembly or similar techniques)
* Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines

Desirable Requirements

* Demonstrable experience in common methodologies for recombinant protein expression such as transient transfection of mammalian cells and baculovirus infected insect cells
* Experience in design of DNA construct for recombinant protein expression is highly desirable
* Experience of automation of molecular biology work flows is highly desirable
* Excellent problem-solving skills

If this sounds like the job for you - please apply today!

More information
For further details around this position you are welcome to contact the recruiting manager Robert Roth (phone +46725826411; email: ). To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them. Visa mindre

Imagine turning your burning passion for science into medicines that change lives whilst working in an agile environment that stimulates your scientific curiosity. Science is what drives AstraZeneca - we keep pushing the boundaries of science to deliver life -changing medicines that address significant unmet medical need in diseases affecting millions of people around the world. If you share our desire to make a real difference to the lives of patients, now and in the future then this might be the role for you!

Respiratory is one of AstraZeneca's main therapy areas. Our aim is to transform asthma and COPD treatment through inhaled combinations at the core of care, biologics for the unmet needs of specific patient populations, and scientific advancements in disease modification. From a research perspective we work to understand, treat, modify and ultimately cure respiratory disease with an emphasis on four diseases with significant unmet medical need; asthma, COPD, Idiopathic Pulmonary Fibrosis (IPF) and Chronic Cough.

To further strengthen our expertise and capacity in each of these strategic research areas we are currently recruiting an ambitious scientists. Are you ready to accept this challenge and join a dynamic and innovative department?

Main Duties and Responsibilities

We are looking to hire a Research Scientists with excellent laboratory skills to join our Bioscience Department. This role will give you the opportunity to support, design, develop and conduct experiments. Your achievements will provide key information to the identification of new targets and biomarkers as well as the progression of drug discovery projects or publishable scientific insights.

This is a lab-based role where you will be involved in multiple ongoing projects with responsibility to analyse samples from experiments/studies from various cells and tissues. We are looking for someone with some experience in cell and molecular biology techniques and quantitative assays (eg immunoassays).

Accountabilities and responsibilities:

* Execute experimental procedures according to study plans agreed with the team leader or other supervisor
* Contribute to the interpretation of experimental data and play an important role in the planning of further experiments
* Identify and tackle problems associated with their experiments and discuss with other team members
* Be an effective team member in supporting projects to meet their objectives
* Possess a range of practical skills and demonstrate flexibility within and across teams
* Effectively communicate results to other members of the project, team or to departments as required
* Maintain awareness of current developments in the literature of scientific methods relevant to their tasks

Essential Requirements

* B.Sc. or M.Sc. degree in relevant subjects or equivalent level of understanding developed through experience in drug discovery or early development
* Excellent scientific laboratory skills and ability to work independently
* Good networking and interpersonal skills and delivery focus

Desirable requirements

* An understanding of Respiratory diseases
* Experience in pharmaceutical R&D

If you are interested, apply now!

For more information about the position please contact Stephen Delaney, Stephen.delaney (@)astrazeneca.com

Welcome with your application no later than February 16th, 2020.

For more information about life in Gothenburg visit www.movetogothenburg.com Visa mindre

AstraZeneca is committed to putting patients first. This strong focus on patients shapes how we manage all aspects of our business. The Patient Centered Science (PCS) group plays an integral role in fulfilling this commitment by developing strategies to capture patient experience and generating impactful evidence to demonstrate the value of our medicines and support decision making by regulators, patients, physicians and payers.

The Associate Director / Director, Patient Centered Science will develop and lead strategies for generating patient experience data to support the evidence needs of regulatory, payers, prescribers and patients. The role is dedicated to our Oncology therapeutic area and will require an in-depth understanding of patient-centered outcomes research within the context of pharmaceutical development.

As a PCS director you will lead the development of patient experience strategies within your area to optimize the needs of various stakeholders. In the role you will:

*

Set and lead TA and study specific strategies to represent the patient experience to regulators, patients, Healthcare Professionals (HCPs) and payers,
*

Determine and deliver guidance on which therapy/disease areas and early projects that will need a PRO as endpoint and description of patient experience,
*

Investigate to what extent Patient Reported Outcomes (PRO) and Clinical Outcome Assessment (COA) endpoints are developed, fit-for-purpose and approved by Regulatory Authorities and how well they will meet AstraZeneca's project needs, to provide the most appropriate PRO strategic recommendation to meet all key stake holder needs work cross-functionally.

The incumbent will be responsible for driving high quality evidence claims by working with assigned therapeutic area (TA), focusing on projects within the Oncology field (and their underlying projects) across the development cycle, in cross functional teams within AstraZeneca.

As a PCS director you will interact with regulatory authorities, payers and key external experts, as well as with relevant AstraZeneca's cross-functional teams, to provide PRO related leadership to assigned projects, and will be accountable for TA PCS standards, the input to Target Product Profiles (TPPs)/ Target Product Claims (TPC) and clinical plans.

Key Accountabilities/Responsibilities

*

Deliver robust TA and project PCS regulatory recommendations globally to meet regulatory, payer and patient needs.
*

Develop relationships with appropriate AstraZeneca teams as well as with key external experts and collaborative groups (within the relevant disease area) to enhance AstraZeneca's reputation of PRO measurement.
*

Deliver expert input on PRO needs to TPPs, TPCs and support PRO dossier and briefing document evidence within clinical plans and regulatory submissions.
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Ensure appropriate PRO and COA input is included at the design stages of clinical programs and drive appropriate data collection plans and analyses to ensure high quality interpretation of the resulting data.
*

Proactively and independently contribute to research planning process and resolution of complex issues, which may impact investment decisions and the external acceptance of evidence for product.
*

Project management and expert consultation supporting patient centered/PRO measurement in clinical programs, and dissemination of results and messages to all key stakeholders in all different phases (design to interpretation).
*

Support regulatory and payer interactions by developing patient experience evidence for inclusion in submissions and support teams via participation in meetings with decision makers (e.g. FDA, EMA, NICE, G-BA, etc.)
*

Advance expertise in PRO/COA research through presentations, publications, and internal/external engagement.

Minimum Requirements -Education and Experience

*

Bachelor's degree in clinical, biological, or social sciences or equivalent
*

Master's degree in relevant field (outcomes research, health services research, epidemiology, health policy or related fields)
*

Doctoral degree in relevant field preferred
*

Relevant experience of COA/PRO scientific work
*

Minimum of 5 years' experience in the biopharmaceutical industry or equivalent
*

Excellent knowledge in clinical development and research study designs and interpretation.
*

Good understanding of qualitative and quantitative analyses to gain insights on patient experience
*

Effectiveness in a scientific advisory role involving both strategic and tactical elements
*

Knowledge of therapeutic area
*

Open to periods of travel

The PCS group at AstraZeneca is passionate about including patient perspective in drug development, we are a vibrant and diverse group that enjoys leading and advancing the field of patient centered science. If you are passionate about patient perspective as we are, send your application now!

For more information about the position please contact: Nikunj Patel, Group Director, Patient Centered Science: Oncology at nikunj.patel(at)astrazeneca.com or +1 202 515 1463

Welcome with your application no later than February 29, 2020 Visa mindre

We are now looking to fill an industrial PhD position in synthetic chemistry within a Marie Sk?odowska-Curie Innovative Training Network

AstraZeneca and the Aarhus University will offer the PhD student a unique opportunity to gain world class knowledge and hands-on experience in various applications of medicinal chemistry and drug discovery at the forefront of biomedical research and development. The successful candidate will also participate in the network's training activities and work placements at the laboratories of the Aarhus University, Denmark and ICIQ, Spain. The degree will be awarded by the Aarhus University.

Projects:

The doctoral training positions advertised herein are to be filled at AstraZeneca R&D Gothenburg, Sweden in conjunction with the Aarhus University, Denmark (where the successful candidates will be registered for a PhD).

The research project will focus on the Development of late-stage and rapid carboxylation techniques with 14CO2 in drug development programs. The objectives of the project are:

1. Investigate the application of alkyl halides and pseudohalides for the synthesis of alkyl-Ni complexes and their ability to undergo rapid carboxylations with 14CO2 in the presence of a reductant

2. Adapt new electrochemical and photolytic methods for the transformation of alkyl silicates to corresponding carboxylates with 14CO2 applying Ni-complexes

3. Apply the developed conditions for late stage 14C labelling of pharmaceutically relevant alkyl carboxylates

The expected results are:

1. New techniques for late-stage carbon-14 isotope labelling adaptable to drug development programs

2. A detailed understanding of the steps involved in transition metal-mediated carboxylations, particularly with nickel.

3. Fast carboxylation reactions with easy-to-prepare intermediates

Tasks include:

The successful candidates will work together with 14 other PhD students within the Co2perate Consortium and will be included in a network-wide training and secondment programme. Travel for up to 6 months will be required.

Qualifications:

* A master's degree in chemistry, medicinal chemistry, or chemical biology or the equivalent, preferably with a research project in organic synthesis. The applicant cannot possess a PhD or MD degree
* At the time of recruitment be in their first 4 years of research career.
* An excellent track record from previous studies, along with experience in organic synthesis or medicinal chemistry.
* Fluent in the English language (spoken and written/proficiency level).

About AstraZeneca:

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. We're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Other:

In accordance with the Marie Sk?odowska-Curie actions mobility requirements, candidates are only eligible for this position when they have spent no more than 12 months of their main activity (work, study) during the last three years in Sweden.

Contact person: Charles S. Elmore (+46 (0) 722 135 480)

Welcome with your application no later than February 23, 2020 Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline.

With the increasing interest of delivering new modalities/biologics via the oral route to improve patient convenience and compliance, we now seek a talented and motivated Associate Principle Scientist to join the ADD group within Pharmaceutical Sciences in Gothenburg, Sweden.

This is an exciting role where you will act as a key member of various project teams and provide your scientific expertise into formulation design and development strategies. You will have responsibilities for defining product design and selecting lead enabling formulations for projects involving oral delivery of biologics to ensure desired clinical performance targets from discovery to Phase II. In addition, you will contribute to a capability build in the area of oral delivery of biologics within AstraZeneca. As such, we are looking for a candidate with previous experience in supporting oral biologics projects and who has a strong understanding of biopharmaceutics, physical chemistry and biology to enable a mechanistic understanding of in vivo drug product performance. The role will be expected to work cross-functionally supporting drug projects from early to late clinical phase and be involved with science & technology initiatives.

We are looking for you, who together with your team will make a difference for patients' lives every day. This through your ability to independently lead and motivate your team to achieve set goals within budget, time and to the right quality.

Essential Requirements

* Ph.D degree and post-doctoral experience in a relevant discipline (such as Pharmaceutics, Biopharmaceutics or Drug Delivery) or equivalent industrial experience within the field of Pharmaceutical/Biopharmaceutical Science
* Good understanding of biology, biopharmaceutics, pharmacokinetics and physical/colloidal chemistry
* Ability to effectively communicate, network and build collaborative relationships with stakeholders across disciplines and cultures, internally and externally and independently lead and influence projects.
* Excellent communication and stakeholder management skills, and the ability to discuss complex ideas in a simple, easy to understand way.
* Ability to tackle complex scientific problems and troubleshooting.
* Good understanding of the overall drug discovery and development process and an appreciation of how Pharmaceutical Sciences disciplines contribute to R&D
* Practical experience in the use of in vitro methodologies to support advanced drug delivery system development
* Track record of scientific excellence in terms of publications, presentations and networking activities. Capable of, and desire for continuing to develop yourself in this area
* Innovative, with a passion driving scientific excellence and a continuous improvement mind-set
* Thorough understanding of principles, applications and management of Safety, Health and Environment (SHE)
* Ability to communicate and write proficiently in English



This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

For more information, please contact: Sara Richardson, Team Leader, +46725821650,

Welcome with your application no later than February 16, 2020. Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Pharmaceutical Sciences at AstraZeneca delivers the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline.

We are now recruiting a talented and motivated Analytical Scientist to join our New Modality GMP Analytics team within the ADD function in Gothenburg, Sweden.

As a Scientist working in the clinical development phase within ADD you will support drug projects from an analytical perspective, from candidate drug nomination over Phase II clinical trials. You will focus on advanced analytical characterization of biomolecules, primarily peptides, but also oligonucleotides, mRNA and other molecules of high complexity as well as drug delivery systems. The role covers development and validation of analytical methods, stability studies, release analysis, contribution to regulatory submissions as well as exploratory science work. Part of the work is performed according to Good Manufacturing Practice (GMP). You will work as a member of cross-functional pharmaceutical project teams and in close collaboration with other analysts, formulators, chemists and biologists at AstraZeneca in Sweden, UK and US.

Main Duties and Responsibilities

* Develop and validate analytical methodologies and specifications for biomolecules, with a focus on peptides.
* Plan and perform stability studies, release analysis and other supportive characterization experiments in clinical drug development projects.
* Generate, evaluate and report data clearly and reliably. Interpret findings and draw conclusions to make recommendations to project teams and other stakeholders.
* Prepare documentation and formal reports in accordance with current standard procedures and where appropriate, according to GMP standards. Generate data and give input to Chemistry, Manufacturing and Control (CMC) documents for regulatory submissions or enquiries.
* Give analytical support to scientific initiatives on new technologies/processes together with specialists and/or technology networks.
* Working as a member of cross-functional drug development project teams, representing your own group or science area.
* Ensure that your own work and the work of others are performed in accordance with appropriate Safety, Health and Environment (SHE), quality and compliance standards.

Essential Requirements

* MSc degree in a relevant scientific discipline (e.g., Analytical Chemistry, Biochemistry or Biotechnology).
* In-depth knowledge of analytical methodologies for peptide/protein characterization, such as chromatography, mass spectrometry and other biophysical/chemical characterization techniques.
* Experience of analytical work with peptides/proteins in pharmaceutical development.
* Thorough understanding of principles and applications of GMP.
* Ability to communicate in English both orally and in writing.

Desirable Requirements

* 3+ years of industrial experience of analytical work with peptides/biomolecules in clinical drug development phase.
* Expertise in analysis of peptide therapeutics for parenteral and oral administration routes.
* Experience of different formulation/delivery systems that may require different sample preparation techniques.
* Qualified to execute analytical work according to GMP.
* An interest in exploratory analytical work related to complex molecules, delivery systems and new technologies.

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

For more information please contact Sara Richardson, Team Leader, +46 725821650,

We will screen candidates on a continuous basis. Welcome with your application no later than February 16, 2020.

Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline.

We now seek a talented, motivated Formulation Senior scientist to join our team in Gothenburg, Sweden. It is a key scientific position that will lead formulation and delivery evaluation from discovery to clinical candidate nomination. The focus is the new modality and advanced drug delivery portfolio of oligonucleotides, RNA and peptides-based therapeutics. You will be reporting to the team leader for CMC Formulation and collaborate closely with other ADD teams located in Waltham, US, Cambridge, UK and Gothenburg, Sweden.

Main Duties and Responsibilities

* Evaluate and develop formulations, delivery systems, and analytical methods for biomolecules with a focus on peptides.
* Lead or support the production of drug products for non-GxP studies and for GMP manufacturing.
* Work flexibly in preclinical and clinical CMC (Chemistry, Manufacturing, and Control).
* Represent the department in the CMC team. Align activities with other functions including drug substance, drug product, quality control, quality assurance, and supply chain, device, and regulatory for CMC team in clinical phase.
* For projects in pre-clinical stage, represent Pharmaceutical sciences and align activities with chemistry, biology, clinical, and preclinical representatives to develop the project strategy.
* Evaluate and lead outsourcing activities. This should be sufficient.Engage in external technology evaluations in collaboration
* Work as a member of cross-functional pharmaceutical project teams, with a large degree of independence representing own group and area of expertise.
* Develop expertise in a scientific skill discipline and continue to demonstrate scientific scholarship.
* Remain up to date with relevant internal and external developments that affect the company and function and share with other members of team or function.
* Ensure that own work and the work of others is performed in accordance with appropriate Safety, Health & Environment (SHE), quality, and compliance standards.

Essential Requirements

* MSc degree in a relevant scientific discipline (e.g., Biochemistry, Pharmaceutics, Biotechnology, Biophysics, or Chemistry)
* Experience developing different administration routes and formulation technologies to enable formulation development and influencing drug product design including parenteral, oral and inhaled delivery of biologics.
* Knowledge of analytical characterization of biomolecules (e.g. H/UPLC, CE, particulate/aggregate analysis, DSC, ITC, fluorescence and scattering)
* Experience working with biomolecules (e.g., peptides or proteins) and the desire to explore new modalities
* Ability to communicate and write proficiently in English.

Desirable Requirements

* Ph.D. degree in a relevant scientific discipline (e.g., Biochemistry, Pharmaceutics, Biotechnology, Biophysics, or Chemistry)
* 1-3 years of work experience in industry focusing on formulation development, biophysical or analytical characterization of proteins and peptide and/or delivery systems.
* Exposure to multiple disciplines in Drug Discovery, Pharmaceutical Sciences, and related functions.

If you are interested, apply now!

We will screen candidates continuously and we need your application at the latest February 16, 2020.

For more information about the role please contact Sara Richardson, Team Leader Advanced Drug Delivery +46725821650 Visa mindre

AstraZeneca is committed to putting patients first. This strong focus on patients shapes how we manage all aspects of our business. The Patient Centered Science (PCS) group plays an integral role in fulfilling this commitment by developing strategies to capture patient experience and generating impactful evidence to demonstrate the value of our medicines and support decision making by regulators, patients, physicians and payers.

We are expanding our team to include Patient Centered Science Manager to play a pivotal role in challenging our scientific capabilities to make a positive impact on changing patients lives and include patient perspective into drug development. The role is dedicated to our Oncology therapeutic area and will require an understanding of patient-centered outcomes research within the context of pharmaceutical development.

As a PCS manager you will work closely with PCS Directors and study teams to implement Patient Reported Outcomes (PRO) and other Clinical Outcomes Assessments (COA) into clinical trials to ensure high quality evidence supporting products regulatory approval, reimbursement and commercialization. In the role you will be driving efficient implementation of PRO into studies, with the following activities:

* To translate the patient experience strategy into a fully implemented program
* Lead PCS function interactions with internal and external teams to apply strategy at the study level to oversee PRO implementation
* Responsible for the scientific aspect of the electronic capture of COA (eCOA) implementation
* Support the patient experience strategy development
* Support development of relevant PRO training materials for patients, investigators and monitors
* Ensure appropriate standards are applied and participate in development of new standards

You will interact with internal AstraZeneca teams and externally with PRO strategic partners, linguistic validation and eCOA providers, with regulatory authorities and key external experts.

Key Accountabilities/Responsibilities

* Drive the everyday work of PRO implementation in studies
* Support PCS directors in the development of patient experience strategies
* Draft Clinical Study Protocol (CSP) text based on the pre-defined patient experience strategy
* Draft PRO (Statistical Analysis Plan) SAP text
* Provide support to manage the relationship with vendors, and oversee their deliverables (strategies, linguistic validation interview studies etc)
* Provide scientific expertise of eCOA implementation
* Perform blinded data review
* Assist with review of results and the preparation of regulatory documents

Minimum Requirements -Education and Experience

* Bachelor's degree in clinical, biological, or social sciences or equivalent
* Familiarity with clinical research from industry or CRO work experience
* Experience with PRO development and usage in clinical studies is preferred but not required

Skills and Capabilities

* Able to implement projects including interactions with stakeholders
* Good written and verbal communication skills
* Ability to define clear scope of projects and provide support
* Ability to look for a champion more efficient and effectively methods/process
* Integrity and high ethical standards

The PCS group at AstraZeneca consist of nearly 20 persons, with a passion for including patient perspective in drug development, we are a group with diversity that enjoy leading and develop the field of patient centered science. Do you want to work in a vibrant group this is your opportunity, send your application now!

For more information about the position please contact: Nikunj Patel, Group Director, Patient Centered Science: Oncology at nikunj.patel(at)astrazeneca.com

Welcome with your application no later than February 9, 2020. Visa mindre

AstraZeneca (AZ) is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AZ, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The arena

Pharmaceutical Sciences is accountable for the design and development of synthetic routes, preclinical and phase I/II formulations, analytical methods and CMC project leadership needed to support early clinical trials, encompassing both small molecules and new modalities such as microRNA, messenger RNA and antisense oligonucleotides, across the whole range of AZ's therapeutic areas.

The manufacturing unit within Early Product Development and Manufacture (EPDM) in Gothenburg is accountable for manufacture of a vast portfolio of early investigational medicinal products (oral solution/suspension, parenteral solutions, capsules, tablets and inhalers), mainly for Phases I and II. We supply drug product to AZ clinical studies globally and are a vital part to enable early phase clinical trials, delivering a critical step on the path from idea to patient. In short, we are the first in line to manufacture what could improve the lives of numerous patients around the globe.

The role

Within the EPDM manufacturing unit, in the GMP (Good Manufacturing Practice) arena, you will make an important contribution in delivering clinical results in the development of new medicines. This role revolves around the manufacturing of drug product where all activities below will have a significant impact on the speed, quality and cost of the AZ development portfolio. We expect the successful candidate to:

* Assume responsibilities toward timely manufacture of numerous drug products in line with the plans agreed within EPDM.
* Focus on practical hands-on work in our GMP facilities, and simultaneously lead and coordinate parallel manufacturing activities performed by assigned co-workers.
* Rapidly develop strong competence within relevant process technologies and build credibility and ability to drive and secure product establishment, scale-up and clinical manufactures.
* Author manufacturing batch records together with other required documentation and setup transactions in material management systems. Monitor, secure and follow up on other regulatory requirements according to GMP through associated IT-systems.
* Assess records and report manufacturing and validation data accurately according to GMP.
* Ensure that SHE (Safety Health and Environment) and GMP standards are upheld and ensure AZ Policies and Standards are understood and followed.
* Being entrepreneurial and drive initiatives to further improve flexibility and productivity, resulting in shorter lead times or increased value for customer.

Experience/requirements

We are looking for a scientist with excellent collaboration, communication, and planning skills, balanced with the ability to work independently and hands-on with complex equipment. You will need a strong sense of responsibility, team work and delivery focus.

You have a MSc in Pharmacy or engineering. Excellent documentation skills, both in English and Swedish is a requirement. You will need proven record of collaboration and team work skills. We expect you to have a keen interest to learn and operate complex manufacturing equipment and develop your expertise in pharmaceutical process technology. Experience from pharmaceutical development or working in a manufacturing or supply chain organisation and knowledge of cGMP is highly advantageous for this role.

More information

For more information about the position please contact Kim Stockfelt at +46 31 776 10 00 or Oskar Hedberg at +46 31 77 62673.

Welcome with your application no later than Monday the 27th of Jan 2020. Visa mindre

Are you a passionate and experienced scientist, eager to join a company in the forefront of sample management technologies? Would you like to contribute to the continuous improvement of life changing projects? Welcome to apply for the role as Senior Scientist to join our Sample Management team at AstraZeneca in Gothenburg.

As a Senior Scientist in the Sample Management department, you will be responsible for the storage and timely supply of chemical compounds to AstraZeneca's drug discovery projects. Highly automated systems will be employed to supply small molecules and larger biological modalities to AstraZeneca scientists and partner organisations. You will be a part of the Discovery Sciences organisation, operating within a first-class scientific environment to support drug discovery across each of AstraZeneca's Therapeutic Areas.

We work collaboratively within a Sample Management team, to provide support within agreed service levels with a strong customer focus. We strive hard to understand what fits their needs and how to add value through our experience and capabilities. Our facility and service are leading edge, implementing fully acoustic sample handling workflows as the first company world-wide. To maintain this position, we actively seek ways to improve our process and exploit new technologies.

Main Duties and Responsibilities

In this position, you will get the opportunity to work in a dynamic and enthusiastic environment, whilst delivering critical support to drug discovery projects. You are focused on supporting drug discovery projects by providing compounds in the requested format - assay ready plates, serially diluted mother plates, formulations and solids. Continuous improvement is also a core activity, performed as individual and group projects within the local team and the global department.

As a Senior Scientist within Sample Management, you will be expected to act upon day-to-day issues that occur whilst processing samples and ensure business continuity. You will run Sample Management development projects to ensure continuous improvement. Furthermore, you will work with the following typical tasks:

* Designing, performing and interpreting experiments independently to investigate process improvements and evaluate new technologies.
* Demonstrating expertise in key innovative aspects of Sample Management, both locally and for representing the dept externally.
* Processing of liquid samples on automated platforms and solid samples.
* Managing customer orders using specialized informatics systems and responding to customer queries via mail or telephone.
* Interacting with other SM groups and collaborators to process global orders.

Minimum requirements

Sample Management is a highly collaborative group, working to tight delivery schedules - so the ability to be comfortable working at a fast, goal-oriented pace, with a team focused attitude is essential to be successful in the role. We also believe you have:

* MSc or PhD in a relevant scientific discipline (Chemistry/Biochemistry/Chemical Engineering).
* A proven passion for science, technology and innovation.
* A track record in the performance of a range of practical skills, including non-routine complex tasks, to a high level.
* Excellent communication skills with a proactive and delivery focused approach.

Desirable Requirements

* Expert user status in operating integrated laboratory automation equipment.
* Great skills to lead process improvement and new technology evaluations.
* The ability to design and carry out key experiments, making use of the literature to aid understanding of experimental methods and improve their design.
* A comprehensive understanding of the drug discovery process and the key role of Sample Management.

If this sounds like the next step for you - apply today!

For more information about the position, please contact hiring manager Vidya Velagapudi at

We look forward to your application no later than the 15th February, 2020.

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Are you a scientist with passion and experience in experimental design and great knowledge of in-vivo studies? Do you want to join a company where your work contributes to the making of life-changing medicines to patients all over the world? Welcome to come join our Animal Sciences and Technologies (AST) department as a Senior Research Scientist- Study Director & Inhalation Specialist at AstraZeneca in Gothenburg!

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. We are proud to have a unique workplace culture that inspires innovation and collaboration. At AstraZeneca, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The Animal Sciences and Technologies (AST) is a global department that delivers in-vivo studies, animal care, and welfare that is compliant to internal standards and external regulations. Principles of the 3Rs are applied to all aspects of animal care and study conduction.

The role

The role is placed in a team that works closely with the Respiratory Inflammation Autoimmunity (RIA) therapy area to support discovery phase projects with investigative toxicological in vivo studies in small and large animals. There are also daily interactions with the Early RIA bioscience and DMPK departments planning and executing PK studies and efficacy studies with safety endpoints. Job tasks in the position includes:

* Study Director for in vivo studies in support of pre-clinical discovery/early development projects
* Maintain and develop models of aerosol drug delivery, including hands on work with the technical set-up to enhance inhalation toxicology capabilities.
* Design and execute inhalation studies, integration and interpretation of scientific data in close collaboration with preclinical representatives.
* Provide scientific and technical inhaled drug delivery expertise.
* Work flexibly across different areas and participate in provision of weekend and out of hours support when required.

Minimum requirements

* Experience as Study Director for Toxicology Studies
* In vivo experience and experimental skills in the use of animal models.
* Problem-solving skills related to in vivo research and data analysis
* Good knowledge in technical engineering and software/computer tools.
* Good written and oral communication skills in English
* As highly motivated, independent scientist be able to work effectively as part of a team and develop ideas by incorporating the views of others
* Experience in the operation and development of inhalation exposure systems including the characterisation of test aerosols.

Preferred experience/requirements

* Ideally have a PhD or a proven track record of in vivo work in a relevant discipline
* Experience in the handling and training of animals for invivo inhalation studies
* Understanding of statistical methods, quality control and data reporting/archiving
* Proven history of oral presentations and publishing scientific data.

If this sounds like the next challenge for you - apply today!

More information

For more information about the position please contact hiring manager Steven Oag at

Welcome with your application no later than 28th of January, 2020.

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/ Visa mindre

Are you passionate about imaging and advanced image analysis? Do you have expertise in applying sophisticated algorithms and image analysis techniques to complex imaging data and have a thirst for applying these skills to advance the boundaries of science to deliver life-changing medicines to patients? We have an opening at our Imaging and Data Analytics department at AstraZeneca!

We are looking for an Image Digitization Scientist to apply cutting edge technologies and advanced image processing and analysis to help derive biological insights from biological tissue and in vivo imaging data to support drug development projects. You will work alongside our team of imaging scientists, Pathologists, biologists and data scientists within Clinical Pharmacology and Safety Sciences (CPSS).

CPSS is changing the way imaging technologies are combined to offer unprecedented insight and impact. Our imaging hubs combine data from histology, digital pathology, multiplex assays, advanced molecular imaging techniques (including mass spectrometry imaging) and a full suite of in vivo imaging technologies.

This position offers the opportunity to be involved in the investigation of both the safety and efficacy of drugs within our projects in both a preclinical and clinical setting. We believe this is a truly exciting opportunity for a hardworking Image Digitization scientist.

The Role

As an Image Digitization Scientist, you will support both imaging data acquisition and analysis and be the link between our imaging teams and advanced image analysis experts. You will apply your expertise in image segmentation, processing and analysis using rule based and machine learning approaches to derive solutions to a range of problems in biomedical images. You will develop innovative and accurate algorithms for multiple therapeutic areas across multiple imaging modalities.

Main Duties and Responsibilities:

* Actively support and participate in the digitization of biomedical images to support drug discovery activities

* Participate in the development of FAIR standards to deliver image management and analysis systems, processes, tools and technology to support current and future analyses and data insights across all biomedical image types to support the AZ drug development portfolio

* Develop and use libraries and machine learning tools aimed at pre-processing / analysing / summarising large and multimodal image data sets

* Build and internalize algorithms and techniques to answer defined digital pathology, mass spectrometry imaging and in vivo imaging questions and ensure that results are scientifically robust and documented.

* Perform data analyses and visualization, including analytics associating image analysis features with drug treatments, response and survival data, genetic features and other sample attributes using AI powered image analysis, statistics and other tools

* Contribute to the publication of technical protocols, scientific abstracts, posters, presentations, manuscripts and/or patent applications

Essential Requirements:

* MSc/PhD in a Biological Science, Biomedical Engineering, Bioinformatics, Computer Science or related discipline with up to 3 or more years of related experience in academia or pharmaceutical/biotech/CRO organisation

* Proven knowledge and experience in image segmentation, pre-processing, reconstruction, feature extraction and image analysis

* Experience and programming skills in one or more of the languages/packages e.g. Python, Tensorflow, Keras, Pytorch, MATLAB, R, Java, HALO, Visiopharm, Definiens to address image analysis questions

* Experience working with and analysis of large quantities of imaging data across modalities e.g. cellular imaging, digital pathology, mass spectrometry imaging and in vivo imaging (CT, MRI, PET)

Desirable Requirements:

* Desirable for experience using mathematics and data science knowledge to apply machine learning and deep learning methods to address image analysis questions.

* Desirable for experience of digital pathology imaging systems for the digitization of pathology images.

* Excellent skills in English, both written and oral communication and strong problem-solving and collaboration skills.

If this sounds like the challenge for you - apply today and join our team!

For questions about the position please contact Arthur Lewis (Associate Director - Imaging & Data Analytics) at

We look forward to your application no later than 24th January 2020. Visa mindre

Are you a Data Science, Artificial Intelligence (AI) and Machine Learning (ML) expert that would like to be a leading player in AstraZeneca's digital transformation? Would you like to make a true difference in patient lives by positioning data science, ML and AI at the heart of drug discovery? Then you might be interested in joining us to lead the data driven discovery and development of future medicines in cardiovascular, renal and metabolism (CVRM) disease!

At AstraZeneca we follow the science and turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. Accelerated efforts within AI, data and digital science is key focus in AstraZeneca's strategic journey into the future. We are thus making significant investment in an array of new computing platforms to enable scientific data and powerful analysis tools to be at the fingertips of our data scientists.

What's in it for you?

The role as Head of Data Science, Early CVRM will give you the opportunity to build, lead and develop a center of excellence for data science and AI expertise within Cardiovascular, Renal and Metabolism (CVRM), one of AstraZeneca's main therapy areas. You will be a key player in the global AstraZeneca data science community impacting identification, development and implementation of cutting-edge advances in the various fields of data science, AI, ML, Augmented drug discovery and Knowledge Management. You will also have the opportunity to demonstrate scientific leadership through high quality publications, conference presentations and by building networks and collaborations with key opinion leaders and academic groups. You will be at the forefront of Data science, driving innovation and scientific excellence within drug discovery to make a difference for our patients. The role is at Director or Senior Director level depending on your experience.

Who are you?

With a PhD in a relevant area e.g. computer science, statistics, data science, machine learning, genetics or other quantitative sciences, you have an understanding of the identification and progression of drug targets through drug discovery and clinical development. You are a true leader that have experience in leading impactful data science projects and teams combined with ability to drive a vision and concrete plans for the identification of drug targets using cutting edge computational approaches. At AstraZeneca you will fit right in if you thrive on team work in a multidisciplinary environment, networking, communication and the ability to influence both people and science.

Would you like some more details about the role before applying?

As head of Data Science within early CVRM, you will lead the adoption and implementation of AI, machine learning and data science in key areas such as next generation 'omics, imaging, clinical and real world evidence data. Both through internal scientific development and external collaborations with world leaders in data science, AI and ML. You work closely with R&D Head of Data Science and AI to drive innovation and scientific excellence in the area. You will report to the Head of CVRM Translational Science and Experimental Medicine (TS&EM;) and you will be part of the TS&EM; leadership team. You can be located at either of AstraZeneca's vibrant R&D sites in Gothenburg Sweden or Cambridge UK.

We would like to know more about you. If you are interested, apply now!

We welcome your application no later than January 26, 2020. Thank You!

Additional information

Our Cambridge site: https://www.astrazeneca.com/our-science/cambridge.html

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Life in Gothenburg and Sweden: https://www.movetogothenburg.com/

#DataAI Visa mindre

At AstraZeneca we believe in the potential of our people and you'll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.


The External Content Platform team will deliver core, centralised platform and services for external content (Literature, Competitive Intelligence, Conference abstracts/reports, patents, etc plus enabling ontologies). The team will enable efficient utilisation of external information - directly by end users and integrated into platforms to underpin Artificial Intelligence, analytics and decision support tools across R&D with the best endeavour's support for Commercial and other parts of the AstraZeneca business.

The Training, Awareness and Utilisation role will work with individuals and teams across R&D to help them to optimise the value we derive from external information (directly and combined with other internal and external information). The individual will actively ensure wide visibility of the information sources (content, databases, data streams), services and platforms/tools that are available across AZ through running ongoing communications campaigns and the provision of digital user guides, training materials and courses. The key focus is on ensuring that individuals know what sources of information are available and how it can be accessed effectively to support research and development and effective, informed decision making. The role holder will work collaboratively across functional and geographical boundaries to support individuals and teams (including ISA and Regulatory specialists) in working with the tools in the context of BioPharma and Oncology R&D projects. With a strong focus on user experience, the role holder will monitor the usage of information and the effectiveness of the available supporting training and awareness materials, actively flagging risks and opportunities for improvement (in the functionality of the platforms and tools, as well as in the sources of information licensed)



Typical Responsibilities

* Responsible for optimising the usage of external information and content in business teams and in day to day decision making
* Ensures wide visibility of the information sources, tools and services available through running communication campaigns (e.g. on Workplace, Nucleus)
* Supports end users through the provision of effective digital user guides, communications and tip-sheets on how to effectively use External Content Platforms
* Coordinates and runs/makes available training programmes - working in partnership with other teams and suppliers (through initiatives such as Customer Success Programmes)
* Coordinates demand for Training, Awareness and Utilisation with 'super users', including Information Science (ISA) specialists in the BioPharma and Oncology R&D teams
* Systematically seeks feedback on the efficiency of the Training, Awareness and Utilisation services and the tools - enabling continuous improvement of what's licensed, the systems and tools.
* Supports the uptake and adoption of specialist tooling, including partnering with IT Data & Analytics technical teams to support the roll out of new functionality, content sources, services and apps



Education, Qualifications and Experience Required

* Relevant degree or qualification (for example in information management, information science, science, engineering, maths)
* A passion to enable the R&D business by maximising the uptake and utilisation of available content sources, services and tools.
* A proven track record of delivering business value and "customer service" attitude - driven to improve the ability of scientists to utilise the right information at the right time with confidence
* Excellent level of knowledge and experience in the utilisation of relevant information systems and tools
* Relevant knowledge of information providers, publishing markets and business awareness of how teams are looking to utilise external information
* Excellent written and verbal communications skills
* Experience of working in a global organisation and across geographies
* Highly collaborative, and responsive teammate
* Proven ability to prioritise time and to manage demand from multiple sources



If this sounds like you - Apply Today! Visa mindre

When we at AstraZeneca see the chance to change, we take this opportunity - for every opportunity, no matter how small, can be the beginning of something big. Delivering medicine that changes people's lives is about having an entrepreneurial spirit - finding moments and understanding its potential.

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline.



We are now looking for two enthusiastic and innovative cell biologists to work on delivering new modalities for gene therapy. One position is to be based in Cambridge, UK and one in Gothenburg, Sweden.



Together with chemists and formulation specialists, you will be responsible for engineering and testing delivery systems for nucleotides and proteins, like CRISPR components. Using automation, multivariate methods and rapid prototyping you will help improve our methods for creating new and better delivery systems. Working with scientific expertise from the UK, US and Sweden, on global drug projects, will be part of your routine. You will also be expected to drive science networks and provide high quality scientific input across the organisation. We expect you to be an active member of the external scientific community, enhancing our reputation as scientific leaders in the advanced drug delivery field.



We are seeking an ambitious scientist with a strong foundation in the delivery sciences and a specialisation in cell biology, and of course, a great passion for experimental science. This is a hands-on, lab-based position where you will work with different teams, so you should enjoy communicating and have the capacity to share your data.



If you are committed to developing your career in the pharmaceutical sciences - this might be the role for you!



Essential Requirements

*

PhD or Master's degree in biology or related discipline, with extensive experience culturing and analysing different cell types
*

High technical aptitude and extensive experience with instrumentation related to cell biology.
*

Molecular biological and cell engineering skills, a working knowledge of CRISPR-related biology and a good knowledge of endosomal biology
*

Strong record of scientific excellence evidenced by publications, patents and presentations
*

Thorough understanding of principles, applications and management of Safety Health and Environment (SHE)



Desirable Requirements

*

Practical experience working with in vivo mouse models is highly desirable
*

Experience with laboratory automation including fluidic handling robots and automated analytical systems (robotic microscopy and image cytometry, flow cytometry, sequencing and/or mass spectrometry)
*

A good understanding of software for handling large multivariate datasets
*

3D culture work or, work with microphysiological systems
*

Experience working with nanomedicines and experience formulating intracellular delivery systems for nucleotides and/or proteins
*

Experience with supervision and/or training of colleagues



Are you already imagining yourself joining our Advanced Drug Delivery team? Good, because we can't wait to hear from you.



For more information about the positions please contact Arpan Desai, Team Leader (UK), at or Sara Richardson, Team Leader - Formulation and Bioassays (Sweden), at



We encourage you to send your application as soon as possible, but no later than January 19, 2020 Visa mindre

Are you passionate about imaging and advanced image analysis? Can you apply these skills to help us in drug discovery? Do you have expertise in applying sophisticated algorithms and image analysis techniques to complex imaging data and have a thirst for applying these skills to advance the boundaries of science to deliver life-changing medicines to patients? Then why not join the Imaging and Data Analytics department at AstraZeneca?


We are looking for an Image Data Integration Scientist to apply cutting edge technologies and advanced image processing and analysis to help derive biological insights from biological tissue and in vivo imaging data to support drug development projects across Oncology, Respiratory and Cardiovascular & Metabolic Disease therapy areas. You will work alongside our team of Imaging Scientists, Pathologists, Biologists and Data Scientists within Clinical Pharmacology and Safety Sciences (CPSS) - as well as collaboration with our global imaging teams.


CPSS is changing the way imaging technologies are combined to offer unprecedented insight and impact. Our imaging hubs combine data from histology, digital pathology, multiplex assays, advanced molecular imaging techniques (including mass spectrometry imaging) and a full suite of in vivo imaging technologies. This position offers the opportunity to be involved in the investigation of both the safety and efficacy of drugs within our projects in both a preclinical and clinical setting. We believe this is a truly exciting opportunity for a hardworking Image Digitization Scientist.

The Role

As an Image Data Integration Scientist, you will be a key link between all our imaging scientists and advanced image analysis experts. You will provide expertise in cutting edge multi-modal image integration workflows of large sets of biomedical images, to build insights into the biological mechanisms of disease. You will provide established and cutting edge image data analysis and integration across modalities using image segmentation, processing and analysis using rule based and machine learning approaches to derive solutions to a range of problems in biomedical images.

Main Duties and Responsibilities:

* Build and internalize algorithms and techniques to answer defined digital pathology, Mass Spectrometry Imaging and in vivo imaging questions and ensure that results are scientifically robust and documented.

* Develop multimodal integration processes to integrate digital pathology (H&E, IHC, mIF), Mass Spectrometry and in vivo imaging data-sets to derive insights into biological mechanisms of disease processes and models

* Develop and use machine learning/AI tools aimed at pre-processing, segmenting, co-registering, feature extraction, analysing and summarising large and multimodal image data sets

* Perform data analyses and visualization, including analytics associating image analysis features with drug treatments, response and survival data, genetic features and other sample attributes using AI powered image analysis, statistics and other tools

* Contribute to the publication of technical protocols, scientific abstracts, posters, presentations, manuscripts and/or patent applications

Essential Requirements:

* MSc/PhD in a Biological Science, Biomedical Engineering, Bioinformatics, Computer Science or related discipline with up to 3 or more years of related experience in academia or pharmaceutical/biotech/CRO organisation

* Proven knowledge and experience in multimodal image integration, segmentation, pre-processing, reconstruction, feature classification and image analysis

* Experience and programming skills in one or more of the languages/packages e.g. Python,Tensorflow, Keras, Pytorch, MATLAB, R, Java, Definiens to address image analysis questions

* Strong mathematics background and experience in application of data science knowledge to apply machine learning and deep learning methods to address image analysis questions e.g. Graphs, SMILY etc.

* Experience working with and analysis of large quantities of imaging data across modalities e.g. cellular imaging, digital pathology, mass spectrometry imaging and in vivo imaging (CT, MRI, PET)

Desirable is also experience of digital pathology imaging systems for the digitization of pathology images.

If you are ready for a challenge - take the opportunity and join our team!

For questions about the position please contact Arthur Lewis (Associate Director - Imaging & Data Analytics) at

We look forward to your application no later than 24th January 2020. Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Pharmaceutical Technology and Development (PT&D) is the bridge which turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines - from supplies for use in clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Our global Clinical Program Supply Chain team is growing, and we are now looking for a Clinical Supply Program Lead to join our team in Gothenburg. Maybe you are the one?

As a Clinical Supply Program Lead (CSPL) you will manage and have responsibility for end to end supply to our clinical studies. These supply chains are complex with typically high variability in demand, long lead times, technical complexity, regulatory constraints and high cost of goods. Our customer expectations are high with a focus on 100% availability of medicine to patients, speed to deliver and at a minimal cost. This complexity is likely to increase, and customer demands will remain high.

The CSPL will lead cross-functional Supply Chain Teams and represent Clinical Manufacturing and Supply on PT&D Project Teams (or similar eg. CMC Teams) throughout the life cycle of the project.

The CSPL works in collaboration with customer functions to influence and manage demand and is responsible for all Clinical Manufacturing and Supply project deliverables to the business through leadership of the Supply Chain Team.

Accountabilities include:

* Collaborating with customers (eg. Global Medicines Development, Global Medical Affairs, and other PT&D and Pharm Sci functions) determine, influence and manage demand for drug substance, drug product and patient packs, including requirements for placebo, comparators and rescue/challenge medication.
* Producing a supply strategy documenting the design, setup and how the supply chain will operate for the project.
* Establishing the Supply Chain for development projects and ensure delivery of the end to end supply of materials, moving from development sources to commercial sources of manufacture.
* Understanding GMP (Good Manufacturing Practice) and the impact it has on supply chain activities.
* Monitoring the performance of the Supply Chain and optimize for higher volume phases of the project, balancing speed, quality and cost with respect to the agreed level of risk.
* Accountable for a significant budget for supply activities and materials for a project.
* Maintaining appropriate information for supply activities in PLANIT on an ongoing basis and in line with RBU.
* Ensuring timely delivery of information to meet internal and external regulatory and legal requirements
* Managing change in demand and supply, resolve issues, escalating when appropriate.



Required Skills & Knowledge

* Degree in supply chain related or drug development discipline or equivalent qualification or experience.
* Extensive experience working in supply chains.
* Significant experience managing and influencing customer demands.
* Significant knowledge of drug development, manufacturing, supply chain and clinical processes including GXP standards.
* Experience of project management.



Additional Requirements

* Demonstrated technical skills and mindset in supply chain management including demand management, supply chain design / optimization and delivery.
* Proven track record of good project management.
* Proven track record of leading global cross functional teams.
* Risk identification and management.
* Good influencing, negotiating and problem-solving skills, including across functional, geographical and cultural boundaries.
* Excellent English written and verbal communication skills.



Are you ready to make a difference? Send in your application, and we'll make it happen together. For more information about the position please contact: Malin Drufva at malin.drufva(at)astrazeneca.com
Welcome with your application no later than January 15, 2020. Visa mindre

Exciting opportunity to join a great team as Respiratory Safety Scientist in the Respiratory, Inflammation and Autoimmunity (RIA) Safety department at AstraZeneca's vibrant R&D site in Gothenburg, Sweden. Is it you we are looking for?

We are searching for a Respiratory Safety Scientist, who will combine experience in biology/toxicology/pharmacology, respiratory science and drug discovery with strong communication and interpersonal skills. You will progress drug candidates to deliver novel medicines to patients and communicate across levels of internal and external stakeholders.

Respiratory, Inflammation and Autoimmunity (RIA) Safety is a leading respiratory safety organization that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel treatments for patients with respiratory disease. We are a diverse international department that comprises project toxicologists, discovery safety specialists, respiratory safety experts and experimental scientists.

As part of Clinical Pharmacology & Safety Sciences (CPSS), which contains all non-clinical safety functions that support the entire AstraZeneca Portfolio, we have a strong focus on talent development. You will be able to develop your skills, competences and scientific leadership by working together with leaders in investigative toxicology, regulatory toxicology, drug discovery and development, cell biology, and predictive safety science.

The role:

To be successful as our new Respiratory Safety Scientist at the RIA Safety department we believe that except your great skills as a scientist, you are a person who wants to contribute to an open, positive, collaborative working climate.

We also rely you to:

* Contribute to development and implement an industry-leading Respiratory / Lung safety strategy.
* Propose, develop and integrate novel in vitro safety assays and technologies to drive our predictive scientific capabilities for Respiratory Safety forward.
* Design and execute experimental strategies to predict, assess and mitigate target- and drug-related safety risks in drug discovery and development programs and develop mechanistic understanding behind (potential) safety concerns.
* Translate theoretical drug target safety assessments into concrete experimental plans and actions.
* Deliver experimental data that impact project decision making with the aim to develop molecules with the "Right Safety" profile.
* Promoting RIA Safety science through developing innovative research proposals, publications, building collaborative networks across AstraZeneca science units and with relevant external experts in order to enhance RIA Safety Science and Discovery capabilities and reputation.


Essential requirements:

* Excellent scientist, with a PhD in cell biology, molecular biology, toxicology, pharmacology, systems biology or related field, and a strong scientific track record.
* Experience with lung cell biology, respiratory science and immunology.
* Theoretical and practical knowledge of and experience with techniques and technologies relevant to in vitro systems, including cell culture and cell-based assay systems utilising cell lines and primary cells as well as utilizing relevant equipment for in vitro assay read-outs (e.g. high content imaging or -omics, etc).
* Experience with design and execution of in vitro experiments to determine the effects of therapeutics on biological systems, including data analysis.
* Extensive experience in generation and interpretation of high quality experimental data and translating scientific findings into applicable information.
* Understanding of the drug discovery process and/or a background in safety and risk assessment from the pharmaceutical industry is an advantage.


If this sounds like the job for you - please apply today and come join our team!

More information
For more information, please contact Anna Ollerstam, Director, RIA Safety Sciences and Discovery,

We look forward to your application no later than January 19, 2020.

Additional information
Visit our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg and Sweden: https://www.movetogothenburg.com/ Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Inhalation Product Development (IPD) at AstraZeneca is a multinational organization that combines decades of experience in inhalation technology whether it is nebulization, pMDI or DPI. Our vision is to develop and provide to patients best-in-class, innovative and sustainable products to deliver medicine via inhalation.

Embedded in the IPD unit is the Analytical Automation and characterization team, which is responsible for the development of automated analytical methods, initially used during the Product Development process, but later also in the commercial QC release. Across the years we have developed and implemented a plethora of automated systems, ranging from small handheld units to large automated robots to pure software applications for the evaluation of analytical data, and we have now set our course towards standardizing on Industry 4.0.

We are now looking for a positive and creative team player with a can-do attitude to join us on our development journey as an Engineering Support Specialist.

Main duties and responsibilities

As an Engineering Support Specialist, you will be an active member in a multi-disciplinary team operating in a creative and enthusiastic environment. As a recognized expert within your area you will:

* Be a key player in launching the world-class Analytical Automation team into the future and Industry 4.0 by actively contributing to the design, development and implementation of novel, first in class, robust, and mainly bespoke, automated systems, both within a Technical and a regulated Good Manufacturing Practice (GMP) environment.
* Actively troubleshoot automated systems, by identifying and addressing the root cause, when issues cannot be handled by day-to-day users.
* Work hands-on with our automation and instruments, e.g. assemble in-house designed prototype robots, as well as being responsible for the automation work-shop.
* Optimize the performance of automated systems within the Business as Usual (BAU) phase of their life cycle.
* Collaborate closely with external suppliers of automated systems across the globe.
* Turn novel or improvement design ideas, from yourself or colleagues, into reality by implementing them into BAU, e.g. transforming a sketch from a colleague into a hardware component.
* Train personnel on how to perform routine maintenance of automated systems.
* Operate and collaborate in a global environment with colleagues based in e.g. Sweden, Germany, France and the US.
* In general, share your knowledge across the IPD unit within your area of expertise to drive projects, such as inhaler device development, forward.

Essential requirements

* Educational background in mechatronics, or equivalent qualifications and experience.
* Vast knowledge and extensive hands-on experience of mechanical design (CAD), pneumatics, vacuum technology, electronics and electrical installations, silicone molding and mechanics, including material properties.
* Extensive experience in developing industrial automation, both prototypes for technical trials as well as fully validated systems.
* Fair knowledge and hands-on experience of metrology, programming of robotic systems and risk analysis.
* Extensive hands-on experience in dealing with technical problems and in simplifying and solving complex issues.
* Experience of working in a regulated environment, preferably GMP, is beneficial.
* Understanding of the overall drug development process, is beneficial.
* Good verbal and written communication skills in English.

AstraZeneca is one of the world's most exciting bio-pharmaceutical companies. From scientists to sales, lab techs to legal, we're on a mission to turn ideas into life-changing medicines that improve patients' lives and benefit society. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world.

If you are interested, apply now! Welcome with your application no later than February 2, 2020. For more information about the role, please contact Maximiliano Zaragoza-Sundqvist, at Maximiliano.Zaragoza- Visa mindre

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.

Pharmaceutical Technology and Development (PT&D) is the bridge that turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices for new medicines and providing expert technical support to all AZ's commercial drug substances and products to ensure we successfully supply medicines to patients.

We are now looking to hire a Senior Project Leader or Project Leader, depending on your background, to join our Chemistry Manufacturing and Controls (CMC) Team within PT&D.

As a Senior CMC Project Leader/CMC Project Leader you are accountable for the development of robust CMC project strategies and efficient delivery of one or several R&D development projects (typically from Ph2b) and/or commercial products where the focus is maximizing the Brand Value. You will be accountable for the CMC contribution when taking projects and portfolio through key business investment decision points, transfer to Operations and CMC related contributions to LCM (Life cycle management).

In this role you will primarily lead projects in the Biopharmaceutical Therapeutic Area (Respiratory, Inflammatory, Autoimmunity (RIA) and Cardiovascular, Renal, Metabolism (CVRM)) but may also be involved in other TA projects (e.g. Oncology).

You will represent PT&D and be a member of the Global Project Team (GPT), working collaboratively in a cross-functional and international environment to influence the development of AZ's development and commercial drug portfolio. You will be representing PT&D when projects interact with key governance bodies (ESPC, LSPC etc) and is expected to consistently demonstrate excellent communication skills and influence with stakeholders in these forums in a way that creates value for AZ. You will also lead the Pharmaceutical Project Team, with representatives from technical functions mainly but not exclusively from PT&D.

Accountabilities include delivering all the CMC related activities associated with Development of New Product (e.g. overall development and technical strategy, clinical trials applications), Business development activities (e.g. divestments, partnering, in-licensing) as well as Life Cycle Management for Commercial Products (e.g. new Clinical studies, filing in new markets, new formulations or devices, Cost of Goods reductions). The role involves a diverse range of problems/opportunities requiring complex judgements and solutions based on highly developed levels of conceptual thought and strategic vision and analysis.

Education, Experience and Capabilities

* Scientific degree (or equivalent) and a good working knowledge of a CMC organisation.
* Global drug development and clinical/commercial supply chain experience with business enterprise mindset and ideally good knowledge of the broader business especially development, commercialization, post-launch technical support and lifecycle management
* A good working knowledge of project leadership approaches within the pharmaceutical industry and experience from working with projects from phase II through commercialisation and LCM. Preferably will have experience from other areas than CMC.
* Understanding of at least one AZ disease area preferably RIA and/or CVRM.
* Track record of Ability to identify and progress innovative approaches, constructively challenging the status quo to achieve best outcome for the project/brand and AZ
* Understanding of Regulatory requirements, the evolving landscape and the constraints/opportunities this presents
* Experience of cost management (resources and $) of larger scale projects.
* Strong credible leadership with enterprise mindset.
* Learning agility, networking & negotiation skills and collaborative approach.
* Excellent interpersonal, influencing and communication skills with ability to set clear direction and objectives for the team and to influence at a senior level in the organisation including Governance groups (GPT/ESPC/LSPC/TALT/Supply Committee and beyond)
* Capable of managing the responsibilities for a diverse range of activities and projects acting as the key sponsor for projects and programmes supporting their project/product portfolio.
* Possess strength and independence of viewpoint and be willing to challenge others in senior roles when appropriate
* Ability to develop & implement end-to-end Pharmaceutical strategy across all CMC areas (API, DP, etc.) aligned with the overall GPT strategy and clinical/commercial supply

This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

For more information contact Petra Edwards, Head of Project Leadership, PT&D at petra.edwards(at)astrazeneca.com Welcome with your application, no later than January 19, 2020 Visa mindre

Are you passionate about imaging and advance image analysis? Can you apply these skills to help us in drug discovery? Do you have expertise in leading a talented team of imaging scientist and are you able to help shape an integrated imaging strategy? Then why not join our Imaging & AI department at AstraZeneca in Gothenburg!

We are looking for an Associate Director Imaging & AI - Imaging & Data Analytics who will manage a group of tissue and in vivo imaging scientists, using groundbreaking technologies and advanced image analysis. The team works to support projects across all our therapy areas. The Associate Director will work as part of a global imaging & AI group within Clinical Pharmacology and Safety Sciences (CPSS).

CPSS is changing the way imaging technologies are combined to offer unprecedented insight and impact. Our imaging hubs combine data from histology, digital pathology, multiplex assays, advanced molecular imaging techniques (including mass spectrometry imaging) and a full suite of in vivo imaging technologies. This position offers the opportunity to lead all aspects of how we investigate both the safety and efficacy of drugs within our projects in both a preclinical and clinical setting. The role combines the management of a dynamic scientific team with opportunity to deliver as a scientific lead. We believe this is a truly exciting opportunity for a hardworking imaging scientist.

The successful candidate will need to be a strong communicator with experience of successful cross-functional collaborations, both as contributor and leader. We feel strongly that AstraZeneca leads the way in advance tissue imaging, and we want you to help us to continue to achieve this.

The role:

As Associate Director you will lead a team that plans and designs of histological, molecular and in vivo imaging studies and you will provide expert and hypothesis-driven scientific advice on specific topics to the team. You will have a strong experience of the management of scientists reviewing, planning, conducting, validating, reporting and outsourcing a variety of studies. As well as a specific domain expertise in advance tissue imaging, a consistent track record in delivery of scientific excellence and evidence in design and delivery of successful scientific strategies in imaging and image analysis.

In this role, you will apply your management skills and lead a team of 10-15 imaging scientists, providing leadership, development and mentorship to the team to ensure staff can apply state of the art techniques to address scientific questions. You will build and maintain network of collaborative scientific links with aligned therapy area partners to maintain overview strategic scientific areas of focus and importance to Imaging, as well as contribute to and be a member of Imaging & AI leadership team and report into Head of Imaging & AI.



Main Duties and Responsibilities:

*

Will coordinate integrated imaging laboratory activities at their site in generation of imaging data and reporting for preclinical safety studies and TA-aligned efficacy support.
* Will lead appropriate technology development at their site as part of overall Imaging & AI strategy; site-specific technology development dependent upon remit of that imaging hub.
* Will liaise with TA-aligned pathologists to schedule and prioritise lab support and biomarker validation. Will manage cross-hub resources or activities as appropriate when necessary.
* Will liaise with Digitization & AI group and external vendors in continued development of AI approaches for imaging.
* Will coordinate externalized contract research as needed in support of efficacy and safety studies.
* Accountability for maintaining standard methodologies and cross-department relationship to Imaging & AI hubs as well as wider AZ imaging groups.
* Accountability for ensuring compliance for all AZ and site specific policies, quality standards, SOPs, regulatory requirements, SHE and Human and Animal Tissue standards (HBS).

Essential requirements:

* Experienced pathology sciences leader with a minimum of 10 years industry/CRO experience. of development and utilization of tissue imaging approaches for preclinical (essential) and clinical (desirable) support.
* Desirable experience and knowledge of other imaging approaches such as MRI and PET
* Strong scientific leadership demonstrated by successful technology development of multidimensional imaging sciences area and publication of this work externally.
* Strong communicator with experience of successful cross-functional collaborations, both as contributor and leader.
* Previous experience of management and shown staff development is needed.

If you are ready for a challenge - take the opportunity and join our team!

For questions about the position please contact Richard Goodwin (Director Science - Imaging & Data Analytics) at

We look forward to your application no later than 17th January 2020. Visa mindre

Are you experienced in experimental design and have great knowledge of in vivo studies? Do you also have management skills and would like to lead a team of engaged employees who work to always develop further? Welcome to come join our Animal Sciences and Technologies (AST) department as an Associate Principal Scientist - Team Leader at AstraZeneca in Gothenburg.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. We are proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The Animal Sciences and Technologies (AST) is a global department that delivers in vivo studies, animal care, and welfare that is compliant to internal standards and external regulations. Principles of the 3Rs are applied to all aspects of animal care and study conduction.

The role:

In this role you will lead a team that works closely with the Cardiovascular renal and metabolic (CVRM) therapy area. The team is responsible for the care and welfare of animals and directing pre-clinical assessment studies. You will chair in vivo study design meetings and participate in global study director initiatives to develop best practices and implement quality control measures based upon current literature. You will train junior staff in scientific method and in vivo study design.

In this role we also believe that you have the ability to engage in constructive and challenging dialogues in cross-functional teams, as well as:

Minimum experience:

* Advanced university degree in biology or related field.
* Specialty certification or experience in laboratory animal science.
* In vivo skills in a variety of animal species
* Experience supervising and managing staff.
* Experience in experimental design and scientific publication

Preferred experience/requirements:

* 5 years' experience in laboratory animal studies, including as a manager
* Experience in GLP and toxicology studies.
* Experience in Cardiovascular, Renal, Metabolic disease areas and research
* Doctoral degree

We look forward to your application no later than 6th of January, 2020.

More information
For more information about the position please contact Hiring Manager: Sofia Östman at Visa mindre

We are curious, creative, and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. Join AstraZeneca and apply your expertise in a company that are following the science and turn ideas into life changing medicines. We have an exciting opportunity for a talented Project Manager to be based in Gothenburg, Sweden.

Drug Product Development (DPD) within Pharmaceutical Development is the sole internal AstraZeneca department that packs, labels and distributes investigational medicinal products to clinical trial patients. We support launched, pre-launch and products under development within all our therapeutic areas. We work in a fast-paced environment where flexibility and agility enable us to deliver high value to early phase clinical trials. To complement our existing DPD team we are seeking:

* Broad project management experience
* Extensive knowledge and expertise in working with automated/semi-automated equipment in an operational environment
* Validation expertise from a GMP regulated environment

Main Duties and Responsibilities

The role holder will contribute to the DPD organization applying their expertise in the complex and regulated GMP environment. The work is focused on project leadership. The area of project leadership varies and depends on business demand and current requirements. It could be to a lead pharmaceutical project as a DPD representative in the Supply Chain Team or to lead facility/equipment/improvement projects. All activities will have a significant impact on the speed, quality and cost of the AZ development portfolio.

As a technical project leader, you will be:
Responsible for establishing core technical requirements, define and implement new equipment strategies, design and provide technical input and directions during capital project design from concept through detailed design and equipment selection. Develop and implement recommendations for improvements on current equipment to increase efficiency and effectiveness.

As an internal pharmaceutical project leader, you will be:
Responsible to optimize the design of clinical trial kits to ensure effective processes for packaging, labelling and distribution to ensure on time delivery to clinical trials.


Essential requirements and skills

* BSc/MSc in chemistry/pharmacy/engineering or equivalent experience. Preferably 5 years' experience within pharmaceutical development
* Great understanding of principles, applications and management of SHE and GMP in an R&D environment
* Good understanding of corporate business goals with the capability to convert them into technical solutions fit for the new drug product portfolio within Astra Zeneca R&D
* Understanding the disciplines in Drug Product Delivery, Supply Chain and Pharmaceutical development in order to contribute to an effective Supply Chain organization
* Business leadership skills and a strong technical background with awareness of innovations and new packaging and engineering technology within the industry
* Demonstrated ability to work with teams in a culturally diverse, complex and changing environment both internally and externally
* Capability of leading and delivering through others
* Curious and innovative mindset with problem solving ability - resolve complex issues with minimal guidance
* Demonstrate the drive and energy to deliver projects with a high degree of personal credibility
* Excellent in decision making skills

Are you ready to bring new ideas and fresh thinking to the table? Fantastic! We have one seat available, apply today and make it yours!

For more information please contact recruiting managers Linda Eriksson or Philippa Rörby at linda.eriksson(at)astrazeneca.com (+46703 - 81 81 61) or phipippa.rorby(at)astrazeneca.com (+46709 - 72 68 03). We welcome your application no later than January 6th, 2020. Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZeneca's therapy areas. Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline.

We now seek a talented, motivated and experienced CMC Project Lead to join to our Respiratory, Inflammation and Autoimmunity (RIA) CMC project leadership teams in Gothenburg, Sweden.

The CMC Project Lead is a key leadership position within the Pharmaceutical Sciences function, delivering a rich portfolio comprising an exciting mixture of small molecules and new modalities. The selected candidate will be accountable for leadership, strategy & planning as well as delivery and budget management for the CMC contribution to a small portfolio of projects prior to phase III.

You are expected to take a holistic view of CMC activities as well a working knowledge of other scientific disciplines in AZ BioPharma R&D and deliver innovative and differentiated strategies that balance scientific risks against return on investment.

This is an important role, giving you a chance to influence R&D science, portfolio strategies and product development, and contribute to the success of AstraZeneca's portfolio. Depending on complexity and the stage of development, you will lead 2-6 projects within your therapeutic area. You will report to the Pharmaceutical Sciences Head of RIA CMC project.

Essential Requirements - Experience, skills, capabilities

* Advanced degree in science (or equivalent) in the relevant scientific discipline and significant experience working within a pharmaceutical development organisation.
* Broad experience of the early development of respiratory and oral dosage forms
* Significant experience of working within a CMC organisation, and insight into how CMC contributes to the wider medicine development process.
* Global drug development experience.
* Experience of project management in a large and complex business environment, preferably within an international environment and experience of working with external partners.
* Proven track record in all aspects of creating and leading large scientific, multi-disciplinary high performing teams, such as: excellent communication skills, strong business acumen and creative problem-solving capabilities, ability to analyse and interpret complex situations in order to provide clear strategic directions for others.

This is an exciting opportunity for professional growth in areas of drug development, science, and leadership If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

If you have any questions about this role, please contact Yorick Kamlag, Head of RIA CMC Projects, at

Welcome with your application no later than January 8, 2020.

Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.



Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline.



We now seek a talented, motivated Associate Director to lead a large preformulation and biopharmaceutics team in Gothenburg, Sweden. The selected candidate will be responsible for the proof-of-concept testing of new drug delivery technologies, and lead formulation efforts for the small molecule discovery portfolio up until GLP tox formulation definition across AstraZeneca's R&D units. In addition, the role will have responsibility for biopharmaceutical assessment of small molecule and new modality (i.e., peptides, oligonucleotides, and RNA based therapeutics) portfolio candidates from discovery to Phase II.



Your broad understanding of the discovery to launch drug development process, and excellent stakeholder management skills will ensure your Preformulation & Biopharmaceutics team provides first class scientific input and enables insight to key functions across Pharmaceutical Sciences, R&D as a whole, and beyond. Drug delivery and CMC is critical for the AstraZeneca pipeline and hence you will be key in developing current and future talent to be successful in the rapidly changing R&D environment.



You will be reporting to the Head of Advanced Drug Delivery and collaborate closely with other ADD teams located in Waltham/US, Cambridge/UK and Gothenburg/Sweden.



Essential Requirements - Experience, skills, capabilities

* Ph.D degree in pharmaceutical sciences, pharmacokinetics, or other relevant scientific discipline.
* Experience in leading, coaching, developing and managing a large team of scientists with a variety of experience levels
* Experience with leading and managing change processes
* Track record as a scientific leader, providing scientific challenge and direction to team members.
* Prior industrial experience in influencing drug discovery with the aim of ensuring CMC developability and/or biopharmaceutics assessment of oral or inhaled drug candidates
* Understanding of the Astra Zeneca's disease areas, and exposure to multiple disciplines in Drug Discovery or Pharmaceutical Development to enable influencing of drug and drug product design.
* Knowledge of the overall drug research and development process from Discovery through to Launch, and an appreciation of how Pharmaceutical Sciences disciplines contribute to R&D and the broader business
* A leader of a product development scientific skill discipline including external visibility through publications, presentations and networking activities. Capable of and desire for continuing to develop self in this arena.
* Innovative, with a passion for driving scientific excellence and a continuous improvement mind-set
* Ability to effectively communicate and manage multiple diverse stakeholders to build strong collaborative relationships across disciplines and cultures, internally and externally
* Strategic thinking - able to develop and influence strategy for business area entailed in position and beyond
* Thorough understanding of principles, applications and management of Safety Health and Environment (SHE).



This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.



For more information about the position please contact Annette Bak, Head Advanced Drug Delivery at



We encourage you to send your application as soon as possible, but no later than December 8, 2019.

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

Are you a chemist with expert knowledge in separation science and chromatography? Would you like to apply your expertise working cross-functionally in an environment using state of the art technology? Then you might be our next member in the Separation Science Laboratory team! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines.

We're looking for a talented and motivated Senior Separation Scientist to join our Separation Science Laboratory team within the Pharmaceutical Science function at AstraZeneca in Gothenburg, Sweden. The position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) across all the AstraZeneca therapy areas. The Separation Science Laboratory within Pharmaceutical Sciences supports the design and evaluation of new candidate drugs through purification and characterisation of new compounds from microgram to kilogram scale. Our portfolio of projects spans traditional small molecules to nucleotide-based therapies and nanomedicines across AstraZeneca's therapy areas.

Major Duties and Responsibilities

As a Separation Scientist you will have the opportunity to combine your practical and theoretical skills to provide separation science expertise into our drug projects. You will join a highly competent team and collaboratively drive the delivery of pure compounds across the R&D organization.

The team is responsible for solving both chiral and achiral separation problems in mg to kg scale, ranging from small molecules to large peptide conjugates. You will:

*

Be a laboratory-based role model working collaboratively with colleagues to ensure delivery
*

Demonstrate expertise in separation science ranging from analytical to preparative scale
*

Contribute to the delivery of the pipeline by owning the progressions of its items
*

Effectively operate with scientists from other functions in a highly cross-disciplinary environment
*

Have a passion for driving scientific excellence through publications and presentations



Essential Requirements

To be successful in this role you will need a strong scientific background together with a problem-solving attitude and delivery focus. It is essential with good communication skills and ability to engage and collaborate across boundaries. You have:

*

University degree or PhD in a relevant scientific discipline and at least three years working experience
*

In-depth scientific knowledge within separation science and chromatography
*

Experience from working with larger molecules like peptides or oligonucleotides
*

Technical skills and experience to use and maintain chromatographic equipment
*

Excellent English, both spoken and written
*

Strong collaborative and communication skills with experience of interacting effectively and work collaboratively across interfaces of disciplines



AstraZeneca is a global biopharmaceutical company committed to the development of the next generation innovative medicines. From scientists to sales, we're on a mission to turn science into life-changing medicines that improve patients' lives and benefit society. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world.

If you are interested, apply now!

For more information about the position please contact hiring manager Hanna Leek,

Welcome with your application no later than January 10, 2020

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

Are you an experienced Regulatory Affairs professional with strategic leadership skills and a deep understanding of global regulatory science in the context of drug development? Would you like to apply your expertise in a global company where we work together across boundaries to make the impossible a reality? If so, you might be interested in joining us to be part of the development of innovative treatment of diseases in the areas of Cardiovascular, Renal and Metabolic (CVRM) or Respiratory, Inflammation and Autoimmunity (RIA)!

AstraZeneca's pipeline of innovative medicines is consistently growing within both CVRM and RIA, two of our major therapy areas. To meet the increasing demand of regulatory expertise, we are now expanding our regulatory functions by recruiting Regulatory Affairs Strategists (at Director and Senior Director level). With us, you will get the opportunity to work across the spectrum of drug development to progress a rich and diverse pipeline of both small and big molecules. You will work across disciplines in an atmosphere of collaboration and inclusion where Regulatory affairs is a respected voice and considered an equal partner.

If you are looking for a new challenge, we are offering opportunities in different disease areas and at different levels, depending on your expertise and previous experience. We are now expanding our regulatory teams at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. You can also be located in Cambridge, UK or Gaithersburg, US depending on your preference.

Main duties and responsibilities

As a Regulatory Affairs professional within AstraZeneca, you will play a key role in channeling our scientific capabilities to make a positive impact on changing patients' lives. In Regulatory Affairs, our teams define the regulatory strategy for our innovative pipeline, influence the development of our therapeutic assets and execute against the health authority engagement and submission plan globally, thereby transforming exciting science into valued new medicines and ensuring patients around the world can access them.

Strategic thinking is key within our function. The more experienced you are, the more accountability you will have for strategic leadership including responsibility for development and implementation of the global regulatory strategy for a product/group of products of increasing complexity.

Requirements

In combination with your regulatory expertise, you will demonstrate competencies of strategic thinking, strategic influencing, innovation, initiative, leadership and excellent oral and written communication skills. It is important that you embrace the concept of novel regulatory tools and technology as well as a culture of sharing experiences with others so that the medicines that we develop will benefit from latest approaches in regulatory science. You are comfortable speaking the regulatory voice at all levels of the organization.

* Academic degree in a science related field or equivalent
* Solid knowledge of regulatory affairs within one or more therapeutic areas in early and late development
* 5-10 years' experience of regulatory drug development including product approval/launch. Successful leadership to at least one major regulatory approval at a global level is required for senior positions.
* Experience in leading Major Health Authority interactions
* Ability to think strategically and critically and evaluate risks to regulatory activities.
* Ability to work strategically within a complex, business critical and high-profile development program.

We are eager to know more about you. If you are interested to know more about us, apply now!

For more information please contact Talent Acquisition Partner Ulrica Marklund at ulrica.marklund1(at)astrazeneca.com.

We welcome your application no later than January 7th, 2020. Please apply as soon as possible as we will be continuously screening and interviewing candidates. Thank You!



Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Culture and atmosphere of the site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Life in Gothenburg and Sweden: https://www.movetogothenburg.com/

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

Are you a toxicologist excited by an opportunity to be a key player in the discovery of safe innovative medicines? Would you like to apply your expertise in a company that is accelerating innovative science and turns ideas into life changing medicines? Join us to be part of the development of future treatments of respiratory diseases!

We are now recruiting a Project Toxicologist / Toxicology Project Leader to join the Respiratory, Inflammation and Autoimmunity (RIA) Safety function at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. For the right candidate, placement in Cambridge, UK is also an option.

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. This role will give you the opportunity to work at the forefront of toxicology and safety science within respiratory diseases, one of AstraZeneca's main therapy areas. In a multidisciplinary environment you will play a key role in progressing a rich and diverse pipeline of both small and large molecules.

As a Project Toxicologist / Toxicology Project Leader, you will combine your experience in toxicology and drug development with strong communication and interpersonal skills to communicate across levels of internal and external stakeholders. In this role, you will be key for the progression of drug candidates to deliver novel medicines to patients within respiratory disease.

Our Function

RIA Safety is a leading respiratory safety organization that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel treatments for patients with respiratory disease. We are a diverse international department that comprises project toxicologists, discovery safety specialists, respiratory safety experts and experimental scientists. As part of Clinical Pharmacology & Safety Sciences (CPSS), which contains all non-clinical safety functions that support the entire AstraZeneca Portfolio, we have a strong focus on talent development. You will be able to develop your skills, competences and scientific leadership by working together with leaders in investigative toxicology, regulatory toxicology, drug discovery and development, cell biology, and predictive safety science.

Main Duties and Responsibilities

* Be responsible to design and deliver nonclinical safety strategies and provide insight and judgement to enable successful development of projects in the RIA portfolio as part of multi-disciplinary teams
* Operate across international boundaries within CPSS and across R&D functions in AstraZeneca to lead and manage projects and stakeholders
* Author high-level regulatory documents (e.g. INDs and IMPDs) and contribute to regulatory interactions with health authorities
* Provide specialist nonclinical expertise for evaluation of in-licensing and out-licensing opportunities
* Contribute to the delivery of the RIA Safety department strategy and objectives

Requirements

* A PhD, or university degree with extensive relevant experience, in Toxicology or equivalent life-science subject is required.
* Experience working within a pharmaceutical project environment, preferably with a primary focus on toxicology science and with knowledge and experience of drug development
* Experience in providing expert design and interpretation of toxicology programs
* Clear project leadership skills required to lead and manage the safety assessment contribution to a portfolio of projects, ability to operate with sensitivity and flexibility within an ever-evolving organisational matrix of project and line management, both functionally and across the business
* Significant skills of influencing and persuasion
* Eagerness for scientific excellence, investigation of mechanisms of toxicity and translation of insights to risk assessment
* Willingness to challenge conventional thinking and implement creative ideas balanced with a high regard and understanding for the regulatory framework in which AstraZeneca operates is expected
* Experience with inhalation toxicology and/or respiratory diseases is an advantage
* A social personality with strong inter-personal skills that contributes to our team culture in which trust, cooperative support, diversity and inclusion enable engaged and motivated colleagues to deliver and develop.

We would like to know more about you. If you are interested, apply now!

For more information please contact Jorrit Hornberg, Head of RIA Safety, jorrit.hornberg(at)astrazeneca.com

Welcome with your application no later than January 7th, 2020.



Additional information

Preferred location is AstraZeneca's dynamic R&D site in Gothenburg, Sweden but for the right candidate Cambridge, UK is also an option.

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Life in Gothenburg and Sweden: https://www.movetogothenburg.com/

AZRespi #GMD

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

We are now looking for a driven Asset Engineering Manager with the habit of working with external suppliers to achieve high reliability and satisfied customers. Do you want to manage buildings where there are ongoing activities that make a difference to people's lives every day? Then AstraZeneca is the company for you!



Our amazing campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've created a series of environments where innovation can happen.



At AstraZeneca, we are united by a common purpose: to push the boundaries of science to deliver life-changing medicines. Our purpose is ambitious and so is our approach. Becoming a more agile and creative company means building a dynamic, inspiring culture where we celebrate diverse, bold thinking and act with a sense of urgency.



Your main focus will be to manage and develop our office buildings from a life cycle perspective with high customer happiness and sustainability as key. Your area of specialty will be building automation and building digitalization strategy for all buildings on site.



Your main duty and passion in the following responsibility areas will be key:

* Take stewardship for our office buildings. Making sure that our property installations are maintained so that the technical life and functionality requirements are met.
* Take stewardship for our Building Management Systems (BMS). Ensure that our strategy for BMS are implemented and well maintained so that the technical life and functionality requirements are met.
* Together with our supplier, act so that repairs and service requests are handled in a timely manner and with the desired quality.
* Secure compliance with applicable laws, regulatory requirements and regulations.
* Assess maintenance needs and prioritize maintenance and reinvestment in your management area (offices) and in your specialist area (building automation).
* You take lead for investments in your management area and in your specialist area.
* You work with our supplier to increase the digitization of our property documentation and to ensure good drawing management.
* You participate in real estate development projects by assisting with technical knowledge of the properties and developing working methods and processes together with other colleagues and our supplier.
* You are responsible for customer satisfaction and financial management in your area.



To be successful in this role we believe the following experience is needed:

* An academic degree in technology with a focus on Facility Management or building automation. Alternatively, corresponding skills and experience acquired through multiple years of work in the field.
* Ability to build good customer relationships and acting as a good client by having a relationship-based and results-based approach together with our external suppliers.
* Knowledge of different systems for building automation and the structure of the systems from controllers, technical networks and building monitoring systems.
* A structured working method and the ability to achieve results through collaboration with colleagues, the business and external suppliers.



DESIRABLE

* Experience in managing and improving work processes with the help of Lean and knowledge of quality system for pharmaceutical manufacturing (GMP).





Are you ready to bring your knowledge to the table? Brilliant! We have one seat available, and we hope it's yours.



For more information about the role, please contact Artur Gunnarsson, Associate Director Facilities, at



Welcome with your application, no later than January 7, 2020.



Additional Information

Location for this position is AstraZeneca's dynamic R&D site in Gothenburg, Sweden

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

At AstraZeneca, science is at the core of everything we do. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. Our purpose is to push the boundaries of science to deliver life-changing medicines. Would you like to be a part of helping us achieve this ambition?

Explore the possibility of joining us as a Clinical Information Science Director (CISD) within one of our key scientific focus areas; Cardiovascular, Renal and Metabolism (CVRM). Embedded in the late stage drug project teams, you will be an authority on innovative use of information and data to help shape our trials, decision making and portfolio.

Role

You will play a leading role in supporting global clinical teams in finding and structuring clinical information for late stage drug development decisions. The position sits within our Information Practice unit who drives optimal use and value of clinical information and scientific knowledge retention for better informed decision-making in clinical development.

Late-stage Development CVRM Biometrics consists of statistical, programming and information experts for drug development in phase II and beyond. You will be part of a truly global team alongside some of the most respected specialists in the industry.

Main Duties and Responsibilities

As a strategic information expert embedded within dynamic drug project teams, you will lead the delivery of information that clinical teams need to make decisions in the drug development process. For example, using a variety of information sources such as scientific literature, competitive intelligence, internal and external clinical trial databases.

You will be accountable for full Information Practice delivery scope in one or more drug projects or across a franchise, by own contribution and leadership of other information practice staff, partners and suppliers. You will also be accountable for proactive development and execution of the Project Information Strategy, providing foresight into what information will be needed to support upcoming drug project needs to achieve goals and milestones, and to drive the active re-use of Information assets and clinical data.

You will be using techniques such as specialist information search and analysis, text mining, data visualization and benchmarking to extract and present key relevant information.

Significant areas for contribution are:

* Support decision-making in clinical design, submission and interpretation by identifying, extracting and presenting back meaningful facts and data via internal and external information sources
* Enable quality decisions by providing comprehensive access to key decisions and rationale for study designs and project milestones from phase II and throughout the project life cycle, helping the organization to grow and maintain scientific knowledge
* Information strategy for project and TA, proactively assessing information gaps that needs to be filled, enable re-use of information between project and TA and define new ways of working cross projects applying knowledge of external environment and trends

Requirements

To succeed in this opportunity you will have a real passion for clinical data and information and proven insightful ability to know what information to seek, how to find it, and how to share it with the teams in a clear and meaningful way. You will be a creative thinker with an appetite for doing things differently.

You'll be excited by the prospect of playing a lead role within late stage drug development projects. An excellent communicator with great listening skills, who can absorb information and respond in a concise manner.

In addition, you will also have:

* Bachelors or advanced degree in a Life Science, or related discipline
* Deep understanding of the pharmaceutical clinical drug development process (with a preference for late-stage drug development in in cardiovascular, renal, and metabolism)
* Good understanding of project management techniques and methods, and proven ability to lead teams towards a common goal
* Experience in clinical information or science information setting in the application of information and knowledge management (settings could include, but are not limited to clinical drug development, medical writing, medical affairs, clinical operations, competitor intelligence, regulatory intelligence)
* Demonstrated leadership capability - including ability to influence stakeholders
* Good organizational skills and the ability to multitask; can set priorities and follow a timeline
* Great attention to detail



For more information about the position please contact hiring manager Åsa Ström at Åsa.H.Strom(@)astrazeneca.com

Welcome with your application no later than December 15.



Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Life in Gothenburg and Sweden: https://www.movetogothenburg.com/

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

AstraZeneca is committed to putting patients first. This strong focus on patients shapes how we manage all aspects of our business. The Patient Centered Science (PCS) group plays an integral role in fulfilling this commitment by developing strategies to capture patient experience and generating impactful evidence to demonstrate the value of our medicines and support decision making by regulators, patients, physicians and payers.



The Patient Centered Science Director will develop and lead strategies for generating patient experience data to support the evidence needs of regulatory, payers, prescribers and patients. The role is dedicated to our Oncology therapeutic area and will require an in-depth understanding of patient-centered outcomes research within the context of pharmaceutical development.



As a PCS director you will lead the development of patient experience strategies within your area to optimize the needs of various stakeholders. In the role you will:

*

Set and lead TA and study specific strategies to represent the patient experience to regulators, patients, Healthcare Professionals (HCPs) and payers,
*

Determine and deliver guidance on which therapy/disease areas and early projects that will need a PRO as endpoint and description of patient experience,
*

Investigate to what extent Patient Reported Outcomes (PRO) and Clinical Outcome Assessment (COA) endpoints are developed, fit-for-purpose and approved by Regulatory Authorities and how well they will meet AstraZeneca's project needs, to provide the most appropriate PRO strategic recommendation to meet all key stake holder needs work cross-functionally.



The incumbent will be responsible for driving high quality evidence claims by working with assigned therapeutic area (TA), focusing on projects within the Oncology field (and their underlying projects) across the development cycle, in cross functional teams within AstraZeneca.



As a PCS director you will interact with regulatory authorities, payers and key external experts, as well as with relevant AstraZeneca's cross-functional teams, to provide PRO related leadership to assigned projects, and will be accountable for TA PCS standards, the input to Target Product Profiles (TPPs)/ Target Product Claims (TPC) and clinical plans.



Minimum Requirements -Education and Experience

*

Bachelor's degree in clinical, biological, or social sciences or equivalent
*

Master's degree in relevant field (outcomes research, health services research, epidemiology, health policy or related fields)
*

Doctoral degree in relevant field preferred
*

Relevant experience of COA/PRO scientific work
*

Minimum of 5 years' experience in the biopharmaceutical industry or equivalent
*

Excellent knowledge in clinical development and research study designs and interpretation.
*

Good understanding of qualitative and quantitative analyses to gain insights on patient experience
*

Effectiveness in a scientific advisory role involving both strategic and tactical elements
*

Knowledge of therapeutic area
*

Open to periods of travel



Skills and Capabilities

*

In-depth or expert knowledge of PRO/COA
*

Knowledge of international healthcare systems and their changing needs for PRO/COA information.
*

PRO /COA and its application to pharmaceutical development at an international level.
*

Comprehensive understanding of the pharmaceutical industry and regulatory requirements from a global perspective and product development processes at all life cycle stages.
*

Strong knowledge of legal and regulatory environment influencing clinical development plans, labeling and promotional claims.
*

Leadership skills and problem-solving capability as demonstrated by ability to evaluate challenges and opportunities for PRO strategy and modify as appropriate.
*

Well-developed conceptual thinking with capability to access internal and external resources for advice.
*

Integrity and high ethical standards



The PCS group at AstraZeneca is passionate about including patient perspective in drug development, we are a vibrant and diverse group that enjoys leading and advancing the field of patient centered science. If you are passionate about patient perspective as we are, send your application now!



For more information about the position please contact: Nikunj Patel, Group Director, Patient Centered Science: Oncology at or +1 202 515 1463

Welcome with your application no later than December 31st 2019.

AstraZeneca is acting as an Employment Agency in relation to this vacancy. Visa mindre

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

Due to sustained growth are hiring across a number of new positions in our Precision Medicine function. As a Senior / Associate Director / Director - Diagnostic Expert you will play a pivotal role in providing medicines that make a real difference to patient care. Precision Medicine is at the heart of our commitment to innovation and growth. Through diagnostic tests to evaluate individual responses to treatments, we aim to match medicines to those patients who will benefit most. We apply Precision medicine approaches across all therapy areas (TAs), and in over 85% of drug projects in our pipeline, which sets us apart from our competitors.

In our state-of-the-art research centres you'll be able to immerse yourself in your work, advance your career and contribute towards scientific excellence. But as well as thriving in our multidisciplinary setting, you'll work collaboratively with external diagnostic companies and world-class research institutes.

If you're inspired by the possibilities of science and precision medicine to make a difference to patients and ready to discover what you can do - join us.

Main duties and responsibilities
As a Diagnostic Expert with experience at the Senior / Associate Director / Director level you'll be a member of the Oncology Companion Diagnostic Unit (CDU) team. Your objective will be to ensure that innovative companion diagnostic tests are delivered to our oncology drug projects. This will entail developing and implementing the diagnostic strategy agreed by the respective early or late development teams, and planning and leading Precision Medicine activities from a technical, financial, risk, regulatory, IP and partnering perspective.

The role will involve contributing to the personal development of project team members. Providing expert advice on strategic and innovative precision medicine approaches and companion diagnostic development to development teams, you'll be instrumental in ensuring that we adopt world-class practice in the field to increase the likelihood of successful drug development, launch and return on investment.

Essential requirements:

* PhD or equivalent experience in a relevant subject
* Significant scientific knowledge in Oncology, companion diagnostic test development expertise and implementation in clinical studies
* Evidence of delivery, and experience of precision medicine approaches and diagnostic development in Oncology
* Excellent skills in communication, leadership, stakeholder influencing, programme management with strong business acumen
* Significant understanding of the functions involved in companion diagnostic development and how they contribute to achieving business objectives.

Desirable requirements:

* Experience of delivering companion diagnostics, regulatory interactions and commercialisation
* Record of publications and strong external reputation in the precision medicine field

To be considered for these exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

Position: Senior / Associate Director / Director- Diagnostic Expert - Oncology
Location: Gothenburg, Sweden or Cambridge, UK or Waltham USA or Gaithersburg, USA
Salary: Competitive

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At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue extraordinary medicines in new ways, combining our people's outstanding skills with those of people from all over the globe.

Patient Safety covers the entire clinical life cycle of a drug from planning before first time in man to withdrawal of a product from the market. We are looking for a Principal Pharmacovigilance (PV) Scientist to work in the Respiratory Therapeutic Area, to join our team in Gothenburg, Sweden.

Main Duties and Responsibilities
As a Principal PV Scientist, you will provide expertise to multiple and/or single but complex products in different stages of development as needed. You will lead the review, analysis and interpretation of safety data obtained from patients who have been administered the assigned medicinal products in collaboration with the Global Safety Physician (GSP) and other PV Scientist(s). You will apply your strong leadership, pharmacovigilance and scientific knowledge skills in guiding the authoring of as well as providing strategic input to safety-related documents. Main responsibilities include:

* Leading the strategy for proactive pharmacovigilance and risk management planning of complex or multiple products, including preparation of the safety aspects of Global Risk Management Plans in partnership with the GSP and others as appropriate.
* Providing subject matter expertise in the therapeutic area and across multiple products.
* Having the ability to lead cross-functional process improvement or other initiatives on behalf of the Patient Safety organization.
* Performing duties as a Safety Strategy and Management Team (SSaMT) Leader for complex and/or multiple products.
* As a Safety expert leading presentation of complex issues to Safety Information Review Committee (SIRC).
* Leading safety strategy for multiple or complex periodic regulatory documents (PBRERs, PSURs, DSURs) according to the agreed process and timelines.
* Leading safety strategy for regulatory submissions of new products, formulations or indications (NDA/BLA, MAA), in partnership with the GSP and other functional experts.
* Leading negotiations and providing expertise to the PS component of contracts/agreements with third parties to ensure quality and integrity of agreements.
* Taking accountability and leading resolution of complex safety issues and mediating cross-functional agreement.
* Having the ability to participate in due diligence activities.
* As a safety expert, providing training and mentorship to new GSPs and PV Scientists in processes and systems.

This role reports to the Pharmacovigilance Science Director, Patient Safety RIAIV.

Essential Requirements

* A life sciences/pharmacy/nursing degree, and demonstrated Patient Safety and/or Clinical Development experience, with proven relevant/related work experience
* Extensive (i.e. at least 10 years) experience in pharmacovigilance and drug development activities
* Advanced knowledge of PV regulations
* Advanced understanding of scientific methodology
* Advanced understanding of epidemiology data
* Clear evidence of leading teams in cross-functional collaborations and delivery
* Proven communication skills, interest in and knowledge of cultural diversity
* Able to influence whilst maintaining independent and objective views
* Proven ability to deal with complexity under time pressure
* Proven planning and organizational skills
* Proven project management skills
* Proven people management skills
* Fluent in written and spoken English
* Maintains high ethical standards in compliance with Good Clinical Practice (GCP)

Desirable Requirements

* Early clinical development experience
* MAA/NDA/BLA submission experience
* Experience in the Respiratory therapy area
* MSc/PhD in scientific discipline

We would like to know more about you. If you are interested, apply now!
Welcome with your application no later than December 15, 2019. For more information about the position please contact Hiring Manager Mona Thorsén (+46 706 76 0005).

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Are you passionate about Safety, Health and Environment (SHE)? Are you resilient, driven and have the ability to thrive in a challenging fast paced environment? Can you work in periods of ambiguity and change, lead a team and see opportunities for improvement? Can you demonstrate outstanding interpersonal skills coupled with the ability to clearly articulate strategic messages in a compelling and exciting way? These qualities will be the foundation to your success!



At AstraZeneca, we are united by a common purpose: to push the boundaries of science to deliver life-changing medicines. Our purpose is ambitious and so is our approach. Becoming a more agile and creative company means building a dynamic, inspiring culture where we celebrate diverse, bold thinking and act with a sense of urgency. We are courageous, taking risks and learning from both success and failure. We are curious, creative, and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. Join us and be part of an extraordinary place to work; an environment that energizes and empowers each of us to achieve our goal to develop and deliver medicines.



We have an exciting opportunity for a talented Head of SHE to be based in Gothenburg, Sweden.

You will be part of the Facilities Management function within AstraZeneca, leading the provision of SHE expertise to around 2500 people at our R&D site in Gothenburg - across science, office and people to ensure AstraZeneca is a great place to work.



We are looking to recruit someone who will be a catalyst for change, someone that wants to be recognised within the business as a Leader and work across Facilities Management and the Business. Your passion and experience in the following areas will be key:

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You will develop and implement the SHE strategy for the Gothenburg site to enable a safe, sustainable and healthy workplace.
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You will own the development and implementation of the Management System and ensure there is a governance framework to provide assurance to the business in all aspects of SHE.
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You will develop and lead a team of SHE experts across a variety of disciplines who provide guidance and support to the Business to enable AstraZeneca to achieve its strategic objectives.
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You will own the relationship with senior stakeholders within AstraZeneca, and externally where required, and influence key decisions appropriately.
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You will have accountability for the SHE budget and overall performance of the SHE team within Gothenburg Facilities Management.
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On behalf of AstraZeneca, you will lead the interface and relationship with relevant external regulatory bodies to ensure AZ is Licensed to Operate.
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You will provide clear leadership and guidance to your team to ensure people are able to work at their best and ensuring all team members have development discussions which provides the framework for their future success.



To be successful in this role we think the following experience is essential:

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Degree qualified in a science, engineering or manufacturing discipline or equivalent.
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Solid experience in Safety, Health or Environment, at leadership / management level.
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Preferred demonstrable experience in a pharmaceutical / biotechnology environment and in developing safe working processes.
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Familiarity with laboratory processes and ability to communicate in depth with scientists.
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Excellent communication skills and be comfortable supporting stakeholders at all levels.
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Ability to coach, mentor and manage teams.
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Great customer and supplier relationship management.
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An understanding and experience of leading Change Projects and delivering them to time, quality and budget.
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A dynamic approach and comfortable working in an agile environment.
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Comfortable making decisions sometimes with limited information.
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Good understanding and approach to risk management.



Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

For more information about the role, please contact Catharina Dahl, Facilities Director, at

Welcome with your application, no later than November 30, 2019.

Find out more about AstraZeneca Gothenburg: https://www.astrazeneca.com/our-science/gothenburg.html

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This is a unique opportunity for enthusiastic, innovative and motivated Formulation Scientists to join the Early Product Development teams at AstraZeneca's vibrant R&D site in Gothenburg, Sweden. Join us and become a member of a dedicated team, working with drug delivery of challenging drug molecules closely together with other skill experts in our common effort to drive the drug projects forward.



AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discover, develop and deliver innovative medicines and healthcare solutions that enrich the lives of patients.

One vision of our global Pharmaceutical Sciences function is to deliver the therapies of the future through scientific leadership in drug delivery. Our portfolio of projects includes traditional small molecules to nucleotide-based therapies and nanomedicines across AstraZeneca's therapy areas.



Early Product Development in Gothenburg focus on developing inhalation, oral and parenteral products for our drug projects. We have the responsibility to progress the candidate compounds from early pre-clinical phase up to Proof of Concept in humans.



We are now looking for skilled formulation experimentalists who will focus on developing formulations for delivery of small molecules. The role covers development of drug products to be used in both preclinical phase and early clinical phase.



Main Duties and Responsibilities

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Develop and deliver different formulation systems for e.g oral, inhalation and parenteral use, supporting projects in preclinical and clinical phase.
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Collaborate closely with other internal functions and external partners to build our capabilities in drug delivery. Engage customers in development of solutions by applying a broader perspective.
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Will work as a member of cross-functional project teams, with a large degree of independence representing own group and area of expertise.
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Plan and conduct lab-based experimental work in accordance with project timelines.
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Prepare documentation and formal reports in accordance with current standards and where appropriate to GMP. May generate documentation for CMC regulatory submissions.
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Apply science and technical knowledge to drug projects and the evaluation of new technologies and processes. Collaborate with specialist scientific and technology networks. Contribute to scientific projects as needed.



Essential Requirements

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Degree (preferably MSc or PhD) in a discipline relevant to formulation science, pharmaceutical technology, surface & colloid chemistry or equivalent qualifications.
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Experience in working with formulation development or similar product development.
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Genuine interest in experimental work and hands-on problem solving.
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Delivery focused and ability to utilize scientific and innovative thinking.
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Excellent communication and collaboration skills.



Desirable Requirements

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Technical competence in the field of drug product formulation development for inhalation, oral and/or parenteral administration.
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Ability to author scientific publications and/or CMC regulatory documentation.
*

Understanding of suitable quality standards (e.g. GLP and GMP)



If you are interested, apply now!



For more information regarding the role please contact Early Product Development Hiring Manager Anna-Carin Hansson (+46 31 7761247)



Welcome with your application no later than 29 November 2019.

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At AstraZeneca, we work together to deliver innovative medicines to patients across global boundaries. We make an impact and find solutions to challenges. We do this with integrity, even in the most difficult situations, because we are committed to doing the right thing.

We are looking for a Project Leader (Career Level G) or Senior Project Leader (Career Level H) in Respiratory, Inflammation and Autoimmunity (Early RIA). You will be based in our vibrant R&D site in Gothenburg, Sweden or Cambridge, UK - depending on your preference.

In this position you will be driven by science and innovation and the desire to develop novel therapies for patients with primarily respiratory, but also inflammation or autoimmunity diseases.

The Projects Department is a key part of the Early RIA organization where you as Project Leader will lead science, preclinical and drug development strategies for early assets in a cross functional matrix, from Discovery Lead Optimization (LO) up to end of Ph2b clinical evaluations.

You will report to the Head of Projects in Early RIA and be accountable to the Early RIA Leadership Team.



Main Duties and Responsibilities

You will be accountable for the strategy and execution of several pre-clinical and clinical stage drug projects, across all modalities. For each project, you will lead cross-functional experts to build a vibrant and ambitious project team focused on the delivery of a clinical proof of concept and a winning novel therapy.

Bold ambitions are balanced with risk management and you constantly seek to build a strong disease area and scientific understanding within the project team to deliver high quality results, in right time, at right cost. To do this, you seek both internal and external senior influence and encourage risk taking. Your colleagues will count on you to provide feedback and mentoring, and you will be challenged to develop and learn via the project leader community.

Your accountabilities will include:

* Driving project strategy and scientific rigor in alignment with disease area and portfolio strategy
* Development of Target Product Profiles for early space assets
* Effective project communication
* Project resourcing and budget
* Initiation and fostering of external collaborations to improve the project portfolio
* Development and mentoring of key talent
* Collaboration with peer project leaders to continuously improve best practice with the aim of building outstanding project leadership



Essential Requirements

We believe that you are an experienced Project Leader with strong integrity and leadership capabilities. You have a scientific background supplemented by a PhD. You possess great stakeholder management skills and you are a natural communicator - promoting innovation and entrepreneurial thinking.

You have:

* Advanced degree in Life Sciences, a PhD degree preferred
* Proven Leadership from cross-functional and cross-cultural environment
* Relevant Drug project experience
* Excellent communication skills



We would like to know more about you. If you are interested, apply now!

Welcome with your application no later than November 30, 2019. For more information about the position please contact Anna Malmgren at

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Are you a medical doctor with passion for science? Would you like to apply your expertise to impact exciting science into life changing medicines? Then AstraZeneca might be of interest to you!



Patient Safety at AstraZeneca is now looking for Safety Physicians to join our Cardiovascular, Renal and Metabolism (CVRM) team in Gothenburg, Sweden. We are offering opportunities at different levels (e.g. Safety Physicians, Senior Safety Physicians and Principal Safety Physicians) depending on your expertise and previous experience.



The core purpose of AstraZeneca Patient Safety is to add value to AstraZeneca products and safeguard investigators, prescribers and patients as well as the success of our business. Patient Safety covers the entire clinical life cycle of a drug from first time into man to withdrawal of a product from the market.



What's in it for you? You will get the opportunity to engage with key internal and external stakeholders to provide scientific leadership and channeling our scientific capabilities to make a positive impact on changing patients' lives. You will get a broad global exposure to other functions involved in the R&D process within AstraZeneca, as well as an overview of how strategic direction is set within the Clinical function and how decisions are made during drug development. Your work will be integrated with cross-functional teams in Clinical Development using your expertise to put a wide variety of issues into a clinical context to make informed decisions.



Who are you? We think that you who will accept the challenge has a Medical Degree, experience from clinical practice and preferably also experience from pharmaceutical industry R&D work. PhD degree is meriting. You have a broad understanding about Health Authority regulations and Good Clinical Practice Standards and if you have experience from working with safety evaluation and risk management - that's great! At AstraZeneca you will fit right in if you thrive on team work, networking, communication and the ability to influence both people and science.



Would you like some more details about the role before applying? You will be responsible for providing medical expertise regarding the safety profile of their product(s) and its disease area while representing the patient and Health Authority perspective. This involves working closely together with global colleagues both from within the Patient Safety Department as well as other groups in AZ. Your key tasks will include using medical judgment to understand case histories, reviewing safety data in various formats to determine any findings of potential importance, helping identify, communicate and manage safety risks and providing a Patient Safety position in meetings and documents.



This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.



We would like to know more about you. If you are interested, apply now!



For more information about the position please contact Kristina Johnsson at Kristina.



We encourage you to send your application as soon as possible, since interviews will be held continuously, but no later than December 6, 2019.

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Welcome to join the Discovery Sciences organization, working within a vibrant scientific environment to support drug discovery. We are seeking an Associate Director to lead our Cell Assay Development team with the position based at AstraZeneca in Gothenburg. In this role you will continue to develop and maintain a high level of scientific and operational knowledge, building on your specialist expertise in specific areas of BioMedical research.

You will lead a team of cell scientists; whose remit is to use cutting edge technologies to deliver cellular assays generation to support pipeline projects. Your skills will include the ability to develop and maximize individual talents, create a high-performing team and build trusting relationships with scientific colleagues. These colleagues will be on site, in the global AZ R&D network and external collaborations. You will make an active contribution to the development of the global Discovery Biology management function through leadership of multi-disciplinary initiatives that deliver value and impact to drug discovery projects.

The Discovery Biology department of Discovery Sciences are responsible for the generation of novel reagents and assays to support projects in all phases of the drug discovery pipeline, from target discovery all the way to clinical candidate. The focus of the Discovery Biology Sweden (DB SE) Department is to support the cardiovascular and metabolic diseases (CVMD) and respiratory, inflammation and auto-immunity (RIA) disease areas.


Accountabilities and Responsibilities:

* Drug Discovery project leadership especially in a matrixed environment
* Develop the scientific strategy of the team & cell assay development discipline across Discovery Biology Department
* Translate and implement Departmental strategy for Cell Assay Development team.
* Work as part of DB Sweden Leadership Team to deliver Discovery Biology Sweden Departmental and team objectives
* Ensure team compliance with local and global company policies
* Sets and maintains professional standards in discipline and influences across functions in projects or strategy


Essential requirements:

You have a Ph.D. degree or corresponding experience in a relevant scientific discipline with several years of relevant experience in drug discovery and/or early development or in a leading academic institution. As well as;

* Recognised assay development expertise
* Experience and high skills in leading teams of highly qualified personnel
* Great knowledge of drug discovery
* A proven record of delivery of complex projects


Desired requirements:

* Knowledge of AstraZeneca business desired
* Managerial expertise desired especially in global, matrixed teams
* Can identify and evaluate external opportunities and threats and influence strategy accordingly
* Recognised in a specialist field nationally/internationally

We welcome your application no later than close of business on the 30th November 2019.

More information
For more information about the position please contact: Rob Howes at +46 (0)70 375 7182 or

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/

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Senior Bioinformatician with Transcriptomics expertise

Would you like to apply bioinformatics and computational solutions to help us evolve our Next Generation Sequencing (NGS) analytics? Are you a dedicated Bioinformatician with an analytical mindset? If so, we welcome you to join us in our journey to develop and deliver novel software solutions, in support of finding new medicines.

At AstraZeneca, we are currently investing in a broad range of multi-omics capabilities (e.g. transcriptomics, epigenomics, proteomics) and want you to join our multi-disciplinary Quantitative Biology team in Gothenburg as a passionate Bioinformatics Scientist - where you will play a key role in supporting, driving and developing multi-omics capabilities and projects.

Our focus is to provide insights into human biology and facilitate discovery of new therapeutics by improving the biological understanding of the target and its engagement. This includes supporting the identification of novel molecular mechanisms of action by providing data analysis solutions to high dimensional datasets. We also drive improvement of the company's ability to prioritize target selection and portfolio projects based on probability of technical success.

Main Duties and Responsibilities

Your main focus will be to:

* Develop software enablements for NGS transcriptomics data processing, analysis toolkits and pipelines, including development or internalization of algorithms and techniques
* Impact, prototype and build local and global data management processes and solutions for capturing and exploiting NGS transcriptomics and other high-dimensional omics data types
* Design and deliver robust and impactful transcriptomics studies via processing, analysis and interpretation of data.
* Ensure scientific excellence in software, processes and results in an efficient and well documented mode


Essential Requirements

You are a skilled Bioinformatician with a proven track record of delivering analytical solutions for business or academic needs. Your ability to convert details into holistic information by collaborating with colleagues as well as customers will be of great importance.

We expect you to have:

* PhD in Bioinformatics, Mathematical Statistics, Computer Science or another quantitative discipline
* Demonstrable experience in data analysis, management and visualization in several of the following core areas: RNA and DNA based NGS, multivariate and/or high dimensional omics integration, single-cell transcriptomics, epigenomics, metagenomics
* Proficiency and deep understanding of modern RNA-seq methodology (Star, Kallisto, Salmon, DESeq2 etc.)
* Fluency in R, Bioconductor, RMarkdown and related tools
* Proficiency in either Python (Pandas and NumPy stack) or a lower level programming language (C++, Java, etc.)
* Proficiency in working in a Linux environment, experience with shell scripting and standard command line tools

Desirable Requirements

* Basic understanding of molecular biology, cell biology and human physiology
* Experience with git, conda and tools such as Snakemake or Nextflow
* Experience in non-NGS transcriptomics technologies

If this sounds like the job and place for you to make a change - apply now!

Welcome with your application no later than 8th of December, 2019.

For more information about the position please contact Hiring Manager, Petr Volkov at +46 31 776 14 78 or

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Are you ready for the next step in your career? Would you like to apply your experience in scientific communications or project management in a truly meaningful setting? If you're confident to lead, willing to collaborate and curious about what science can do, then you're our kind of person.

Early RIA is a global department with a focus on research and development of Respiratory medicines. Our ambitious aim is bold - we seek to achieve early intervention, durable remission and disease modification in areas of unmet need and increasing prevalence. We are a global team with diverse backgrounds, and you can be based in Gothenburg, Sweden or Cambridge, UK.



Main duties and responsibilities

In this role, you will be responsible for supporting the management of publications projects and processes. You will work in close collaboration with the Publications Lead and other partners to make sure that scientific presentations and manuscripts are delivered and published according to the strategy.



Your responsibilities will include:

* Maintaining and supporting the delivery of publication strategies for Early RIA in collaboration with the Publications Lead, Project Team Leader, and vendors
* Management and oversight of vendors, including providing templates, checklists and other training material to ensure quality and consistency
* Maintain financial contracts and and track budgets, purchase orders, and invoices within the internal financial management system
* Attend publication meetings and workshops, as appropriate to understand timelines, and supports the Publication Lead with deliverables



Essential Requirements

* BSc in science, health, communications or equivalent work experience
* Familiarity with Scientific or Medical terminology and the scientific publication process
* Proven ability to actively and independently drive projects forward from conception to completion in a fast-paced environment
* Excellent interpersonal skills
* Proficiency in relevant software, such as Microsoft Office



Desirable Requirements

* Experience in project management and budget management
* Experience in publications management systems (e.g. Datavision or equivalent)
* Familiarity with Good Publications Practice
* Relevant pharmaceutical/biotechnology industry/communications experience preferred



We would like to know more about you. If you are interested, apply now!

Welcome with your application no later than November 24, 2019. For more information about the position please contact Claire Landqvist at



AZRespi #GMD

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Do you have experience in clinical study management and would like a role where your expertise, as well as your leadership skills, will be highly appreciated? Are you team oriented and do you, as we do, put patients first in your work to make a difference? Then AstraZeneca might be the right place for you to contribute and thrive.

We are recruiting for a Study Management Associate (SMA), who will join our BioPharmaceuticals R&D Study Management Early team - as a part within the Development Operations function. The position will be based on one of our vibrant R&D sites in Gothenburg, Sweden; Cambridge, UK or Gaithersburg, US.

In the position as Study Management Associate (SMA), you will support the delivery of global early clinical studies from study set-up through maintenance, close-out and study archiving. It is a role where you work cross-functionally with internal and external partners to lead and deliver aspects of the clinical study according to applicable trial regulations (ex ICH-GCP), AstraZeneca Standard Operating Procedures (SOPs), and in line with AstraZeneca's policies and values.

BioPharmaceuticals Study Management Early, are accountable for delivering high quality, cost efficient early phase clinical studies (phase 1 to phase 2b) that support drug development within CVRM, RIA and Infectious Disease.

Responsibilities in the role:

In the position as Study Management Associate (SMA), you will play a key role in the study team and assist the study leader to fulfil their accountabilities through coordinating activities that ensures quality, consistency and integration of study data. You will maintain and facilitate interactions with both internal & external functions to provide oversight and ensure efficient study delivery to time, costs and quality objectives, in both internally-run and outsourced studies. The exact accountabilities will differ depending on the exact nature of the clinical program so a high degree of flexibility is required.

The responsibilities will also include:

* Support the Study leader in project management as per agreed delegation.
* Lead to the preparation of delegated study documents (e.g. Informed Consent Form, applicable study plans, etc.), and external service provider-related documents such as specifications, study specific procedures, contracts etc.
* Ensure adequate supply of study materials by liaising with Clinical Supply Chain or external service providers as appropriate.
* Proactively contribute to risk and issue identification, identification of critical to quality factors, development of mitigation and/or action plans for identified risks and issues.
* Adhere to AZ SOPs, global process, applicable Quality & Compliance manual documents and international guidelines (e.g. ICH-GCP) to ensure study is inspection ready at all times.
* Take on assignments on non-drug project work in process improvements and/or leading improvement projects as discussed and agreed upon with their line manager.

To succeed in the role, we also believe that you are team oriented and have ability to prioritize appropriately and manage multiple deliverables. We would like you to have demonstrated leadership skills and hope that you enjoy managing change and actively seek and champion more efficient and effective processes. You work independently and have good communication, collaboration and interpersonal skills.

Essential Requirements:

* University degree (or equivalent educational/work experience), preferably in medical or biological sciences or discipline associated with clinical research.
* Experience from pharmaceutical industry and/or clinical trial experience.
* Good understanding of the drug development process, study management, drug handling and data management as well as deep understanding of ICH-GCP, relevant regulatory/ethics requirements and clinical/drug development.
* Proven organizational, time management and analytical skills; demonstrate very high quality in English, both in written & verbal communication.

Desirable Requirements:

* Working experience from early clinical studies
* Knowledge about our therapeutic areas (CVRM and/or RIA)
* Experience from independently leading workstreams within clinical studies
* Experience from working with third-party vendors from set-up through maintenance to closure

If this sound like the challenge for you, we look forward taking part of your application no later than November 24th, 2019.

For more information about the position please contact Hiring Manager, Lisa Harlin (Associate Director Study Operations) at

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At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.


Pharmaceutical Technology and Development (PT&D) is the bridge that turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices for new medicines and providing expert technical support to all AZ's commercial drug substances and products to ensure we successfully supply medicines to patients.



We are now looking to hire a Senior Project Leader or Project Leader, depending on your background, to join our Chemistry Manufacturing and Controls (CMC) Team within PT&D.

As a Senior CMC Project Leader/CMC Project Leader you are accountable for the development of robust CMC project strategies and efficient delivery of one or several R&D development projects (typically from Ph2b) and/or commercial products where the focus is maximizing the Brand Value. You will be accountable for the CMC contribution when taking projects and portfolio through key business investment decision points, transfer to Operations and CMC related contributions to LCM (Life cycle management).

In this role you will primarily lead projects in the Biopharmaceutical Therapeutic Area (Respiratory, Inflammatory, Autoimmunity (RIA) and Cardiovascular, Renal, Metabolism (CVRM)) but may also be involved in other TA projects (e.g. Oncology).

You will represent PT&D and be a member of the Global Project Team (GPT), working collaboratively in a cross-functional and international environment to influence the development of AZ's development and commercial drug portfolio. You will be representing PT&D when projects interact with key governance bodies (ESPC, LSPC etc) and is expected to consistently demonstrate excellent communication skills and influence with stakeholders in these forums in a way that creates value for AZ. You will also lead the Pharmaceutical Project Team, with representatives from technical functions mainly but not exclusively from PT&D.

Accountabilities include delivering all the CMC related activities associated with Development of New Product (e.g. overall development and technical strategy, clinical trials applications), Business development activities (e.g. divestments, partnering, in-licensing) as well as Life Cycle Management for Commercial Products (e.g. new Clinical studies, filing in new markets, new formulations or devices, Cost of Goods reductions). The role involves a diverse range of problems/opportunities requiring complex judgements and solutions based on highly developed levels of conceptual thought and strategic vision and analysis.



Education, Experience and Capabilities

* Scientific degree (or equivalent) and a good working knowledge of a CMC organisation.
* Global drug development and clinical/commercial supply chain experience with business enterprise mindset and ideally good knowledge of the broader business especially development, commercialization, post-launch technical support and lifecycle management
* A good working knowledge of project leadership approaches within the pharmaceutical industry and experience from working with projects from phase II through commercialisation and LCM. Preferably will have experience from other areas than CMC.
* Understanding of at least one AZ disease area preferably RIA and/or CVRM.
* Track record of Ability to identify and progress innovative approaches, constructively challenging the status quo to achieve best outcome for the project/brand and AZ
* Understanding of Regulatory requirements, the evolving landscape and the constraints/opportunities this presents
* Experience of cost management (resources and $) of larger scale projects.
* Strong credible leadership with enterprise mindset.
* Learning agility, networking & negotiation skills and collaborative approach.
* Excellent interpersonal, influencing and communication skills with ability to set clear direction and objectives for the team and to influence at a senior level in the organisation including Governance groups (GPT/ESPC/LSPC/TALT/Supply Committee and beyond)
* Capable of managing the responsibilities for a diverse range of activities and projects acting as the key sponsor for projects and programmes supporting their project/product portfolio.
* Possess strength and independence of viewpoint and be willing to challenge others in senior roles when appropriate
* Ability to develop & implement end-to-end Pharmaceutical strategy across all CMC areas (API, DP, etc.) aligned with the overall GPT strategy and clinical/commercial supply



This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.



For more information contact Petra Edwards, Head of Project Leadership, PT&D at



Welcome with your application, no later than November 20, 2019 Visa mindre